Upregulated NOX1 expression in gallbladder cancer ‑associated fibroblasts predicts a poor prognosis.
Upregulated NOX1 expression in gallbladder cancer‑associated fibroblasts predicts a poor prognosis. Oncol Rep. 2019 Jul 25;: Authors: Wang FT, Hassan M, Ansari KH, Xu GL, Li XP, Fan YZ Abstract Gallbladder cancer (GBC) is a lethal aggressive malignant neoplasm of the biliary tract. Potential prognostic markers and therapeutic targets for this disease are urgently required. Cancer‑associated fibroblasts (CAFs) play a key role in tumorigenesis and the development of cancer. Nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1) expression has been reported to be involved in tumorigenesis and us...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Transcriptional regulation of FoxM1 by HIF ‑1α mediates hypoxia‑induced EMT in prostate cancer.
Transcriptional regulation of FoxM1 by HIF‑1α mediates hypoxia‑induced EMT in prostate cancer. Oncol Rep. 2019 Jul 25;: Authors: Tang C, Liu T, Wang K, Wang X, Xu S, He D, Zeng J Abstract Hypoxia is a tumorigenesis‑related microenvironment change which usually occurs in the earliest stage of prostate cancer (PCa) development. Accumulating evidence has demonstrated that hypoxia/hypoxia‑inducing factor (HIF) is involved in the induction of epithelial‑mesenchymal transition (EMT) and increased metastatic potential in PCa. However, the mechanism by which hypoxia/HIF regulates EMT ...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulation of JMJD2A promotes migration and invasion in bladder cancer through regulation of SLUG.
Authors: Wang F, Li Y, Shan F, Zhang Q, Wang L, Sheng B, Cheng G Abstract Jumonji domain‑containing protein 2A (JMJD2A) has been identified to promote cell proliferation in bladder cancer; however, it remains undetermined whether JMJD2A regulates cell migration and invasion in bladder cancer. The aim of the present study was to further investigate the roles of JMJD2A in bladder cancer. The expression levels of JMJD2A in bladder cancer tissues and cell lines were established by RT‑qPCR assays and western blot analysis. Moreover, by gain‑ and loss‑of‑function assays, the effects of JMJD2A on migration and i...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Comprehensive multigene mutation spectra of breast cancer patients from Northeast China obtained using the Ion Torrent sequencing platform.
The objectives of the present study were to obtain the multigene mutation spectra of female breast cancer patients in Northeast China, to explore the correlation between mutations and clinicopathological characteristics, and to identify genetic mutations that correlate with the prognosis and survival of breast cancer patients. An Ion Torrent sequencing platform was used to detect mutations, including 31 known gene mutations associated with breast cancer, in 621 specimens from 286 breast cancer patients. A total of 286 patients were enrolled in this study. Eleven harmful/pathogenic gene mutations were found in 54.2% (155/28...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cancer ‑associated fibroblast‑derived exosomal miR‑382‑5p promotes the migration and invasion of oral squamous cell carcinoma.
In this study, according to the α‑SMA staining with immunohistochemistry, 47 OSCC patients were divided into CAFs‑rich and CAFs poor groups, and association of CAF density and clinicopathologic features of the OSCC patients were analyzed with Pearson χ2 test. Transwell assay was used for evaluating cell migration and invasion ability of OSCC cells after being co‑cultured with NFs or CAFs, or after added exosomes. qPCR was used to detect the expression of miR‑382‑5p. Western blot analysis was used to measure the expression of migration and invasion‑associated proteins. In the present study, the CA...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑126‑3p inhibits the proliferation, migration, invasion, and angiogenesis of triple‑negative breast cancer cells by targeting RGS3.
MicroRNA‑126‑3p inhibits the proliferation, migration, invasion, and angiogenesis of triple‑negative breast cancer cells by targeting RGS3. Oncol Rep. 2019 Jul 26;: Authors: Hong Z, Hong C, Ma B, Wang Q, Zhang X, Li L, Wang C, Chen D Abstract Triple‑negative breast cancer (TNBC) is characterized by fast progression with high potential for metastasis, and poor prognosis. The dysregulation of microRNAs (miRNAs) occurring in the initiation or progression of cancers often leads to aberrant gene expression. The aim of the present study was to explore the function of miR‑126 in TNBC cells. Expressi...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of CPXM2 predicts an unfavorable prognosis and promotes the proliferation and migration of gastric cancer.
