Mina53 nuclear localization is an important indicator of prognosis in patients with colorectal cancer after adjuvant chemotherapy.
Authors: Fujino S, Kinugasa T, Sudo T, Mizobe T, Yoshida T, Yoshida N, Ohchi T, Tajiri K, Yuge K, Nagasu S, Katagiri M, Akagi Y Abstract The aim of this study was to investigate the status of the c‑Myc‑related molecule Mina53 and the clinical impact of Mina53 nuclear localization in patients with stage II and III colorectal cancer (CRC). Patients (n=250) who underwent complete resection of CRC at our department were enrolled in this study, and tissue microarray samples were constructed from resected specimens. Mina53 expression in the nuclei of tumor cells was analyzed using immunohistochemistry (IHC)...
Source: Oncology Reports - May 12, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-150 inhibits the proliferation and metastasis potential of colorectal cancer cells by targeting iASPP.
Authors: Li C, Du X, Xia S, Chen L Abstract In the present study, the function of miR-150 and its downstream target iASPP in the growth and metastasis of colorectal cancer (CRC) cells was investigated. The expression of miR-150 and iASPP was first investigated in clinical CRC samples. Subsequently, the effects of miR-150 overexpression and iASPP inhibition on cell viability, cell cycle distribution, apoptosis, migration and invasion were detected with CCK-8, flow cytometry, scratch and Transwell assays. The interaction between miR-150 and iASPP was confirmed using a dual-luciferase assay. Subsequently, the key role...
Source: Oncology Reports - May 12, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anticancer effects of a novel chroman analog in HeLa cells are associated with G2 ‑phase arrest and mitochondrial‑mediated apoptosis.
Anticancer effects of a novel chroman analog in HeLa cells are associated with G2‑phase arrest and mitochondrial‑mediated apoptosis. Oncol Rep. 2018 Apr 27;: Authors: Jeong H, Shin Y, Kim DK Abstract In the present study, the anticancer activity of 1‑[(3S,4R)‑2,2‑dimethyl‑3‑oxo‑4‑(2‑piperidonyl)chroman‑6‑yl]‑3‑phenylurea (S32) was investigated by testing its effect in vitro on the growth of HeLa cells. First, we showed that the IC50 value of S32 was ~70 µM by using WST‑8 assay, and that it significantly inhibited the proliferation and viability of HeLa cells in a dos...
Source: Oncology Reports - May 12, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cross-link regulation of precursor N-cadherin and FGFR1 by GDNF increases U251MG cell viability.
Authors: Tang CX, Gu YX, Liu XF, Tong SY, Ayanlaja AA, Gao Y, Ji GQ, Xiong Y, Huang LY, Gao DS Abstract Glial cell line-derived neurotrophic factor (GDNF) is considered to be involved in the development of glioma. However, uncovering the underlying mechanism of the proliferation of glioma cells is a challenging work in progress. We have identified the binding of the precursor of N-cadherin (proN-cadherin) and GDNF on the cell membrane in previous studies. In the present study, we observed increased U251 Malignant glioma (U251MG) cell viability by exogenous GDNF (50 ng/ml). We also confirmed that the high expre...
Source: Oncology Reports - May 12, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A novel monoclonal antibody targeting a novel epitope of VE ‑cadherin inhibits vasculogenic mimicry of lung cancer cells.
A novel monoclonal antibody targeting a novel epitope of VE‑cadherin inhibits vasculogenic mimicry of lung cancer cells. Oncol Rep. 2018 Apr 16;: Authors: Ding J, Jia X, Zuo B, He J, Yang J, He Y Abstract Vascular endothelial cadherin (VE‑cadherin) was first found in vascular endothelial cells to maintain normal vascular structures and regulate endothelial cell permeability by homology adhesion. New evidence indicates that certain invasive tumor cells also express VE‑cadherin, which is involved in vasculogenic mimicry to provide a blood supply required for tumor growth and metastasis. EC1 and EC3...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HSPB8 promotes cancer cell growth by activating the ERK ‑CREB pathway and is indicative of a poor prognosis in gastric cancer patients.
