CADM2 inhibits human glioma proliferation, migration and invasion.
Authors: Liu N, Yang C, Bai W, Wang Z, Wang X, Johnson M, Wang W, Zhang P, Yang H, Liu H, Cheng Y, Tu Y Abstract Malignant glioma is one of the most common malignant tumors in the brain parenchyma with a poor prognosis. Cell adhesion molecules (CADMs) immunoglobulin super family is involved in the maintenance of cell adhesion, polarity and tumor suppression. However, the role and mechanisms of CADM2 in human glioma have yet to be elucidated. Therefore, the present study evaluated the expression level of CADM2 and demonstrated that CADM2 was markedly downregulated in human glioma tissues compared with normal brain t...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulated Kr üppel‑like factor 4 expression is associated with the aggressiveness of prostate cancer.
Downregulated Krüppel‑like factor 4 expression is associated with the aggressiveness of prostate cancer. Oncol Rep. 2019 Jan 22;: Authors: Zhang N, Su P, Li X, Xi J, Li X, Xu L Abstract Krüppel‑like factor 4 (KLF4) is a transcription factor and putative tumor suppressor. However, little is known about its role in the progression of prostate cancer. The aim of the present study was to examine the expression and potential role of KLF4 in prostate cancer. KLF4 and E‑cadherin expression in 60 prostate cancer tissues and 60 benign prostatic hyperplasia tissues was characterized by immun...
Source: Oncology Reports - February 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miRNA-223 is an anticancer gene in human non-small cell lung cancer through the PI3K/AKT pathway by targeting EGFR.
Authors: Ma HP, Kong WX, Li XY, Li W, Zhang Y, Wu Y Abstract The present study aimed to further explore the molecular mechanisms of miRNA-223 in non-small cell lung cancer (NSCLC). Data prospectively collected from NSCLC patients and volunteers from March 2016 to MayMAP2016 at Tsinghua Changgung Hospital were analyzed. Cell proliferation was measured using MTT assay, while cell apoptosis and caspase-3/9 activity were measured using flow cytometry and caspase-3/9 activity kit. Bax, EGFR, PI3K and p-Akt protein were also investigated using western blotting. The results revealed that the serum levels of miRNA-223 in ...
Source: Oncology Reports - February 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non ‑small cell lung cancer A549 cells via the JAK/STAT3 signaling pathway.
Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non‑small cell lung cancer A549 cells via the JAK/STAT3 signaling pathway. Oncol Rep. 2019 Jan 22;: Authors: Zhang T, Ma L, Wu P, Li W, Li T, Gu R, Dan X, Li Z, Fan X, Xiao Z Abstract Gallic acid (3,4,5‑trihydroxybenzoic acid; GA), a plant‑derived natural phenolic compound, has been reported to prevent the development and progression of various types of cancers. However, there has been little elaboration of the anticancer effects and underlying mechanisms of GA alone and/or in combination with cisplatin in non...
Source: Oncology Reports - February 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Stanniocalcin ‑1 promotes cell proliferation, chemoresistance and metastasis in hypoxic gastric cancer cells via Bcl‑2.
Stanniocalcin‑1 promotes cell proliferation, chemoresistance and metastasis in hypoxic gastric cancer cells via Bcl‑2. Oncol Rep. 2019 Jan 23;: Authors: Wang Y, Qi Z, Zhou M, Yang W, Hu R, Li G, Ma X, Zhang Z Abstract Gastric cancer (GC) is one of the most lethal diseases worldwide, but the mechanism of GC development remains elusive. In the present study, the roles of stanniocalcin‑1 (STC1) in GC were investigated. It was demonstrated that overexpression of STC1 mRNA and protein were associated with poor survival of patients with GC. The expression of STC1 was enhanced in hypoxic GC cells and ov...
Source: Oncology Reports - February 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Peroxiredoxin2 downregulation enhances hepatocellular carcinoma proliferation and migration, and is associated with unfavorable prognosis in patients.