Authors: Niu G, Yang Y, Ren J, Song T, Hu Z, Chen L, Hong R, Xia J, Ke C, Wang X Abstract Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human disorders such as developmental diseases. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. In the present study, we used clinical samples from gastric cancer (GC) patients to investigate potential roles of CPXM2 in GC. We also analyzed datasets from the Oncomine database, The Cancer Genome Atlas (TCGA), and the Kaplan‑Meier Plotter to validate these results. We found that CPXM2 was overexpressed in G...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TNF ‑α‑mediated upregulation of SOD‑2 contributes to cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma.
TNF‑α‑mediated upregulation of SOD‑2 contributes to cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma. Oncol Rep. 2019 Jul 26;: Authors: Zuo J, Zhao M, Liu B, Han X, Li Y, Wang W, Zhang Q, Lv P, Xing L, Shen H, Zhang X Abstract Intrinsic and acquired resistance of cancer to radio‑and chemotherapy is one of the major challenges in the treatment of esophageal squamous cell carcinoma (ESCC). Elevated reactive oxygen species (ROS) play an important role in the resistance to cisplatin in ESCCs. Super dismutase [Mn], mitochondrial (SOD‑2), an important primary ...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tetramethylpyrazine downregulates transcription of the CXC receptor  4 (CXCR4) via nuclear respiratory factor‑1 (Nrf‑1) in WERI‑Rb1 retinoblastoma cells.
Tetramethylpyrazine downregulates transcription of the CXC receptor 4 (CXCR4) via nuclear respiratory factor‑1 (Nrf‑1) in WERI‑Rb1 retinoblastoma cells. Oncol Rep. 2019 Jul 15;: Authors: Wu N, Yang Y, Yu N, Wu Y, Han X, Chen S, Zhang J, Chen X, Wu C, Yang M, Qiu J, Ge J, Yu K, Zhuang J Abstract Tetramethylpyrazine (TMP; an extract of the Chinese herbal medicine, Chuanxiong) has been shown to exert remarkable antiretinoblastoma (RB) effects. Based on our previous study, the target gene was found to be C‑X‑C chemokine receptor type 4 (CXCR4). CXCR4 is a prognostic marker in various ty...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Antipsychotic agent pimozide promotes reversible proliferative suppression by inducing cellular quiescence in liver cancer.
In conclusion, elucidation of pimozide's reversible proliferation inhibition in liver cancer and additive activity with a well‑established anticancer drug warrants further exploration of the potential of pimozide as an adjuvant anticancer therapy. PMID: 31322218 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑505 suppresses prostate cancer progression by targeting NRCAM.
In conclusion, the present study revealed the inhibitory effects of miR‑505 on PCa tumorigenesis, which potentially occur by targeting NRCAM. The combined analysis of NRCAM and miR‑505 may predict disease progression in patients with PCa following radical prostatectomy. PMID: 31322225 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of Nemo ‑like kinase promotes metastasis in non‑small‑cell lung cancer.
Knockdown of Nemo‑like kinase promotes metastasis in non‑small‑cell lung cancer. Oncol Rep. 2019 Jul 09;: Authors: Shi C, Xu L, Tang Z, Zhang W, Wei Y, Ni J, Zhang S, Feng J Abstract The evolutionarily conserved serine/threonine kinase Nemo‑like kinase (NLK) serves an important role in cell proliferation, migration, invasion and apoptosis by regulating transcription factors among various cancers. In the present study, the function of NLK in human non‑small cell lung cancer (NSCLC) was investigated. Immunohistochemical analysis and western blotting demonstrated that NLK expression was signific...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA00887 reduces the invasion and metastasis of non‑small cell lung cancer by causing the degradation of miRNAs.