HSPB8 promotes cancer cell growth by activating the ERK‑CREB pathway and is indicative of a poor prognosis in gastric cancer patients. Oncol Rep. 2018 Apr 18;: Authors: Shen J, Li M, Min L Abstract Gastric cancer (GC) is one of the most commonly diagnosed malignancies worldwide, especially in East Asia. Discovery of new biomarker and the elucidation of the molecular mechanisms involved in GC development and progression continue to be important issues for both researchers and clinicians. In the present study, we report that siRNA knockdown of heat shock protein family B (small) member 8 (HSP...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Spermidine ‑induced growth inhibition and apoptosis via autophagic activation in cervical cancer.
Spermidine‑induced growth inhibition and apoptosis via autophagic activation in cervical cancer. Oncol Rep. 2018 Apr 18;: Authors: Chen Y, Zhuang H, Chen X, Shi Z, Wang X Abstract Cervical cancer is the most common malignancy of the female reproductive tract, and the poor response to prophylactic vaccines and the toxicity of high‑dose chemotherapeutic drugs have limited their clinical application. Spermidine, a natural polyamine detected in all eukaryotic organisms, exhibits functions that promote longevity in multiple model systems and may constitute a promising agent for cancer treatment. However...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-33b-5p is overexpressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: An in vivo and in vitro study.
Authors: Yang Y, Jiang H, Xiao L, Yang X Abstract Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease, but its pathogenesis remains largely unknown. The present study explored the role of microRNA‑33b‑5p (miR‑33b‑5p) in PCOS pathogenesis, with a particular focus on its role in regulating glucose transporter 4 (GLUT4). A rat model of PCOS was developed by injecting female SD rats with insulin and HCG. miR‑33b‑5p, GLUT4, sterol regulatory element‑binding protein 1 (SREBF1), and high mobility group A2 (HMGA2) expression in rat ovarian tissues was examined...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1.
MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1. Oncol Rep. 2018 Apr 23;: Authors: Han S, Liu Z, Wang Y, Wang L, Yao B, Guo C, Song T, Tu K, Liu Q Abstract Research has confirmed that abnormally expressed miRNAs are involved in the occurrence and development of hepatocellular carcinoma (HCC). In the present study, we confirmed that miR‑577 expression both in HCC tissues and cell lines was markedly downregulated. Clinically, downregulated expression of miR‑577 is notably related to malignant clinicopathological features, such as venous in...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Lower endogenous p53 levels and degradation of AKT protein contribute to potent suppression of the new antibiotic Xiakemycin  A on tumor cells.
Lower endogenous p53 levels and degradation of AKT protein contribute to potent suppression of the new antibiotic Xiakemycin A on tumor cells. Oncol Rep. 2018 Apr 18;: Authors: Chen C, Jiang Z, Ou X, Zhang H, Sun C, He Q Abstract Xiakemycin A (XKA), a new pyranonaphthoquinone antibiotic, is isolated from the fermentation broth of Streptomyces sp. CC8-201. It exerts potent suppression of cell proliferation on some types of tumor cells. In the present study, its underlying mechanism on tumor cells has been investigated. In contrast to the specific AKT inhibitor triciribine hydrate, XKA dem...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Assessing stemness and proliferation properties of the newly established colon cancer 'stem' cell line, CSC480 and novel approaches to identify dormant cancer cells.
In conclusion, the CSC480 cell line was an important model to be used in unravelling the underlying mechanisms that control fast‑dividing and partially self‑renewing stem cells (SCs) that may give rise to cancer. PMID: 29693155 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect of curcumin on the cell surface markers CD44 and CD24 in breast cancer.
In conclusion, these results indicated that curcumin may be used to improve the proportion of CD44+/CD24+ cells and decrease the proportion of CD44+/CD24- cells. Therefore, it may be suggested that curcumin decreased cancerous types of breast cells. PMID: 29693159 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the Akt ‑GSK3β and MAPK/ERK signaling cascades.
