Targeting the differentiation of gastric cancer cells (KATO ‑III) downregulates epithelial‑mesenchymal and cancer stem cell markers.
In conclusion, the induction of the differentiation of cancer stem cells into non‑proliferating cells offers the possibility for novel drug design to overcome the issues associated with metastasis, drug resistance and systemic toxicity with improved therapeutic efficacy. PMID: 31233198 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3 α signaling pathway in C2C12 myotubes and mice.
Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice. Oncol Rep. 2019 Jun 19;: Authors: Chen L, Chen L, Wan L, Huo Y, Huang J, Li J, Lu J, Xin B, Yang Q, Guo C Abstract Skeletal muscle wasting is a feature of cancer cachexia that increases patient morbidity and mortality. Matrine, the main bioactive component of Sophora flavescens, has been approved for the prevention and therapy of cancer cachexia in China. However, to the best of our knowledge, its mechanism in improving muscle wasting remains...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Keratin 6, induced by chronic cisplatin exposure, confers chemoresistance in human gastric carcinoma cells.
Authors: Lim SC, Parajuli KR, Han SI Abstract Currently, various types of keratins have been reported to be highly expressed in cancer cells and to be associated with a malignant phenotype. In the present study, it was found that expression levels of keratin 6 (K6), keratin 16 (K16), and keratin 17 (K17) were highly elevated in SNU601 cells resistant to cisplatin (SNU601‑cis2 and SNU601‑cis10), but not in the parental SNU601 cells as confirmed by quantitative PCR, immunoblotting, and immunofluorescence assays. K6 is a type II keratin and is known to form a keratin filament in conjugation with type I keratin, K1...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

let ‑7 and miR‑17 promote self‑renewal and drive gefitinib resistance in non‑small cell lung cancer.
In this study, it was found that let‑7 family expression was downregulated and miR‑17 family expression was upregulated in gefitinib‑resistant PC9/GR cells compared with gefitinib‑sensitive PC9 cells. The downregulation of let‑7 and upregulation of miR‑17 have significant clinical relevance to gefitinib resistance in NSCLC. Moreover, it was shown that downregulation of let‑7 and upregulation of miR‑17 promoted resistance to gefitinib by regulating the self‑renewal capability of NSCLC cells. In addition, let‑7 participated in the maintenance of stem cell characteristics by regulating the target gene MYC,...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

IL ‑10 secreted by cancer‑associated macrophages regulates proliferation and invasion in gastric cancer cells via c‑Met/STAT3 signaling.
In conclusion, the present results demonstrated that IL‑10 secreted by CAMs may be involved in the pathogenesis of gastric cancer, suggesting that IL‑10 may serve as a potential therapeutic target for the treatment of gastric cancer. PMID: 31233202 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CD8+ T  cells stimulated by exosomes derived from RenCa cells mediate specific immune responses through the FasL/Fas signaling pathway and, combined with GM‑CSF and IL‑12, enhance the anti‑renal cortical adenocarcinoma effect.
CD8+ T cells stimulated by exosomes derived from RenCa cells mediate specific immune responses through the FasL/Fas signaling pathway and, combined with GM‑CSF and IL‑12, enhance the anti‑renal cortical adenocarcinoma effect. Oncol Rep. 2019 Jun 20;: Authors: Xu HY, Li N, Yao N, Xu XF, Wang HX, Liu XY, Zhang Y Abstract A satisfactory cure rate for renal cell carcinoma (RCC) is difficult to achieve through traditional immunotherapy. RCC has a relatively high spontaneous regression rate due to tumor immune escape. However, tumor‑derived exosomes (TEXs), which effectively carry tumor‑associ...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Synergistic antitumor effect of BRMS1 and sorafenib via inhibition of the PI3K/AKT/mTOR/ERK signaling pathway.
In conclusion, overexpression of BRMS1 potentiated the effect of sorafenib via PI3K/AKT/mTOR/ERK signaling, while knockdown of BRMS1 expression attenuated this effect. These findings may present a novel therapeutic strategy for liver cancer. PMID: 31233204 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cucurbitacin E inhibits the Yes ‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model.
Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model. Oncol Rep. 2019 Jun 20;: Authors: Hsu PC, Tian B, Yang YL, Wang YC, Liu S, Urisman A, Yang CT, Xu Z, Jablons DM, You L Abstract Human non‑small cell lung cancer (NSCLC) is associated with an extremely poor prognosis especially for the 40% of patients who develop brain metastasis, and few treatment strategies exist. Cucurbitacin E (CuE), an oxygenated tetracyclic triterpenoid isolated from plants particularly of the family Cucurbitaceae, has sh...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

( ‑)‑Epigallocatechin‑3‑gallate inhibits bladder cancer stem cells via suppression of sonic hedgehog pathway.
(‑)‑Epigallocatechin‑3‑gallate inhibits bladder cancer stem cells via suppression of sonic hedgehog pathway. Oncol Rep. 2019 May 24;: Authors: Sun X, Song J, Li E, Geng H, Li Y, Yu D, Zhong C Abstract Cancer stem cells (CSCs) are associated with the occurrence and metastasis of human malignant tumors, and targeting CSCs is an important strategy for cancer prevention and overcoming drug resistance. (‑)‑Epigallocatechin‑3‑gallate (EGCG), a bioactive polyphenol from green tea, has been studied extensively for its beneficial effects on various tumors including bladder cancer. However, ...
Source: Oncology Reports - June 12, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑92a contributes to cell proliferation, apoptosis and doxorubicin chemosensitivity in gastric carcinoma cells.
miR‑92a contributes to cell proliferation, apoptosis and doxorubicin chemosensitivity in gastric carcinoma cells. Oncol Rep. 2019 May 23;: Authors: Tao XC, Zhang XY, Sun SB, Wu DQ Abstract MicroRNAs (miRNAs) are a class of short noncoding RNAs that negatively regulate gene expression and act as oncogenes or tumor suppressors. Numerous miRNAs have been reported be associated with the occurrence and development of gastric carcinoma (GC). For instance, miR‑92a has been observed to be overexpressed in GC; however, the precise mechanisms underlying the role of miR‑92a in GC and its role in clinical th...
Source: Oncology Reports - June 12, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PRP ‑1 significantly decreases the ALDHhigh cancer stem cell population and regulates the aberrant Wnt/β‑catenin pathway in human chondrosarcoma JJ012 cells.
PRP‑1 significantly decreases the ALDHhigh cancer stem cell population and regulates the aberrant Wnt/β‑catenin pathway in human chondrosarcoma JJ012 cells. Oncol Rep. 2019 May 24;: Authors: Hoyt AK, Moran A, Granger C, Sedani A, Saigh S, Brown J, Galoian KA Abstract Chondrosarcomas are malignant bone tumors refractory to chemotherapy and radiation treatment; thus, novel therapeutic strategies are required. Proline‑rich polypeptide 1 (PRP‑1) has previously demonstrated antitumor properties in chondrosarcoma. To further investigate the role of PRP‑1 in chondrosarcoma cells, its effec...
Source: Oncology Reports - June 12, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gene expression alterations of human liver cancer cells following borax exposure.
Authors: Wu L, Wei Y, Zhou WB, Zhang YS, Chen QH, Liu MX, Zhu ZP, Zhou J, Yang LH, Wang HM, Wei GM, Wang S, Tang ZG Abstract Borax is a boron compound that is becoming widely recognized for its biological effects, including lipid peroxidation, cytotoxicity, genotoxicity, antioxidant activity and potential therapeutic benefits. However, it remains unknown whether exposure of human liver cancer (HepG2) cells to borax affects the gene expression of these cells. HepG2 cells were treated with 4 mM borax for either 2 or 24 h. Gene expression analysis was performed using Affymetrix GeneChip Human Gene 2.0 ST Arrays, which...