Long non‑coding RNA00887 reduces the invasion and metastasis of non‑small cell lung cancer by causing the degradation of miRNAs. Oncol Rep. 2019 Jul 11;: Authors: Tian Y, Yu M, Sun L, Liu L, Huo S, Shang W, Sheng S, Wang J, Sun J, Hu Q, Dou Y, Zhu J, Ren X, Yang S Abstract Long non‑coding RNAs (lncRNAs) can act as carcinogenic or cancer suppressive factors during the pathogenesis, invasion and metastasis of non‑small cell lung cancer (NSCLC). The current study explored the role of long intergenic non‑protein coding RNA 00887 (LINC00887) and competing endogenous RNAs (ceRNAs). It was revealed ...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus ‑related hepatocellular carcinoma.
Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma. Oncol Rep. 2019 Jul 05;: Authors: Han Q, Wang X, Liao X, Han C, Yu T, Yang C, Li G, Han B, Huang K, Zhu G, Liu Z, Zhou X, Su H, Shang L, Gong Y, Song X, Peng T, Ye X Abstract The aim of the present study was to investigate the diagnostic and prognostic value of Wingless‑type MMTV integration site (WNT) gene family expression in patients with hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC). The clinical data of the patients and gene expression levels were downloaded f...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of ubiquitin ‑specific protease 14 promotes connexin 32 internalization and counteracts cisplatin cytotoxicity in human ovarian cancer cells.
Inhibition of ubiquitin‑specific protease 14 promotes connexin 32 internalization and counteracts cisplatin cytotoxicity in human ovarian cancer cells. Oncol Rep. 2019 Jul 15;: Authors: Luo H, Wang X, Ge H, Zheng N, Peng F, Fu Y, Tao L, Wang Q Abstract Although cisplatin is one of the most accepted therapies for ovarian cancer, recurrence and drug resistance remain problematic. Both the ubiquitin‑proteasome system (UPS) and connexin (Cx) are closely related to tumor progression. However, the role of ubiquitin‑specific protease 14 (USP14) and Cx in mediating drug resistance rem...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑543 acts as a novel oncogene in oral squamous cell carcinoma by targeting CYP3A5.
In conclusion, the results of the present study suggest that miR‑543 acts as a tumor promoter and serves a vital role in OSCC proliferation and invasion. These results confirm that miR‑543 may serve as a potential novel target for the treatment of OSCC. PMID: 31322243 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The analysis of miRNA expression profiling datasets reveals inverse microRNA patterns in glioblastoma and Alzheimer's disease.
Authors: Candido S, Lupo G, Pennisi M, Basile MS, Anfuso CD, Petralia MC, Gattuso G, Vivarelli S, Spandidos DA, Libra M, Falzone L Abstract There is recent evidence to indicate the existence of an inverse association between the incidence of neurological disorders and cancer development. Concurrently, the transcriptional pathways responsible for the onset of glioblastoma multiforme (GBM) and Alzheimer's disease (AD) have been found to be mutually exclusive between the two pathologies. Despite advancements being made concerning the knowledge of the molecular mechanisms responsible for the development of GB...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HNF ‑4α downregulation promotes tumor migration and invasion by regulating E‑cadherin in renal cell carcinoma.
HNF‑4α downregulation promotes tumor migration and invasion by regulating E‑cadherin in renal cell carcinoma. Oncol Rep. 2019 Jun 27;: Authors: Gao Y, Yan Y, Guo J, Zhang Q, Bi D, Wang F, Chang Z, Lu L, Yao X, Wei Q Abstract Renal cell carcinoma (RCC) is the most common malignant disease of the kidneys in adults. Patients with metastatic RCC have an unusually poor prognosis and exhibit resistance to all current therapies. Therefore, it is necessary to explore novel molecules involved in the progression of RCC and to identify effective therapeutic targets. Hepatocyte nuclear factor‑4α ...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model.
Authors: Ishikura N, Yorozu K, Kurasawa M, Yanagisawa M, Sugimoto M, Yamamoto K Abstract Although bevacizumab maintenance following bevacizumab in combination with chemotherapy has demonstrated significant prolongation of progression-free survival in clinical studies in patients with ovarian cancer, the majority of the cancer cases in the study were of the serous histotype; therefore, data regarding clear cell carcinoma is limited. Furthermore, the efficacy of bevacizumab beyond progression has not yet been demonstrated in ovarian cancer. A xenograft model using the human ovarian clear cell carcinoma cell line RMG-...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer.
