Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma.
In conclusion, the present study revealed that LINC00982 and PRDM16 may serve as biomarkers or potential drug targets for the diagnosis and therapy of LUAD. PMID: 30132554 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tumor associated macrophages induce epithelial to mesenchymal transition via the EGFR/ERK1/2 pathway in head and neck squamous cell carcinoma.
Authors: Gao L, Zhang W, Zhong WQ, Liu ZJ, Li HM, Yu ZL, Zhao YF Abstract The development of head and neck squamous cell carcinoma (HNSCC) is closely associated with inflammation. Tumor associated macrophages (TAMs), the largest population of inflammatory cells in the tumor stroma, serve an important role in accelerating cancer progression. The present study aimed to investigate the role of TAMs in the metastasis of HNSCC. TAM biomarkers and epithelial to mesenchymal transition (EMT)‑associated proteins were detected using immunohistochemical and immunofluorescence staining in HNSCC. Then, direct and indirect coâ...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Regulatory mechanism of fatty acid ‑CoA metabolic enzymes under endoplasmic reticulum stress in lung cancer.
Regulatory mechanism of fatty acid‑CoA metabolic enzymes under endoplasmic reticulum stress in lung cancer. Oncol Rep. 2018 Aug 21;: Authors: Liu KT, Yeh IJ, Chou SK, Yen MC, Kuo PL Abstract The endoplasmic reticulum (ER) is an organelle involved in various physiological processes such as lipid metabolism, protein synthesis and folding, and cellular calcium storage. In a physiological tumor microenvironment, hypoxia, nutrient deprivation, and calcium dysregulation cause accumulation of unfolded and misfolded proteins. Such accumulation induces ER stress and unfolded protein responses (UPRs). Increase...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

B7 ‑H3 promotes malignant progression of muscle‑invasive bladder cancer.
The objective of the present study was to investigate the expression of B7 homologue 3 (B7‑H3) in muscle‑invasive bladder cancer (MIBC) tissues, evaluate its correlation with patient clinicopathological characteristics, and to explore the effect of B7‑H3 on MIBC cells. B7‑H3 expression levels in tumor tissues from 115 patients undergoing radical cystectomy for MIBC were detected by immunohistochemical staining, followed by analysis of the association with clinicopathological characteristics and survival. A B7‑H3‑silenced cell line was established by RNA interference (RNAi). Alterations in cell prolife...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Profile and validation of dysregulated long non ‑coding RNAs and mRNAs in ovarian cancer.
In conclusion, dysregulated lncRNA and mRNA expression could promote OC development. Further study may validate a number as OC markers and provide novel insights into ovarian cancer biology. PMID: 30132558 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Antitumor activity of the plant extract morin in tongue squamous cell carcinoma cells.
In conclusion, the data from the present study demonstrated that morin produces anti‑TSCC activity in vitro through activation of the Hippo signaling pathway and the downstream suppression of YAP activity in TSCC cells. Future studies should assess the clinical antitumor effects of morin. PMID: 30132559 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Human umbilical vein endothelial cell vaccine suppresses the angiogenesis of esophageal squamous cell carcinoma in a humanized mouse model.
In conclusion, the present study demonstrated the anti‑angiogenic effect of the HUVEC vaccine on ESCC in a humanized mouse model, and set an experimental foundation for the application of the HUVEC vaccine in ESCC patients. PMID: 30132560 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Lactate dehydrogenase is correlated with clinical stage and grade and is downregulated by si ‑STAB1 in ovarian cancer.
Lactate dehydrogenase is correlated with clinical stage and grade and is downregulated by si‑STAB1 in ovarian cancer. Oncol Rep. 2018 Aug 17;: Authors: Xiang J, Zhou L, Zhuang Y, Zhang J, Sun Y, Li S, Zhang Z, Zhang G, He Y Abstract Lactate, which is regulated by gene expression, is largely believed to favor tumor growth and survival. Elevated lactate dehydrogenase (LDH) is a negative prognostic biomarker because it is a key enzyme involved in cancer metabolism. Our previous study revealed that special AT‑rich‑binding protein 1 (SATB1), a genome‑organizing protein, was strongly associated ...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma.