Authors: Bai B, Lin Y, Hu J, Wang H, Li L, Zhao S, Zhang J, Meng W, Yue P, Bai Z, Li X Abstract It has been revealed by our previous proteomic study that the expression profile is different between well‑differentiated and poorly differentiated hepatocellular carcinoma (HCC). Among those differently expressed proteins, peroxiredoxin2 (PRDX2) was our protein of interest. The present study aimed to further investigate the value of PRDX2 as a prognostic factor in HCC. Tissue microarrays were used to investigate the expression difference between HCC tissues and their adjacent normal liver tissues. The expression of PR...
Source: Oncology Reports - February 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of BAG ‑1 in T47D cells promotes resistance to tamoxifen via activation of the PI3K/Akt/mTOR signaling pathway.
In conclusion, there results of the present study indicated that suppression of BAG‑1 expression may activate the phosphoinositide 3‑kinase/Akt/mTOR pathway and protect ER‑positive breast cancer cells from tamoxifen‑induced inhibition of proliferation. ER‑positive breast cancer cells exhibiting low BAG‑1 expression appeared to be more sensitive to treatment with the mTOR inhibitor rapamycin. Furthermore, the results indicated that combination treatment targeting ER with tamoxifen and targeting mTOR with rapamycin may significantly potentiate the inhibitory effect in BAG‑1‑silenced cells. PMID: 3074...
Source: Oncology Reports - February 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

17 β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation.
17β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation. Oncol Rep. 2019 Jan 23;: Authors: Lu X, Kong L, Wang X, Liu W, Ma P, Jiang L Abstract Accumulating evidence has implicated that the activation of signal transducer and activator of transcription 3 (STAT3) contributes to the progression of liver cancer by affecting the expression of proliferation‑associated genes. A previous study reported that elevated levels of 17β‑hydroxysteroid dehydrogenase 4 (HSD17B4) are observed in patients with liver cancer. The current study inves...
Source: Oncology Reports - February 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Wnt7a predicts poor prognosis, and contributes to growth and metastasis in tongue squamous cell carcinoma.
Authors: Jia B, Qiu X, Chu H, Sun X, Xu S, Zhao X, Zhao J Abstract Regional and distant metastases are the principal reasons underlying the high mortality rate associated with tongue squamous cell carcinoma (TSCC); however, the precise molecular mechanisms involved in tongue tumorigenesis remain unknown. The present study aimed to determine the expression and mechanism of regulation of Wnt7a in the growth and metastasis of TSCC. Wnt7a mRNA and protein expression levels were examined in TSCC tissues using reverse transcription‑quantitative polymerase chain reaction and immunohistochemical staining. A loss‑of‑f...
Source: Oncology Reports - February 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A 6 ‑gene risk score system constructed for predicting the clinical prognosis of pancreatic adenocarcinoma patients.
In conclusion, the 6‑gene risk score system may be a promising strategy for predicting the outcome of PAC patients. PMID: 30747226 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - February 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Combined inhibition of sonic Hedgehog signaling and histone deacetylase is an effective treatment for liver cancer.
In conclusion, the combined use of SHH signaling and HDAC inhibitors may be an effective therapeutic strategy for liver cancer. PMID: 30747231 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - February 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SPAG9/MKK3/p38 axis is a novel therapeutic target for liver cancer.
Authors: Luo S, Ren B, Zou G, Liu J, Chen W, Huang Y, Chen X, Fu Y Abstract Sperm‑associated antigen 9 (SPAG9) is a biomarker and potential therapeutic target for several cancers; however, its involvement in liver cancer progression is not clear. The aim of the present study was to determine whether SPAG9 regulates proliferation of liver cancer. Immunohistochemistry and cell immunofluorescence were used to confirm the expression and the localization of SPAG9 in human liver cancer tissues and the liver cancer‑derived HepG2 cells. A small interfering RNA (siRNA) designed to target SPAG9 was transiently transfecte...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Autophagy and apoptotic machinery caused by Polygonum  cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells.