Authors: Wang Y, Song Z, Leng P, Liu Y Abstract Serum deprivation response (SDPR) gene has been recently characterized as a gene signature marker or serving a tumor suppressor role in specific types of cancer. However, gene expression alterations of SDPR in various types of cancer and their relevance to clinical outcomes remain unclear. In the present study, SDPR expression was profiled using the Oncomine database, and SDPR downregulation was indicated in most types of cancer. In agreement with previously reported breast cancer cases, downregulation of SDPR was indicated to be significantly associated with poor sur...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑143 acts as a novel Big mitogen‑activated protein kinase 1 suppressor and may inhibit invasion of glioma.
miR‑143 acts as a novel Big mitogen‑activated protein kinase 1 suppressor and may inhibit invasion of glioma. Oncol Rep. 2019 Jul 03;: Authors: Chen WY, Lang ZQ, Ren C, Yang P, Zhang B Abstract Upregulation of the Big mitogen‑activated protein kinase (BMK)1 has been reported in glioma and other epithelial tumors. In addition, the decreased expression of BMK1 inhibits tumorigenesis, leading to the broad consensus that it functions as cell‑autonomous epithelial tumor promoter. Using two online miRNA target prediction databases, microRNA (miR)‑143 was predicted as the potential miRNA regulator o...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Evaluation of the STAT3 inhibitor GLG ‑302 for the prevention of estrogen receptor‑positive and ‑negative mammary cancers.
Evaluation of the STAT3 inhibitor GLG‑302 for the prevention of estrogen receptor‑positive and ‑negative mammary cancers. Oncol Rep. 2019 Jul 04;: Authors: Shoemaker RH, Fox JT, Juliana MM, Moeinpour FL, Grubbs CJ Abstract Signal transducer and activator of transcription 3 (STAT3) plays a key role in the transformation of normal cells to cancerous cells. Although inhibitors of STAT3 have been shown to suppress the growth of multiple cancer types in vitro and in vivo, such agents are of particular interest for the prevention of breast cancer, which affects over 200,000 women an...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Diagnostic and prognostic values of integrin α subfamily mRNA expression in colon adenocarcinoma.
Diagnostic and prognostic values of integrin α subfamily mRNA expression in colon adenocarcinoma. Oncol Rep. 2019 Jun 28;: Authors: Gong YZ, Ruan GT, Liao XW, Wang XK, Liao C, Wang S, Gao F Abstract The integrin α (ITGA) subfamily genes play a fundamental role in various cancers. However, the potential mechanism and application values of ITGA genes in colon adenocarcinoma (COAD) remain elusive. The present study investigated the significance of the expression of ITGA genes in COAD from the perspective of diagnosis and prognosis. A COAD RNA‑sequencing dataset was obtained from The Cancer G...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DEPDC1 drives hepatocellular carcinoma cell proliferation, invasion and angiogenesis by regulating the CCL20/CCR6 signaling pathway.
In conclusion, DEPDC1 facilitated cell proliferation, invasion and angiogenesis via the CCL20/CCR6 pathway in HCC. PMID: 31322256 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Erythropoietin receptor induces a paclitaxel resistance phenotype in mammary adenocarcinoma cells.
Authors: Zsóková E, Ilkovičová L, Kimáková P, Fecková B, Solár P Abstract While erythropoietin (EPO) regulates erythropoiesis, the erythropoietin receptor (EPOR) has been identified in many non‑hematopoietic cells, including cancer. Our previous study demonstrated that overexpression of EPOR altered the cell growth and the sensitivity of RAMA 37 breast cancer cells to tamoxifen. Indeed, results of the present study uncovered the role of EPOR in the resistance of EPOR‑overexpressing RAMA 37‑28 cells to paclitaxel chemotherapy. In this regard, EPOR silencing in ...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulation of interleukin ‑17F in colorectal cancer promotes tumor invasion by inducing epithelial‑mesenchymal transition.
