Knockdown of Nedd8 ‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells.
Knockdown of Nedd8‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells. Oncol Rep. 2019 Sep 20;: Authors: Zhao B, Gao C, Shi D, Mao J, Zhao J, Guo L, Guo J, Jiao Z Abstract As an important regulator of neddylation, neural precursor cell expressed developmentally downregulated 8 (Nedd8)‑conjugating enzyme E2M (UBE2M) mediates cullin neddylation. Upregulation of the neddylation pathway is associated with tumor progression in intrahepatic cholangiocarcinoma (ICC). The present study was designed to assess the effects of Nedd...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Diagnostic and prognostic values of C ‑X‑C motif chemokine ligand 3 in patients with colon cancer.
Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer. Oncol Rep. 2019 Sep 19;: Authors: Ruan GT, Gong YZ, Liao XW, Wang S, Huang W, Wang XK, Zhu GZ, Liao C, Gao F Abstract The diagnostic and prognostic mechanisms of C‑X‑C motif chemokine ligand 3 (CXCL3) in colon cancer (CC) have not yet been reported. Therefore, the objective of the present study was to use cohorts of patients from Guangxi Medical University and the Gene Expression Omnibus (GEO) database to investigate and validate CXCL3 for the diagnosis and prognosis of CC, and to explore its prosp...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer.
Authors: Tan WX, Xu TM, Zhou ZL, Lv XJ, Liu J, Zhang WJ, Cui MH Abstract Cisplatin is a common chemotherapeutic agent against ovarian cancer; however, drug resistance is a major limiting factor for its use in clinical treatment. The underlying mechanisms of cisplatin resistance in ovarian cancer have not yet been fully elucidated. Thus, this study aimed to elucidate some of the mechanisms responsible for resistance to cisplatin in ovarian cancer. The results demonstrated that the cisplatin‑resistant human ovarian cancer cell lines, SKOV3/DDP and A2780/DDP, exhibited higher autophagy levels than the control ovaria...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SMC1 promotes proliferation and inhibits apoptosis through the NF ‑κB signaling pathway in colorectal cancer.
SMC1 promotes proliferation and inhibits apoptosis through the NF‑κB signaling pathway in colorectal cancer. Oncol Rep. 2019 Aug 08;: Authors: Li J, He J, Wang Y, Shu Y, Zhou J Abstract Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer‑associated mortality globally. Increasing evidence has indicated that structural maintenance of chromosomes 1 (SMC1) may serve an important role in solid tumors as a tumor enhancer. In the present study, it was identified via reverse transcription‑quantitative PCR and western blot analyses that expression of SMC1 was s...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

β2‑adrenergic receptor signaling promotes neuroblastoma cell proliferation by activating autophagy.
In conclusion, the present study uncovered a novel regulatory mechanism of β2‑AR‑activated autophagy in NB cell growth and provides a novel potential therapeutic approach for treating NB by targeting autophagy and the β2‑AR pathway. PMID: 31524241 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Emodin: Its role in prostate cancer ‑associated inflammation (Review).
Emodin: Its role in prostate cancer‑associated inflammation (Review). Oncol Rep. 2019 Aug 06;: Authors: Tu Y, Wu Z, Tan B, Yang A, Fang Z Abstract Prostate cancer is one of the most common malignancies diagnosed in males. Cancer‑related inflammatory factors include tumor necrosis factor, inflammasomes, cytokines, chemokines, transcription factors, infiltrating or circulating immune cells, reactive oxygen species, and sex hormone receptors. These are mainly associated with the local immune response at the tumor site. Emodin, a chemical compound that can be isolated from the plant rhubarb among other...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The impact of the bone marrow microenvironment on multiple myeloma (Review).
Authors: Hou J, Wei R, Qian J, Wang R, Fan Z, Gu C, Yang Y Abstract Multiple myeloma (MM) is characterized by the accumulation of monoclonal plasma cells in the bone marrow (BM). The interaction between the BM microenvironment and MM plasma cells can influence cell proliferation, drug resistance and prognosis of the disease. The BM microenvironment (BMME) consists of a cellular and non‑cellular compartment. The cellular compartment includes stromal cells, endothelial cells, osteoclasts and osteoblasts, and the non‑cellular compartment includes the extracellular matrix (ECM) and the liquid milieu, which contains...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Monoclonal anti ‑MUC1 antibody with novel octahydropyrazino[2,1‑a:5,4‑a']diisoquinoline derivative as a potential multi‑targeted strategy in MCF‑7 breast cancer cells.