Source: Oncology Reports - June 12, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Targeting lactate dehydrogenase ‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells.
Targeting lactate dehydrogenase‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells. Oncol Rep. 2019 May 24;: Authors: Muramatsu H, Sumitomo M, Morinaga S, Kajikawa K, Kobayashi I, Nishikawa G, Kato Y, Watanabe M, Zennami K, Kanao K, Nakamura K, Suzuki S, Yoshikawa K Abstract Docetaxel (DOC) is one of the most effective chemotherapeutic agents against castration‑resistant prostate cancer (CRPC). Despite an impressive initial clinical response, the majority of patients eventually develop resistance to DOC. In tumor metabolism, where tumors prefer...
Source: Oncology Reports - June 12, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect of platinum ‑based chemotherapy on the expression of natural killer group 2 member D ligands, programmed cell death‑1 ligand 1 and HLA class I in non‑small cell lung cancer.
Effect of platinum‑based chemotherapy on the expression of natural killer group 2 member D ligands, programmed cell death‑1 ligand 1 and HLA class I in non‑small cell lung cancer. Oncol Rep. 2019 Jun 03;: Authors: Okita R, Maeda A, Shimizu K, Nojima Y, Saisho S, Nakata M Abstract Platinum‑based chemotherapy improves the clinical outcome of patients with non‑small cell lung cancer (NSCLC), although tumors often become refractory after treatment. Immunohistochemical staining was performed to investigate the expression levels of natural killer group 2 member D (NKG2D) ligands...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High relative levels of satellite alpha transcripts predict increased risk of bilateral breast cancer and multiple primary cancer in patients with breast cancer and lacking BRCA ‑related clinical features.
In this study, we elucidated the significance of SAT in the development of multiple tumors in patients with breast cancer. Relative expression of SAT (rSAT) was calculated in normal and tumor tissues from 167 patients. In total, 27 patients developed bilateral breast cancer (BBC) and 27 patients showed multiple primary cancer (MPC), with patients with BBC and MPC showing higher rSAT levels in tumor tissues than those in patients with single breast cancer (SBC) (P=0.0312 and P=0.0420, respectively). Additionally, higher rSAT levels in tumor tissues from patients with BBC were a significant factor according to univariate ana...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of gossypol on apoptosis ‑related gene expression in racially distinct triple‑negative breast cancer cells.
In conclusion, the data obtained in this study provide a molecular understanding of the GOSS‑induced apoptosis effect and suggest the importance of this polyphenol compound targeted towards TNBC treatment, particularly in African‑American women. PMID: 31173249 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of microRNAs associated with the aggressiveness of prolactin pituitary tumors using bioinformatic analysis.
Authors: Wang Z, Gao L, Guo X, Feng C, Deng K, Lian W, Xing B Abstract Aggressive prolactin pituitary tumors, which exhibit aggressive behaviors and resistance to conventional treatments, are a huge challenge for neurosurgeons. Many studies have investigated the roles of microRNAs (miRNAs) in pituitary tumorigenesis, invasion and metastasis, but few have explored aggressiveness‑associated miRNAs in aggressive pituitary tumors. Differentially expressed miRNAs (DEMs) between aggressive and nonaggressive prolactin pituitary tumors were screened using the GSE46294 miRNA expression profile downloaded from the GEO data...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CHD1L is associated with poor survival and promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma.
Authors: Li S, Chai Y, Ding Y, Yuan T, Wu C, Huang C Abstract Chromodomain helicase/ATPase DNA‑binding protein 1‑like gene (CHD1L) is a new oncogene which has been confirmed to be crucial to the progression of many solid tumors. In the present study, the expression of CHD1L was found to be upregulated in intrahepatic cholangiocarcinoma (ICC), which was significantly associated with histological differentiation (P=0.011), vascular invasion (P=0.002), lymph node metastasis (P=0.008) and TNM stage (P=0.001). Kaplan‑Meier survival analysis revealed that ICC patients with positive CHD1L expression had shorter...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Development of high ‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma.
