Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways.
Authors: Li W, Wang Z, Xiao X, Han L, Wu Z, Ma Q, Cao L Abstract The relationship between diabetes mellitus and pancreatic cancer is complex. Diabetes has been postulated to be both an independent risk factor and a consequence of pancreatic cancer. Our previous study confirmed that curcumin plays a vital role in inhibiting the epithelial-mesenchymal transition of pancreatic cancer cells. However, whether curcumin attenuates hyperglycemia-induced cancer invasive and migratory abilities and the underlying mechanisms are not yet well understood. As high glucose is able to induce the expression of epidermal growth fact...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑466 inhibits the aggressive behaviors of hepatocellular carcinoma by directly targeting metadherin.
MicroRNA‑466 inhibits the aggressive behaviors of hepatocellular carcinoma by directly targeting metadherin. Oncol Rep. 2018 Oct 03;: Authors: Jia C, Tang D, Sun C, Yao L, Li F, Hu Y, Zhang X, Wu D Abstract Numerous microRNAs (miRNAs) have been demonstrated to be downregulated or upregulated in hepatocellular carcinoma (HCC) and play important roles in its occurrence and development. Therefore, the investigation of miRNAs and their functions implicated in the genesis and development of HCC may provide key clues for the identification of effective therapeutic approaches for patients with this disease....
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of miR ‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer.
Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer. Oncol Rep. 2018 Oct 08;: Authors: Peng Y, Zhang X, Lin H, Deng S, Huang Y, Qin Y, Feng X, Yan R, Zhao Y, Cheng Y, Wei Y, Wang J, Chen W, Fan X, Ashktorab H, Smoot D, Meltzer SJ, Li S, Zhang Z, Jin Z Abstract A mounting body of evidence has revealed that microRNAs (miRs) serve pivotal roles in various developmental processes, and in tumourigenesis, by binding to target genes and subsequently regulating gene expression. Continued activation of the Wnt/β‑catenin signalling is positively associated with...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SMAD specific E3 ubiquitin protein ligase  1 promotes ovarian cancer cell migration and invasion via the activation of the RhoA/ROCK signaling pathway.
SMAD specific E3 ubiquitin protein ligase 1 promotes ovarian cancer cell migration and invasion via the activation of the RhoA/ROCK signaling pathway. Oncol Rep. 2018 Oct 31;: Authors: Wang W, Du H, Liu H, Hu F, Liu G Abstract SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) serves a pivotal role in a variety of pathological processes and in tumor cell migration and invasion; however, its functional mechanism in ovarian cancer (OC) remains unknown. Previously, we observed overexpression of SMURF1 in OC tissues. In the present study, the role of SMURF1 in OC metastasis was investigated. Th...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Rapamycin enhances the sensitivity of ER ‑positive breast cancer cells to tamoxifen by upregulating p73 expression.
Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression. Oncol Rep. 2018 Nov 01;: Authors: Zhu L, Li XX, Shi L, Wu J, Qian JY, Xia TS, Zhou WB, Sun X, Zhou XJ, Wei JF, Ding Q Abstract A total of 70% of breast cancers express the estrogen receptor (ER)α; therefore, targeting the ER may be an effective endocrine therapy with which to inhibit breast cancer growth. Tamoxifen is the most common‑used clinically used drug for the treatment of advanced or metastatic ER‑positive (ER+) breast cancer. However, a substantial proportion of patien...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of miR ‑224‑5p in prostate cancer and its relevant molecular mechanism via TCGA, GEO database and in silico analyses.
Downregulation of miR‑224‑5p in prostate cancer and its relevant molecular mechanism via TCGA, GEO database and in silico analyses. Oncol Rep. 2018 Oct 03;: Authors: Gan BL, Zhang LJ, Gao L, Ma FC, He RQ, Chen G, Ma J, Zhong JC, Hu XH Abstract The function of the expression of microRNA (miR)‑224‑5p in prostate adenocarcinoma (PCa) remains to be elucidated, therefore, the present study aimed to investigate the clinical significance and potential molecular mechanism of miR‑224‑5p in PCa. Data on the expression of miR‑224‑5p in PCa were extracted from The Cancer Genome Atlas ...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis.