Monoclonal anti‑MUC1 antibody with novel octahydropyrazino[2,1‑a:5,4‑a']diisoquinoline derivative as a potential multi‑targeted strategy in MCF‑7 breast cancer cells. Oncol Rep. 2019 Aug 02;: Authors: Gornowicz A, Szymanowski W, Bielawska A, Szymanowska A, Czarnomysy R, Kałuża Z, Bielawski K Abstract The aim of the present study was to examine the multi‑targeted potential of a monoclonal antibody against mucin‑1 (MUC1) and novel octahydropyrazin[2,1‑a:5,4‑a']diisoquinoline derivative (OM‑86II) in estrogen receptor‑positive MCF‑7 human breast cancer cells. The cell viability wa...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role and mechanism of organic cation transporter 3 in oxaliplatin treatment of colon cancer in vitro and in vivo.
Authors: Gu J, Wang L, Li T, Tang S, Wang Y, Zhang W, Jiang X Abstract Oxaliplatin (OXA) is routinely used as the first‑line treatment for colorectal cancer (CRC). The addition of OXA to chemotherapy has significantly improved the prognosis of patients with CRC; however, some cases are resistant to OXA. The present study explored the influence of organic cation transporter 3 (OCT3) expression on the effects of OXA on CRC cell viability, and investigated the direct effects of OCT3 on viability, invasion and migration of CRC cells using MTT assay, wound healing assay, reverse transcription‑quantitative polymerase...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] CHD1L is associated with poor survival and promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma.
Authors: Li S, Chai Y, Ding Y, Yuan T, Wu C, Huang C Abstract Subsequent to the publication of the above paper, the authors have realized that the second affiliation for the second named author, Yi Chai, was not included with the affiliations. His second affiliation should have been listed as: "Department of Neurosurgery, Yuquan Hospital, School of Clinical Medicine, Tsinghua University, Beijing 100040, China." Therefore, the author affiliations for this paper should have appeared as follows: SHIMIAO LI1*, YI CHAI2,3*, YANBAO DING4, TINGHAO YUAN4, CHANGWEN WU5 and CHANGWEN HUANG1. 1Department of...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High resolution analysis of the intracellular proteome of cervical cancer cell lines unveils novel regulators of cervical carcinogenesis.
In conclusion, the shortlist of consistently deregulated proteins between cervical cancer cell lines and normal cervical keratinocytes can be used for validation in clinical samples and in functional investigation experiments that could ultimately lead to the discovery of novel disease biomarkers and drug targets. PMID: 31524267 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Casiopeina II ‑gly acts on lncRNA MALAT1 by miR‑17‑5p to inhibit FZD2 expression via the Wnt signaling pathway during the treatment of cervical carcinoma.
Casiopeina II‑gly acts on lncRNA MALAT1 by miR‑17‑5p to inhibit FZD2 expression via the Wnt signaling pathway during the treatment of cervical carcinoma. Oncol Rep. 2019 Aug 08;: Authors: Xu Y, Zhang Q, Lin F, Zhu L, Huang F, Zhao L, Ou R Abstract The present study investigated the underlying regulatory network involved in the differential expression of metastasis associated lung adenocarcinoma transcript 1 (MALAT1) long non‑coding (lnc)RNA, microRNA‑17‑5p (miR‑17‑5p) and frizzled class receptor 2 (FZD2) mRNA under the influence of Casiopeina II‑gly (Cas‑II‑gly) via the Wnt signal...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High expression of VAT1 is a prognostic biomarker and predicts malignancy in glioblastoma.
Authors: Shan X, Wang K, Tong X, Wang Z, Wu F, Liu X, Yang P, Wang J Abstract Vesicle amine transport protein 1 (VAT1) has been reported as a pathogenic factor in a variety of tumors. VAT1 has been revealed to be upregulated in glioblastoma (GBM) and promotes cell migration. However, the possible mechanism of VAT1 in promoting malignant development in GBM is unclear. The present study applied transcriptome data and functional experiments to explore the exact role of VAT1. Kaplan‑Meier survival analysis, univariate and multivariate Cox analyses were used to perform survival analysis. Furthermore, Gene&nb...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Emodin attenuates adenosine triphosphate ‑induced pancreatic ductal cell injury in vitro via the inhibition of the P2X7/NLRP3 signaling pathway.
