Hsp90 inhibitor 17 ‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway.
Hsp90 inhibitor 17‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway. Oncol Rep. 2020 Apr 28;: Authors: Shu X, Liu H, Zhen R, Jie Y, Chen L, Qi H, Wang C, Wang R, Chen D, Ran Y Abstract Multiple drug resistance is a major obstacle to the successful treatment of osteosarcoma (OS). Recent studies have demonstrated that a subset of cells, referred to as OS stem cells (OSCs), play a crucial role in the acquisition of multiple drug resistance. Therefore, an improved understanding of OS biology and pathogenesis is required to advance the d...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

VL30 retrotransposition is associated with induced EMT, CSC generation and tumorigenesis in HC11 mouse mammary stem ‑like epithelial cells.
VL30 retrotransposition is associated with induced EMT, CSC generation and tumorigenesis in HC11 mouse mammary stem‑like epithelial cells. Oncol Rep. 2020 Apr 28;: Authors: Thrasyvoulou S, Vartholomatos G, Markopoulos G, Noutsopoulos D, Mantziou S, Gkartziou F, Papageorgis P, Charchanti A, Kouklis P, Constantinou AI, Tzavaras T Abstract Retrotransposons copy their sequences via an RNA intermediate, followed by reverse transcription into cDNA and random insertion, into a new genomic locus. New retrotransposon copies may lead to cell transformation and/or tumorigenesis through insertional mutagenesis. ...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect of the natural compound trans ‑resveratrol on human MCM4 gene transcription.
Effect of the natural compound trans‑resveratrol on human MCM4 gene transcription. Oncol Rep. 2020 Apr 28;: Authors: Uchiumi F, Katsuda C, Akui M, Kusaka M, Tanaka M, Asai M, Tanuma SI Abstract trans‑Resveratrol (Rsv) is a natural compound contained in red wine and grape skins that has various beneficial effects for organisms such as lengthening of their life span. Rsv induces expression of the human TP53 and HELB genes, which are involved in the regulation of DNA maintenance. In the present study, a luciferase expression vector containing 309 bp of the 5' upstream end of the human MCM4 gene w...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑193b exhibits mutual interaction with MYC, and suppresses growth and metastasis of osteosarcoma.
miR‑193b exhibits mutual interaction with MYC, and suppresses growth and metastasis of osteosarcoma. Oncol Rep. 2020 Apr 29;: Authors: Gao J, Ma S, Yang F, Chen X, Wang W, Zhang J, Li Y, Wang T, Shan L Abstract Emerging evidence has indicated that microRNAs (miRs) are involved in the malignant behavior of cancer. The present study explored the role of miR‑193b in the development and metastasis of osteosarcoma. Compared with F4 osteosarcoma cells, which have a relatively low metastatic potential, highly metastatic F5M2 cells exhibited a lower expression of miR‑193b. Furthermore, miR‑193b exerted...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ciprofloxacin promotes polarization of CD86+CD206 ‑ macrophages to suppress liver cancer.
In conclusion, the findings of the present study indicated that ciprofloxacin may inhibit liver cancer by upregulating the expression of CD86+CD206‑ macrophages. This study further revealed the biological mechanism underlying the potential value of ciprofloxacin in antitumor therapy and provided new targets for the treatment of liver cancer. PMID: 32377744 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor ‑stromal crosstalk under hypoxic conditions via the IL‑6/ERK/NF‑κB axis.
Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor‑stromal crosstalk under hypoxic conditions via the IL‑6/ERK/NF‑κB axis. Oncol Rep. 2020 Apr 28;: Authors: Li W, Sun L, Lei J, Wu Z, Ma Q, Wang Z Abstract Hypoxic microenvironment and pancreatic stellate cells (PSCs) play important roles in pancreatic cancer progression. PSCs secrete a number of soluble factors, such as interleukin (IL)‑6, to facilitate cancer metastasis. Our previous study revealed that curcumin inhibited the invasive ability of pancreatic cancer cells by modulating epithelial‑to‑mesen...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Kindlin ‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction.
Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction. Oncol Rep. 2020 May 04;: Authors: Wu G, Long Y, Lu Y, Feng Y, Yang X, Xu X, Yao D Abstract Kindlin‑2 plays a carcinogenic or tumor‑suppressor role in various tumors. However, its role in cervical cancer remains unclear. In the present study, kindlin‑2 expression was first analyzed using public expression data and clinical specimens. It was revealed that kindlin‑2 was downregulated in cervical cancer tissues, and low expression of kindlin‑2 was associated with poor disease‑free survival. In...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Morpho ‑functional study of the hypothalamic proline‑rich polypeptide apoptotic activity against mouse Ehrlich ascites carcinoma.
Morpho‑functional study of the hypothalamic proline‑rich polypeptide apoptotic activity against mouse Ehrlich ascites carcinoma. Oncol Rep. 2020 May 04;: Authors: Abrahamyan S, Sahakyan I, Tumasyan N, Kocharyan N, Simonyan A, Aroutiounian R, Chailyan G, Chailyan S, Davtyan T, Galoian K Abstract A new type of bioactive polypeptides of the neurosecretory hypothalamus called proline‑rich peptides (PRPs), which are isolated from bovine neurosecretory granules of the neurohypophysis, are synthesized in the form of a common precursor protein (neurophysin vasopressin‑associated glycoprotein). Proline...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Estrogen promotes the metastasis of non ‑small cell lung cancer via estrogen receptor β by upregulation of Toll‑like receptor 4 and activation of the myd88/NF‑κB/MMP2 pathway.
Estrogen promotes the metastasis of non‑small cell lung cancer via estrogen receptor β by upregulation of Toll‑like receptor 4 and activation of the myd88/NF‑κB/MMP2 pathway. Oncol Rep. 2020 Apr 02;: Authors: Fan S, Liao Y, Qiu W, Huang Q, Xiao H, Liu C, Li D, Cao X, Li L, Liang H, Ai B, Zhou S Abstract Estrogen promotes non‑small cell lung cancer (NSCLC) metastasis via estrogen receptor β (ERβ)‑mediated invasiveness‑associated matrix metalloprotease 2 (MMP2) upregulation. However, how ERβ increases the aggressiveness of NSCLC cells remains unclear. ...
Source: Oncology Reports - May 5, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Targeted deep sequencing contributes to guiding personalized targeted therapy for advanced biliary tract cancer patients with non ‑radical resection: A real‑world study.
Targeted deep sequencing contributes to guiding personalized targeted therapy for advanced biliary tract cancer patients with non‑radical resection: A real‑world study. Oncol Rep. 2020 Feb 06;: Authors: Feng F, Cheng Q, Zhang D, Li B, Qin H, Xu C, Han M, Yu Y, Li Z, Li JY, Qiu Z, Xiong L, Liu C, Li F, Yi B, Jiang X Abstract Targeted therapy based on specific genetic alterations has been proven to be an effective treatment for various types of cancer. In the present study, we aimed to explore the efficacy of personalized targeted therapy guided by targeted deep sequencing for patients with advanced ...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2 ‑UDP glucuronosyltransferase 1A metabolic axis activation.
Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2‑UDP glucuronosyltransferase 1A metabolic axis activation. Oncol Rep. 2020 Feb 10;: Authors: Hao Q, Wang M, Sun NX, Zhu C, Lin YM, Li C, Liu F, Zhu WW Abstract The long pre‑cancerous state of colorectal cancer (CRC) provides an opportunity to prevent the occurrence and development of CRC. The detoxification of CRC food‑borne carcinogenic heterocyclic amines is highly dependent on UDP glucuronosyltransferase 1A (UGT1A)‑mediated glucuronidation. Sulforaphane (SFN), a phytochemical, possesses antioxidant, anti‑i...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Activation of NLRP3 inflammasome promotes the proliferation and migration of esophageal squamous cell carcinoma.
Authors: Yu S, Yin JJ, Miao JX, Li SG, Huang CZ, Huang N, Fan TL, Li XN, Wang YH, Han SN, Zhang LR Abstract Inflammasomes can identify endogenous danger signals as an inflammatory immune response. As the most common inflammasome, the NLR pyrin family domain containing 3 (NLRP3) inflammasome is associated with the pathogenesis of different tumors. However, the function of the NLRP3 inflammasome in esophageal cancer (EC) has rarely been reported. Herein, the expression levels of the components of NLRP3 inflammasome and Ki‑67 were analyzed by immunohistochemistry. Furthermore, correlations between the NLRP...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway.