Authors: Xiao M, Liu L, Zhang S, Yang X, Wang Y Abstract Several putative biomarkers have been reported to identify cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC). Herein, we aimed to demonstrate the validity and the underlying relationship for these biomarkers in HNSCC. Bioinformatic analyses for the reported CSC biomarkers of HNSCC were performed based on the TCGA primary HNSCC cohort using the UCSC Xena browser. Targeted strategies for the validated biomarkers were searched and summarized. A total of 27 reported CSC biomarkers for HNSCC were identified and comprehensivel...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PI3K β inhibitor AZD6482 exerts antiproliferative activity and induces apoptosis in human glioblastoma cells.
PI3Kβ inhibitor AZD6482 exerts antiproliferative activity and induces apoptosis in human glioblastoma cells. Oncol Rep. 2018 Nov 02;: Authors: Xu PF, Yang JA, Liu JH, Yang X, Liao JM, Yuan FE, Liu BH, Chen QX Abstract Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis is particularly complicated. Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic activating mutations in PIK3CA. In the present study, we investigat...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anticancer activity of gomisin  J from Schisandra chinensis fruit.
Anticancer activity of gomisin J from Schisandra chinensis fruit. Oncol Rep. 2018 Nov 02;: Authors: Jung S, Moon HI, Kim S, Quynh NTN, Yu J, Sandag Z, Le DT, Lee H, Lee H, Lee MS Abstract In attempting to identify effective anticancer drugs from natural products that are harmless to humans, we found that the gomisin J from Schisandra chinensis fruit has anticancer activity. Schisandra chinensis fruits are used in traditional herbal medicine and gomisin J is one of their chemical constituents. In the present study, we examined the anticancer activity of gomisin J in MCF7 and MDA-MB-2...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anoikis ‑resistant human osteosarcoma cells display significant angiogenesis by activating the Src kinase‑mediated MAPK pathway.
Anoikis‑resistant human osteosarcoma cells display significant angiogenesis by activating the Src kinase‑mediated MAPK pathway. Oncol Rep. 2018 Oct 29;: Authors: Gao Z, Zhao GS, Lv Y, Peng D, Tang X, Song H, Guo QN Abstract Tumor cells must resist anoikis to metastasize. There is a key role of angiogenesis in the growth and metastasis of tumors. However, the relationship between anoikis resistance and angiogenesis has not been well explored in human osteosarcoma. In the present study, we reported the higher expression of vascular endothelial growth factor‑A (VEGF‑A) in osteosarcoma cells that w...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MiR ‑381 regulates cell motility, growth and colony formation through PIK3CA in endometriosis‑associated clear cell and endometrioid ovarian cancer.
MiR‑381 regulates cell motility, growth and colony formation through PIK3CA in endometriosis‑associated clear cell and endometrioid ovarian cancer. Oncol Rep. 2018 Oct 09;: Authors: Hsu CY, Hsieh TH, Er TK, Chen HS, Tsai CC, Tsai EM Abstract Ovarian cancer is the one of the most lethal gynecological cancer types. MicroRNAs (miRs) are noncoding RNAs that modulate the translation of their target mRNAs via binding to a complementary sequence in the target 3' untranslated region, and the dysregulation of certain miRs has been demonstrated to contribute to cancer progression. In this regard, the current...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑744 inhibits migration and invasion of hepatocellular carcinoma cells by targeting SOX12.
MicroRNA‑744 inhibits migration and invasion of hepatocellular carcinoma cells by targeting SOX12. Oncol Rep. 2018 Oct 08;: Authors: Zhang W, Liu K, Liu S, Ji B, Liu Y Abstract MicroRNA‑744 (miR‑744) reportedly plays an oncogenic or tumor‑suppressive role in different human malignancies. Although a previous study demonstrated that miR‑744 significantly inhibits hepatocellular carcinoma (HCC) proliferation in vitro, the role of miR‑744 in the migration and invasion of HCC cells remains largely unknown. The present study investigated the significance of miR‑744 in HCC tissues and cell ...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gap junction β‑2 expression is negatively associated with the estrogen receptor status in breast cancer tissues and is a regulator of breast tumorigenesis.