This study suggests that emodin may be further developed for its application in future medical therapy. PMID: 31524270 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration.
Authors: Sawayama T, Nakashima K, Ichimura T, Sakai R, Uekita T Abstract CUB domain‑containing protein 1 (CDCP1) is phosphorylated by Src family kinases (SFK), and is thought to serve an important role in tumor metastasis through downstream signaling subsequent to its interaction with protein kinase C δ. The present study investigated the mechanisms of activation for CDCP1 signaling, and demonstrated that CDCP1 is able to activate SFK via a homophilic complex of the extracellular complement C1r/C1s, urchin embryonic growth factor, bone morphogenetic protein 1 (CUB) 2 domain. Deletion of the extracellular CD...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of the role of TRPM8 in glioblastoma and its effect on proliferation, apoptosis and invasion of the U251 human glioblastoma cell line.
Authors: Zeng J, Wu Y, Zhuang S, Qin L, Hua S, Mungur R, Pan J, Zhu Y, Zhan R Abstract Glioblastoma multiforme (GBM) is the most commonly occurring brain cancer, and is characterized by its poor patient outcomes. The present study examined the mRNA expression levels of the transient receptor potential melastatin (TRPM) family in various types of cancer using the ONCOMINE database, along with their corresponding expression profiles in an array of cancer cell lines based on the Cancer Cell Line Encyclopedia (CCLE) datasets. Kaplan‑Meier plotter survival analysis via the Chinese Glioma Genome Atlas (CGGA) database w...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Differential contribution of protein phosphatase 1 α to cell transformation of different cell types.
Differential contribution of protein phosphatase 1α to cell transformation of different cell types. Oncol Rep. 2019 Aug 08;: Authors: Chen JM, Chen KC, Chiu SC, Chen RY, Hsia JY, Huang YJ, Yu CR Abstract Protein phosphorylation plays roles in cell transformation. Numerous protein kinase enzymes actively participate in the formation of various types of cancer by phosphorylating downstream substrates. Aurora‑A is a widely known Serine/Threonine (Ser/Thr) oncogenic kinase, which is upregulated in more than twenty types of human cancer. This enzyme phosphorylates a wide range of substrates. For exa...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Differential expression of extracellular matrix ‑related genes DCN, EPHA4, FN1, SPARC, SPON2 and SPP1 in colorectal carcinogenesis.
Differential expression of extracellular matrix‑related genes DCN, EPHA4, FN1, SPARC, SPON2 and SPP1 in colorectal carcinogenesis. Oncol Rep. 2019 Aug 09;: Authors: Žlajpah M, Hauptman N, Boštjančič E, Zidar N Abstract During colorectal carcinogenesis, a spectrum of lesions is formed with different malignant potentials and occasionally with ambiguous morphologic features. To identify novel biomarkers, we previously performed a bioinformatics study to detect differentially expressed genes between colorectal adenoma (CRA) and colorectal carcinoma (CRC). The present study validated the diagnos...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High expression of bone morphogenetic protein (BMP) 6 and BMP7 are associated with higher immune cell infiltration and better survival in estrogen receptor ‑positive breast cancer.
High expression of bone morphogenetic protein (BMP) 6 and BMP7 are associated with higher immune cell infiltration and better survival in estrogen receptor‑positive breast cancer. Oncol Rep. 2019 Aug 12;: Authors: Katsuta E, Maawy AA, Yan L, Takabe K Abstract There are conflicted experimental results on the role of bone morphogenetic proteins (BMPs) in cancer. Some results suggest that BMPs act as tumor suppressors while other findings indicate that BMPs are oncogenic factors. In the present study, we aimed to investigate the association of BMP expression and the survival of breast cancer patients ut...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The efficacy of third generation anti ‑HER2 chimeric antigen receptor T cells in combination with PD1 blockade against malignant glioblastoma cells.