In conclusion, downregulation of the PI3K/Akt/mTOR pathway was shown to assist in the process of preventing chemoresistance. PMID: 32323781 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of MMP ‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT.
Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT. Oncol Rep. 2020 Feb 06;: Authors: Wang K, Zheng J, Yu J, Wu Y, Guo J, Xu Z, Sun X Abstract The present study aimed to investigate the role of matrix metalloproteinase‑1 (MMP‑1) in the development of colorectal cancer and reveal the mechanism underlying this progression. Bioinformatics methods and a public dataset were first used to analyze MMP‑1 gene expression in a public dataset. MMP‑1 expression in colorectal cancer patients was assessed by immunohistochemistry; i...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Catalpol ‑mediated microRNA‑34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer.
In conclusion, miR‑34a is involved in regulating catalpol‑mediated autophagy and malignant behavior by directly inhibiting SIRT1 in CRC. PMID: 32323786 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Epigenetic control of the EWS ‑FLI1 promoter in Ewing's sarcoma.
Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma. Oncol Rep. 2020 Feb 05;: Authors: Montoya C, Rey L, Rodríguez J, Fernández MJ, Troncoso D, Cañas A, Moreno O, Henríquez B, Rojas A Abstract Ewing sarcoma (ES) is a primary bone marrow tumor that very rarely develops in extra‑osseous tissues, such as lung. The hallmark of ES tumors is a translocation between chromosomes 11 and 22, resulting in a fusion protein, commonly referred to as EWS‑FLI1. The epigenetic profile (histone acetylation and methylation enrichment of the promoter region) that may regulate t...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA LINC00858 promotes TP53‑wild‑type colorectal cancer progression by regulating the microRNA‑25‑3p/SMAD7 axis.
Long non‑coding RNA LINC00858 promotes TP53‑wild‑type colorectal cancer progression by regulating the microRNA‑25‑3p/SMAD7 axis. Oncol Rep. 2020 Feb 18;: Authors: Zhan J, Tong J, Fu Q Abstract Long non‑coding RNAs (lncRNAs) are involved in colorectal cancer (CRC) progression, however the mechanisms remain largely unknown. The present study aimed to reveal the role and possible molecular mechanisms of a new LNCRNA, LINC00858, in CRC. LINC00858 was increased in CRC tumor tissues, and patients with high LINC00858 expression had a shorter survival time. Knockdown of LINC00858 expression suppres...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑95 promotes osteosarcoma growth by targeting SCNN1A.
miR‑95 promotes osteosarcoma growth by targeting SCNN1A. Oncol Rep. 2020 Feb 24;: Authors: Geng Y, Zhao S, Jia Y, Xia G, Li H, Fang Z, Zhang Q, Tian R Abstract Osteosarcoma (OS) is a common malignant bone tumor, presenting particularly in children and young adults, and accounts for approximately 19% of all malignant bone cancers. Despite advances in OS treatment, long‑term prognosis remains poor. miRNAs are non‑coding single‑stranded RNAs ~22 nucleotides in length. Increasing evidence suggests that numerous miRNAs may play critical roles in tumorigenesis and tumor progression; however, the role...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Single ‑cell RNA sequencing of t(8;21) acute myeloid leukemia for risk prediction.
Single‑cell RNA sequencing of t(8;21) acute myeloid leukemia for risk prediction. Oncol Rep. 2020 Feb 18;: Authors: Xiong Q, Huang S, Li YH, Lv N, Lv C, Ding Y, Liu WW, Wang LL, Chen Y, Sun L, Zhao Y, Liao SY, Zhang MQ, Zhu BL, Yu L Abstract Single‑cell RNA sequencing (scRNA‑seq) of bone marrow or peripheral blood samples from patients with acute myeloid leukemia (AML) enables the characterization of heterogeneous malignant cells. A total of 87 cells from two patients with t(8;21) AML were analyzed using scRNA‑seq. Clustering methods were used to separate leukemia cells into different sub...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Oroxylin  A exerts anticancer effects on human ovarian cancer cells via the PPARγ‑dependent reversal of the progesterone receptor membrane component 1/2 expression profile.