Gap junction β‑2 expression is negatively associated with the estrogen receptor status in breast cancer tissues and is a regulator of breast tumorigenesis. Oncol Rep. 2018 Oct 03;: Authors: Shettar A, Damineni S, Mukherjee G, Kondaiah P Abstract Gap junction β‑2 gene (GJB2, also known as connexin 26) is a member of the connexin family which forms gap junction channels. Many connexin genes have been considered to be tumor suppressor genes. However, the overexpression of GJB2 has been found to be associated with a poor prognosis in several human cancers. In our previous microarray stud...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Exosomal microRNAs as potential biomarkers for cancer cell migration and prognosis in hepatocellular carcinoma patient-derived cell models.
Authors: Yu LX, Zhang BL, Yang Y, Wang MC, Lei GL, Gao Y, Liu H, Xiao CH, Xu JJ, Qin H, Xu XY, Chen ZS, Zhang DD, Li FG, Zhang SG, Liu R Abstract Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, and current treatments exhibit limited efficacy against advanced HCC. The majority of cancer-related deaths are caused by metastasis from the primary tumor, which indicates the importance of identifying clinical biomarkers for predicting metastasis and indicating prognosis. Patient-derived cells (PDCs) may be effective models for biomarker identification. In the present study, a wound hea...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Histone methyltransferase SUV39H2 serves oncogenic roles in osteosarcoma.
Authors: Piao L, Yuan X, Zhuang M, Qiu X, Xu X, Kong R, Liu Z Abstract Suppressor of variegation 3‑9 homologue 2 (SUV39H2), a SET domain‑containing histone methyl-transferase, trimethylates histone H3 at lysine 9 and serves crucial roles in heterochromatin organization and genome stability. SUV39H2 is overexpressed in various types of human cancer, whereas it is almost undetectable in normal adult tissues, except testis. The aim of this study was to investigate a potential role of SUV39H2 in osteosarcoma. In the present study, increased SUV39H2 expression levels were observed in osteosarcoma...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity.
Authors: Hu JQ, Deng F, Hu XP, Zhang W, Zeng XC, Tian XF Abstract Liver cancer is the leading cause of cancer‑related mortality worldwide and its incidence is increasing. Considerable effort has been made in recent decades to improve the diagnosis and treatment of liver cancer. Advanced liver cancer often exhibits a poor response to chemotherapy and poor prognosis due to acquired chemoresistance and tumor recurrence. Understanding the precise molecular mechanisms that are responsible for chemotherapeutic drug‑induced cell death could potentially identify novel therapeutic targets and improve liver cancer treatm...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Induction of apoptosis and erythroid differentiation of human chronic myelogenous leukemia K562 cells by low concentrations of lidamycin.
Authors: Zhang C, Guo LY, Mu D, Gong JH, Chen J Abstract Apoptosis induction and differentiation of promyelocytic leukemic cells into mature cells are major strategies for the drug-based treatment of leukemia. Lidamycin (LDM) which is a member of the enediyne antibiotic family exhibits extreme cytotoxicity. In the present study, the induction of apoptosis and differentiation in human chronic myeloid leukemia K562 cells by low concentrations of lidamycin were investigated. K562 cells were treated with lidamycin at various concentrations for 48 h, and accumulated in the metaphase as determined in previous experi...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of KLF9 in pancreatic cancer and its effects on the invasion, migration, apoptosis, cell cycle distribution, and proliferation of pancreatic cancer cell lines.
Authors: Zhong Z, Zhou F, Wang D, Wu M, Zhou W, Zou Y, Li J, Wu L, Yin X Abstract Kruppel-like factor 9 (KLF9), a transcription factor, is critical for the inhibition of growth and development of tumors, whereas its effects in pancreatic cancer remains unclear. The purpose of the present study was to investigate the expression and functional significance of KLF9 in vitro, by assessing the expression of KLF9 in pancreatic cancer tissue samples and its association with the total survival of patients and clinicopathological data. The levels of KLF9 expression in adjacent tissues and pancreatic cancer tissues were...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulation of thyroid hormone receptor interactor  13 is associated with human hepatocellular carcinoma.