The efficacy of third generation anti‑HER2 chimeric antigen receptor T cells in combination with PD1 blockade against malignant glioblastoma cells. Oncol Rep. 2019 Aug 05;: Authors: Shen L, Li H, Bin S, Li P, Chen J, Gu H, Yuan W Abstract Without effective treatment, glioblastoma is one of the deadliest cancers worldwide. The aim of the present study was to explore whether combinational immunotherapy is effective for treating malignant glioblastoma in vitro. The therapeutic efficacy of third generation anti‑human epidermal growth factor receptor 2 (HER2) chimeric antigen receptor (CAR)‑T cel...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Perfluorooctanoic acid induces migration and invasion and inhibits apoptosis through the PI3K/AKT signaling pathway in human rhabdomyosarcoma cells.
Authors: Zhang Q, Wang J, Chen C, Kong Y, Yan H, Duan J, Wang C, Sha Y, Wen X, Wang C Abstract The present study aimed to investigate the effects of perfluorooctanoic acid (PFOA) on tumor cell migration, invasion and apoptosis by activation of the PI3K/AKT signaling pathway in human rhabdomyosarcoma (RMS). PFOA is a persistent, synthetic organic environment pollutant, which has been previously associated with multiple diseases, including cancer. The present study aimed to confirm whether PFOA can elicit cell growth in the RD subline of RBS. RD cells were treated with different concentrations of PFOA. Cell prolifera...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

FKBP3 mediates oxaliplatin resistance in colorectal cancer cells by regulating HDAC2 expression.
Authors: Tong J, Shen Y, Chen X, Wang R, Hu Y, Zhang X, Zhang Z, Han L Abstract Colorectal cancer (CRC), a commonly occurring malignant tumor in the gastrointestinal tract, is the third leading cause of cancer‑related deaths worldwide. FK506‑binding proteins (FKBPs) comprise an immunophilin family that are involved in the carcinogenesis, progression and chemoresistance of cancers, including CRC. FKBP3 (also known as FKBP25) is a nuclear protein that is a member of the FKBP family and is correlated with the activity of histone deacetylase 2 (HDAC2). However, the role of FKBP3 and HDAC2 in oxaliplatin resistance ...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Linc01105 acts as an oncogene in the development of neuroblastoma.
In conclusion, linc01105 may contribute to neuroblastoma tumorigenesis and development. The present findings indicated that the interplay between the p53/caspase pathway and the linc01105/miR‑6769b‑5p/VEGFA axis may have important roles in the development of neuroblastoma. PMID: 31524279 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Co ‑culturing with hypoxia pre‑conditioned mesenchymal stem cells as a new strategy for the prevention of irradiation‑induced fibroblast‑to‑myofibroblast transition.
Co‑culturing with hypoxia pre‑conditioned mesenchymal stem cells as a new strategy for the prevention of irradiation‑induced fibroblast‑to‑myofibroblast transition. Oncol Rep. 2019 Aug 23;: Authors: Zhuang L, Xia W, Hou M Abstract Cardiac fibrosis is a pathological consequence of radiation‑induced fibroblast proliferation and fibroblast‑to‑myofibroblast transition (FMT). Mesenchymal stem cell (MSC) transplantation has been revealed to be an effective treatment strategy to inhibit cardiac fibrosis. We identified a novel MSC‑driven mechanism that inhibited cardiac fibrosis, via the regu...
Source: Oncology Reports - September 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells.
Authors: Kim SH, Choo GS, Yoo ES, Woo JS, Han SH, Lee JH, Jung JY Abstract Apoptosis is regarded as a therapeutic target because it is typically disturbed in human cancer. Silymarin from milk thistle (Silybum marianum) has been reported to exhibit anticancer properties via regulation of apoptosis as well as anti‑inflammatory, antioxidant and hepatoprotective effects. In the present study, the effects of silymarin on the inhibition of proliferation and apoptosis were examined in human gastric cancer cells. The viability of AGS human gastric cancer cells was assessed by MTT assay. The migration of AGS cells was inv...
Source: Oncology Reports - September 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑192 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting caveolin 1.
MicroRNA‑192 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting caveolin 1. Oncol Rep. 2019 Aug 30;: Authors: Chen P, Feng Y, Zhang H, Shi X, Li B, Ju W, Yu X, Zhang N, Luo X Abstract It has been demonstrated that microRNA‑192 (miR‑192) serves important roles in different cancer types, including breast cancer, prostate cancer and colorectal cancer. However, its biological role and function in breast cancer remains largely unknown. The present study aimed to determine the role of miR‑192 in breast cancer. In the present study, one normal breast and two breast t...