Development of high‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma. Oncol Rep. 2019 Jun 05;: Authors: Vaclavikova R, Klajic J, Brynychova V, Elsnerova K, Alnaes GIG, Tost J, Kristensen VN, Rob L, Kodet R, Skapa P, Mrhalova M, Soucek P Abstract Multidrug resistance to anticancer drugs, which is often associated with enhanced expression of the ATP‑binding cassette (ABC) transporter P‑glycoprotein (encoded by the ABCB1 gene) may limit the effects of cancer therapy. Epigenetic regulation of ABCB1 expression may thus have a clinical im...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of tRNA ‑derived fragments in colon cancer by comprehensive small RNA sequencing.
This study could provide valuable cues for further research into the roles of tRFs in colon cancer. PMID: 31173257 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation.
In conclusion, the miR‑29a/b1 and miR‑29b2/c genes have methylated CpG sequences at promoter and enhancer regions that may contribute to the regulation of miR‑29 expression in BL tumours. The present findings indicated interplay between MYC and miR‑29 regulation, highlighting the potential role of EBV‑miRNAs in miR‑29 regulation for BL pathogenesis. PMID: 31173259 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of 4 ‑aminobutyrate aminotransferase (ABAT) and the lncRNA co‑expression network in the development of myelodysplastic syndrome.
Role of 4‑aminobutyrate aminotransferase (ABAT) and the lncRNA co‑expression network in the development of myelodysplastic syndrome. Oncol Rep. 2019 May 29;: Authors: Chen Y, Zhao G, Li N, Luo Z, Wang X, Gu J Abstract IncRNAs play an important role in the regulation of gene expression. The present study profiled differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in myelodysplastic syndrome (MDS) to construct a 4‑aminobutyrate aminotransferase (ABAT)‑DEL‑DEM co‑expression network in MDS development using the Agilent human BeadChips and Gene Ontology (GO) and Kyoto Encyclopedia of Genes...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of a long non ‑coding RNA‑mediated competitive endogenous RNA network in hepatocellular carcinoma.
Identification of a long non‑coding RNA‑mediated competitive endogenous RNA network in hepatocellular carcinoma. Oncol Rep. 2019 Jun 03;: Authors: He H, Chen D, Cui S, Piao H, Tang H, Wang X, Ye P, Jin S Abstract The present study was designed to identify the endogenous RNA regulatory networks involved in hepatocellular carcinoma (HCC) by bioinformatic analysis. Both miRNA interaction network‑based correlation analysis and expression‑based Spearman correlation coefficients were utilized to identify potential mRNA‑lncRNA interactions. Then, a competitive endogenous (ce)RNA network was construc...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sulfasalazine ‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor.
In conclusion SAS could trigger ferroptosis in breast cancer cells, especially in cells with low ER expression. Therefore, SAS is a potential agent for breast cancer treatment. PMID: 31173262 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Aberrantly elevated Bmi1 promotes cervical cancer tumorigenicity and tumor sphere formation via enhanced transcriptional regulation of Sox2 genes.
Authors: Xu R, Chen L, Yang WT Abstract The exact molecular mechanisms underlying cervical tumorigenesis are poorly understood. Polycomb complex protein Bmi1 (Bmi1) is involved in the malignant transformation and biological aggressiveness of several human carcinomas. Therefore, the present study assessed the expression of Bmi1 protein in human cervical cancer tissues and examined the mechanisms involved in cervical carcinogenesis. The expression of Bmi1 protein was examined by immunohistochemistry in cervical carcinoma tissues (n=71), high‑grade squamous intraepithelial lesions (n=41) and normal cervical tis...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of transforming growth factor β1 in the inhibition of gastric cancer cell proliferation by melatonin in vitro and in vivo.
