Recombinant adenoviruses expressing apoptin suppress the growth of MCF ‑7 breast cancer cells and affect cell autophagy.
In conclusion, apoptin‑induced cell death may involve both autophagy and apoptosis. The induction of autophagy may inhibit apoptosis, whereas apoptosis may inhibit autophagy; however, occasionally both pathways operate at the same time and involve apoptin. This apoptin‑associated selection between tumor cell survival and death may provide a potential therapeutic strategy for breast cancer. PMID: 30896879 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Targeting P16INK4A in uterine serous carcinoma through inhibition of histone demethylation.
Authors: Xiao Z, He Y, Liu C, Xiang L, Yi J, Wang M, Shen T, Shen L, Xue Y, Shi H, Liu P Abstract Uterine serous carcinoma (USC) is a subtype of endometrial cancer. Compared with endometrial endometroid carcinoma, the majority of USC cases are more aggressive. Cyclin-dependent kinase inhibitor 2A (P16INK4A) is a canonical tumor suppressor that blocks cell cycle progression; however, P16INK4A is overexpressed in USC. The aim of the present study was to determine the role of P16INK4A in P16INK4A‑positive endometrial cancer, with the hope of elucidating a novel therapeutic approach for this type of malignancy. A tot...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of cytokeratin 18 enhances BCRP-mediated multidrug resistance through induction of epithelial-mesenchymal transition and predicts poor prognosis in breast cancer.
Authors: Shi R, Wang C, Fu N, Liu L, Zhu D, Wei Z, Zhang H, Xing J, Wang Y Abstract Multiple drug resistance (MDR) and metastasis have been identified as the two major causes of the poor prognosis of patients with breast cancer. However, the relationship between MDR and metastasis has not been characterized. Epithelial‑mesenchymal transition (EMT), a process known to promote metastasis in cancer, has been shown to be associated with the MDR phenotype of many tumor types. Reduced cytokeratin 18 (CK18) expression is thought to be one of the hallmarks of EMT, and the role of CK18 in MDR of metastatic breast cancer r...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Transcriptome ‑wide piRNA profiling in human gastric cancer.
In conclusion, we conclude that piRNAs are abundant in human stomachs and may play important roles in the etiological processes of gastric cancers. PMID: 30896887 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Y ‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer.
Y‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer. Oncol Rep. 2019 Feb 28;: Authors: Nagasu S, Sudo T, Kinugasa T, Yomoda T, Fujiyoshi K, Shigaki T, Akagi Y Abstract Y‑box‑binding protein 1 (YB‑1) is a DNA/RNA‑-binding protein and an important transcription and translation factor in carcinogenesis. However, the biological function and molecular correlation of YB‑1 in colorectal cancer are not fully understood. The aim of the present study was to determine the significance of YB‑1 expression and its biological role in colorectal cancer. Cell prolif...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Proteins of the Wnt signaling pathway as targets for the regulation of CD133+ cancer stem cells in glioblastoma.
This study aimed to analyze the crucial role that proteins of the Wnt signaling pathway play in stem cell proliferation. The identified proteins were analyzed for their association with the Wnt signaling pathway using the international open databases PubMed, Protein Analysis Through Evolutionary Relationships, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes and Search Tool for the Retrieval of Interacting Genes/Proteins. An increased expression of 12 proteins associated with the Wnt signaling pathway were identified in GBM CD133+ CSCs, which included catenin β‑1, disheveled associated activator of morphogenes...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3 β/cyclin D1 signaling pathway.
Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway. Oncol Rep. 2019 Mar 05;: Authors: Lin JX, Xie XS, Weng XF, Qiu SL, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Li P, Huang CM, Zheng CH Abstract Cyclin‑dependent kinase 5 regulatory subunit‑​associated protein 3 (CDK5RAP3 or C53) is involved in the development of various types of tumor, and alternative splicing of C53 results in numerous transcription variants that encode different isoforms. The present study aimed to clone human C53 isoform d (IC...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity.
Authors: Li Y, Zhao C, Liu J, Lu Z, Lu M, Gu J, Liu R Abstract Dendritic cells (DCs), as professional antigen‑presenting cells are essential for the initial activation of adaptive antitumor immunity. CD1d is considered to present phospholipid and glycosphingolipid antigens to NKT cells. However, it is currently unknown whether CD1d expression on DCs is capable of enhancing antitumor immunity, particularly T‑cell related immunity. We observed that CD1d was predominantly expressed on DCs in 3LL tumor‑bearing mice, whilst a deficiency of CD1d promoted tumor growth. Notably, CD1d expression on DCs was not only re...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CD147 ‑mediated reprogrammed glycolytic metabolism potentially induces immune escape in the tumor microenvironment (Review).