In conclusion, our findings are the first to suggest that PCE may be potentially efficacious for the treatment of cisplatin‑resistant human oral cancer. PMID: 30720102 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Prostaglandin  D2 expression is prognostic in high‑grade serous ovarian cancer.
Prostaglandin D2 expression is prognostic in high‑grade serous ovarian cancer. Oncol Rep. 2019 Jan 28;: Authors: Alves MR, Do Amaral NS, Marchi FA, Silva FIB, Da Costa AABA, Carvalho KC, Baiocchi G, Soares FA, De Brot L, Rocha RM Abstract To identify biomarkers that could predict response or lack of response to conventional chemotherapy at the time of diagnosis of high‑grade serous ovarian carcinoma (HGSOC), the present study compared large‑scale gene expression from patients with short or long disease‑free survival times, according to the last cycle of chemotherapy, and validated these fi...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8 ‑AS1:28.
MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8‑AS1:28. Oncol Rep. 2019 Feb 01;: Authors: Zhang Y, Li F, Chen J Abstract As a common malignancy of the endocrine system, papillary thyroid carcinoma (PTC) seriously affects the quality of life of patients. lncRNA PAX8‑AS1:28, or lnc‑PSD4‑1:14 has been reported to be abnormally expressed in PTC. However, the function of PAX8‑AS1:28 in PTC is still unknown. Therefore, the present study aimed to investigate the functions of PAX8‑AS1:28 in PTC, and to explore the possible mechanisms of action...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MELK inhibition targets cancer stem cells through downregulation of SOX2 expression in head and neck cancer cells.
Authors: Ren L, Deng B, Saloura V, Park JH, Nakamura Y Abstract Maternal embryonic leucine zipper kinase (MELK) has been reported to serve critical roles in the maintenance of stemness of cancer cells, although its mechanism remains unclear. Since SRY‑box 2 (SOX2) was demonstrated to be involved in self‑renewal and tumorigenicity of head and neck squamous cell carcinoma (HNSCC) and is aberrantly expressed in HNSCC tumors, the association between MELK and SOX2 was examined. Firstly, MELK inhibition was performed by small interfering RNA or MELK inhibitor OTS167, and it was determined that MELK inhibition by thes...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLC γ.
TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ. Oncol Rep. 2019 Jan 30;: Authors: Zhang X, Shi G, Gao F, Liu P, Wang H, Tan X Abstract Pancreatic cancer (PC), a malignancy of the digestive system, has one of the highest rates of metastasis and mortality. It is characterized by the detachment, migration, implantation and infiltration of tumor cells to form metastases or recurrent foci. Tetraspanin 1 (TSPAN1), a novel member of the TSPAN superfamily, is highly expressed in many types of cancer, including gastric, colon, liver and esophageal cancer. It has ...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of protein disulfide isomerase  A3 and its clinicopathological association in gastric cancer.
Expression of protein disulfide isomerase A3 and its clinicopathological association in gastric cancer. Oncol Rep. 2019 Feb 05;: Authors: Shimoda T, Wada R, Kure S, Ishino K, Kudo M, Ohashi R, Fujita I, Uchida E, Yoshida H, Naito Z Abstract Protein disulfide isomerase A3 (PDIA3) is a chaperone protein that supports the folding and processing of synthesized proteins. Its expression is associated with the prognosis of laryngeal cancer, hepatocellular carcinoma, diffuse glioma and uterine cervical cancer. In the present study, the expression levels of PDIA3 and its clinicopathological association wer...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Icariin suppresses cell cycle transition and cell migration in ovarian cancer cells.
Authors: Wang P, Zhang J, Xiong X, Yuan W, Qin S, Cao W, Dai L, Xie F, Li A, Liu Z Abstract Ovarian cancer is the third most common type of gynecological tumor, in addition to being the most lethal. Cytoreductive surgery with chemotherapy is the standard treatment for ovarian cancer. It is necessary to identify novel chemotherapeutic methods, since current chemotherapy treatments are rarely effective for patients with advanced‑stage or recurrent ovarian cancer and may cause acute systemic toxicity. Icariin (ICA) is a prenylated flavonol glycoside derived from Herba Epimedii, a medicinal plant with a variety of ph...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

NSPc1 polycomb protein complex binds and cross ‑talks to lncRNAs in glioma H4 cells.