Role of transforming growth factor β1 in the inhibition of gastric cancer cell proliferation by melatonin in vitro and in vivo. Oncol Rep. 2019 Jun 06;: Authors: Liu H, Zhu Y, Zhu H, Cai R, Wang KF, Song J, Wang RX, Zhou RX Abstract Transforming growth factor β (TGF‑β) is a polypeptide growth factor with various biological activities, and is widely distributed in various tissues. In mammals, TGF‑β has three isoforms: TGF‑β1, 2, and 3, of which TGF‑β1 is most abundant in the TGF‑β family. TGF‑β1 is closely related to the occurrence and development of t...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ethyl pyruvate suppresses the growth, invasion and migration and induces the apoptosis of non ‑small cell lung cancer cells via the HMGB1/RAGE axis and the NF‑κB/STAT3 pathway.
Ethyl pyruvate suppresses the growth, invasion and migration and induces the apoptosis of non‑small cell lung cancer cells via the HMGB1/RAGE axis and the NF‑κB/STAT3 pathway. Oncol Rep. 2019 May 30;: Authors: Liu Q, Huo Y, Zheng H, Zhao J, Jia L, Wang P Abstract As an inhibitor of high mobility group protein B1 (HMGB1), ethyl pyruvate (EP) has been associated with various inflammatory diseases. Recent studies have investigated the relationship between EP and cancer. The present study aimed to determine the antitumor efficacy of EP in non‑small cell lung cancer (NSCLC) cells and elucid...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PTPN1 promotes the progression of glioma by activating the MAPK/ERK and PI3K/AKT pathways and is associated with poor patient survival.
In conclusion, it was demonstrated that PTPN1 is upregulated in glioma tissue and the overexpression of PTPN1 predicted the poor prognosis of patients with glioma. PTPN1 promotes the progression of glioma by activating the MAPK/ERK and PI3K/AKT pathways. PMID: 31173266 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Bile cell ‑free DNA as a novel and powerful liquid biopsy for detecting somatic variants in biliary tract cancer.
Bile cell‑free DNA as a novel and powerful liquid biopsy for detecting somatic variants in biliary tract cancer. Oncol Rep. 2019 May 31;: Authors: Shen N, Zhang D, Yin L, Qiu Y, Liu J, Yu W, Fu X, Zhu B, Xu X, Duan A, Chen Z, Wang X, Cao X, Zhao T, Zhou Z, Yu L, Qin H, Fang Z, Li JY, Liu Y, Xiong L, Yuan B, Li F, Zhang Y Abstract Tissue sampling of biliary tract carcinomas (BTCs) for molecular characterization is challenging. The aim of this study was to investigate the possibility of identifying individual actionable mutations derived from bile cell‑free DNA (cfDNA) using targeted deep sequencing....
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification and characterization of a murine model of BCR ‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis.
Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis. Oncol Rep. 2019 Jun 03;: Authors: Yu X, Zhang H, Yuan M, Zhang P, Wang Y, Zheng M, Lv Z, Odhiambo WO, Li C, Liu C, Ma Y, Ji Y Abstract Breakpoint cluster region (BCR)‑Abelson murine leukemia (ABL)1+ acute B‑lymphoblastic leukemia (B‑ALL) is a disease associated with a dismal prognosis and a high incidence of central nervous system (CNS) metastasis. However, BCR‑ABL1+ B‑ALL with CNS infiltration has not been previously characterized, at least to the best...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DNA ‑PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy.
This study was designed to investigate the effects and potential mechanism of radiosensitization associated with DNA‑dependent protein kinase catalytic subunit (DNA‑PKcs) inhibitor in human GC cell lines in vitro. Among the six GC cell lines (SGC7901, HGC‑27, MKN45, MKN74, BGC823 and MGC803) that were exposed to increasing doses of IR (0, 2, 4, 6 and 8 Gy), the mean lethal dose and quasi‑threshold dose measurements indicated that BGC823 and MGC803 were relatively insensitive to ionizing radiation (IR). IR induced significant elevation of γ H2A histone family member X (γH2AX) in MKN45 cells compared with...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Engineered human mesenchymal stem cells for neuroblastoma therapeutics.