Upregulation of thyroid hormone receptor interactor 13 is associated with human hepatocellular carcinoma. Oncol Rep. 2018 Oct 04;: Authors: Ju L, Li X, Shao J, Lu R, Wang Y, Bian Z Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. Thyroid hormone receptor interactor 13 (TRIP13) has been reported to promote nonhomologous end joining (NHEJ). However, the role of TRIP13 in the molecular pathogenesis of HCC remains to be elucidated. The aim of the present study was to investigate the role and potential mechanism of TRIP13 in ...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Lymphoma transformation of tumor infiltrating lymphocytes observed in testicular patient ‑derived xenograft models.
Lymphoma transformation of tumor infiltrating lymphocytes observed in testicular patient‑derived xenograft models. Oncol Rep. 2018 Oct 05;: Authors: Kalavska K, Kucerova L, Schmidtova S, Toro L, Kozovska Z, Plank L, Chovanec M, Palacka P, Pindak D, Macak D, Mardiak J, Mego M Abstract Testicular germ cell tumors (TGCTs) are highly sensitive to cisplatin‑based chemotherapy. Nevertheless, there are metastatic tumors that do not completely respond to front‑line chemotherapy. For these tumors, surgical resection of residual masses is necessary to achieve long‑term disease control. Resected tissues r...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non-coding RNA LOC285194 functions as a tumor suppressor by targeting p53 in non-small cell lung cancer.
This study intended to investigate the biological role of LOC285194 and its clinical significance in NSCLC. LOC285194 was detected by qRT-PCR, and its correlation with clinicopathological features of NSCLC was analyzed. The expression of LOC285194 was knocked down or ectopically expressed in lung cancer cells (A549 and H1299) and tumor cell growth, migration and invasion in vitro were investigated. In addition, the interaction of LOC285194 and target proteins was assessed by RNA pulldown and RNA immunoprecipitation in vitro. The results revealed that the expression of LOC285194 was significantly lower in tumor ti...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of biomarkers for the prediction of relapse ‑free survival in pediatric B‑precursor acute lymphoblastic leukemia.
Identification of biomarkers for the prediction of relapse‑free survival in pediatric B‑precursor acute lymphoblastic leukemia. Oncol Rep. 2018 Nov 02;: Authors: Jing W, Li J Abstract B‑precursor acute lymphoblastic leukemia (B‑ALL) is the most common cancer diagnosed in children and adolescents. Despite the fact that the 5‑year survival rate has increased from 60 to 90%, approximately a quarter of children suffer from relapse with poor outcome. To improve the clinical management of B‑ALL, there is an urgent need for prognostic biomarkers for the prediction of B‑ALL outcomes. In the prese...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma.
Authors: Kobayashi S, Saio M, Fukuda T, Kimura K, Hirato J, Oyama T Abstract Nuclear size and shape are important components in the diagnosis of pathological specimens. However, a qualitative evaluation is typically applied rather than a quantitative evaluation technique. In the present study, we sought to evaluate the nuclear morphological characteristics of lung adenocarcinoma using whole-slide imaging (WSI) and computer-assisted image analysis (IA). We evaluated the nuclear characteristics of 106 cases of surgically resected lung adenocarcinoma according to Feulgen staining and immunohistochemistry (IHC) for the...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ubiquitin ‑specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial‑mesenchymal transition.
Ubiquitin‑specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial‑mesenchymal transition. Oncol Rep. 2018 Oct 31;: Authors: Zeng Q, Li Z, Zhao X, Guo L, Yu C, Qin J, Zhang S, Zhang Y, Yang X Abstract Osteosarcoma (OS) is the most common primary malignant bone tumour among adolescents and young adults; however, its molecular pathogenesis has not been completely elucidated. Ubiquitin‑specific protease 7 (USP7), a member of the deubiquitinating enzyme family, plays a role in the malignancy process of various cancer types by targeting the key oncoprotein; however, its biologi...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Pectolinarigenin inhibits non ‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway.
Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway. Oncol Rep. 2018 Oct 02;: Authors: Xu F, Gao X, Pan H Abstract Lung cancer is the principal cause of cancer‑-associated mortality. Pectolinarigenin (Pec) reportedly has effective antitumor activity against certain cancer types. Phosphatase and tensin homolog (PTEN) is a well‑known tumor suppressor and serves a vital role in cancer progression. However, the effect of Pec on non‑small cell lung cancer (NSCLC) cell proliferation and metastasis, and the underlying mechanism, has not ye...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tumor ‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer.
In conclusion, H19 promoted gefitinib resistance of NSCLC cells by packaging into exosomes. Therefore, exosomal H19 may be a promising therapeutic target for EGFR+ NSCLC patients. PMID: 30542738 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

sFRP1 exerts effects on gastric cancer cells through GSK3 β/Rac1‑mediated restraint of TGFβ/Smad3 signaling.
sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1‑mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 2018 Oct 31;: Authors: Peng JX, Liang SY, Li L Abstract Secreted frizzled‑related protein 1 (sFRP1) is an inhibitor of canonical Wnt signaling; however, previous studies have determined a tumor‑promoting function of sFRP1 in a number of different cancer types. A previous study demonstrated that sFRP1 overexpression was associated with an aggressive phenotype and the activation of transforming growth factor β (TGFβ) signaling. sFRP1 overexpression and...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hydrogen gas restores exhausted CD8+ T  cells in patients with advanced colorectal cancer to improve prognosis.
Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis. Oncol Rep. 2018 Nov 01;: Authors: Akagi J, Baba H Abstract Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, the present study investigated whether it restores exhausted CD8+ T ce...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer.
Authors: Li N, Li D, Du Y, Su C, Yang C, Lin C, Li X, Hu G Abstract Researchers hold the view that PLAGL2 is overexpressed in many malignancies and that it can promote tumor proliferation, migration, invasion and self‑renewal; however, there is no evidence revealing a relationship between PLAGL2 and colorectal cancer (CRC). In the present study, genes that are overexpressed in CRC were screened using the COSMIC database and GEPIA database and the expression of PLAGL2 in carcinoma tissues and pericarcinomatous tissues was detected by RT‑qPCR and western blot assays. A Cell Counting Kit‑8 assay, a cell cycle an...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ten genes associated with MGMT promoter methylation predict the prognosis of patients with glioma.
In conclusion, these 10 genes may be mediated by MGMT promoter methylation in glioma. In addition, the ten‑gene combination may be associated with the prognosis of patients with glioma. PMID: 30535433 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis.
miR‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis. Oncol Rep. 2018 Dec 07;: Authors: Liu J, Yuan J, Feng T, Zhao Y, Sun Q, Chen J, Chen J, Jin M, Xue B Abstract Lymphangioleiomyomatosis (LAM) is a rare neoplastic disease that leads to progressive destruction of lung function. However, the mechanisms underlying the progression of LAM remain unknown. Recent studies demonstrated that miR‑124‑3p (hereinafter referred to as miR‑124) is a downregulated miRNA in tumors and it is still unclear whether miR‑124 participates in LAM. In th...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lincRNA ‑p21 inhibits the progression of non‑small cell lung cancer via targeting miR‑17‑5p.
lincRNA‑p21 inhibits the progression of non‑small cell lung cancer via targeting miR‑17‑5p. Oncol Rep. 2018 Nov 30;: Authors: Ao X, Jiang M, Zhou J, Liang H, Xia H, Chen G Abstract Non‑small‑cell lung cancer (NSCLC) is well established as one of the major subtypes of human lung cancer. NSCLC is characterized by a high incidence rate and poor patient prognosis. Previous studies have identified that long intergenic non-coding RNA (lincRNA) serves a key role in the development of tumor and malignant metastasis. However, the majority of the underlying mechanisms for lincRNA deregulation in vari...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sodium cantharidinate suppresses human osteosarcoma MG ‑63 cell proliferation and induces cell cycle arrest by inhibition of PI3K/AKT activation.