Upregulation of interleukin‑17F in colorectal cancer promotes tumor invasion by inducing epithelial‑mesenchymal transition. Oncol Rep. 2019 Jul 04;: Authors: Chen Y, Yang Z, Wu D, Min Z, Quan Y Abstract Interleukin‑17F (IL‑17F) is a member of the IL‑17 family of proteins. Previous studies concerning IL‑17F have mainly focused on its proinflammatory responses, whereas the present study explored its role as an oncogene in colorectal cancer (CRC). The present study investigated the expression of IL‑17F in 69 patients with CRC. IL‑17F was significantly overexpressed in tumor mucos...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

NAMPT: A potential prognostic and therapeutic biomarker in patients with glioblastoma.
Authors: Guo Q, Han N, Shi L, Yang L, Zhang X, Zhou Y, Yu S, Zhang M Abstract Glioblastoma (GBM) is the most common primary intracranial malignancy. GBM still exhibits high recurrence and mortality rates even following combined treatment with surgery, radiotherapy and chemotherapy, Therefore, the identification of novel therapeutic targets is urgent. Previous research has shown that nicotinamide phosphoribosyltransferase (NAMPT) plays a key role in cell metabolism and is closely related to the occurrence and development of many tumor types; yet, little is known concerning its relationship with GBM. Oncomine da...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification and characterization of sexual dimorphism ‑linked gene expression profile in hepatocellular carcinoma.
Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma. Oncol Rep. 2019 Jun 28;: Authors: Wu Y, Yao N, Feng Y, Tian Z, Yang Y, Zhao Y Abstract Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present study, functional signatures of differentially expressed genes (DEGs) were screened in f...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑198 suppresses prostate tumorigenesis by targeting MIB1.
MicroRNA‑198 suppresses prostate tumorigenesis by targeting MIB1. Oncol Rep. 2019 Jul 15;: Authors: Ray J, Hoey C, Huang X, Jeon J, Taeb S, Downes MR, Boutros PC, Liu SK Abstract MicroRNAs are small non‑coding RNA molecules which act as modulators of gene function, and have been identified as playing important roles in cancer as both tumor suppressors and oncogenes. The present study aimed to examine the role of miR‑198 in prostate cancer aggression by analyzing how it influences several hallmarks of cancer. Abundance of miR‑198 in prostate cancer and association with clinical characteristics w...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hedyotis diffusa Willd. inhibits VEGF ‑C‑mediated lymphangiogenesis in colorectal cancer via multiple signaling pathways.
Hedyotis diffusa Willd. inhibits VEGF‑C‑mediated lymphangiogenesis in colorectal cancer via multiple signaling pathways. Oncol Rep. 2019 Jul 05;: Authors: Li H, Lai Z, Yang H, Peng J, Chen Y, Lin J Abstract Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies worldwide. For patients diagnosed with the presence of metastatic disease, surgery is not suitable for the majority of them. Lymphangiogenesis is a key factor during cancer metastasis and is regulated by vascular endothelial growth factor C (VEGF‑C). Hedyotis diffusa Willd. (HDW) is a Chinese herb of the Rubiaceae famil...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gene expression and DNA methylation regulation of arsenic in mouse bladder tissues and in human urothelial cells.
Authors: Jou YC, Wang SC, Dai YC, Chen SY, Shen CH, Lee YR, Chen LC, Liu YW Abstract According to a report of the International Agency for Research on Cancer, arsenic and inorganic arsenic compounds are classified into Group 1 carcinogens with regard to human health. Epidemiological studies indicate that arsenic is one of the main risk factors for the development of bladder cancer. In the present study, arsenic‑altered gene expression in mouse bladder tissues and in human urothelial cells was compared. In the mouse model, sodium arsenite‑induced mouse urothelial hyperplasia and intracellular inclusions were pre...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hypoxia ‑induced mitochondrial translocation of DNM1L increases mitochondrial fission and triggers mPTP opening in HCC cells via activation of HK2.
Hypoxia‑induced mitochondrial translocation of DNM1L increases mitochondrial fission and triggers mPTP opening in HCC cells via activation of HK2. Oncol Rep. 2019 Jun 27;: Authors: Cai M, He P, Fang DL Abstract Disturbed mitochondrial dynamics are closely associated with the progression of different types of cancer including hepatocellular carcinoma (HCC). However, the manner in which mitochondrial dynamics are regulated in HCC remains largely unclear. In the present study, via immunofluorescence, real‑time PCR and western blot analysis, the effects of dynamin‑1‑like (DNM1L) on mitochondrial tr...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Genome ‑wide investigation of the clinical significance and prospective molecular mechanisms of kinesin family member genes in patients with lung adenocarcinoma.