Source: Oncology Reports - September 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Trk inhibitor GNF ‑5837 suppresses the tumor growth, survival and migration of renal cell carcinoma.
Trk inhibitor GNF‑5837 suppresses the tumor growth, survival and migration of renal cell carcinoma. Oncol Rep. 2019 Aug 28;: Authors: Chen Y, Wang H, Chen Y, Wang M, Ding G, Li T Abstract The clinical treatment of renal cell carcinoma (RCC) remains a major challenge. A number of novel agents and therapeutic strategies are currently undergoing active investigation. In the present study, we investigated the potential of GNF‑5837, a Trk inhibitor, in the treatment of RCC. Tropomyosin‑related kinases (Trk), a family of neurotrophin receptors, are vital for neural development and have also been identi...
Source: Oncology Reports - September 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tanshinone IIA inhibits glucose metabolism leading to apoptosis in cervical cancer.
Authors: Liu Z, Zhu W, Kong X, Chen X, Sun X, Zhang W, Zhang R Abstract Cancer requires aerobic glycolysis to supply the energy required for proliferation. Existing evidence has revealed that blocking glycolysis results in apoptosis of cancer cells. Tanshinone IIA (Tan IIA) is a diterpenoid naphthoquinone found in traditional Chinese medicine, Danshen (Salvia sp.). Tan IIA exhibits potential anticancer activity. However, its effect on cell viability of human cervical cancer cells and its mechanism are unknown. The aim of the present study was to determine the effect of Tan IIA on proliferation and glucose metabolis...
Source: Oncology Reports - September 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MTMR3 is upregulated in patients with breast cancer and regulates proliferation, cell cycle progression and autophagy in breast cancer cells.
Authors: Wang Z, Zhang M, Shan R, Wang YJ, Chen J, Huang J, Sun LQ, Zhou WB Abstract As a member of the myotubularin family, myotubularin related protein 3 (MTMR3) has been demonstrated to participate in tumor development, including oral and colon cancer. However, little is known about its functional roles in breast cancer. In the present study, the expression of MTMR3 in breast cancer was evaluated by immunohistochemical staining of tumor tissues from 172 patients. Online data was then used for survival analysis from the PROGgeneV2 database. In vitro, MTMR3 expression was silenced in MDA‑MB‑231 cells...
Source: Oncology Reports - September 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PD ‑L1/PD‑1 axis serves an important role in natural killer cell‑induced cytotoxicity in osteosarcoma.
PD‑L1/PD‑1 axis serves an important role in natural killer cell‑induced cytotoxicity in osteosarcoma. Oncol Rep. 2019 Sep 03;: Authors: Zhang ML, Chen L, Li YJ, Kong DL Abstract Osteosarcoma is a serious malignancy in pediatric patients, which comprises 2.4% of fatal cancer in children and achieves 20% of all primary bone cancers. In the present study, we employed three human osteosarcoma cell lines MG‑63, HOS and U2OS for susceptibility to cytolytic activity of freshly isolated healthy donor NK cells. Cells were lysed by NK cells in a dose dependent manner. MG‑63 cells exhibited less suscept...
Source: Oncology Reports - September 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

In  vivo effects of mutant RHOA on tumor formation in an orthotopic inoculation model.
In vivo effects of mutant RHOA on tumor formation in an orthotopic inoculation model. Oncol Rep. 2019 Sep 03;: Authors: Nishizawa T, Nakano K, Fujii E, Komura D, Kuroiwa Y, Ishimaru C, Monnai M, Aburatani H, Ishikawa S, Suzuki M Abstract Ras homolog family member A (RHOA) mutations are driver genes in diffuse‑type gastric cancers (DGCs), and we previously revealed that RHOA mutations contribute to cancer cell survival and cell migration through their dominant negative effect on Rho‑associated kinase (ROCK) signaling in vitro. However, how RHOA mutations contribute to DGC development in&nb...
Source: Oncology Reports - September 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A.