In conclusion, the present results indicate that the antiproliferative effect of eupatilin on esophageal cancer TE1 cells is associated with inhibition of the Akt and ERK pathways. PMID: 29693162 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR-146a promotes cervical cancer cell viability via targeting IRAK1 and TRAF6.
Authors: Hu Q, Song J, Ding B, Cui Y, Liang J, Han S Abstract Cervical cancer is the third most common type of cancer in women, and microRNAs play an important role in this type of cancer. The elevated expression of miR-146a is involved in the pathogenesis of cancers generally, but its role in cervical cancer has not been fully elucidated. In the present study, we assessed the expression of miR-146a in G>C polymorphisms and confirmed that the overexpression of miR-146a promoted cervical cancer cell viability. The recombinant expression plasmids pre-miR-146a-G or pre-miR-146a-C including single nucleotide polymor...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Nodal induced by hypoxia exposure contributes to dacarbazine resistance and the maintenance of stemness in melanoma cancer stem ‑like cells.
Nodal induced by hypoxia exposure contributes to dacarbazine resistance and the maintenance of stemness in melanoma cancer stem‑like cells. Oncol Rep. 2018 Apr 23;: Authors: Li H, Chen J, Wang X, He M, Zhang Z, Cen Y Abstract Nodal signaling has a critical role in the processes of embryogenesis and is necessary for maintaining cell stemness. However, its upregulation in melanoma is positively correlated with malignant potential, including cancer progression, metastasis and recurrence, and a recent report has revealed its role in promoting self‑renewal capacity in melanoma. Our study aimed to explor...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Microvesicles shed from bortezomib-treated or lenalidomide-treated human myeloma cells inhibit angiogenesis in  vitro.
In conclusion, bortezomib and lenalidomide treatment of cultured myeloma cells can block MV-induced angiogenesis and hence provides another mechanism for anti-angiogenic therapy. PMID: 29693175 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identifying genes as potential prognostic indicators in patients with serous ovarian cancer resistant to carboplatin using integrated bioinformatics analysis.
In conclusion, GNAI1, NCAPH, MMP9, AURKA and EZH2 should be examined in further studies for the possibility of their participation in the carcinogenesis and carboplatin response of SOC. PMID: 29693178 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑30a inhibits epithelial‑mesenchymal transition and metastasis in triple‑negative breast cancer by targeting ROR1.
miR‑30a inhibits epithelial‑mesenchymal transition and metastasis in triple‑negative breast cancer by targeting ROR1. Oncol Rep. 2018 Apr 18;: Authors: Wang X, Qiu H, Tang R, Song H, Pan H, Feng Z, Chen L Abstract Triple‑negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks effective targeted therapies. In the present study, we revealed that the expression of miR‑30a was significantly decreased in TNBC, and TNBC patients with low expression of miR‑30a were associated with high histological grade and more lymph node metastasis. Moreover, we found that miR‑30...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Bioinformatics analysis of differentially expressed miRNA-related mRNAs and their prognostic value in breast carcinoma.
In conclusion, these results constitute a novel model for miRNA-mRNA differential expression patterns, and further studies may provide potential targets for diagnosing and understanding the mechanisms of breast carcinoma. PMID: 29693181 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High expression of fructose-bisphosphate aldolase  A induces progression of renal cell carcinoma.
This study aimed to detect expression of ALDOA in human RCC tissue samples and to explore its function in RCC cell lines. Reverse transcription-polymerase chain reaction was used to quantify ALDOA in human RCC samples. A total of 139 RCC tissue samples obtained after surgery were analyzed in tissue microarray for ALDOA immunohistochemistry-based protein expression. Assays for cell cycle, viability, migration, and invasion were performed to assess phenotypic changes in RCC cells after ALDOA knockdown by small interfering RNA-mediated gene silencing approach and ALDOA upregulation by overexpression plasmids. Western blo...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of miR ‑138‑5p and miR‑204‑5p on the migration and proliferation of gastric cancer cells by targeting EGFR.