Authors: Nieddu V, Piredda R, Bexell D, Barton J, Anderson J, Sebire N, Kolluri K, Janes SM, Karteris E, Sala A Abstract Drug-resistant neuroblastoma remains a major challenge in paediatric oncology and novel and less toxic therapeutic approaches are urgently needed to improve survival and reduce the side effects of traditional therapeutic interventions. Mesenchymal stem cells (MSCs) are an attractive candidate for cell and gene therapy since they are recruited by and able to infiltrate tumours. This feature has been exploited by creating genetically modified MSCs that are able to combat cancer by delivering therap...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Radixin knockdown improves the accumulation and efficiency of methotrexate in tumor cells.
In conclusion, the present study provides information on radixin as a target molecule for the modulation of MRP activity in tumor cells. PMID: 31115547 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

ZNF492 and GPR149 methylation patterns as prognostic markers for clear cell renal cell carcinoma: Array ‑based DNA methylation profiling.
ZNF492 and GPR149 methylation patterns as prognostic markers for clear cell renal cell carcinoma: Array‑based DNA methylation profiling. Oncol Rep. 2019 May 07;: Authors: Kim YJ, Jang W, Piao XM, Yoon HY, Byun YJ, Kim JS, Kim SM, Lee SK, Seo SP, Kang HW, Kim WT, Yun SJ, Shon HS, Ryu KH, Kim SW, Ha YS, Yoon GS, Lee SC, Kwon TG, Kim WJ Abstract The present study aimed to identify novel methylation markers of clear cell renal cell carcinoma (ccRCC) using microarray methylation analysis and evaluate their prognostic relevance in patient samples. To identify cancer‑specific methylated biomarkers, microa...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Investigation of the clinical significance and prospective molecular mechanisms of cystatin genes in patients with hepatitis B virus ‑related hepatocellular carcinoma.
Investigation of the clinical significance and prospective molecular mechanisms of cystatin genes in patients with hepatitis B virus‑related hepatocellular carcinoma. Oncol Rep. 2019 May 09;: Authors: Zhou X, Wang X, Huang K, Liao X, Yang C, Yu T, Liu J, Han C, Zhu G, Su H, Qin W, Han Q, Liu Z, Huang J, Gong Y, Ye X, Peng T Abstract The present study aimed to investigate the clinical significance and prospective molecular mechanism of cystatin (CST) genes in patients with hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC). The role of CST genes in the molecular mechanism of HCC was reve...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Differential gene methylation patterns in cancerous and non ‑cancerous cells.
Differential gene methylation patterns in cancerous and non‑cancerous cells. Oncol Rep. 2019 May 15;: Authors: Kamińska K, Białkowska A, Kowalewski J, Huang S, Lewandowska MA Abstract Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation and histone modification markers. Changes in the epigenome significantly contribute to the initiation and progression of cancer. The goal of the present study was to characterize the prostate cancer malignant transformation model using the CpG island met...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Annexin  A2 regulates glioma cell proliferation through the STAT3‑cyclin D1 pathway.
Annexin A2 regulates glioma cell proliferation through the STAT3‑cyclin D1 pathway. Oncol Rep. 2019 May 09;: Authors: Chen L, Lin L, Xian N, Zheng Z Abstract Annexin A2 (ANXA2) acts as a calcium‑dependent phospholipid‑binding protein that is widely expressed in vertebrate cells and has abnormally high expression in various tumor cells. However, the detailed molecular mechanism underlying the effects of ANXA2 on glioma cells remains unclear. The present study aimed to investigate the role and underlying molecular mechanisms of ANXA2 in glioma cell proliferation. The results revealed that...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Small RNA sequencing revealed aberrant piRNA expression profiles in colorectal cancer.