Sodium cantharidinate suppresses human osteosarcoma MG‑63 cell proliferation and induces cell cycle arrest by inhibition of PI3K/AKT activation. Oncol Rep. 2018 Dec 06;: Authors: Kong DL, Liu Y, Wang JY, Liu G, Zhang ML Abstract The function and mechanism of sodium cantharidininate (SC) underlying its suppression of human osteosarcoma (OS) MG‑63 cells were investigated for the first time in the present study. MG‑63 cell proliferation was determined by WST‑1 assay post SC treatment at 0, 12, 24, 48 and 72 h. The results showed that SC effectively inhibited MG‑63 cell proliferation and induced ...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hypoxia ‑induced galectin‑3 enhances RhoA function to activate the motility of tumor cells in non‑small cell lung cancer.
Hypoxia‑induced galectin‑3 enhances RhoA function to activate the motility of tumor cells in non‑small cell lung cancer. Oncol Rep. 2018 Dec 07;: Authors: Kataoka Y, Ohshio Y, Teramoto K, Igarashi T, Asai T, Hanaoka J Abstract Galectin‑3 plays crucial roles in tumor progression. However, in non‑small cell lung cancer (NSCLC), it remains unclear whether the hypoxic tumor microenvironment enhances galectin‑3‑induced cell motility. We investigated galectin‑3 expression in NSCLC cells under hypoxia, and the possible molecular mechanisms by which galectin‑3 influences tumor aggressiveness....
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Caspase ‑dependent apoptotic death by gadolinium chloride (GdCl3) via reactive oxygen species production and MAPK signaling in rat C6 glioma cells.
In conclusion, ROS production and MAPKs signaling pathways contribute to GdCl3‑induced caspase cascade‑mediated apoptosis in C6 cells. Our findings provide a better understanding of the molecular mechanisms underlying the role of GdCl3 in rat glioma C6 cells. PMID: 30535448 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Potential efficacy and prognosis of silencing the CRLF2 ‑mediated AKT/mTOR pathway in pediatric acute B‑cell lymphoblastic leukemia.
Potential efficacy and prognosis of silencing the CRLF2‑mediated AKT/mTOR pathway in pediatric acute B‑cell lymphoblastic leukemia. Oncol Rep. 2018 Dec 07;: Authors: Jiang M, Zou X, Lu L Abstract Acute B‑cell lymphoblastic leukemia (B‑ALL) is a common type of blood cancer, which is associated with aberrant gene expression. Cytokine receptor‑like factor 2 (CRLF2) serves a crucial role in the growth and allergic and inflammatory responses of dendritic cells and T cells. The purpose of the present study was to investigate the potential therapeutic and prognostic effect of silencing the CRLF2‑m...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Resveratrol epigenetically regulates the expression of zinc  finger protein 36 in non‑small cell lung cancer cell lines.
Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non‑small cell lung cancer cell lines. Oncol Rep. 2018 Nov 30;: Authors: Fudhaili A, Yoon NA, Kang S, Ryu J, Jeong JY, Lee DH, Kang SS Abstract Zinc finger protein 36 (ZFP36) is an AU‑rich element protein that binds to 3'‑untranslated regions and promotes the decay of target mRNAs. Downregulation of ZFP36 expression in turn results in stabilization of target mRNAs. A recent study indicated that downregulation of ZFP36 expression in human liver cancer is caused by epigenetic mechanisms. The purpose...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

YWHAZ promotes ovarian cancer metastasis by modulating glycolysis.
Authors: Shi J, Ye J, Fei H, Jiang SH, Wu ZY, Chen YP, Zhang LW, Yang XM Abstract Ovarian cancer is one of the three most deadly gynecological cancers, with the highest mortality rate. As the main cause of death, metastasis is considered to be a crucial factor that reduces the survival time of ovarian carcinoma patients. YWHAZ (also known as 14‑3‑3ζ) influences diverse vital cellular processes such as metabolism, signal transduction, apoptosis and cell cycle regulation. In the present study, we determined that YWHAZ is upregulated in ovarian cancers in contrast to normal tissues by immunohistochemical stai...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Mechanical, nanomorphological and biological reconstruction of early ‑stage apoptosis in HeLa cells induced by cytochalasin B.