NSPc1 polycomb protein complex binds and cross‑talks to lncRNAs in glioma H4 cells. Oncol Rep. 2019 Feb 05;: Authors: Wang Y, Liang Z, Li H, Tao J, Sun Y, Gong Y Abstract Recently, emerging evidence shows that a number of long non‑coding RNAs (lncRNAs) recruit polycomb group (PcG) proteins to specific chromatin loci to silence relevant gene expression. In the present study, we provided evidence that lncRNA candidates, selected by bioinformatic analysis and nervous system polycomb 1 (NSPc1), a key polycomb repressive complex 1 (PRC1) member, were highly expressed in glioma H4 cells in contrast to th...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Erratum] OBP ‑801, a novel histone deacetylase inhibitor, induces M‑phase arrest and apoptosis in rhabdomyosarcoma cells.
[Erratum] OBP‑801, a novel histone deacetylase inhibitor, induces M‑phase arrest and apoptosis in rhabdomyosarcoma cells. Oncol Rep. 2019 Feb 01;: Authors: Tomoyasu C, Kikuchi K, Kaneda D, Yagyu S, Miyachi M, Tsuchiya K, Iehara T, Sakai T, Hosoi H Abstract Subsequent to the publication of the above article, the authors have realized that errors were introduced into Fig. 4 at the typesetting stage. Essentially, in Fig. 4B, the P‑value should have read as "P=0.13" (not as 0.013), and in Fig 4D, the labels for OBP- and OBP+ were set the wrong way around. The correct version ...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cellular and radiobiological effects of carbonic anhydrase IX in human breast cancer cells.
In conclusion, combination of CAIX inhibition and irradiation is a promising treatment strategy against breast cancer with hypoxia‑induced CAIX expression. PMID: 30720123 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Isoliquiritigenin inhibits the proliferation, apoptosis and migration of osteosarcoma cells.
Authors: Li C, Zhou X, Sun C, Liu X, Shi X, Wu S Abstract The overall survival rate of patients with osteosarcoma has remained unchanged for the last several decades. Therefore, novel drugs for osteosarcoma treatment are required. Isoliquiritigenin (ISL), a natural compound, has been demonstrated to inhibit the growth of various tumors. However, it is unclear whether ISL is able to inhibit the growth of osteosarcoma. In the present study, it was identified that ISL was able to inhibit the growth of the osteosarcoma cell line Saos‑2 cells in vitro and in xenograft tumors primarily by attenuating tumor cell prolife...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SHIP1 inhibits cell growth, migration, and invasion in non ‑small cell lung cancer through the PI3K/AKT pathway.
SHIP1 inhibits cell growth, migration, and invasion in non‑small cell lung cancer through the PI3K/AKT pathway. Oncol Rep. 2019 Jan 30;: Authors: Fu Q, Huang Y, Ge C, Li Z, Tian H, Li Q, Li H, Li R, Tao X, Xue Y, Wang Y, Yang G, Fang W, Song X Abstract Src homology 2‑containing inositol‑5'‑phosphatase 1 (SHIP1) serves a vital role in the occurrence and development of hematological tumors, but there is limited knowledge regarding the role of SHIP1 in various solid tumors, including lung cancer. In the present study, the aim was to investigate the expression and functional mechanisms of SHIP1 in ...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA linc00239 promotes malignant behaviors and chemoresistance against doxorubicin partially via activation of the PI3K/Akt/mTOR pathway in acute myeloid leukaemia cells.