Authors: Yin J, Qi W, Ji CG, Zhang DX, Xie XL, Ding Q, Jiang XY, Han J, Jiang HQ Abstract Piwi‑interacting RNAs (piRNAs), a novel class of non‑coding RNAs, are enriched in germ cells and implicated in spermatogenesis. Emerging evidence demonstrated deregulated expression of piRNAs in numerous tumor types. However, changes in piRNA expression profiles in colorectal cancer (CRC) have not yet been investigated. In the present study, small RNA sequencing was used to evaluate the differences in piRNA expression profiles between CRC and adjacent non‑tumor tissues, as well as to screen for differentially expressed p...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Intratumoral injection of dendritic cells overexpressing interleukin ‑12 inhibits melanoma growth.
Intratumoral injection of dendritic cells overexpressing interleukin‑12 inhibits melanoma growth. Oncol Rep. 2019 May 21;: Authors: Yao W, Li Y, Zeng L, Zhang X, Zhou Z, Zheng M, Wan H Abstract The present study aimed to investigate the antitumor effects of an intratumoral injection of dendritic cells (DCs) overexpressing interleukin-12 (IL‑12) on melanoma. DCs, isolated from mouse spleen, were gene‑modified using an IL‑12 overexpression vector. Melanoma B6 cells were injected into C57BL/6 mice to generate tumors. Thereafter, DCs overexpressing IL‑12 were injected into the tumors, and tumor v...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MEIS2 promotes cell migration and invasion in colorectal cancer.
Authors: Wan Z, Chai R, Yuan H, Chen B, Dong Q, Zheng B, Mou X, Pan W, Tu Y, Yang Q, Tu S, Hu X Abstract Colorectal cancer (CRC) is one of the most common types of malignancy worldwide. Distant metastasis is a key cause of CRC‑associated mortality. MEIS2 has been identified to be dysregulated in several types of human cancer. However, the mechanisms underlying the regulatory role of MEIS2 in CRC metastasis remain largely unknown. For the first time, the present study demonstrated that MEIS2 serves a role as a promoter of metastasis in CRC. In vivo and in vitro experiments revealed that knockdown of MEIS2 signific...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of miR ‑181a on the biological function of multiple myeloma.
Effects of miR‑181a on the biological function of multiple myeloma. Oncol Rep. 2019 May 15;: Authors: Liu N, Yang J, Yuan R, Peng J, Liu L, Guo X Abstract The present study aimed to investigate the role of miR‑181a in multiple myeloma (MM) cell lines. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect the expression of microRNA (miR)‑181a. The MM cell line RPMI 8226 stably transduced with miR‑181a mimics or inhibitor was established via lentiviral vectors. A Cell Counting Kit‑8 proliferation assay, flow cytometry and a Transwell assay were conducted ...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑497 suppresses malignant phenotype in non‑small cell lung cancer via targeting KDR.
miR‑497 suppresses malignant phenotype in non‑small cell lung cancer via targeting KDR. Oncol Rep. 2019 May 16;: Authors: Xia Y, Hu C, Lian L, Hui K, Wang L, Qiao Y, Liu L, Liang L, Jiang X Abstract The aim of the present study was to evaluate the expression of microRNA‑497 (miR‑497) in non‑small cell lung cancer (NSCLC) tissues and cell lines, and to investigate possible mechanisms associated with its regulatory role on cell behaviors. The expression level of miR‑497 was evaluated in 15 cases of NSCLC tissues and 8 adjacent normal tissues, and in 8 NSCLC cell lines, including H1975, A549, ...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HOXC10 overexpression promotes cell proliferation and migration in gastric cancer.
Authors: Kim J, Bae DH, Kim JH, Song KS, Kim YS, Kim SY Abstract Homeodomain‑containing gene 10 (HOXC10) is a member of the homeobox transcription factors that plays an important role in the development of multicellular organisms. HOXC10 is overexpressed in a variety of human cancers, and recent studies have revealed that HOXC10 is upregulated in gastric cancer as well. However, its mechanism of action is not fully understood, thus, the role of HOXC10 was investigated in the present study in human gastric cancer. First, HOXC10 expression was revealed to be significantly increased in gastric cancer tissues compare...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Conditionally replicative adenovirus carrying shRNA targeting EZH2 inhibits prostate cancer growth and invasion.