In this study, we aimed to analyze the effect of miR‑139‑3p on the progression of breast cancer and the mechanism involved. Through bioinformatics analysis and in vitro experimental studies, we found that miR‑139‑3p was decreased in breast cancer tissues and cell lines, and decreased miR‑139‑3p is associated with a poor prognosis in breast cancer patients. Overexpression of miR‑139‑3p by transfection significantly inhibits cell proliferation, migration, and invasion of breast cancer cells. Bioinformatics analysis and luciferase reporter gene assay confirmed that RAB1A was a potential target of miR‑13...
Source: Oncology Reports - September 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Synergistic combination of chemo ‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment.
Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment. Oncol Rep. 2019 Aug 21;: Authors: Kwon YM, Je JY, Cha SH, Oh Y, Cho WH Abstract Chemo‑photothermal therapy for cancer treatment has received increasing attention due to its selective therapeutic effects. In the present study, the anticancer effects of drug‑loaded Fe3O4 magnetic nanoparticles (MNPs) by chemo‑photothermal therapy on U‑87 MG human glioblastoma cells was investigated. Anticancer drug‑loaded Fe3O4 MNPs were prepared by loading temozolomide (TMZ) a...
Source: Oncology Reports - August 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Emetine exhibits anticancer activity in breast cancer cells as an antagonist of Wnt/ β‑catenin signaling.
Emetine exhibits anticancer activity in breast cancer cells as an antagonist of Wnt/β‑catenin signaling. Oncol Rep. 2019 Aug 22;: Authors: Sun Q, Fu Q, Li S, Li J, Liu S, Wang Z, Su Z, Song J, Lu D Abstract Emetine, an amoebicidal drug, exerts potent anticancer activity against various solid tumors, however, the underlying molecular mechanism remains unclear. In the present study, the effects of emetine were investigated on various proteins involved in the Wnt/β‑catenin signaling pathway, which has been linked to various human cancers. It was revealed that emetine blocked Wnt/β‑cat...
Source: Oncology Reports - August 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Autophagy modulation in bladder cancer development and treatment (Review).
Authors: Li F, Guo H, Yang Y, Feng M, Liu B, Ren X, Zhou H Abstract Bladder cancer (BC) is a potentially life‑threatening malignancy. Due to a high recurrence rate, frequent surveillance strategies and intravesical drug therapies, BC is considered one of the most expensive tumors to treat. As a fundamental evolutionary catabolic process, autophagy plays an important role in the maintenance of cellular environmental homeostasis by degrading and recycling damaged cytoplasmic components, including macromolecules and organelles. Scientific studies in the last two decades have shown that autophagy acts as a double‑e...
Source: Oncology Reports - August 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Curcumin decreases epithelial ‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells.
Curcumin decreases epithelial‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells. Oncol Rep. 2019 Aug 21;: Authors: Aedo-Aguilera V, Carrillo-Beltrán D, Calaf GM, Muñoz JP, Guerrero N, Osorio JC, Tapia JC, León O, Contreras HR, Aguayo F Abstract Curcumin is a natural antioxidant polyphenol, which decreases epithelial‑mesenchymal transition (EMT) and cell migration in cervical cancer cells. However, the mechanism by which such a decrease occurs is unclear. It is well established that cervical cancer can be caused by high‑risk human papillomav...
Source: Oncology Reports - August 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

WT1 regulates cyclin  A1 expression in K562 cells.
In this study, the WT1 and CCNA1 mRNA levels were found to be elevated in bone marrow samples from pediatric acute promyelocytic leukemia (APL or AML‑M3) patients, and to be quite varied in pediatric acute lymphocytic leukemia (ALL) patients, compared to non‑leukemic bone marrow controls. Consistent with the observed upregulation of both WT1 and CCNA1 in APL, WT1 overexpression elevated the CCNA1 mRNA levels in K562 leukemia cells. Treatment with curcumin decreased the WT1 levels in K562 cells, and also decreased CCNA1 protein expression. The examination of the CCNA1 promoter identified potential canonical WT1 bin...
Source: Oncology Reports - August 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Dehydrogenase/reductase SDR family member  2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression. Oncol Rep. 2019 Aug 22;: Authors: Li JM, Jiang GM, Zhao L, Yang F, Yuan WQ, Wang H, Luo YQ Abstract Oxaliplatin (Oxa)‑based chemotherapy is widely used as the first‑line treatment for colorectal cancer (CRC). However, Oxa‑resistance is common for many postoperative CRC patients. To explore drug resistance in CRC, an Oxa‑resistant cell line, HCT116/Oxa, was established from parental HCT116 cells. ...