Oroxylin A exerts anticancer effects on human ovarian cancer cells via the PPARγ‑dependent reversal of the progesterone receptor membrane component 1/2 expression profile. Oncol Rep. 2020 Feb 21;: Authors: Shen JJ, Zhu XF, Xu J, Wang ZF, Gu WJ, Chen Y Abstract Ovarian cancer is the most lethal gynecological cancer worldwide. To date, the therapeutic approaches available for the treatment of ovarian cancer are still very limited. The present study first demonstrated that the Chinese herb, Oroxylin A, exerts inhibitory effects on both the migratory ability and viability of ovarian cancer cel...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

AREG mediates the epithelial ‑mesenchymal transition in pancreatic cancer cells via the EGFR/ERK/NF‑κB signalling pathway.
AREG mediates the epithelial‑mesenchymal transition in pancreatic cancer cells via the EGFR/ERK/NF‑κB signalling pathway. Oncol Rep. 2020 Feb 27;: Authors: Wang L, Wang L, Zhang H, Lu J, Zhang Z, Wu H, Liang Z Abstract Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and is expressed in a plethora of cancers. The biological roles of AREG in the regulation of the epithelial‑mesenchymal transition (EMT) in pancreatic cancer remain unclear. To investigate the expression of epidermal growth factor receptor (EGFR) and AREG in pancreatic cancer cell lines, RT‑qPCR, we...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lncRNA TPTEP1 competitively sponges miR ‑328‑5p to inhibit the proliferation of non‑small cell lung cancer cells.
lncRNA TPTEP1 competitively sponges miR‑328‑5p to inhibit the proliferation of non‑small cell lung cancer cells. Oncol Rep. 2020 Feb 26;: Authors: Cao F, Wang Z, Feng Y, Zhu H, Yang M, Zhang S, Wang X Abstract Accumulating evidence suggests that lncRNAs are involved in almost all normal physiological processes and that aberrant expression of lncRNAs may be involved in the development of diseases, including non‑small cell lung cancer (NSCLC). However, the roles of lncRNA‑TPTE pseudogene 1 (TPTEP1) in lung cancer and the underlying molecular mechanisms have remained elusive. In the present...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PLC ε knockdown enhances the radiosensitivity of castration‑resistant prostate cancer via the AR/PARP1/DNA‑PKcs axis.
PLCε knockdown enhances the radiosensitivity of castration‑resistant prostate cancer via the AR/PARP1/DNA‑PKcs axis. Oncol Rep. 2020 Feb 26;: Authors: Pu J, Li T, Liu N, Luo C, Quan Z, Li L, Wu X Abstract Radiotherapy (RT) has been used as a therapeutic option for treatment of prostate cancer (PCa) for a number of years; however, patients frequently develop RT resistance, particularly in castration‑resistant PCa (CRPC), although the underlying mechanisms remain unknown. Understanding the underlying mechanism of RT resistance in CRPC may potentially highlight novel targets to improve thera...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

ORP8 induces apoptosis by releasing cytochrome  c from mitochondria in non‑small cell lung cancer.
ORP8 induces apoptosis by releasing cytochrome c from mitochondria in non‑small cell lung cancer. Oncol Rep. 2020 Feb 24;: Authors: Li J, Cui J, Li Z, Fu X, Li J, Li H, Wang S, Zhang M Abstract Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer, and numerous oncogenes are associated with this disease. Oxysterol‑binding protein‑related protein 8 (ORP8) is essential for cell growth, migration and the modulation of mitochondrial respiration and morphology. However, the underlying role of ORP8 in NSCLC remains unclear. In the present study, it was reported that the ...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

METTL14 promotes the migration and invasion of breast cancer cells by modulating N6 ‑methyladenosine and hsa‑miR‑146a‑5p expression.