We examined differences in the expression levels of EGFR in GC and adjacent non‑cancerous tissues. Bioinformatics analyses and dual luciferase reporter assays were used to confirm the putative relationship between miR‑138 or miR‑204 and EGFR, and their relationship was further detected using western blotting, RT‑PCR, and a series of cell studies. EGFR proteins were abundantly expressed in GC tissues, however EGFR mRNA levels remained indistinctive. Consequently, EGFR was revealed as a putative target of miR‑138 and miR‑204 which bound to the 3'UTR of EGFR mRNA. Further analysis revealed that miR‑138 and miR...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-384 inhibits the progression of breast cancer by targeting ACVR1.
In conclusion, our findings revealed functional and mechanistic links between miR-384 and ACVR1 in the progression of breast cancer. miR-384 not only plays an important role in the progression of breast cancer, but has promise as a potential therapeutic target for breast cancer especially for TNBC. PMID: 29693185 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MALAT1 affects ovarian cancer cell behavior and patient survival.
In conclusion, our results indicated that MALAT1 was overexpressed in EOC. Silencing of MALAT1 decreased EOC cell viability and inhibited EOC cell migration and invasion. These data revealed that MALAT1 may serve as a new therapeutic target of human EOC. PMID: 29693187 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

RIP2 promotes glioma cell growth by regulating TRAF3 and activating the NF ‑κB and p38 signaling pathways.
RIP2 promotes glioma cell growth by regulating TRAF3 and activating the NF‑κB and p38 signaling pathways. Oncol Rep. 2018 Apr 23;: Authors: Cai X, Yang Y, Xia W, Kong H, Wang M, Fu W, Long M, Hu Y, Xu D Abstract Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis. However, the function of RIP2 in human astrocytoma remains unclear. In the present study, we showed that the expressions of RIP2 and Bcl‑xL were positively correlated with the malignant grade in 28 cases of astrocytoma of various grades and 6&nb...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation.
In this study, we found the following: (i) gallic acid (GA), a phenolic compound, potentiated the capacity of PTX to decrease proliferation and to cause G2/M cycle arrest in the PTX-resistant A2780AD ovarian cancer cell line; (ii) GA exerted a pro-oxidant action by increasing the production of reactive oxygen species (ROS), and co-treatment with the antioxidant agent N‑acetyl-L‑cysteine (NAC) prevented GA+PTX-induced cell proliferation inhibition and G2/M phase arrest; (iii) PTX stimulated ERK phosphorylation/activation, and co-treatment with the MEK/ERK inhibitor PD98049 potentiated the proliferati...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑186 functions as a tumor suppressor in osteosarcoma cells by suppressing the malignant phenotype and aerobic glycolysis.
miR‑186 functions as a tumor suppressor in osteosarcoma cells by suppressing the malignant phenotype and aerobic glycolysis. Oncol Rep. 2018 Apr 23;: Authors: Xiao Q, Wei Z, Li Y, Zhou X, Chen J, Wang T, Shao G, Zhang M, Zhang Z Abstract Osteosarcoma (OS) is the most common primary bone malignancy among children and adolescents. Deregulation of microRNAs has been well documented in OS, while the putative effects of miR‑186 have not been identified yet. In the present study, we assessed the expression of miR‑186 in a cohort of 40 OS tissues and explored its effects on OS cells. As expected, miR‑...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis.
Authors: Kong YH, Xu SP Abstract Salidroside (SR) is a main component of Rhodiola rosea L. and exhibits a variety of pharmacologic properties. The present study was carried out to explore the potential effect of SR against skin cancer induced by 7,12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13‑acetate (TPA) in female Institute for Cancer Research (ICR) mice and to reveal the underlying molecular targets regulated by SR. The mice were randomly divided into 4 groups: control, DMBA/TPA, DMBA/TPA+SR (20 mg/kg) and DMBA/TPA+SR (40 mg/kg). SR was administered to mice five times a we...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Corilagin induces the apoptosis of hepatocellular carcinoma cells through the mitochondrial apoptotic and death receptor pathways.