CD147‑mediated reprogrammed glycolytic metabolism potentially induces immune escape in the tumor microenvironment (Review). Oncol Rep. 2019 Mar 04;: Authors: Li X, Xu W Abstract Impaired antitumor immunity or induced immunosuppression in the tumor microenvironment contributes significantly to tumor progression and resistance to immunotherapy. It is becoming increasingly recognized that dynamic metabolic programming orchestrates appropriate immune responses, whereas incorrect metabolic reprogramming may underlie aberrant immune remodeling. Furthermore, pathways that control cellular metabolism and imm...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Non ‑covalent proteasome inhibitor PI‑1840 induces apoptosis and autophagy in osteosarcoma cells.
In conclusion, the present study revealed PI‑1840 to be a promising drug for the treatment of OS. PMID: 30864717 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LncRNA ‑AB209371 promotes the epithelial‑mesenchymal transition of hepatocellular carcinoma cells.
In conclusion, to the best of our knowledge, the present study confirmed for the first time that the high expression of AB209371 is favorable for the EMT in HCC cells and may be a direct cause of hsa‑miR199a‑5p inactivation (an HCC metastasis suppressor). Additionally, AB209371 silencing combined with hsa‑miR199a‑5p overexpression may be an effective means to inhibit the metastasis of HCC and the EMT of HCC cells. PMID: 30864719 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Transcribed ultraconserved region Uc.63+ promotes resistance to cisplatin through regulation of androgen receptor signaling in bladder cancer.
Authors: Sekino Y, Sakamoto N, Ishikawa A, Honma R, Shigematsu Y, Hayashi T, Sentani K, Oue N, Teishima J, Matsubara A, Yasui W Abstract Cisplatin (CDDP)‑based combination chemotherapy is the standard for muscle‑invasive bladder cancer (MIBC). However, nearly all patients undergoing CDDP chemotherapy become refractory due to the development of CDDP resistance. Therefore, clarification of the mechanisms of CDDP resistance is urgently needed. The transcribed ultraconserved regions (T‑UCRs) are a novel class of non‑coding RNAs that are highly conserved across species and are associated with carcinogenesis and ...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6.
miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6. Oncol Rep. 2019 Mar 07;: Authors: Li T, Li M, Xu C, Xu X, Ding J, Cheng L, Ou R Abstract The aim of the present study was to investigate whether miRNA‑146a regulated the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis. miR‑146a expression was increased in human cervical cancer. Both overall survival (OS) and disease‑free survival (DFS) of low miR‑146a expression were higher than those ...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Induction of HSP27 and HSP70 by constitutive overexpression of Redd1 confers resistance of lung cancer cells to ionizing radiation.
Authors: Jin HO, Hong SE, Kim JY, Kim MR, Chang YH, Hong YJ, Lee JK, Park IC Abstract Redd1 is a stress response protein that functions as a repressor of mTORC1, a central regulator of protein translation, resulting in the inhibition of cell growth and metabolism. However, paradoxically, high Redd1 expression favors cancer progression and generates resistance to cancer therapy. Herein, we revealed that constitutive overexpression of Redd1 induced HSP27 and HSP70 expression in lung cancer cells. The expression of Redd1, HSP27 and HSP70 was highly increased in lung cancer tissues compared with that in normal lung tis...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of estrogen receptor β inhibits lung adenocarcinoma cell growth.
Downregulation of estrogen receptor β inhibits lung adenocarcinoma cell growth. Oncol Rep. 2019 Mar 05;: Authors: Chen W, Xin B, Pang H, Han L, Shen W, Zhao Z, Duan L, Cao P, Liu L, Zhang H Abstract Estrogen receptor β (ERβ) is an important ER subtype in lung adenocarcinoma. However, the functions and mechanisms of ERβ have not been fully elucidated. The aim of the present study was to investigate the biological effects and relevant mechanisms of ERβ in lung adenocarcinoma. The protein expression of ERβ was found to be higher in lung adenocarcinoma tissues compared with th...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Combination of phospholipase C ε knockdown with GANT61 sensitizes castration‑resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway.