Authors: Sumita Y, Yamazaki M, Maruyama S, Abé T, Cheng J, Takagi R, Tanuma JI Abstract Transcription factor SRY‑box 9 (SOX9) is a key regulator of chondrocyte differentiation and sex determination, and it is also involved in the progression of various types of human cancer. However, its putative association with oral squamous cell carcinoma (OSCC) remains elusive. The aim of the present study was to investigate the expression profiles of SOX9 in various oral epithelial lesions, including OSCC. We performed immunohistochemical analysis of SOX9 expression in surgical specimens of OSCC, which simultaneo...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Serum ‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2.
Serum‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2. Oncol Rep. 2018 Aug 17;: Authors: Wu J, Shang AQ, Chen C, Wang WW, Xiong CQ, Guo NZ Abstract The aim of the present study was to investigate the mechanisms and protective effect of serum‑free‑medium‑type fetal placental mesenchymal stem cell (fPMSC) culture supernatant on A549 lung epithelial cells following treatment with hydrogen peroxide (H2O2). A549 lung epithelial cells were stimulated with different concentrations of H2O2,...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

C ‑C chemokine receptor type 2 promotes epithelial‑to‑mesenchymal transition by upregulating matrix metalloproteinase‑2 in human liver cancer.
C‑C chemokine receptor type 2 promotes epithelial‑to‑mesenchymal transition by upregulating matrix metalloproteinase‑2 in human liver cancer. Oncol Rep. 2018 Aug 17;: Authors: Li H, Li H, Li XP, Zou H, Liu L, Liu W, Duan T Abstract C‑C chemokine receptor type 2 (CCR2) is aberrantly expressed in a variety of tumor cells, and participates in the regulation of tumor cell progression, metastasis and immune escape. However, the mechanism of action of CCR2 in liver cancer remains unclear. In the present study, the aim was to elucidate the molecular mechanism underlying the regulation of e...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

microRNA ‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis.
microRNA‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis. Oncol Rep. 2018 Aug 17;: Authors: Pan X, Li Z, Zhao L, Quan J, Zhou L, Xu J, Xu W, Guan X, Li H, Yang S, Gui Y, Lai Y Abstract Renal cell carcinoma (RCC) is the third most common urological malignancy in the USA and represents 2‑3% of all adult malignancies. Furthermore, the incidence of RCC has been progressively increasing over recent years. Although the morbidity of treatment has decreased with the use of multidisciplinary synthetic therapy, the prognosis of terminal cancer remains poor, with a 5â...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of POLE2 expression suppresses lung adenocarcinoma cell malignant phenotypes in  vitro.
Knockdown of POLE2 expression suppresses lung adenocarcinoma cell malignant phenotypes in vitro. Oncol Rep. 2018 Aug 17;: Authors: Li J, Wang J, Yu J, Zhao Y, Dong Y, Fan Y, Li N, Zhang Y, Wang Y Abstract In the present study, we profiled β‑elemene‑regulated gene expression and investigated the effects of the silencing of the DNA polymerase epsilon 2, accessory subunit (POLE2) in lung cancer cells. Differently expressed genes were profiled in A549 cells incubated in the presence or absence of β‑elemene by Affymetrix Human Gene Expression Array. POLE2 shRNA was then constructed...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HOXA10 ‑AS: A novel oncogenic long non‑coding RNA in glioma.
HOXA10‑AS: A novel oncogenic long non‑coding RNA in glioma. Oncol Rep. 2018 Aug 21;: Authors: Dong CY, Cui J, Li DH, Li Q, Hong XY Abstract Glioma is the most common primary malignant tumor of the central nervous system. Emerging evidence has demonstrated that long non‑coding RNAs (lncRNAs) serve a major role of regulation in various types of human cancer, including glioma. However, the biological roles of thousands of lncRNAs remain unknown and require further identification. The present study investigated the functional role of lncRNA‑HOXA10‑AS in glioma. The present study examined the expr...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Clinical relevance of the multidrug resistance ‑associated protein 1 gene in non‑small cell lung cancer: A systematic review and meta‑analysis.