Authors: Deng Y, Li X, Li X, Zheng Z, Huang W, Chen L, Tong Q, Ming Y Abstract Corilagin, a gallotannin, is one of the major active components of many ethnopharmacological plants and exhibits antitumor, anti-inflammatory and antioxidative properties. In recent years, corilagin has provoked much attention due to its antitumor activity, yet the mechanisms attributed to its anticancer actions are largely unknown. In our previous research, our group reported that corilagin could inhibit the proliferation of hepatocellular carcinoma (HCC) cells by inducing G2/M phase arrest. In the present study, observation o...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Glycine and succinic acid are effective indicators of the suppression of epithelial-mesenchymal transition by fucoxanthinol in colorectal cancer stem-like cells.
Authors: Terasaki M, Mima M, Kudoh S, Endo T, Maeda H, Hamada J, Osada K, Miyashita K, Mutoh M Abstract Fucoxanthinol (FxOH) is a strong anticancer metabolite of fucoxanthin that accumulates in abundance in edible brown algae and promises human health benefits. FxOH has been shown to suppress tumorigenicity and sphere formation in human colorectal cancer stem cell (CCSC)-like spheroids (colonospheres, Csps). In the present study, we aimed to clarify the inhibitory activity of FxOH on epithelial-mesenchymal transition (EMT), which is essential for cancer recurrence and distant metastasis, and to identify intracellul...
Source: Oncology Reports - April 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Autophagy inhibition potentiates SAHA ‑mediated apoptosis in glioblastoma cells by accumulation of damaged mitochondria.
Autophagy inhibition potentiates SAHA‑mediated apoptosis in glioblastoma cells by accumulation of damaged mitochondria. Oncol Rep. 2018 Apr 16;: Authors: Lohitesh K, Saini H, Srivastava A, Mukherjee S, Roy A, Chowdhury R Abstract Glioblastoma multiforme (GBM), often referred to as a grade IV astrocytoma, is the most invasive type of tumor arising from glial cells. The main treatment options for GBM include surgery, radiation and chemotherapy. However, these treatments tend to be only palliative rather than curative. Poor prognosis of GBM is due to its marked resistance to standard therapy. Curre...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review).
Authors: Jin S, Wei J, You L, Liu H, Qian W Abstract Autophagy, a physiological process in which cellular components are degraded by the lysosome for cell homeostasis, plays an important role in cell metabolism, including cell proliferation, differentiation, survival and apoptosis. Recent studies indicate that autophagy serves as a survival mechanism by eliminating misfolded proteins and attenuating DNA damage. Autophagy can also suppress tumor growth, depending upon the cell context and functional status. Dysfunction of autophagy may be closely linked to the initiation and development of various diseases, includin...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cucurbitacin D impedes gastric cancer cell survival via activation of the iNOS/NO and inhibition of the Akt signalling pathway.
In conclusion, CuD inhibited Akt and activated the iNOS pathway, leading to higher ROS and nitric oxide production, which accelerated gastric cancer cell apoptosis. PMID: 29658590 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells induced by bufalin.
Authors: Sheng X, Zhu P, Qin J, Li Q Abstract Autophagy is an important mechanism which regulates the processes of cell growth and death. The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells by bufalin remains unknown. In the present study we investigated the effect of bufalin on autophagy of liver cancer cells. The growth inhibition and autophagy of liver cancer cells were detected using acridine orange fluorescence staining, flow cytometry and transmission electron microscopy. Combined with autophagy inhibitors (3‑MA and CQ), CCK8 staining and western blot analy...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

In vitro cytotoxic effect of PARP inhibitor alone and in combination with nab ‑paclitaxel on triple‑negative and luminal A breast cancer cells.