Authors: Xu SG, Yu JJ, Shi Q, Niu Q, Guo Z, Guo BY, Zhou GC, Gu X, Wu YX Abstract The present study aimed to construct conditionally replicative adenovirus (CRAds) carrying small hairpin (sh)RNA targeting enhancer of zeste homolog 2 (EZH2), in order to study its effect on inhibiting prostate cancer (PCa) cell growth and invasion. Immunohistochemical analyses of EZH2 was performed in tumor tissue samples from PCa and benign prostate hyperplasia (BPH). The human telomerase reverse transcriptase (hTERT) promoter was chosen to transcriptionally control EZH2 gene expression to obtain adenoviral replication (Ad‑hTERT...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Promotion of ovarian cancer cell invasion, migration and colony formation by the miR ‑21/Wnt/CD44v6 pathway.
Promotion of ovarian cancer cell invasion, migration and colony formation by the miR‑21/Wnt/CD44v6 pathway. Oncol Rep. 2019 May 09;: Authors: Wang Y, Yang X, Yuan M, Xian S, Zhang L, Yang D, Cheng Y Abstract Ovarian cancer (OC) has the highest mortality rate among female malignant tumors, and OC commonly relapses and metastasizes. The mechanisms underlying the occurrence and development of ovarian cancer are numerous and complicated. The aim of the present study was to explore an important molecular mechanism that may provide a theoretical basis for the clinical treatment of ovarian cancer. In the pr...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑21 inhibitor facilitates the anticancer activity of doxorubicin loaded nanometer in melanoma.
In this study, in vitro and animal models were used to explore the effect of DLN combined with miR‑21 inhibitor on melanoma cells. The data demonstrated that treatment with 5 µl DLN (final concentration of doxorubicin 5 mg/ml) for 72 h effectively inhibited melanoma cell growth (~75% inhibition). The experiments were then divided into five groups: Control group, vector group, DLN group, miR‑21 inhibitor group and miR‑21 inhibitor + DLN group. Compared with the control group, DLN (5 µl) or miR‑21 inhibitor significantly reduced migration and invasion of melanoma cells, promoted apoptosis and arrested cel...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cytokeratin 18 regulates the transcription and alternative splicing of apoptotic ‑related genes and pathways in HeLa cells.
In conclusion, the present study indicated that CK18 played a role in apoptosis, which may be mediated via a feed‑back regulation loop and may involve regulation of transcription and alternative splicing of a number of genes in apoptotic pathways. PMID: 31115582 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12.
miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12. Oncol Rep. 2019 May 13;: Authors: Zhang J, Xu S, Xu J, Li Y, Zhang J, Zhang J, Lu X Abstract A growing body of evidence implicates aberrant expression of microRNAs (miRNAs) and dysregulation of mRNA translation in the development and growth of cancer cells. However, little is known about the mechanisms of action of miRNAs in glioma, the most common form of adult‑onset malignant brain tumor. In the present study, the expression and function of miR‑767‑5p were examined in human glioblastoma multiforme (GBM) tissue speci...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The combination of temsirolimus and chloroquine increases radiosensitivity in colorectal cancer cells.
In conclusion, the combination of TEM and CQ increased radiosensitivity in CRC cells through co‑inhibition of mTOR and autophagy. PMID: 31059051 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR ‑384/pleiotrophin axis.
Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis. Oncol Rep. 2019 Apr 24;: Authors: Yao Y, Rao C, Zheng G, Wang S Abstract Luteolin (3,4,5,7‑tetrahydroxyflavone) is a natural flavonoid that has been found to exhibit anticancer properties in certain types of cancers. In the present study, the role of luteolin and its underlying mechanisms were explored in colorectal cancer (CRC) cells. First, the effects of luteolin on CRC cells proliferation, migration and invasion were examined by CCK‑8, wound healing and Transwell assays, respectively. It was...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research