Genome‑wide investigation of the clinical significance and prospective molecular mechanisms of kinesin family member genes in patients with lung adenocarcinoma. Oncol Rep. 2019 Jul 16;: Authors: Zhang L, Zhu G, Wang X, Liao X, Huang R, Huang C, Huang P, Zhang J, Wang P Abstract The current study aimed to identify the potential clinical significance and molecular mechanisms of kinesin (KIF) family member genes in lung adenocarcinoma (LUAD) using genome‑wide RNA sequencing (RNA‑seq) datasets derived from The Cancer Genome Atlas (TCGA) database. Clinical parameters and RNA‑seq data ...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Protein kinase A activation by β‑Lapachone is associated with apoptotic cell death in NQO1‑overexpressing breast cancer cells.
Protein kinase A activation by β‑Lapachone is associated with apoptotic cell death in NQO1‑overexpressing breast cancer cells. Oncol Rep. 2019 Jul 19;: Authors: Zada S, Hwang JS, Ahmed M, Lai TH, Pham TM, Kim DH, Kim DR Abstract One million females are diagnosed worldwide every year with breast cancer, and the mortality rate of these patients remains high. Several treatments, including surgery, are available for breast cancer. β‑Lapachone (β‑Lap), a natural quinone compound, has been developed for cancer treatment due to its strong cytotoxic effect through its action on NAD(P)H:q...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Poly(ADP ‑ribose) polymerase 1/2 inhibitors decrease the ubiquitination of ALC1 mediated by CHFR in breast cancer.
In conclusion, PARP1/2 inhibitors decrease the ubiquitination of ALC1 leading to the accumulation of ALC1, which affects the therapeutic effects of DNA damage response drugs in breast cancer treatment. PMID: 31322269 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of circular RNA CDR1 ‑AS in colon cancer cells increases cell surface PD‑L1 protein levels.
Expression of circular RNA CDR1‑AS in colon cancer cells increases cell surface PD‑L1 protein levels. Oncol Rep. 2019 Jul 19;: Authors: Tanaka E, Miyakawa Y, Kishikawa T, Seimiya T, Iwata T, Funato K, Odawara N, Sekiba K, Yamagami M, Suzuki T, Ishibashi R, Otsuka M, Koike K Abstract The expression of CDR1‑AS, a representative circular RNA, is closely linked with poor prognosis in gastrointestinal cancers, such as colon, liver, and pancreatic cancers. Although it is well known that CDR1‑AS antagonizes microRNA‑7 function through its sequence similarities in the brain, its biological function a...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A germline MBD4 mutation was identified in a patient with colorectal oligopolyposis and early ‑onset cancer: A case report.
A germline MBD4 mutation was identified in a patient with colorectal oligopolyposis and early‑onset cancer: A case report. Oncol Rep. 2019 Jul 17;: Authors: Tanakaya K, Kumamoto K, Tada Y, Eguchi H, Ishibashi K, Idani H, Tachikawa T, Akagi K, Okazaki Y, Ishida H Abstract A 42‑year‑old woman presented with ~30 adenomatous polyps of the left sided‑colon with early rectosigmoid cancer. The patient had no previous medical history and no familial history of inherited colorectal disease. No germline gene mutations associated with colorectal adenomatous polyposis, including APC regulator of WNT s...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MDM4 expression in fibrolamellar hepatocellular carcinoma.
Authors: Karki A, Putra J, Kim SS, Laquaglia MJ, Perez-Atayde AR, Sadri-Vakili G, Vakili K Abstract Fibrolamellar hepatocellular carcinoma (FL‑HCC) is a variant of hepatocellular carcinoma (HCC) that most commonly affects adolescents and young adults and is associated with an extremely poor prognosis due to the lack of effective chemotherapeutic agents. Mutations in p53 are a common oncogenic driver in HCC but not in FL‑HCC. However, in tumors lacking a p53 mutation, the tumor suppressor activity of p53 has been revealed to be dysregulated in several different cancer types. One mechanism has been attributed to ...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Growth inhibition and transcriptional effects of ribavirin in lymphoma.