Source: Oncology Reports - August 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Efficient primary culture model of patient ‑derived tumor cells from colorectal cancer using a Rho‑associated protein kinase inhibitor and feeder cells.
Efficient primary culture model of patient‑derived tumor cells from colorectal cancer using a Rho‑associated protein kinase inhibitor and feeder cells. Oncol Rep. 2019 Aug 20;: Authors: Hong HK, Pyo DH, Kim TW, Yun NH, Lee YS, Song SJ, Lee WY, Cho YB Abstract In vitro culture of patient‑derived tumor cells offers many advantages in the development of novel therapies for colorectal cancer. Although various culture systems have been developed, the long‑term expansion of patient‑derived tumor cells remains challenging. The present results suggested that tumor cells isolated from colorectal ...
Source: Oncology Reports - August 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

EMX2 is epigenetically silenced and suppresses epithelial ‑mesenchymal transition in human esophageal adenocarcinoma.
EMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma. Oncol Rep. 2019 Aug 20;: Authors: Wang L, Jin J, Zhou Y, Tian Z, He B, Huang Y, Ding F Abstract Esophageal adenocarcinoma (EAC) is an aggressive and challenging disease to treat, with an overall five‑year survival rate of
Source: Oncology Reports - August 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of miR ‑34 in gastric cancer: From bench to bedside (Review).
Role of miR‑34 in gastric cancer: From bench to bedside (Review). Oncol Rep. 2019 Aug 16;: Authors: Xiong S, Hu M, Li C, Zhou X, Chen H Abstract Gastric cancer (GC) is a prevalent digestive system malignancy that is associated with a poor prognosis specifically for advanced‑stage patients. MicroRNAs (miRNAs) are small, non‑coding RNAs that have been reported to play roles as oncogenes or tumour suppressors in all types of cancer, including GC, by post‑transcriptionally regulating cancer‑related genes. Recently, miR‑34a and miR‑34b/c, members of the microRNA‑34 (miR‑34) family, were id...
Source: Oncology Reports - August 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways.
Authors: Zhang L, Tao X, Fu Q, Ge C, Li R, Li Z, Zhu Y, Tian H, Li Q, Liu M, Hu H, Zeng B, Lin Z, Li C, Luo R, Song X Abstract Despite the increasing number of available therapeutic methods, the prognosis of non‑small cell lung cancer (NSCLC) remains poor. Furthermore, side effects are an important limiting factor in the treatment of NSCLC. Therefore, developing an efficacious, safe, affordable and easily accessible chemotherapeutic agent is necessary for NSCLC treatment. As a natural chemical produced by Zingiberaceae plants, curcumin exerts distinct antitumor effects on several tumor types. In the present study...
Source: Oncology Reports - August 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria ‑mediated apoptosis.
Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria‑mediated apoptosis. Oncol Rep. 2019 Aug 16;: Authors: Geng N, Zheng X, Wu M, Yang L, Li X, Chen J Abstract Cisplatin (cis‑dichlorodiamine platinum, CDDP) is a potent antitumor agent. However, its clinical application is limited by its side effects and the development of drug resistance. Tannic acid (TA) has previously been reported to suppress tumor growth in different types of cancer. The present study evaluated the anticancer efficacy of TA in combination with CDDP on the liver can...
Source: Oncology Reports - August 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Clinical significance and prospective molecular mechanism of C ‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy.
Clinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy. Oncol Rep. 2019 Aug 13;: Authors: Zhou X, Liao X, Wang X, Huang K, Yang C, Yu T, Liu J, Han C, Zhu G, Su H, Qin W, Han Q, Liu Z, Huang J, Gong Y, Ye X, Peng T Abstract The present study aimed to determine the clinical significance and potential molecular mechanisms of C‑C motif chemokine receptor (CCR) genes in patients with early‑stage pancreatic ductal adenocarcinoma (PDAC). The transcriptomic, survival and clin...
Source: Oncology Reports - August 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Disrupting myddosome assembly in diffuse large B ‑cell lymphoma cells using the MYD88 dimerization inhibitor ST2825.