In conclusion, the findings from this study suggest that increase in MRP1 gene expression is associated with being a non‑smoker, adenocarcinoma, advanced clinical stages and a poor response to chemotherapy in patients with NSCLC. The results from the most extensive and updated data on MRP1 support the requirement for continued investigation into the potential use of MRP1 as a biomarker/clinical indicator for NSCLC. PMID: 30132569 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of miR ‑21 promotes cell apoptosis in oral squamous cell carcinoma by upregulating PTEN.
Inhibition of miR‑21 promotes cell apoptosis in oral squamous cell carcinoma by upregulating PTEN. Oncol Rep. 2018 Aug 21;: Authors: Zheng Y, Xie J, Jiang F, Li Y, Chang G, Ma H Abstract MicroRNA‑21 (miR‑21) has been identified as an oncogene and confirmed to serve an important role in carcinogenesis in various types of cancer. However, the effect and mechanism of miR‑21 in oral squamous cell carcinoma (OSCC) has not been fully elucidated. In the present study, miR‑21 inhibitor and empty vector were transfected into OSCC cells, and non‑transfected cells were used as a blank control. The res...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non-coding RNA MYU promotes prostate cancer proliferation by mediating the miR-184/c-Myc axis.
Authors: Wang J, Yang X, Li R, Wang L, Gu Y, Zhao Y, Huang KH, Cheng T, Yuan Y, Gao S Abstract Long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and cancer progression. The c-Myc upregulated lncRNA MYU (VPS9D1 antisense RNA1, annotated as VPS9D1-AS1) has been reported in several common types of human cancers, which has revealed that lncRNA MYU could function as either an oncogene or a tumor-suppressor gene in different cancer types. However, the function of lncRNA MYU in prostate cancer remains unknown. In the present study, we demonstrated that lncRNA MYU is significantly upregulated in prostate ...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑20b negatively regulates VEGF expression by targeting STAT3 in H22 hepatocellular carcinoma cells.
miR‑20b negatively regulates VEGF expression by targeting STAT3 in H22 hepatocellular carcinoma cells. Oncol Rep. 2018 Aug 17;: Authors: Luo Y, He J, Tao X, Wang H, Fang Q, Guo S, Song C Abstract Vascular endothelial growth factor (VEGF) promotes angiogenesis during tumor growth, and its expression involves multiple signaling pathways and transcription factors. In the present study, transforming growth factor (TGF)‑β1 promoted upregulation of VEGF and downregulation of microRNA (miR)‑20b expression in mouse H22 hepatocellular carcinoma cells. miR‑20b negatively regulated both constitutive ...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3.
miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3. Oncol Rep. 2018 Aug 10;: Authors: Zhou N, Sun Z, Li N, Ge Y, Zhou J, Han Q, Zhao L, Bai C Abstract The incidence and mortality of colorectal cancer (CRC) have been rising rapidly in China. A number of miRNAs have been confirmed to be involved in diverse biological processes of CRC. However, whether miR‑197 plays a role in migration and invasion of CRC has never been explored. In the present study Transwell chambers were used in in vitro migration and invasion ass...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CIP2A depletion potentiates the chemosensitivity of cisplatin by inducing increased apoptosis in bladder cancer cells.
Authors: Gao F, Wang X, Chen S, Xu T, Wang X, Shen Y, Dong F, Zhong S, Shen Z Abstract Poor response and chemotherapy resistance to cisplatin (DDP)‑based therapy frequently lead to treatment failure in advanced bladder cancer; however the underlying mechanism is extremely complex and unclear. Furthermore, cancerous inhibitor of protein phosphatase 2A (CIP2A), a recently identified human oncoprotein, has been shown to play important regulatory roles in cancer cell survival. The present study aimed to investigate the correlation of CIP2A with sensitivity to DDP in bladder cancer cells. In the present study, knockdo...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cryptotanshinone inhibits cellular proliferation of human lung cancer cells through downregulation ofIGF-1R/PI3K/Akt signaling pathway.