In vitro cytotoxic effect of PARP inhibitor alone and in combination with nab‑paclitaxel on triple‑negative and luminal A breast cancer cells. Oncol Rep. 2018 Apr 12;: Authors: Topçul M, Çeti N İL, Özbaş Turan S, Kolusayin Ozar MÖ Abstract In the present study, the in vitro cytotoxic effect of poly(ADP‑ribose) polymerase (PARP) inhibitor alone and in combination with nab‑paclitaxel was evaluated on human triple‑negative breast cancer (TNBC) cell line MDA‑MB‑231 and human luminal A breast cancer cell line MCF‑7. For this purpose, cell in...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Laterally spreading features of gastrointestinal stromal tumors: A clinicopathological study.
Authors: Matsukuma S, Murayama M, Utsumi Y, Sumi K, Miyai K, Takeo H Abstract To elucidate the histopathological features of laterally spreading gastrointestinal stromal tumors (GISTs), we retrospectively examined 52 GISTs grossly completely resected from 50 patients. Laterally spreading features were identified in 7 GISTs (13%), and were localized within non‑thickened regions of the muscularis propria adjacent to the main GISTs, ranging in length from 0.12 to 0.7 cm (mean, 0.3 cm). The laterally spreading features involved the muscular surgical margins in 2 cases. The morphologies o...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Huaier suppresses proliferative and metastatic potential of prostate cancer PC3 cells via downregulation of Lamin  B1 and induction of autophagy.
This study sheds new light on the mechanisms underlying the activity of Huaier against prostate cancer and provides a new theoretical basis for the clinical application of Huaier in prostate cancer. PMID: 29658595 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-616 promotes the progression of ovarian cancer by targeting TIMP2.
Authors: Chen Z, Zhu J, Zhu Y, Wang J Abstract MicroRNAs (miRNAs), a group of short (~20 nt) non‑coding RNAs, play critical roles in the development and progression of ovarian cancer (OC). The role of miR‑616, a recently identified cancer-associated miRNA, has never been examined in OC before. The present study demonstrated that the level of miR‑616 was increased in OC tissues. A high miR‑616 level was associated with poor tumor differentiation and advanced tumor-node-metastasis (TNM) stage. Survival analysis revealed that an elevated level of miR‑616 was associated with poor prognosis of OC patients...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Protein kinase, membrane ‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer.
Protein kinase, membrane‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer. Oncol Rep. 2018 Apr 13;: Authors: Jeong D, Kim H, Kim D, Ban S, Oh S, Ji S, Kang D, Lee H, Ahn TS, Kim HJ, Bae SB, Lee MS, Kim CJ, Kwon HY, Baek MJ Abstract The protein kinase, membrane‑associated tyrosine/threonine 1 (PKMYT1) is known to inhibit precocious entry into mitosis by phosphorylating CDK1 at Thr14 and Tyr15 residues. However, the functional importance of PKMYT1 in colorectal cancer (CRC) remains unknown. Thus, it is important to elucidate whether PKYMT1 is indispens...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Screening potential biomarkers for colorectal cancer based on circular RNA chips.
Authors: Chen S, Zhang L, Su Y, Zhang X Abstract The aim of the present study was to screen colorectal cancer (CRC) tissue and adjacent tissue for differences in circular RNA (circRNA) expression, to analyze the related miRNAs and messenger RNAs (mRNAs), and to investigate the circRNA expression in CRC and its function. The circRNA expression profile was generated using CapitalBio microarray technology. The differentially expressed circRNAs were identified with GeneSpring 12.5 software. Subsequently, the related mRNAs of the differentially expressed circRNAs were annotated with the molecule anno...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PDK1 inhibitor GSK2334470 synergizes with proteasome inhibitor MG ‑132 in multiple myeloma cells by inhibiting full AKT activity and increasing nuclear accumulation of the PTEN protein.