METTL14 promotes the migration and invasion of breast cancer cells by modulating N6‑methyladenosine and hsa‑miR‑146a‑5p expression. Oncol Rep. 2020 Feb 24;: Authors: Yi D, Wang R, Shi X, Xu L, Yilihamu Y, Sang J Abstract Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer‑related death among women worldwide. Evidence indicates that posttranscriptional N6‑methyladenosine (m6A) modification modulates BC development. In the present study, we assessed BC and normal tissues to investigate this connection. RNA m6A levels were determined by methylation quanti...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cutoff of 25% for Ki67 expression is a good classification tool for prognosis in colorectal cancer in the AJCC ‑8 stratification.
Cutoff of 25% for Ki67 expression is a good classification tool for prognosis in colorectal cancer in the AJCC‑8 stratification. Oncol Rep. 2020 Feb 21;: Authors: Tong G, Zhang G, Liu J, Zheng Z, Chen Y, Niu P, Xu X Abstract Ki‑67 expression has been widely used in clinical practice as an index to evaluate the proliferative activity of tumor cells. The cutoff for Ki67 expression in order to increase the prognostic value of Ki67 expression in colorectal cancer varies. The present study assessed the relationship between the 25% cutoff for Ki67 expression and prognosis in colorectal cancer in the AJCC...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

N6 ‑methyladenosine RNA methylation regulators participate in malignant progression and have prognostic value in clear cell renal cell carcinoma.
N6‑methyladenosine RNA methylation regulators participate in malignant progression and have prognostic value in clear cell renal cell carcinoma. Oncol Rep. 2020 Feb 28;: Authors: Zheng Z, Mao S, Guo Y, Zhang W, Liu J, Li C, Yao X Abstract N6‑methyladenosine (m6A) RNA methylation is the most prevalent type of mRNA modification; however, little is known about its function in clear cell renal cell carcinoma (ccRCC). The present study aimed to establish and validate a m6A‑related risk signature as a prognostic factor for patients with ccRCC. Consensus clustering was used to divide patients with ccRCC...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

GSK ‑3 inhibitor CHIR99021 enriches glioma stem‑like cells.
GSK‑3 inhibitor CHIR99021 enriches glioma stem‑like cells. Oncol Rep. 2020 Feb 28;: Authors: Yang Y, Wang QQ, Bozinov O, Xu RX, Sun YL, Wang SS Abstract Glioblastoma (GBM) is the most prevalent and lethal primary intrinsic brain cancer. The disease is essentially incurable, with glioblastomas characterized by resistance to both chemotherapy and radiotherapy, as well as by rapid tumor progression, all of which are mainly ascribed to glioma stem‑like cells (GSLCs). In the present study, an improved model that is more similar to clinical GBM was constructed. Twenty clinical glioma samples were colle...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

p62 promotes proliferation, apoptosis ‑resistance and invasion of prostate cancer cells through the Keap1/Nrf2/ARE axis.
p62 promotes proliferation, apoptosis‑resistance and invasion of prostate cancer cells through the Keap1/Nrf2/ARE axis. Oncol Rep. 2020 Feb 28;: Authors: Jiang G, Liang X, Huang Y, Lan Z, Zhang Z, Su Z, Fang Z, Lai Y, Yao W, Liu T, Hu, Wang F, Huang H, Liu L, Jiang X Abstract Prostate cancer poses a public health threat to hundreds of people around the world. p62 has been identified as a tumor suppressor, however, the mechanism by which p62 promotes prostate cancer remains poorly understood. The present study aimed to investigate whether p62 promotes proliferation, apoptosis resistance and invasion o...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

α‑Solanine inhibits growth and metastatic potential of human colorectal cancer cells.
α‑Solanine inhibits growth and metastatic potential of human colorectal cancer cells. Oncol Rep. 2020 Feb 26;: Authors: Yan X, Li M, Chen L, Peng X, Que ZJ, An HM, Shen KP, Hu B Abstract Solanum nigrum L. (Longkui) is one the most widely used anticancer herbs in traditional Chinese medicine. α‑Solanine is an important ingredient of S. nigrum L. and has demonstrated anticancer properties in various types of cancer. However, the effects of α‑solanine on colorectal cancer remain elusive. The aim of the present study was to assess the effects of α‑solanine on human...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑126‑3p suppresses HeLa cell proliferation, migration and invasion, and increases apoptosis via the PI3K/PDK1/AKT pathway.