Mechanical, nanomorphological and biological reconstruction of early‑stage apoptosis in HeLa cells induced by cytochalasin B. Oncol Rep. 2018 Dec 07;: Authors: Su X, Zhang L, Kang H, Zhang B, Bao G, Wang J Abstract There is a growing interest in the fact that mechanical signals may be as important as biological signals in evaluating cell viability. To investigate the alterations in biomechanics, nanomorphology and biological apoptotic signals during early apoptosis, an apoptosis model was established for cervical cancer HeLa cells induced by cytochalasin B (CB). The cellular mechanical propertie...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MAPT (Tau) expression is a biomarker for an increased rate of survival for low ‑grade glioma.
MAPT (Tau) expression is a biomarker for an increased rate of survival for low‑grade glioma. Oncol Rep. 2018 Nov 28;: Authors: Zaman S, Chobrutskiy BCI, Sikaria D, Blanck G Abstract The association of MAPT (Tau) with various tauopathies and other neurological disorders has long been established. However, the role of microtubule‑associated protein Tau (MAPT) expression in brain cancer is largely unknown. To determine whether MAPT expression is related to low‑grade glioma (LGG) survival rates, RNASeq data representing samples from the Cancer Genome Atlas (TCGA) were assessed. Results revealed that ...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of autophagy enhances adenosine ‑induced apoptosis in human hepatoblastoma HepG2 cells.
Inhibition of autophagy enhances adenosine‑induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2018 Nov 30;: Authors: Zhou XT, Pu ZJ, Liu LX, Li GP, Feng JL, Zhu HC, Wu LF Abstract In cancer research, autophagy acts as a double‑edged sword: it increases cell viability or induces cell apoptosis depending upon the cell context and functional status. Recent studies have shown that adenosine (Ado) has cytotoxic effects in many tumors. However, the role of autophagy in Ado‑induced apoptosis is still poorly understood. In the present study, Ado‑induced apoptotic death and autophagy in h...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB ‑2‑HIF‑1α axis.
Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis. Oncol Rep. 2018 Nov 28;: Authors: Ma J, Xue M, Zhang S, Cheng L, Qian W, Duan W, Shen X Abstract Resveratrol is a type of polyphenol that is abundantly present in knotweed and grapes, and has been confirmed to have tumor‑inhibitory properties. However, the effect of resveratrol on tumor cells under chronic stress conditions remains unclear. The aim of the present study was to demonstrate that resveratrol exerts a significant inhibitory effect on the growth and proliferation of tumor cells under...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of cyclin  B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane.
Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane. Oncol Rep. 2018 Dec 07;: Authors: Żuryń A, Krajewski A, Klimaszewska-Wiśniewska A, Grzanka A, Grzanka D Abstract Sulforaphane (SFN) was first isolated from broccoli sprout and it is present at high concentrations in plants belonging to the Cruciferae family. The chemotherapeutic and anti‑cancerogenic capacities of SFN have been demonstrated by inhibition of cancer cell proliferation in several cancer cell lines. The aim of the present study was to evaluate the effect of SFN on ...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑138‑5p modulates the expression of excision repair cross‑complementing proteins ERCC1 and ERCC4, and regulates the sensitivity of gastric cancer cells to cisplatin.
miR‑138‑5p modulates the expression of excision repair cross‑complementing proteins ERCC1 and ERCC4, and regulates the sensitivity of gastric cancer cells to cisplatin. Oncol Rep. 2018 Dec 06;: Authors: Ning J, Jiao Y, Xie X, Deng X, Zhang Y, Yang Y, Zhao C, Wang H, Gu K Abstract The microRNA (miR)‑138‑5p affects the chemotherapeutic sensitivity of several human cancer types. In the present study, the expression and regulatory mechanisms of miR‑138‑5p were investigated in the gastric cancer cell line SGC7901 and its cisplatin‑resistant derivative SGC7901/DDP. Gene microarray and reverse...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Association between interleukin ‑33 and ovarian cancer.