Disrupting myddosome assembly in diffuse large B‑cell lymphoma cells using the MYD88 dimerization inhibitor ST2825. Oncol Rep. 2019 Aug 19;: Authors: Wang X, Tan Y, Huang Z, Huang N, Gao M, Zhou F, Hu J, Feng W Abstract Diffuse large B‑cell lymphoma (DLBCL), the most common type of non‑Hodgkin's lymphoma, is classified into germinal center and activated B cell (ABC) subtypes. The myeloid differentiation primary response gene 88 (MYD88) L265P mutation is the most prevalent oncogenic mutation among patients with ABC DLBCL, the subtype that has the more inferior outcome. MYD88 oligomerization driven...
Source: Oncology Reports - August 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of LXR ‑β, ABCA1 and ABCG1 in human triple‑negative breast cancer tissues.
Expression of LXR‑β, ABCA1 and ABCG1 in human triple‑negative breast cancer tissues. Oncol Rep. 2019 Aug 14;: Authors: Pan H, Zheng Y, Pan Q, Chen H, Chen F, Wu J, Di D Abstract Previous studies have reported that liver X receptor (LXR), ATP‑binding cassette sub‑family G number 1 (ABCG1) and ATP‑binding cassette transporter number 1 (ABCA1), which are associated with cholesterol metabolism, may be associated with the development and progression of breast cancer. The expression levels of LXR‑β, ABCA1 and ABCG1 in triple‑negative breast cancer (TNBC) tissues and in non‑canc...
Source: Oncology Reports - August 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑378a‑3p inhibits cellular proliferation and migration in glioblastoma multiforme by targeting tetraspanin 17.
miR‑378a‑3p inhibits cellular proliferation and migration in glioblastoma multiforme by targeting tetraspanin 17. Oncol Rep. 2019 Aug 20;: Authors: Guo XB, Zhang XC, Chen P, Ma LM, Shen ZQ Abstract Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and patients with this disease tend to have poor clinical outcome. MicroRNAs (miRs) are important regulators of a number of key pathways implicated in tumor pathogenesis. Recently, the expression of miR‑378 was shown to be dysregulated in several different types of cancer, including gastric cancer, colorectal cancer and oral ca...
Source: Oncology Reports - August 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HMQ ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway. Oncol Rep. 2019 Jul 23;: Authors: Dai B, Yu R, Fan M, Yang T, Wang B, Zhang Y Abstract Epithelial‑mesenchymal transition (EMT) is closely related to tumor metastasis, and offers insight into novel strategies for cancer treatment. HMQ‑T‑F2 (F2) is a taspine derivative, which has excellent anticancer activity in human cervical cancer. The present study aimed to evaluate the effect of F2 on in vitro migration of HeLa cells. The present data demonstrated that F2 inh...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Plasma miR ‑15b‑5p and miR‑590‑5p for distinguishing patients with bladder cancer from healthy individuals.
Plasma miR‑15b‑5p and miR‑590‑5p for distinguishing patients with bladder cancer from healthy individuals. Oncol Rep. 2019 Jul 24;: Authors: Tölle A, Buckendahl L, Jung K Abstract MicroRNAs (miRNAs/miRs) act as markers for various cancers, including bladder cancer (BC). Plasma miRNAs are potential biomarkers for the noninvasive diagnosis and long‑term surveillance of BC. The aim of the present study was to identify diagnostically reliable miRNAs in the plasma and examine their potential monitoring capacity. miRNAs were measured by reverse transcription‑quantitative polymerase chain rea...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑124 negatively regulates chloride intracellular channel 1 to suppress the migration and invasion of liver cancer cells.
MicroRNA‑124 negatively regulates chloride intracellular channel 1 to suppress the migration and invasion of liver cancer cells. Oncol Rep. 2019 Jul 25;: Authors: Yue X, Cui Y, You Q, Lu Y, Zhang J Abstract The dysregulation of microRNAs (miRNAs) is associated with the development and progression of a variety of cancers, including liver cancer. Aberrant expression of miRNA (miR)‑124 has been demonstrated in liver cancer, but its functional mechanism in liver cancer is still largely unknown. Metastasis of liver cancer is one of the most common causes of mortality. The present study showed that ...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research