MicroRNA‑126‑3p suppresses HeLa cell proliferation, migration and invasion, and increases apoptosis via the PI3K/PDK1/AKT pathway. Oncol Rep. 2020 Feb 21;: Authors: Ichikawa R, Kawasaki R, Iwata A, Otani S, Nishio E, Nomura H, Fujii T Abstract We previously reported that relative to normal cervical mucus, microRNA 126‑3p (miR‑126‑3p) is present in significantly greater amounts in the cervical mucus of patients with overt cervical cancer or precursor lesions. Here, we investigated the effects of enforced miR‑126‑3p expression in the cervical cancer cell line, HeLa, on proliferation, migrat...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samples.
Authors: Dong S, Men W, Yang S, Xu S Abstract Lung adenocarcinoma is one of the most common malignant tumors worldwide. Although efforts have been made to clarify its pathology, the underlying molecular mechanisms of lung adenocarcinoma are still not clear. The microarray datasets GSE75037, GSE63459 and GSE32863 were downloaded from the Gene Expression Omnibus (GEO) database to identify biomarkers for effective lung adenocarcinoma diagnosis and therapy. The differentially expressed genes (DEGs) were identified by GEO2R, and function enrichment analyses were conducted using the Kyoto Encyclopedia of Genes and Genome...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cold atmospheric plasma ‑activated Ringer's solution inhibits the proliferation of osteosarcoma cells through the mitochondrial apoptosis pathway.
Cold atmospheric plasma‑activated Ringer's solution inhibits the proliferation of osteosarcoma cells through the mitochondrial apoptosis pathway. Oncol Rep. 2020 Feb 25;: Authors: Xu S, Wang Y, Que Y, Ma C, Cai S, Wang H, Yang X, Yang C, Cheng C, Zhao G, Hu Y Abstract The present study aimed to investigate the effects of cold atmospheric plasma (CAP)‑activated Ringer's solution on osteosarcoma cell lines MG63 and U2OS, and to identify the molecular mechanism underlying these effects. CAP‑activated Ringer's solution was used to treat osteosarcoma cell lines MG63 and U2OS for 30 min. Cell viab...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ropivacaine inhibits cervical cancer cell growth via suppression of the miR ‑96/MEG2/pSTAT3 axis.
Ropivacaine inhibits cervical cancer cell growth via suppression of the miR‑96/MEG2/pSTAT3 axis. Oncol Rep. 2020 Feb 26;: Authors: Chen X, Liu W, Guo X, Huang S, Song X Abstract Ropivacaine, one of the most commonly used local anesthetics in clinical practice, has shown potent antitumor activity in multiple types of cancer cells. However, its effect on cervical cancer cell growth remains unknown. In the present study, it was found that ropivacaine inhibited cervical cancer cell growth by suppressing cell cycle progression and promoting cell apoptosis, as determined by CCK‑8 assay, cell cycle and ap...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cutaneous neurofibroma cells with active YAP promotes proliferation of macrophages resulting in increased accumulation of macrophages by modulating CCL5 and TGF ‑β1.
Cutaneous neurofibroma cells with active YAP promotes proliferation of macrophages resulting in increased accumulation of macrophages by modulating CCL5 and TGF‑β1. Oncol Rep. 2020 Feb 21;: Authors: Jia J, Zhang H, He L, Zhang H, Shu M Abstract Cutaneous neurofibromas (cNFs) are present in the majority of patients with neurofibromatosis type 1 (NF1), and results in disfigurements of the body, which is associated with psychological distress. A hallmark feature of cNF is the infiltration of inflammatory cells, among which macrophages are an important component of the microenvironment. Loss of...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Transcriptome sequencing analysis of mono ‑ADP‑ribosylation in colorectal cancer cells.
Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells. Oncol Rep. 2020 Feb 24;: Authors: Zhang NN, Lin T, Xiao M, Li QS, Li X, Yang L, Wang CL, Wang YL Abstract Colorectal cancer (CRC) is a global health concern. The role of epigenetics in tumors has garnered increasing interest. ADP ribosylation is an epigenetic modification that is associated with a variety of biological functions and diseases, and its association with tumor development and progression has been hypothesized. However, due to the limitations of available techniques and methods, ADP ribosylation of sp...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Patient ‑derived orthotopic xenograft glioma models fail to replicate the magnetic resonance imaging features of the original patient tumor.
In conclusion, the data demonstrated that the MRI features of patient‑derived xenograft glioma models in mice were different compared with those of the original patient tumors. Differential gene expression may underlie the differences noted in the MRI features between original tumors and corresponding xenografts. The results of the present study highlight the precautions that should be taken when extrapolating data from patient‑derived xenograft studies, and their applicability to humans. PMID: 32323818 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

BMI ‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor.
BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor. Oncol Rep. 2020 Mar 10;: Authors: Yu J, Chen L, Bao Z, Liu Y, Liu G, Li F, Li L Abstract Endometrial adenocarcinoma is one of the most common types of gynecological malignancies and its incidence and mortality rates are increasing. Due to tumor recurrence and metastasis, the overall five‑year survival rate of patients with endometrial adenocarcinoma is shortened. The aim of the present was to investigate the role of the polycomb group protein B‑lymphoma Mo‑MLV insertion region 1 (BMI‑1) ...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LOXL2 upregulates hypoxia ‑inducible factor‑1α signaling through Snail‑FBP1 axis in hepatocellular carcinoma cells.
LOXL2 upregulates hypoxia‑inducible factor‑1α signaling through Snail‑FBP1 axis in hepatocellular carcinoma cells. Oncol Rep. 2020 Mar 10;: Authors: Fan Z, Zheng W, Li H, Wu W, Liu X, Sun Z, Hu H, Du L, Jia Q, Liu Q Abstract Lysyl oxidase‑like 2 (LOXL2), a member of the lysyl oxidase gene family, is involved in the progression of hepatocellular carcinoma progression and metastasis. Increased expression of LOXL2 has been identified in several types of cancer, including hepatocellular carcinoma. Recently, LOXL2 has been reported to promote epithelial‑mesenchymal transition by reducin...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Thymus ‑expressed chemokine secreted by breast cancer cells promotes metastasis and inhibits apoptosis.
Thymus‑expressed chemokine secreted by breast cancer cells promotes metastasis and inhibits apoptosis. Oncol Rep. 2020 Apr 03;: Authors: Chen L, Zhang S, Shen Y, Qi L, Zhang Z, Tian H, Zou Z Abstract The aim of the present study was to investigate the underlying mechanisms of thymus‑expressed chemokine (TECK) autocrine signaling, and its effect on carcinogenesis and the development of breast cancer. The present study also assessed epithelial‑mensenchymal transition (EMT) and cell migration, invasion, proliferation and apoptosis. Breast cancer cell lines MCF‑7 and MDA‑MB‑231 were used in the...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TEAD2 as a novel prognostic factor for hepatocellular carcinoma.
In conclusion, increased mRNA expression of TEAD2 is associated with a poor prognosis in patients with HCC. TEAD2 may serve as a prognostic factor for HCC and a novel therapeutic target. PMID: 32323824 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Antitumor effect of lenalidomide in malignant glioma cell lines.
In conclusion, lenalidomide exerts an antitumor effect on glioma cells due to alterations in cell cycle distribution. PMID: 32323826 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑363‑3p inhibits cell proliferation and induces apoptosis in retinoblastoma cells via the Akt/mTOR signaling pathway by targeting PIK3CA.
MicroRNA‑363‑3p inhibits cell proliferation and induces apoptosis in retinoblastoma cells via the Akt/mTOR signaling pathway by targeting PIK3CA. Oncol Rep. 2020 Mar 12;: Authors: Ma X, Jin L, Lei X, Tong J, Wang R Abstract There is extensive evidence suggesting that microRNAs (miRs) can modulate the activity of oncogenes and tumor suppressors, and are associated with the occurrence of cancer. In the present study, the function of miR‑363‑3p in the progression of retinoblastoma (RB) was investigated. miR‑363‑3p expression in RB was decreased, and miR‑363‑3p protein levels were found to ...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Iodine ‑125 seed radiation induces ROS‑mediated apoptosis, autophagy and paraptosis in human esophageal squamous cell carcinoma cells.