Long non‑coding RNA linc00239 promotes malignant behaviors and chemoresistance against doxorubicin partially via activation of the PI3K/Akt/mTOR pathway in acute myeloid leukaemia cells. Oncol Rep. 2019 Jan 31;: Authors: Yang Y, Dai W, Sun Y, Zhao Z Abstract Long non‑coding RNAs (lncRNAs) are known to be involved in the processes of tumourigenesis and malignant behaviours in many types of cancer, including acute myeloid leukaemia (AML). Accumulating evidence has revealed that novel lncRNAs exerted critical roles in these processes. In the present study, we investigated the effects of lncRNA linc002...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CHAF1B promotes proliferation and reduces apoptosis in 95 ‑D lung cancer cells and predicts a poor prognosis in non‑small cell lung cancer.
CHAF1B promotes proliferation and reduces apoptosis in 95‑D lung cancer cells and predicts a poor prognosis in non‑small cell lung cancer. Oncol Rep. 2019 Feb 01;: Authors: Duan Y, Liu T, Li S, Huang M, Li X, Zhao H, Li J Abstract Chromatin assembly factor 1 subunit B (CHAF1B) participates in DNA synthesis and repair. High CHAF1B expression has been associated with a poor prognosis in several types of cancers. However, no study has evaluated the clinical significance and biological function of CHAF1B in non‑small cell lung cancer (NSCLC). In the present study, we aimed to investigate CHAF1B expre...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Monocarboxylate transporter  1 is an independent prognostic factor in esophageal squamous cell carcinoma.
Monocarboxylate transporter 1 is an independent prognostic factor in esophageal squamous cell carcinoma. Oncol Rep. 2019 Jan 31;: Authors: Chen X, Chen X, Liu F, Yuan Q, Zhang K, Zhou W, Guan S, Wang Y, Mi S, Cheng Y Abstract The monocarboxylate transporter 1 (MCT1) has been reported to have significant prognostic value in several solid tumors. The present study aimed to explore its clinical significance in esophageal squamous cell carcinoma (ESCC). After acquiring and analyzing MCT1 (solute carrier family 16 member; SLC16A1) mRNA expression in The Cancer Genome Atlas (TCGA) database, the prognost...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression and prognostic significance of insulin ‑like growth factor-2 receptor in human hepatocellular carcinoma and the influence of transarterial chemoembolization.
In conclusion, these data suggested an important role for IGF2R expression in HCC, particularly with regards to TACE treatment prior to surgery. PMID: 30720132 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Promoter hypermethylation of SOX11 promotes the progression of cervical cancer in  vitro and in vivo.
Promoter hypermethylation of SOX11 promotes the progression of cervical cancer in vitro and in vivo. Oncol Rep. 2019 Feb 01;: Authors: Li X, Wu X, Li Y, Cui Y, Tian R, Singh N, Ding M, Yang Y, Gao Y Abstract The development of cervical cancer (CC) is a multi‑gene, multi‑step carcinogenic process that involves complex genetic and epigenetic mechanisms. SRY‑related HMG‑box gene 11 (SOX11) is a member of the SOX family of transcription factors with an emerging crucial role in the development of various tumor types. To elucidate the function of SOX11 in cervical carcinogenesis, the e...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The PI3K/AKT signaling pathway regulates ABCG2 expression and confers resistance to chemotherapy in human multiple myeloma.
Authors: Wang L, Lin N, Li Y Abstract Side population (SP) cells are involved in the development of multidrug resistance (MDR) in human multiple myeloma (MM), due to their cancer stem cell (CSC)‑like phenotypes. ATP‑binding cassette (ABC) drug transporter proteins have been reported to be closely associated with MDR in leukemia; however, the correlation between ABC proteins and the progression of MM remains unclear. The present study used MM cell lines and clinical samples to determine the role of ABC subfamily G member 2 (ABCG2) in MM via flow cytometry, reverse transcription‑quantitative polymerase chain re...
Source: Oncology Reports - January 22, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Shikonin induces an anti ‑tumor effect on murine mammary cancer via p38‑dependent apoptosis.