In conclusion, the results of the present study indicated that CPT inhibits the proliferation and migration of lung cancer cells via a mechanism that involves inhibiting the IGF-1R-mediated phosphoinositide 3-kinase/Akt signaling pathway. The data provides evidence that CPT could be developed as a potential therapeutic agent for the treatment of lung cancer. PMID: 30106122 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Risk assessment model constructed by differentially expressed lncRNAs for the prognosis of glioma.
Authors: Hu C, Zhou Y, Liu C, Kang Y Abstract A risk assessment model was constructed using differentially expressed long non‑coding (lnc)RNAs for the prognosis of glioma. Transcriptome sequencing of the lncRNAs and mRNAs from glioma samples were obtained from the TCGA database. The samples were divided into bad and good prognosis groups based on survival time, then differently expressed lncRNAs between these two groups were screened using DEseq and edgeR packages. Multivariate Cox regression analysis was performed to establish a risk assessment system according to the weighted regression coefficient of lncRNA ex...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑342‑3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42.
MicroRNA‑342‑3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42. Oncol Rep. 2018 Aug 10;: Authors: Shi L, Xiao R, Wang M, Zhang M, Weng N, Zhao X, Zheng XFS, Wang H, Mai S Abstract Deregulated microRNAs play an important role in the development and progression of various types of cancer. In our previous study, we observed that microRNA‑342‑3p (miR‑342‑3p) was one of the most markedly downregulated microRNAs in two nasopharyngeal carcinoma (NPC) cell lines compared to non‑neoplastic cells by using whole genome small RNA sequencing. In the...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect and mechanisms of celastrol on the apoptosis of HOS osteosarcoma cells.
Authors: Chen Y, Ou Y, Tao Y, Liu H, Yin H, Zhong S, Yu H, Zhao Z, He B Abstract Osteosarcoma is the most common primary malignant tumor of the bone found predominantly in children and teenagers and results in early metastasis and poor prognosis. The present study primarily focused on the impact of celastrol on apoptosis and autophagy of osteosarcoma HOS cells, as well as the related mechanisms. Following the appropriate treatment, the human osteosarcoma cell line HOS was assessed for viability, Ca2+ in cells, apoptosis and changes in cell morphology using Cell Counting Kit-8, flow cytometry, inverted phase contras...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Impact of RNA ‑binding motif 3 expression on the whole transcriptome of prostate cancer cells: An RNA sequencing study.
Impact of RNA‑binding motif 3 expression on the whole transcriptome of prostate cancer cells: An RNA sequencing study. Oncol Rep. 2018 Aug 01;: Authors: Dong Q, Lv C, Zhang G, Yu Z, Kong C, Fu C, Zeng Y Abstract RNA‑binding motif 3 (RBM3) is a cold‑shock protein that has been previously shown to attenuate cancer stem cell‑like features in prostate cancer (PCa) cells. However, the mechanism underlying RBM3 regulation in PCa cells is largely unknown. The present study investigated the impact of RBM3 expression on the whole transcriptome of PCa cells using high‑throughput RNA sequencing (RNA‑s...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

α7‑nAchR agonist GTS‑21 reduces radiation‑induced lung injury.
α7‑nAchR agonist GTS‑21 reduces radiation‑induced lung injury. Oncol Rep. 2018 Aug 01;: Authors: Mei Z, Tian X, Chen J, Wang Y, Yao Y, Li X, Yang C, Zhang S, Xie C Abstract Radiation‑induced lung injury (RILI) is a major complication of thoracic radiotherapy that starts as exudative inïŹ‚ammation and proceeds to lung ïŹbrosis, and additional studies are required to develop methods to ameliorate RILI. The aim of this study was to explore whether the nicotinic acetylcholine receptor subtype‑7 (α7‑nAChR) agonist GTS‑21 has a protective effect against RILI. C57BL6 mice were irrad...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Netrin ‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation.
Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation. Oncol Rep. 2018 Aug 01;: Authors: Yin K, Shang M, Dang S, Wang L, Xia Y, Cui L, Fan X, Qu J, Chen J, Xu Z Abstract Netrin‑1 (NTN1) has been demonstrated to promote tumorigenesis in multiple types of cancer; however, its role in the growth of gastric cancer (GC) cells has not been described in detail. In the present study, the data suggested that NTN1 knockdown significantly decreased the proliferation of GC cells, whereas NTN1 overexpression had an opposing effect. Furthermore, the use ...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of the potential molecular mechanism and driving mutations in the pathogenesis of familial intestinal gastric cancer by whole exome sequencing.
Authors: Chen H, Wang J, Zhuang Y, Wu H Abstract The genetic alterations in familial intestinal gastric cancer (FIGC) have not been clearly understood. Aiming to explore the molecular basis and the driving mutations underlying the pathogenesis of FIGC, we performed exome sequencing of the blood samples of the members of an extended family with FIGC. The differences in mutation patterns between family members with gastric cancer and controls were analysed and the overlapped variants were screened by comparing previously published data for blood and tumours from gastric cancer patients. The overlapped genes harb...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Staurosporine alleviates cisplatin chemoresistance in human cancer cell models by suppressing the induction of SQSTM1/p62.
Authors: Alsamman K, El-Masry OS Abstract Cancer is one of the leading causes of mortality worldwide. Platinum‑based chemotherapeutic agents such as cisplatin are the first line of treatment for many types of cancers. However, the development of cisplatin resistance after prolonged treatment is a common cause of cancer recurrence. In the present study, we investigated an approach designed to overcome resistance to cisplatin involving co‑treatment with a second chemotherapeutic agent, staurosporine, and examined the role of sequestosome 1 (SQSTM1/p62) in enhancing cellular sensitivity to cisplatin. We utili...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sonodynamic therapy improves anti ‑tumor immune effect by increasing the infiltration of CD8+ T cells and altering tumor blood vessels in murine B16F10 melanoma xenograft.
Sonodynamic therapy improves anti‑tumor immune effect by increasing the infiltration of CD8+ T cells and altering tumor blood vessels in murine B16F10 melanoma xenograft. Oncol Rep. 2018 Aug 01;: Authors: Peng Y, Jia L, Wang S, Cao W, Zheng J Abstract Sonodynamic therapy (SDT) uses a combination of sonosensitizers and low‑intensity therapeutic ultrasound to destroy tumor cells. However, its effects on the tumor microenvironment, particularly on the immune state, remain unknown. The purpose of the present study was to examine the capacity and potency of the antitumor immunity induced by SDT. In the ...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Decreasing O-GlcNAcylation affects the malignant transformation of MCF-7 cells via Hsp27 expression and its O-GlcNAc modification.
Authors: Netsirisawan P, Chaiyawat P, Chokchaichamnankit D, Lirdprapamongkol K, Srisomsap C, Svasti J, Champattanachai V Abstract O-GlcNAcylation is a dynamic posttranslational modification of nucleoplasmic proteins. Previously, we reported that the O-GlcNAcylation level was increased in primary breast and colorectal cancer tissues. However, its precise roles in cancer development and progression are still largely unexplored. The aim of the present study was to investigate the roles of O-GlcNAcylation in the malignant transformation of cancer cell lines. O-GlcNAcylation level was examined in six cancer cell lines i...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Transcriptome-wide analysis of alternative mRNA splicing signature in the diagnosis and prognosis of stomach adenocarcinoma.
This study provides a comprehensive portrait of global changes in mRNA splicing signatures that occur in gastric cancer. These results allowed the identification of a core set of AS in gastric cancer and indicated that AS events may serve as prognostic indicators. PMID: 30106437 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase ‑dependent pathway.
Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase‑dependent pathway. Oncol Rep. 2018 Aug 02;: Authors: Dong X, Ni B, Fu J, Yin X, You L, Leng X, Liang X, Ni J Abstract Emodin‑induced hepatotoxicity in vivo and in vitro has been gaining increasing attention. However, the exact molecular pathways underlying these effects remain poorly clarified. The aim of the present study was to evaluate the cytotoxic effect of emodin on HepaRG cells and to define the underlying mechanism. The results demonstrated that emodin evidently inhibited HepaRG c...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Zinc enhances chemosensitivity to paclitaxel in PC ‑3 prostate cancer cells.
Zinc enhances chemosensitivity to paclitaxel in PC‑3 prostate cancer cells. Oncol Rep. 2018 Aug 02;: Authors: Zhang P, Li Y, Tang X, Guo R, Li J, Chen YY, Guo H, Su J, Sun L, Liu Y Abstract Paclitaxel‑based chemotherapy is a promising approach for prostate cancer treatment. However, single‑drug chemotherapy is associated with an increased risk of drug resistance. Therefore, novel combination chemotherapy regimens are a popular topic of research. Zinc participates in the regulation of apoptosis, for example in the form of Zn2+ and via zinc‑dependent enzymes. Zinc can either induce or suppress ap...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SET7/9 promotes hepatocellular carcinoma progression through regulation of E2F1.
In conclusion, the present study revealed an oncogenic function of SET7/9 in HCC and demonstrated that SET7/9 may be responsible for alterations in the proliferative ability, aggressiveness and invasive/metastatic potential of HCC cells through post‑translational regulation of E2F1. PMID: 30106440 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Farnesoid X receptor inhibits proliferation of human colorectal cancer cells via the miR ‑135A1/CCNG2 signaling pathway.
In conclusion, activation of FXR by GW4064 suppresses cell proliferation and causes cell cycle arrest in CRC, and the miR‑135A1/CCNG2 pathway was suggested to be involved in this step. PMID: 30106441 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑874 is downregulated in cervical cancer and inhibits cancer progression by directly targeting ETS1.
MicroRNA‑874 is downregulated in cervical cancer and inhibits cancer progression by directly targeting ETS1. Oncol Rep. 2018 Aug 02;: Authors: Liao H, Pan Y, Pan Y, Shen J, Qi Q, Zhong L, Han W, Wang Q, Jiang Y Abstract An increasing number of studies have reported that microRNAs (miRNAs) are dysregulated in cervical cancer and serve critical roles in cervical oncogenesis and progression. Therefore, identifying the aberrantly expressed miRNAs implicated in the formation and progression of cervical cancer may provide key clues for the development of effective therapeutic targets in treating patients w...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Higenamine enhances the antitumor effects of cucurbitacin B in breast cancer by inhibiting the interaction of AKT and CDK2.
Authors: Jin ZQ, Hao J, Yang X, He JH, Liang J, Yuan JW, Mao Y, Liu D, Cao R, Wu XZ, Li X, Chen D Abstract Cucurbitacin B (Cu B), a tetracyclic triterpenoid derived from Trichosanthes kirilowii Maxim, exhibits anticancer effects against various types of tumor. Higenamine, isolated from Radix Aconiti Lateralis Preparata, has been used as a dietary supplement for regulating metabolic function. The present study suggested that higenamine enhances Cu B-induced cytotoxicity in breast cancer cells and in vivo. Network pharmacology analysis was used to identify the possible mechanism of action. Cu B alone i...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of YAP reverses primary resistance to EGFR inhibitors in colorectal cancer cells.