Combination of phospholipase Cε knockdown with GANT61 sensitizes castration‑resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway. Oncol Rep. 2019 Mar 07;: Authors: Sun W, Li L, Du Z, Quan Z, Yuan M, Cheng H, Gao Y, Luo C, Wu X Abstract Castration‑resistant prostate cancer (CRPC) is a major challenge in the treatment of prostate cancer (PCa). Phospholipase Cε (PLCε), an oncogene, has been found to be involved in the carcinogenesis, tumor proliferation and migration of several types of cancer. The effects, however, of PLC&epsil...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PD ‑L1 promotes head and neck squamous cell carcinoma cell growth through mTOR signaling.
PD‑L1 promotes head and neck squamous cell carcinoma cell growth through mTOR signaling. Oncol Rep. 2019 Mar 07;: Authors: Zheng A, Li F, Chen F, Zuo J, Wang L, Wang Y, Chen S, Xiao B, Tao Z Abstract Programmed death‑ligand 1 (PD‑L1), an immune co‑stimulatory molecule, is expressed on various cancer cells and the surface of immune cells. Its overexpression on tumor cells suppresses the immune response to promote tumor cell immune escape. The present study demonstrated that PD‑L1 was critical in head and neck squamous cell carcinoma (HNSCC) carcinogenesis. Immunohistochemical analysis of HNSCC...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tropomodulin  3 promotes liver cancer progression by activating the MAPK/ERK signaling pathway.
In conclusion, TMOD3 was shown to promote liver cancer cell growth, invasion and migration through the MAPK/ERK signaling pathway, and it may serve as a candidate biomarker and therapeutic target in liver cancer. PMID: 30864730 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PLC ε promotes urinary bladder cancer cells proliferation through STAT3/LDHA pathway‑mediated glycolysis.
PLCε promotes urinary bladder cancer cells proliferation through STAT3/LDHA pathway‑mediated glycolysis. Oncol Rep. 2019 Mar 13;: Authors: Cheng H, Hao Y, Gao Y, He Y, Luo C, Sun W, Yuan M, Wu X Abstract Phospholipase Cε (PLCε) and anaerobic glycolysis were determined to be involved in the development of human urinary bladder cancer (UBC), but the mechanisms remain unclear. In the present study, 64 bladder cancer specimens and 42 adjacent tissue specimens were obtained from 64 patients, and immunochemistry indicated that PLCε and lactate dehydrogenase (LDHA) are overex...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] NHE1 is upregulated in gastric cancer and regulates gastric cancer cell proliferation, migration and invasion.
Authors: Xie R, Wang H, Jin H, Wen G, Tuo B, Xu J Abstract After the publication of the article, the authors informed us that they had consent from the patients involved in the study, but not from the next‑of‑kin of the patients, for their clinical data to have been published (Fig. 1A‑E). Following on from a request made by the Ethics Committee of the Affiliated Hospital of Zunyi Medical College that these data either be replaced in the article, or that the article be retracted, the authors identified 10 new volunteers and asked the patients and their families to sign informed consent according to ethica...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Wound fluid enhances cancer cell proliferation via activation of STAT3 signal pathway in vitro.
In conclusion, surgery leads to excessive release of mitogenic factors. The contact of non‑resected cancer cells and these factors may have a negative impact on patient outcome. Future investigations should specifically focus on the inhibition of mitogenic factors following cancer surgery in order to prevent early metastasis and cancer recurrence. PMID: 30864735 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Interaction with tumor ‑associated macrophages promotes PRL‑3‑induced invasion of colorectal cancer cells via MAPK pathway‑induced EMT and NF‑κB signaling‑induced angiogenesis.
Interaction with tumor‑associated macrophages promotes PRL‑3‑induced invasion of colorectal cancer cells via MAPK pathway‑induced EMT and NF‑κB signaling‑induced angiogenesis. Oncol Rep. 2019 Mar 07;: Authors: Zhang T, Liu L, Lai W, Zeng Y, Xu H, Lan Q, Su P, Chu Z Abstract Protein phosphatase of regenerating liver‑3 (PRL‑3) is considered to be metastasis‑associated phosphatase and is associated with a poor prognosis. Additionally, tumor‑associated macrophages (TAMs) participate in cancer progression. A previous study demonstrated that PRL‑3 promotes invasion and metastasis ...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Analysis of microRNA expression profiles reveals a 5 ‑microRNA prognostic signature for predicting overall survival time in patients with gastric adenocarcinoma.