Association between interleukin‑33 and ovarian cancer. Oncol Rep. 2018 Dec 07;: Authors: Liu X, Hansen DM, Timko NJ, Zhu Z, Ames A, Qin C, Nicholl MB, Bai Q, Chen X, Wakefield MR, West G, Fang Y Abstract Ovarian cancer is the leading cause of cancer‑ associated mortality in the female reproductive system. Interleukin (IL)‑33 and its receptor IL 1 receptor like 1 (also termed ST2) are expressed by many cell types including epithelial cells. The role of IL‑33 in the pathogenesis of neoplasia remains controversial. The authors previously demonstrated that IL‑33 inhibits the growth of pancreatic ...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TP53 upregulates α‑smooth muscle actin expression in tamoxifen‑resistant breast cancer cells.
TP53 upregulates α‑smooth muscle actin expression in tamoxifen‑resistant breast cancer cells. Oncol Rep. 2018 Dec 06;: Authors: Kim S, You D, Jeong Y, Yu J, Kim SW, Nam SJ, Lee JE Abstract In a previous study, we reported that α‑smooth muscle actin (α‑SMA), one of the mesenchymal marker proteins, is highly expressed in tamoxifen‑resistant breast cancer (TamR) cells. However, the exact mechanism of α‑SMA expression in TamR cells is not fully understood. Here, we investigated the effect of TP53 on α‑SMA expression in breast cancer cells. The levels of α...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of miR-95 in gastric cancer promotes EMT via regulation of Slug, thereby promoting migration and invasion.
Authors: Zhang W, Sun J, Chen J, Xu C, Zhang L Abstract miR-95 has been revealed to be aberrantly expressed in multiple types of cancer and to regulate tumor development. Moreover, miR-95 has been revealed to be downregulated in gastric cancer. However, the detailed function of miR-95 in gastric cancer has remained largely unknown. In the present study, we found that miR-95 was downregulated in 63 pairs of gastric cancer tissue samples and adjacent normal tissue samples, as well as gastric cancer cell lines. Additionally, the expression of miR-95 was associated with tumor size, tumor‑node‑metastasis (TNM) stage...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Wnt/ β‑catenin inhibition reverses multidrug resistance in pediatric acute lymphoblastic leukemia.
Wnt/β‑catenin inhibition reverses multidrug resistance in pediatric acute lymphoblastic leukemia. Oncol Rep. 2018 Dec 04;: Authors: Fu J, Si L, Zhuang Y, Zhang A, Sun N, Li D, Hao B, Ju X Abstract Although ~80% of newly diagnosed pediatric patients with acute lymphoblastic leukemia (ALL) become disease‑free following appropriate treatment, relapses frequently occur, with dismal prognosis. Therefore, it is urgent to develop novel therapeutic modalities. Resistance to chemotherapy is a major obstacle for the treatment of relapsed ALL. It has been indicated that Wnt pathway is potentially associa...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of ID1 promotes tumor progression in penile squamous cell carcinoma.
Authors: Hu X, Chen M, Li Y, Wang Y, Wen S, Jun F Abstract Penile squamous cell carcinoma (PSCC) occurs more frequently in developing countries, and is commonly diagnosed at an advanced stage with an unfavorable prognosis. At present, few biomarkers for PSCC have been identified and used in clinical practice. Aberrant expression of inhibitor of DNA binding 1 (ID1) has been suggested as a potential regulator of tumor progression in various types cancer. Herein, we evaluated ID1 expression in PSCC and analyzed its association with the clinicopathological parameters of PSCC. Our findings indicated that ID1 overex...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA DANCR promotes HMGA2‑mediated invasion in lung adenocarcinoma cells.
Long non‑coding RNA DANCR promotes HMGA2‑mediated invasion in lung adenocarcinoma cells. Oncol Rep. 2018 Nov 30;: Authors: Zhang N, Jiang W Abstract Long non‑coding RNAs (lncRNAs) have been reported to be key regulators in various types of cancer, including lung adenocarcinoma (LAD). The roles of the lncRNA differentiation antagonizing non‑protein coding RNA (DANCR) and high mobility group AT‑hook 2 (HMGA2) in LAD remain unclear. In the present study, it was revealed that the lncRNA DANCR was upregulated in LAD tissue and cell lines, compared with para‑tumor tissue and a normal lung ce...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research