In conclusion, ribavirin was proposed to exert growth inhibitory effects on lymphoma cell lines, particularly Hut78 cells, a cutaneous T‑cell lymphoma cell line. Of note, these effects may depend on, at least in part, the activation of canonical immune pathways regulated by the key factors STAT1 and interferon‑γ. Our results provide insight into the anti‑lymphoma potential of ribavirin; however, further investigations in preclinical and clinical studies are required to determine the effectiveness of ribavirin as a therapeutic agent for treating lymphoma. PMID: 31322273 [PubMed - as supplied by publisher] (S...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Low lncRNA ZNF385D ‑AS2 expression and its prognostic significance in liver cancer.
Low lncRNA ZNF385D‑AS2 expression and its prognostic significance in liver cancer. Oncol Rep. 2019 Jul 16;: Authors: Zhang Z, Wang S, Liu Y, Meng Z, Chen F Abstract Hepatocellular carcinoma (HCC) is a common digestive system disease with no curative treatment. Zinc finger protein 385D antisense RNA 2 (ZNF385D‑AS2) is a long non‑coding RNA (lncRNA) that has been predicted to function in human diseases, including several types of cancer. Yet, it has not been investigated in relation to liver cancer. Thus, the present study was designed with an aim to elucidate the prognostic significance of ln...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

AML ‑derived mesenchymal stem cells upregulate CTGF expression through the BMP pathway and induce K562‑ADM fusiform transformation and chemoresistance.
In this study, we aimed to explore the interaction of possible pathways in AML‑derived mesenchymal stem cells (AML‑MSCs) co‑cultured with the K562 and K562‑ADM cell lines. AML‑MSCs were co‑cultured with K562/K562‑ADM cells, and the interactions between the cells were verified by morphological detection, peroxidase staining (POX), reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and fluorescence in situ hybridization (FISH). The proliferation of K562/K562‑ADM cells under co‑culture conditions was detected by flow cytometry. The expression levels of BMP4 and CTGF wer...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells.
Authors: Kongsema M, Wongkhieo S, Khongkow M, Lam EW, Boonnoy P, Vongsangnak W, Wong-Ekkabut J Abstract Breast cancer is the most common type of malignancies in women worldwide, and genotoxic chemotherapeutic drugs are effective by causing DNA damage in cancer cells. However,>90% of patients with metastatic cancer are resistant to chemotherapy. The Forkhead box M1 (FOXM1) transcription factor plays a pivotal role in the resistance of breast cancer cells to chemotherapy by promoting DNA damage repair following genotoxic drug treatment. The aim of the present study was to investigate the inhibition of the FOXM1 pr...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of ribonucleotide reductase regulatory subunit M2 increases the drug sensitivity of chronic myeloid leukemia to imatinib ‑based therapy.
Knockdown of ribonucleotide reductase regulatory subunit M2 increases the drug sensitivity of chronic myeloid leukemia to imatinib‑based therapy. Oncol Rep. 2019 Jun 11;: Authors: Liu C, Li Y, Hu R, Han W, Gao S Abstract Imatinib‑based targeted treatment is the standard therapy for chronic myeloid leukemia (CML); however, drug resistance is an inevitable issue for imatinib‑based CML treatment. Imatinib resistance can be ascribed to Bcr‑Abl‑dependent and independent resistance. In the present study, peripheral blood samples were collected from imatinib‑sensitive (IS) and imatinib‑resistant...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Comparison of cofilin ‑1 and Twist‑1 protein expression in human non‑small cell lung cancer tissues.
Comparison of cofilin‑1 and Twist‑1 protein expression in human non‑small cell lung cancer tissues. Oncol Rep. 2019 Jun 10;: Authors: Chang CY, Chang SL, Leu JD, Chang YC, Hsiao M, Lin LT, Lin HN, Lee YJ Abstract Metastasis is the primary cause of mortality in patients with non‑small cell lung cancer (NSCLC). Actin cytoskeletal reorganization is usually accompanied by the epithelial‑mesenchymal transition (EMT)‑induced invasion and metastasis of cancer cells. In the present study, expression levels of the actin‑associated protein cofilin‑1 and of the pivotal EMT molecule Twist‑1 were ...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer.
