Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction
Oncol Rep. 2024 May;51(5):70. doi: 10.3892/or.2024.8729. Epub 2024 Apr 5.ABSTRACTColorectal cancer (CRC) ranks as the second leading cause of cancer‑related death worldwide due to its aggressive nature. After surgical resection, >50% of patients with CRC require adjuvant therapy. As a result, eradicating cancer cells with medications is a promising method to treat patients with CRC. In the present study, a novel compound was synthesized, which was termed compound 225#. The inhibitory activity of compound 225# against CRC was determined by MTT assay, EdU fluorescence labeling and colony formation assay; the effects of ...
Source: Oncology Reports - April 5, 2024 Category: Cancer & Oncology Authors: Xiaoxue Zhang Liujun He Yong Li Yifei Qiu Wujing Hu Wanying Lu Huihui Du Donglin Yang Source Type: research
[Retracted] Sulforaphane sensitizes human cholangiocarcinoma to cisplatin via the downregulation of anti ‑apoptotic proteins
Oncol Rep. 2024 May;51(5):69. doi: 10.3892/or.2024.8728. Epub 2024 Apr 5.ABSTRACTFollowing the publication of the above article and a corrigendum that was published in October 2023 to address the issue of misplaced control β‑actin western blots comparing between Figs. 3 and 4A (doi: 10.3892/or.2023.8646), an attentive reader drew to the authors' attention that the first author had apparently made additional unreported corrections to the revised version of Fig. 4 presented in the corrigendum. Although these image discrepancies did not alter the study's primary conclusions, they were such that they did cast doubt on the d...
Source: Oncology Reports - April 5, 2024 Category: Cancer & Oncology Authors: Rokas Ra čkauskas Dachen Zhou Simonas Ūselis K ęstutis Strupas Ingrid Herr Peter Schemmer Source Type: research
Butyrate increases methylglyoxal production through regulation of the JAK2/Stat3/Nrf2/Glo1 pathway in castration ‑resistant prostate cancer cells
Oncol Rep. 2024 May;51(5):71. doi: 10.3892/or.2024.8730. Epub 2024 Apr 5.ABSTRACTCancer cells are characterized by increased glycolysis, known as the Warburg effect, which leads to increased production of cytotoxic methylglyoxal (MGO) and apoptotic cell death. Cancer cells often activate the protective nuclear factor erythroid 2‑related factor2 (Nrf2)/glyoxalase1 (Glo1) system to detoxify MGO. The effects of sodium butyrate (NaB), a product of gut microbiota, on Nrf2/Glos/MGO pathway and the underlying mechanisms in prostate cancer (PCa) cells were investigated in the present study. Treatment with NaB induced the cell de...
Source: Oncology Reports - April 5, 2024 Category: Cancer & Oncology Authors: Yi-Jan Hsia Zhang-Min Lin Taolan Zhang Tz-Chong Chou Source Type: research
Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction
Oncol Rep. 2024 May;51(5):70. doi: 10.3892/or.2024.8729. Epub 2024 Apr 5.ABSTRACTColorectal cancer (CRC) ranks as the second leading cause of cancer‑related death worldwide due to its aggressive nature. After surgical resection, >50% of patients with CRC require adjuvant therapy. As a result, eradicating cancer cells with medications is a promising method to treat patients with CRC. In the present study, a novel compound was synthesized, which was termed compound 225#. The inhibitory activity of compound 225# against CRC was determined by MTT assay, EdU fluorescence labeling and colony formation assay; the effects of ...
Source: Oncology Reports - April 5, 2024 Category: Cancer & Oncology Authors: Xiaoxue Zhang Liujun He Yong Li Yifei Qiu Wujing Hu Wanying Lu Huihui Du Donglin Yang Source Type: research
[Retracted] Sulforaphane sensitizes human cholangiocarcinoma to cisplatin via the downregulation of anti ‑apoptotic proteins
Oncol Rep. 2024 May;51(5):69. doi: 10.3892/or.2024.8728. Epub 2024 Apr 5.ABSTRACTFollowing the publication of the above article and a corrigendum that was published in October 2023 to address the issue of misplaced control β‑actin western blots comparing between Figs. 3 and 4A (doi: 10.3892/or.2023.8646), an attentive reader drew to the authors' attention that the first author had apparently made additional unreported corrections to the revised version of Fig. 4 presented in the corrigendum. Although these image discrepancies did not alter the study's primary conclusions, they were such that they did cast doubt on the d...
Source: Oncology Reports - April 5, 2024 Category: Cancer & Oncology Authors: Rokas Ra čkauskas Dachen Zhou Simonas Ūselis K ęstutis Strupas Ingrid Herr Peter Schemmer Source Type: research
Butyrate increases methylglyoxal production through regulation of the JAK2/Stat3/Nrf2/Glo1 pathway in castration ‑resistant prostate cancer cells
Oncol Rep. 2024 May;51(5):71. doi: 10.3892/or.2024.8730. Epub 2024 Apr 5.ABSTRACTCancer cells are characterized by increased glycolysis, known as the Warburg effect, which leads to increased production of cytotoxic methylglyoxal (MGO) and apoptotic cell death. Cancer cells often activate the protective nuclear factor erythroid 2‑related factor2 (Nrf2)/glyoxalase1 (Glo1) system to detoxify MGO. The effects of sodium butyrate (NaB), a product of gut microbiota, on Nrf2/Glos/MGO pathway and the underlying mechanisms in prostate cancer (PCa) cells were investigated in the present study. Treatment with NaB induced the cell de...
Source: Oncology Reports - April 5, 2024 Category: Cancer & Oncology Authors: Yi-Jan Hsia Zhang-Min Lin Taolan Zhang Tz-Chong Chou Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