PDK1 inhibitor GSK2334470 synergizes with proteasome inhibitor MG‑132 in multiple myeloma cells by inhibiting full AKT activity and increasing nuclear accumulation of the PTEN protein. Oncol Rep. 2018 Apr 12;: Authors: Zhang J, Yang C, Zhou F, Chen X Abstract Phosphoinositide‑dependent kinase 1 (PDK1) is generally active in multiple myeloma (MM) and higher expression than other hematopoietic cells, which is associated with the drug resistance and the disease progression. Previous studies have demonstrated that PDK1 can be targeted therapeutically in MM. In the present study, we examined the co...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anticancer effect of exogenous hydrogen sulfide in cisplatin ‑resistant A549/DDP cells.
Anticancer effect of exogenous hydrogen sulfide in cisplatin‑resistant A549/DDP cells. Oncol Rep. 2018 Apr 12;: Authors: Ma Y, Yan Z, Deng X, Guo J, Hu J, Yu Y, Jiao F Abstract Despite huge advances in lung cancer treatment, resistance to cisplatin‑based chemotherapy remains one of the major obstacles, and the elucidation of cisplatin resistance remains challenging. As an important biological and pharmacological mediator, hydrogen sulfide (H2S) performs a variety of homeostatic functions related to cancer formation and development. However, the effects of H2S on cisplatin‑resistance lung cancer r...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial ‑mediated apoptosis.
Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial‑mediated apoptosis. Oncol Rep. 2018 Apr 12;: Authors: Liu L, Han C, Yu H, Zhu W, Cui H, Zheng L, Zhang C, Yue L Abstract Chloroquine (CQ) has been revealed to exhibit antitumor activity in several human tumors including lung cancer as mono‑ or add‑on therapy. The antitumor effect of CQ appears to depend on the tumor type, stage and genetic context. Few studies have focused on the mechanism concerning the antitumor effect of CQ monotherapy and the cause and effect relationship amo...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia.
Authors: Chen N, Feng L, Qu H, Lu K, Li P, Lv X, Wang X Abstract Interleukin‑9 (IL‑9) can function as both a positive and negative regulator of immune response, however the role of IL‑9 in tumor immunity is poorly understood. Chronic lymphocytic leukemia (CLL) is the most common chronic lympho‑proliferative disorder. Twenty CLL patients from 2010 to 2011 were recruited in the study. Expression and phosphorylation of transcription factor STAT3 and differential microRNAs (miRs) in peripheral blood mononuclear cells (PBMCs) from CLL patient samples were analyzed. In a previous study, we found a ...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer.
Authors: García-Vázquez R, Gallardo Rincón D, Ruiz-García E, Meneses García A, Hernández De La Cruz ON, Astudillo-De La Vega H, Isla-Ortiz D, Marchat LA, Salinas-Vera YM, Carlos-Reyes Á, López-González S, Ramos-Payan R, López-Camarillo C Abstract Altered expression of microRNAs contributes to the heterogeneous biological behavior of human malignancies and it may correlate with the clinical pathological features of patients. The let-7 microRNA family is frequently downregulated in human cancers and its aberrant expression may be a useful marker fo...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Detection of survivin expression in bladder cancer and renal cell carcinoma using specific monoclonal antibodies.
Authors: Chen D, Xu J, Zhang Q Abstract Survivin, which is highly expressed in the majority of tumors, but not in most normal adult tissues, has been identified to have significant clinical applications. In the present study, using survivin‑specific monoclonal antibodies (mAbs), we aimed to establish methods for detecting the expression of survivin in cancer cell lines, serum samples, urine samples and cancer tissues from patients with bladder cancer (BCa) and renal cell carcinoma (RCC), and to evaluate the efficacy of survivin as a tumor marker in the surveillance of BCa and RCC. First, mAbs were ...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Doxycycline targets aldehyde dehydrogenase ‑positive breast cancer stem cells.