Authors: Liang L, Zhao K, Zhu JH, Chen G, Qin XG, Chen JQ Abstract FK506 binding protein 10 (FKBP10) has been reported to be dysregulated in numerous types of cancer; however, few reports have investigated FKBP10 in gastric cancer (GC). The aim of the present study was to investigate FKBP10 expression in GC and to analyze its association with the prognosis of patients with GC. FKBP10 mRNA expression was evaluated using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The standardized mean differences of the meta‑analysis were comprehensively evaluated for FKBP10 expression from a series...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Activation of AKT/AP1/FoxM1 signaling confers sorafenib resistance to liver cancer cells.
Authors: Yan D, Yan X, Dai X, Chen L, Sun L, Li T, He F, Lian J, Cai W Abstract Sorafenib is the first‑line drug used in the treatment of liver cancer; however, drug resistance seriously limits the clinical response to sorafenib. The present study investigated the molecular mechanisms of sorafenib resistance in liver cancer cells. The data indicated that forkhead box M1 (FoxM1) was significantly overexpressed in sorafenib‑resistant cells, at the mRNA and protein levels. Knockdown of FoxM1 rendered drug‑tolerant cells sensitive to sorafenib. Furthermore, FoxM1 was upregulated at the transcriptional level....
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Epithelial membrane protein 1 promotes glioblastoma progression through the PI3K/AKT/mTOR signaling pathway.
Authors: Miao L, Jiang Z, Wang J, Yang N, Qi Q, Zhou W, Feng Z, Li W, Zhang Q, Huang B, Chen A, Zhang D, Zhao P, Li X Abstract Glioblastoma multiforme (GBM) is the most malignant intracranial tumor. Although the affected patients are usually treated with surgery combined with radiotherapy and chemotherapy, the median survival time for GBM patients is still approximately 12‑14 months. Identifying the key molecular mechanisms and targets of GBM development may therefore lead to the development of improved therapies for GBM patients. In the present study, the clinical significance and potential function of epithelia...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tumor ‑infiltrating M2 macrophages driven by specific genomic alterations are associated with prognosis in bladder cancer.
Tumor‑infiltrating M2 macrophages driven by specific genomic alterations are associated with prognosis in bladder cancer. Oncol Rep. 2019 Jun 12;: Authors: Xue Y, Tong L, LiuAnwei Liu F, Liu A, Zeng S, Xiong Q, Yang Z, He X, Sun Y, Xu C Abstract The present study aimed to explore the mechanism by which the immune landscape of the tumor microenvironment influences bladder cancer. CIBERSORT and ssGSEA analyses revealed that M2 macrophages accounted for the highest proportion from 22 subsets of tumor‑infiltrating immune cells and were enriched in higher histologic grade and higher pathologic stag...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Mutual editing of alternative splicing between breast cancer cells and macrophages.
Authors: Ding W, Li D, Zhang P, Shi L, Dai H, Li Y, Bao X, Wang Y, Zhang H, Deng L Abstract Breast cancer is a highly heterogeneous disease and numerous secreted factors may differentially contribute to a macrophage phenotype whose extensive infiltration is generally regarded as indicative of an unfavorable outcome. How different breast tumor cells and macrophage cells interplay or influence each other on the alternative splicing (AS) level have not been characterized. Here, we exploited one previous study, which investigated the interplay between macrophages and estrogen receptor‑positive (ER+) breast cancer and...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of microRNAs in glucocorticoid ‑resistant B‑cell precursor acute lymphoblastic leukemia.
Role of microRNAs in glucocorticoid‑resistant B‑cell precursor acute lymphoblastic leukemia. Oncol Rep. 2019 Jun 10;: Authors: Sakurai N, Komada Y, Hanaki R, Morimoto M, Ito T, Nakato D, Hirayama M Abstract Acute lymphoblastic leukemia (ALL) is the most common malignant disorder in children and intensive combination therapy has markedly improved patient prognosis. However, efficacy of the treatment still fails in 10‑15% of patients. Glucocorticoids (GCs) such as prednisone and dexamethasone (DEX) are essential drugs used for ALL chemotherapy, and the response to GC treatment is a strong independe...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research