In conclusion, shikonin is a potential anti‑tumor drug for breast cancer. PMID: 30664166 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 22, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR663a ‑TTC22V1 axis inhibits colon cancer metastasis.
miR663a‑TTC22V1 axis inhibits colon cancer metastasis. Oncol Rep. 2019 Jan 16;: Authors: Tian W, Du Y, Ma Y, Zhang B, Gu L, Zhou J, Deng D Abstract An increasing number of studies have demonstrated that microRNAs (miRs) may act as oncogenes or anti‑oncogenes in various types of cancer, including colon cancer (CC). However, the clinical and biological significance of miR663a in the prognosis of CC and its underlying molecular mechanisms remain unknown. Using the reverse transcription‑quantitative polymerase chain reaction on CC and surgical margin tissue samples from 172 patients with CC, it was ...
Source: Oncology Reports - January 22, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review).
Authors: Fontes-Sousa M, Amorim M, Salta S, Palma De Sousa S, Henrique R, Jerónimo C Abstract Notwithstanding the marked progress in breast cancer (BC) management, it still constitutes the most common malignancy in women and a major cause of morbidity and mortality, thus remaining a major health issue worldwide. Most BC cases are hormone receptor (HR) positive (luminal A or B molecular subtypes) and endocrine treatment (ET) is an important therapeutic modality at all disease stages. Nevertheless, despite substantial improvements in BC patient outcome, effectiveness of ET is limited, as up to 40% of patients ...
Source: Oncology Reports - January 22, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Momelotinib sensitizes glioblastoma cells to temozolomide by enhancement of autophagy via JAK2/STAT3 inhibition.
Authors: Liu T, Li A, Xu Y, Xin Y Abstract Temozolomide (TMZ) is a widely used chemotherapeutic agent for glioblastoma multiforme (GBM). However, chemoresistance to TMZ is still a major obstacle for GBM patients. An abundance of candidates has been reported to improve the chemotherapeutic sensitization of TMZ. In the present study, it was demonstrated that momelotinib (MTB) enhanced the sensitivity of glioma cells to TMZ in vitro, as evidenced by a noticeable decrease in cell growth and a significant increase in apoptosis and autophagy following treatment with the combination of TMZ and MTB compared to TMZ alone. M...
Source: Oncology Reports - January 22, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Interaction between C2ORF68 and HuR in human colorectal cancer.
In conclusion, it is suggested that c2orf68 is a potential carcinogenesis factor in rectal cancer. Furthermore, c2orf68 may have a synergistic effect with HuR in the onset and development of CRC. PMID: 30664176 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 22, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression profiles and potential functions of circular RNAs in extracellular vesicles isolated from radioresistant glioma cells.
In conclusion, using RNA‑seq and bioinformatics, it was found that circATP8B4 in RR‑EVs acts as a U251 miR‑766 sponge, which may be involved in glioma radioresistance. PMID: 30664179 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 22, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑3653 inhibits the growth and metastasis of hepatocellular carcinoma by inhibiting ITGB1.
MicroRNA‑3653 inhibits the growth and metastasis of hepatocellular carcinoma by inhibiting ITGB1. Oncol Rep. 2019 Jan 16;: Authors: Zhang L, Zhang T, Deng Z, Sun L Abstract microRNAs (miRNAs) play critical roles in hepatocellular carcinoma (HCC). However, the expression and biological function of miR‑3653 in HCC remain unknown. The present study demonstrated that miR‑3653 expression was significantly decreased in HCC tissues and cells using qRT‑PCR. A decreased miR‑3653 level was associated with unfavorable clinical features and poor prognosis of HCC patients. MTT, BrdU, Transwell and western...
Source: Oncology Reports - January 22, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CX3CL1 promotes lung cancer cell migration and invasion via the Src/focal adhesion kinase signaling pathway.
Authors: Liu W, Liang Y, Chan Q, Jiang L, Dong J Abstract The present study investigated the role of C‑X3‑C motif chemokine ligand 1 (CX3CL1) in lung cancer cell migration and invasion and its potential mechanism. The expression levels of C‑X3‑C motif chemokine receptor 1 (CX3CR1) in six human lung cancer cell lines and one human bronchial epithelial cell line were assessed using reverse transcription‑quantitative polymerase chain reaction and western blotting. Cell proliferation was assessed using the Cell Counting Kit‑8 assay. Cell migration and invasion were examined using the Transwell assay, with a...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Intravesical treatment of chemotherapeutic agents sensitizes bacillus Calmette ‑Guerin by the modulation of the tumor immune environment.