Authors: Liu BS, Xia HW, Zhou S, Liu Q, Tang QL, Bi NX, Zhou JT, Gong QY, Nie YZ, Bi F Abstract Mutant KRAS and BRAF are associated with primary EGFR inhibitor resistance in colorectal cancer (CRC). However, other biomarkers that could predict EGFR inhibitor resistance remain elusive. In the present study, immunoblotting and cell proliferation results revealed that yes‑associated protein (YAP), a downstream effector of the Hippo pathway, was positively associated with primary cetuximab resistance in CRC cells. YAP knockdown enhanced the cytotoxicity of cetuximab in CRC cells. Simvastatin, a 3‑hydroxy‑3‑meth...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑590‑5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression.
miR‑590‑5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression. Oncol Rep. 2018 Aug 07;: Authors: Mou K, Ding M, Han D, Zhou Y, Mu X, Liu W, Wang L Abstract The microRNAs (miRNAs/miRs) involved in the carcinogenesis and progression of malignant melanoma (MM) remain unclear. In the present study, miR‑590‑5p was identified to be upregulated in MM cells compared with human melanocytes using a reverse transcription‑quantitative polymerase chain reaction to screen established oncogenic and tumor suppressor miRNAs. miR‑590‑5p was demonstrated to inhibit the cell prolifera...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase  B/survivin signaling.
Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling. Oncol Rep. 2018 Aug 02;: Authors: Zhang G, Fang T, Chang M, Li J, Hong Q, Bai C, Zhou J Abstract Gefitinib, an epidermal growth factor receptor (EGFR)‑specific drug, is effective for ~1 year, after which resistance is inevitable. Calpain 2 (CAPN2) is known to serve a role in the drug response and resistance in certain cancer therapies. However, the full function of CAPN2, particularly in non‑small cell lung cancer, has not yet be...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNAs in small cell lung cancer: A potential opening to combat the disease (Review).
Long non‑coding RNAs in small cell lung cancer: A potential opening to combat the disease (Review). Oncol Rep. 2018 Aug 07;: Authors: Li TT, He RQ, Ma J, Li ZY, Hu XH, Chen G Abstract Lung cancer is the top cause of cancer‑associated mortality in men and women worldwide. Small cell lung cancer (SCLC) is a subtype that constitutes ~15% of all lung cancer cases. Long non‑coding RNAs (lncRNAs), possessing no or limited protein‑coding ability, have gained extensive attention as a potentially promising avenue by which to investigate the biological regulation of human cancer. lncRNAs can modulate gen...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑181a promotes cell proliferation and inhibits apoptosis in gastric cancer by targeting RASSF1A.
MicroRNA‑181a promotes cell proliferation and inhibits apoptosis in gastric cancer by targeting RASSF1A. Oncol Rep. 2018 Aug 07;: Authors: Yu J, Qi J, Sun X, Wang W, Wei G, Wu Y, Gao Q, Zheng J Abstract MicroRNA (miR)‑181a is a member of the miR‑181 family that serves a key role in the pathogenesis of various cancer types. The present study aimed to investigate the interaction between miR‑181a and Ras association domain family protein1 isoform A (RASSF1A), and their roles in gastric carcinogenesis. The interaction between miR‑181a and RASSF1A was assessed in cell lines and cancer tissues. The...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibitor of apoptosis protein ‑like protein‑2: A novel growth accelerator for breast cancer cells.
Inhibitor of apoptosis protein‑like protein‑2: A novel growth accelerator for breast cancer cells. Oncol Rep. 2018 Aug 03;: Authors: Zhu L, Zhou W, Zhu X, Xiang S, Wang S, Peng Y, Lu B, Tang P, Chen Q, Wu M, Peng X, Chen Z, Sun Z, Yang K, Xiang M, Yu D Abstract Although the inhibitor of apoptosis protein‑like protein‑2 (ILP‑2) has been shown as a serological biomarker for breast cancer, its effect on breast cancer cell growth remains elusive. The present study aimed to determine the role of ILP‑2 in breast cancer cell growth. We used immunohistochemistry to analyze ILP‑2 expression in 59 ...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non ‑small cell lung cancer.
Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non‑small cell lung cancer. Oncol Rep. 2018 Aug 07;: Authors: Gao J, Qiu X, Xi G, Liu H, Zhang F, Lv T, Song Y Abstract Gasdermin D (GSDMD) is a newly discovered pyroptosis executive protein, which can be cleaved by inflammatory caspases and is essential for secretion of IL‑1β, making it a critical mediator of inflammation. However, the precise role of GSDMD in carcinogenesis remains nearly unknown. Considering the v...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Association between Tim ‑3 and Gal‑9 expression and gastric cancer prognosis.
Association between Tim‑3 and Gal‑9 expression and gastric cancer prognosis. Oncol Rep. 2018 Aug 06;: Authors: Wang Y, Zhao E, Zhang Z, Zhao G, Cao H Abstract The T‑cell immunoglobulin and mucin domain‑containing protein 3 (Tim‑3)/galectin 9 (Gal‑9) pathway, which serves a pivotal role in immune regulation, is similar to the programmed death (PD)‑1/PD‑ligand 1 pathway. Recent evidence has suggested that Tim‑3 is differentially regulated in a variety of tumors and is a potential therapeutic target. The aim of the present study was to evaluate Tim‑3 and Gal‑9 expression an...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Integrin  ÎČ4 reduces DNA damage‑induced p53 activation in colorectal cancer.
Integrin β4 reduces DNA damage‑induced p53 activation in colorectal cancer. Oncol Rep. 2018 Aug 06;: Authors: Wu J, Zhao R, Lin J, Liu B Abstract Integrin contributes to the maintenance of cell adhesion. In turn, cell adhesion triggers certain integrin signaling cascades, and influences cell biological behavior. In the present study, we explored the role and mechanism of integrin β4 in the DNA damage response in colorectal cancer (CRC) using a three‑dimensional (3D) cell culture model. Under 3D culture condition, dispersed CRC cells automatically formed multicellular spheroids, ...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Conditioned medium mimicking the tumor microenvironment augments chemotherapeutic resistance via ataxia ‑telangiectasia mutated and nuclear factor‑ÎșB pathways in gastric cancer cells.
Conditioned medium mimicking the tumor microenvironment augments chemotherapeutic resistance via ataxia‑telangiectasia mutated and nuclear factor‑κB pathways in gastric cancer cells. Oncol Rep. 2018 Aug 07;: Authors: Zhuang X, Li X, Zhang J, Hu Y, Hu B, Shi Y, Sun Y, Hong G Abstract The tumor microenvironment affects the processes involved in the development of gastric cancer and contributes to multidrug resistance (MDR). Although the metabolism of gastric cancer cells is known to be associated with the development of the tumor microenvironment, the exact role of metabolism in microenvironmen...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Estrogen enhances tumor growth and angiogenesis indirectly via mediation of bone marrow ‑derived cells as well as directly through stimulation of tumor and endothelial cells.
Estrogen enhances tumor growth and angiogenesis indirectly via mediation of bone marrow‑derived cells as well as directly through stimulation of tumor and endothelial cells. Oncol Rep. 2018 Aug 07;: Authors: Zhuo Y, Li X, Zheng Q, Fan X, Ma W, Chen J, Zhao X, Zhao P, Liu X, Tang F, Cheng K, Feng W Abstract Estradiol (E2) is a prime culprit for enhancing the progression of female hormone‑related cancers. Bone marrow‑derived cells (BMDCs) have been found to play a pivotal role in tumor growth. Estrogen receptors (ERs) are also found on certain subtypes of BMDCs, in addition to endothelial cells (EC...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis.
Authors: Wang H, He Z, Xia L, Zhang W, Xu L, Yue X, Ru X, Xu Y Abstract PSMB4, proteasome subunit β4, is a member of the ubiquitin-proteasome family, and is elevated in a variety of malignancies. However, the expression level and related mechanism of PSMB4 in breast cancer remains unclear. Therefore, the present study investigated the expression level of PSMB4 in eight pairs of breast cancer and adjacent normal tissues. In addition, the relationship between the expression of PSMB4 and the clinical data of 92 breast cancer patients was discussed. First, it was found that PSMB4 expression was obviously...
Source: Oncology Reports - August 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research