Doxycycline targets aldehyde dehydrogenase‑positive breast cancer stem cells. Oncol Rep. 2018 Mar 27;: Authors: Lin CC, Lo MC, Moody RR, Stevers NO, Tinsley SL, Sun D Abstract Targeting cancer stem cells (CSCs) is a key strategy to prevent cancers from developing drug resistance and metastasis. Mitochondria have been reported to be a vulnerability of CSCs by multiple studies. Here, we report that doxycycline, functioning as an inhibitor of mitochondrial biogenesis, can effectively target breast cancer stem cells (BCSCs). Our results revealed that doxycycline significantly decreased the frequency of a...
Source: Oncology Reports - April 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anthricin ‑induced caspase‑dependent apoptosis through IGF1R/PI3K/AKT pathway inhibition in A549 human non‑small lung cancer cells.
Anthricin‑induced caspase‑dependent apoptosis through IGF1R/PI3K/AKT pathway inhibition in A549 human non‑small lung cancer cells. Oncol Rep. 2018 Mar 27;: Authors: Park BR, Lee SA, Moon SM, Kim CS Abstract Anthricin (deoxypodophyllotoxin) is a major lignan in Anthriscus sylvestris and possesses many bioactivities such as antiproliferative, antitumor, anti‑platelet aggregation, antiviral and anti‑inflammatory actions. However, the anticancer effects of anthricin on A549 human non‑small cell lung cancer cells and potential molecular mechanisms remain unknown. Therefore, we investigated the a...
Source: Oncology Reports - April 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Translational control of the undifferentiated phenotype in ER ‑positive breast tumor cells: Cytoplasmic localization of ERα and impact of IRES inhibition.
Translational control of the undifferentiated phenotype in ER‑positive breast tumor cells: Cytoplasmic localization of ERα and impact of IRES inhibition. Oncol Rep. 2018 Mar 23;: Authors: Vaklavas C, Zinn KR, Samuel SL, Meng Z, Grizzle WE, Choi H, Blume SW Abstract Using a series of potential biomarkers relevant to mechanisms of protein synthesis, we observed that estrogen receptor (ER)-positive breast tumor cells exist in two distinct yet interconvertible phenotypic states (of roughly equal proportion) which differ in the degree of differentiation and use of IRES-mediated translation. Nascentl...
Source: Oncology Reports - April 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CT ‑1042, a novel anticancer agent, exhibits effects by activating p53 and inhibiting survivin.
CT‑1042, a novel anticancer agent, exhibits effects by activating p53 and inhibiting survivin. Oncol Rep. 2018 Apr 04;: Authors: Yang J, Li L, Xu C, Yang D, Wang S, Yuan S Abstract A novel small molecular compound, 4‑ethyl‑8‑fluoro‑hydroxy‑9‑methoxy‑11‑methyl‑1,12‑dihydro‑4H‑2‑oxa‑6,12a‑diaza‑dibenzo[b,h]fluorene‑3,13‑dione (CT‑1042) exhibits potent antitumor activity against many tumor cells in vitro. However, the effects and underlying mechanisms of CT‑1042 in non‑small cell lung cancer (NSCLC) remain unclear. The present study was designed to determin...
Source: Oncology Reports - April 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑29a suppresses IL‑13‑induced cell invasion by inhibiting YY1 in the AKT pathway in lung adenocarcinoma A549 cells.
miR‑29a suppresses IL‑13‑induced cell invasion by inhibiting YY1 in the AKT pathway in lung adenocarcinoma A549 cells. Oncol Rep. 2018 Apr 04;: Authors: Zhang Y, He S, Mei R, Kang Y, Duan J, Wei R, Xiang C, Wu Y, Lu X, Cai Z, Xiong L Abstract IL‑13 is a proinflammatory cytokine associated with multiple pathological conditions and the promotion of metastasis in lung cancer. Previous studies have demonstrated that IL‑13 and YY1 are associated with PI3K/AKT signaling. In addition, miR‑29a has been found to play a critical role in cell invasion in lung cancer. However, the molecular mechanism o...
Source: Oncology Reports - April 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research