Intravesical treatment of chemotherapeutic agents sensitizes bacillus Calmette‑Guerin by the modulation of the tumor immune environment. Oncol Rep. 2019 Jan 10;: Authors: Hori S, Miyake M, Tatsumi Y, Morizawa Y, Nakai Y, Onishi S, Onishi K, Iida K, Gotoh D, Itami Y, Tanaka N, Fujimoto K Abstract Intravesical treatment with bacillus Calmette‑Guerin (BCG) is the most common treatment for preventing progression and recurrence of non‑muscle invasive bladder cancer. Our previous study using the N‑butyl‑N‑(4‑hydroxybutyl) nitrosamine (BBN)‑induced orthotopic bladder cancer model demonstrated ...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect of NELL1 on lung cancer stem ‑like cell differentiation.
Effect of NELL1 on lung cancer stem‑like cell differentiation. Oncol Rep. 2019 Jan 03;: Authors: Zhai Y, Wei R, Sha S, Lin C, Wang H, Jiang X, Liu G Abstract The cancer stem cell theory recently has received enormous attention in cancer biology. Lung cancer stem‑like cells are a subpopulation of undifferentiated lung tumor cells critical for lung cancer tumorigenesis, metastasis and resistance to therapy and disease relapse. The neural EGFL like 1 (NELL1) is a potent growth factor believed to preferentially target cells committed to the osteochondral lineage; yet, its expression and function i...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ubiquitination ‑deubiquitination in the Hippo signaling pathway (Review).
Ubiquitination‑deubiquitination in the Hippo signaling pathway (Review). Oncol Rep. 2019 Jan 08;: Authors: Liu Y, Deng J Abstract The Hippo signaling pathway is considered to be a tissue growth regulator and tumor suppressor pathway that controls cell proliferation, differentiation, survival, regeneration and tissue homeostasis. Defects in Hippo kinases and hyperactivation of transcriptional co‑activator with PDZ‑binding motif and Yes‑associated protein (YAP) may contribute to the development of different types of cancer. The Hippo pathway is regulated in a variety of way, of which ubiquitinati...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] Oncogenic function of Plac1 on the proliferation and metastasis in hepatocellular carcinoma cells.
Authors: Wu Y, Lin X, Di X, Chen Y, Zhao H, Wang X Abstract Following the publication of this article, the authors have realized that Table I contained some important errors. The data shown for the positive or negative HBsAg patient characteristic in terms of the no. of patients, Plac1 (+) and Plac1 (‑) were incorrect. A corrected version of the Table is shown below (the corrected data are highlighted in bold). The authors sincerely apologize for the errors that were introduced during the preparation of this Table. Furthermore, they regret any inconvenience that this mistake has caused. [the original ar...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer (Review).
Authors: Hu M, Zhu S, Xiong S, Xue X, Zhou X Abstract Gastric carcinogenesis arises from complicated interactions among host, environmental and bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor‑suppressive genes. MicroRNAs (miRNAs), a class of small non‑coding RNAs that post‑transcriptionally regulate ~30% human genes, may serve as oncogenes or tumor‑suppressors in malignancies, including gastric cancer (GC). Although miRNA dysregulation commonly exists in GC, exact roles miRNAs serve in the pathogenesis and promotion of this tumor remain undetermined. Recently, resu...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer.
In conclusion, the findings of the present study demonstrated that high‑dose MTX enhanced anticancer activity in α‑TOS‑treated TNBC, while low‑dose MTX reduced anticancer activity in α‑TOS‑treated TNBC. PMID: 30628707 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy.