Iodine‑125 seed radiation induces ROS‑mediated apoptosis, autophagy and paraptosis in human esophageal squamous cell carcinoma cells. Oncol Rep. 2020 Apr 03;: Authors: Wang C, Li TK, Zeng CH, Fan R, Wang Y, Zhu GY, Guo JH Abstract Iodine‑125 (125I) seed brachytherapy has been proven to be a safe and effective treatment for advanced esophageal cancer; however, the mechanisms underlying its actions are not completely understood. In the present study, the anti‑cancer mechanisms of 125I seed radiation in human esophageal squamous cell carcinoma (ESCC) cells (Eca‑109 and KYSE‑150) were determine...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Exosomes derived from Piwil2 ‑induced cancer stem cells transform fibroblasts into cancer‑associated fibroblasts.
Exosomes derived from Piwil2‑induced cancer stem cells transform fibroblasts into cancer‑associated fibroblasts. Oncol Rep. 2020 Feb 10;: Authors: Zhang D, Li D, Shen L, Hu D, Tang B, Guo W, Wang Z, Zhang Z, Wei G, He D Abstract Recently, several studies have demonstrated that cancer cell‑derived exosomes can facilitate tumor development and metastasis formation. However, the detailed function of exosomes released by cancer stem cells (CSCs) requires further investigation. The aim of the present study was to investigate the role of CSC‑derived exosomes in tumor development. For this purpose, Pi...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Thapsigargin promotes colorectal cancer cell migration through upregulation of lncRNA MALAT1.
In conclusion, to the best of our knowledge, this study is the first report that lncRNA MALAT1 expression is regulated by the IRE1/XBP1 pathway in CRC. PMID: 32323831 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.
Authors: Yang L, Han N, Zhang X, Zhou Y, Chen R, Zhang M Abstract Glioblastoma (GBM) is the most aggressive primary intracranial tumor in adults. Chemoradiotherapy resistance and recurrence after surgery are the main malignant progression factors, leading to a high mortality rate. Therefore, the exploration of novel biomarkers and molecular mechanisms of GBM is urgent. Differentially expressed genes (DEGs) of GBM were screened in a TCGA dataset. Homo sapiens ZW10 interacting kinetochore protein (ZWINT) was found to be upregulated in GBM, which was confirmed by immunohistochemical staining of a tissue microarra...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF ‑7 cells.
In conclusion, these data indicated that TCRP1 could induce tamoxifen resistance by regulating the PDK1/SGK1 signaling pathway. Thus, TCRP1 could be explored as a promising candidate for treating tamoxifen‑resistant breast cancer in the future. PMID: 32323833 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A radiomics model to predict the invasiveness of thymic epithelial tumors based on contrast ‑enhanced computed tomography.
A radiomics model to predict the invasiveness of thymic epithelial tumors based on contrast‑enhanced computed tomography. Oncol Rep. 2020 Feb 11;: Authors: Chen X, Feng B, Li C, Duan X, Chen Y, Li Z, Liu Z, Zhang C, Long W Abstract In the present study, we aimed to construct a radiomics model using contrast‑enhanced computed tomography (CT) to predict the pathological invasiveness of thymic epithelial tumors (TETs). We retrospectively reviewed the records of 179 consecutive patients (89 females) with histologically confirmed TETs from two hospitals. The 82 low‑ and 97 high‑risk TETs were assign...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of MiD49 contributes to tumor growth and metastasis of human pancreatic cancer.
Authors: Bai L, Liang J, Li L, Li E Abstract Changes in mitochondrial morphology by dysregulated mitochondrial fission‑fusion proteins have been increasingly recognized as a hallmark of cancer. MiD49 (mitochondrial dynamics protein of 49 kDa) is a newly identified mitochondrial fission protein involved in the dynamic regulation of mitochondrial morphology. However, the expression pattern and biological functions of MiD49 in human cancers remain largely unexplored, especially in pancreatic cancer (PC). In the present study, the expression and clinical significance of MiD49 was firstly determined by RT‑qPCR ...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research