Authors: Wang X, Liao X, Yang C, Huang K, Yu T, Yu L, Han C, Zhu G, Zeng X, Liu Z, Zhou X, Qin W, Su H, Ye X, Peng T Abstract Hepatocellular carcinoma (HCC) is a lethal malignancy with high morbidity and mortality rates worldwide. The identification of prognosis‑associated biomarkers is crucial to improve HCC patient survival. The present study aimed to explore potential predictive biomarkers for HCC. Differentially expressed genes (DEGs) were analyzed in the GSE36376 dataset using GEO2R. Hub genes were identified and further investigated for prognostic value in HCC patients. A risk score model and nomogram were ...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Electrochemotherapy of radioresistant head and neck squamous cell carcinoma cells and tumor xenografts.
Authors: Zakelj MN, Prevc A, Kranjc S, Cemazar M, Todorovic V, Savarin M, Scancar J, Kosjek T, Groselj B, Strojan P, Sersa G Abstract Electrochemotherapy is an established local ablative method used for the treatment of different tumor types, including tumors of the head and neck area. Clinical studies have demonstrated a lower response rate of tumors that recur in pre‑irradiated area. The aim of the present study was to explore the response of experimentally induced radioresistant cells and tumors to electrochemotherapy with cisplatin or bleomycin. The radioresistant cells (FaDu‑RR) were established by fractio...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CTHRC1 overexpression promotes cervical carcinoma progression by activating the Wnt/PCP signaling pathway.
Authors: Zheng M, Zhou Q, Liu X, Wang C, Liu G Abstract The tumorigenesis and metastasis of tumors are associated with human collagen triple helix repeats containing 1 (CTHRC1). To study the effects and possible impacting mechanisms of CTHRC1 on human cervical carcinoma development, samples of paraffin‑embedded cervical carcinoma and HeLa cells were examined. Immunofluorescence, cell wound scratch assay, western blot analysis and Transwell invasion assay were used to evaluate HeLa cells in response to silencing of the CTHRC1 gene in cervical carcinoma. The expression levels of gap‑associated proteins of the Wnt...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4.
miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4. Oncol Rep. 2019 Jan 09;: Authors: Zheng Y, Pan C, Chen M, Pei A, Xie L, Zhu S Abstract Ischemic stroke is the main cause of brain injury and results in a high rate of morbidity, disability and mortality. In the present study, we aimed to determine whether miR‑29a played a protective role in oxygen glucose deprivation (OGD) injury via regulation of the water channel protein aquaporin 4 (AQP4). Real‑time PCR and western blotting were used to assess miR‑29a levels and AQP4 protein levels,...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Introduction of exogenous wild ‑type p53 mediates the regulation of oncoprotein 18/stathmin signaling via nuclear factor‑κB in non‑small cell lung cancer NCI‑H1299 cells.
Introduction of exogenous wild‑type p53 mediates the regulation of oncoprotein 18/stathmin signaling via nuclear factor‑κB in non‑small cell lung cancer NCI‑H1299 cells. Oncol Rep. 2019 Jan 10;: Authors: Chen S, Zhao Y, Shen F, Long D, Yu T, Lin X Abstract Our previous studies demonstrated that high expression of oncoprotein 18 (Op18)/stathmin promotes malignant transformation of non‑small cell lung cancer NCI‑H1299 cells. Investigation of the cellular settings determined that NCI‑H1299 cells were genetically p53 deficient. In order to determine whether p53 deficiency is associ...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

XPC inhibition rescues cisplatin resistance via the Akt/mTOR signaling pathway in A549/DDP lung adenocarcinoma cells.
Authors: Teng X, Fan XF, Li Q, Liu S, Wu DY, Wang SY, Shi Y, Dong M Abstract Xeroderma pigmentosum, complementation group C (XPC) is an accessory recognition gene involved in the nucleotide excision repair (NER) pathway, which is activated during the initial DNA damage recognition stage. It participates in the regulation of DNA damage‑induced proliferation and apoptosis. Emerging evidence demonstrates that upregulation of XPC increases the resistance of several tumor cell types to cytotoxic drugs. In addition, it can predict poor patient outcome for non‑small cell lung cancer (NSCLC). However, the mechanisms li...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research