In conclusion, the present 5‑miRNA signature is a potential independent risk factor for patient outcomes. The risk model based on the 5‑miRNA signature performed well in predicting overall survival time in patients with gastric adenocarcinoma. PMID: 30864737 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PARG regulates the proliferation and differentiation of DCs and T  cells via PARP/NF‑κB in tumour metastases of colon carcinoma.
PARG regulates the proliferation and differentiation of DCs and T cells via PARP/NF‑κB in tumour metastases of colon carcinoma. Oncol Rep. 2019 Mar 07;: Authors: Wang JQ, Tang Y, Li QS, Xiao M, Li M, Sheng YT, Yang Y, Wang YL Abstract The present study investigated the effect of poly(ADP‑ribose) glycohydrolase (PARG) on the immune response in tumour metastases of colon carcinoma. CT26 cells were transfected with lentivirus PARG‑short hairpin RNA (shRNA). A liver metastasis model of colon carcinoma was successfully established by splenic subcapsular inoculation of the various groups of ...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/ β-catenin signaling pathway.
MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway. Oncol Rep. 2019 Mar 07;: Authors: Xie Q, Wang S, Zhao Y, Zhang Z, Qin C, Yang X Abstract The aim of the present study was to investigate the potential anticancer effects of microRNA-216a on the growth of human breast cancer and the possible underlying mechanisms. The results demonstrated that serum microRNA-216a was significantly decreased in patients with breast cancer compared with healthy controls. MicroRNA-216a overexpression led to a decrease in cell proliferation and...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CDCA3 is a potential prognostic marker that promotes cell proliferation in gastric cancer.
Authors: Zhang Y, Yin W, Cao W, Chen P, Bian L, Ni Q Abstract Gastric cancer (GC) is an aggressive and highly lethal gastrointestinal cancer, with an exceedingly poor prognosis. In the present study, the carcinogenic mechanism of human GC and the role of cell division cycle‑associated 3 (CDCA3) were investigated. The expression levels of CDCA3 were investigated in GC samples and matched, peritumoral tissues by reverse transcription‑quantitative polymerase chain reaction and immunohistochemical analysis. The effects of CDCA3 on cell proliferation were explored by Cell Counting Kit‑8, colony formation, flow cyt...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Deoxypodophyllotoxin inhibits cell viability and invasion by blocking the PI3K/Akt signaling pathway in human glioblastoma cells.
In conclusion, DPT effectively inhibited the expression of PI3K and downregulated PI3K/Akt‑mediated signaling pathways to prevent glioblastoma progression. PMID: 30816477 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Polo ‑like kinase 4 promotes tumorigenesis and induces resistance to radiotherapy in glioblastoma.
Polo‑like kinase 4 promotes tumorigenesis and induces resistance to radiotherapy in glioblastoma. Oncol Rep. 2019 Feb 14;: Authors: Wang J, Zuo J, Wang M, Ma X, Gao K, Bai X, Wang N, Xie W, Liu H Abstract Glioblastoma (GBM) is one of the most malignant tumors in adults, associated with severe outcomes (median survival,
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of Opa interacting protein  5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation.
Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation. Oncol Rep. 2019 Feb 11;: Authors: Li Y, Xiao F, Li W, Hu P, Xu R, Li J, Li G, Zhu C Abstract Opa interacting protein 5 (OIP5) overexpression is associated with human carcinoma. However, its biological function, underlying mechanism and clinical significance in liver cancer remain unknown. In the present study, the effects of OIP5 expression on liver cancer, and the mechanisms regulating these effects, were investigated. OIP5 expression was measured in human hepatocellular c...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Establishment and characterization of novel human oral squamous cell carcinoma cell lines from advanced ‑stage tumors of buccal mucosa.
Establishment and characterization of novel human oral squamous cell carcinoma cell lines from advanced‑stage tumors of buccal mucosa. Oncol Rep. 2019 Feb 07;: Authors: Gawas NP, Navarange SS, Chovatiya GL, Chaturvedi P, Waghmare SK Abstract Oral squamous cell carcinoma (OSCC) is a leading cause of mortality in India owing to the high percentage of tobacco chewers, smokers and alcohol consumption. OSCC is highly heterogeneous in nature; therefore poses a challenge in the treatment of the patient. To better understand the heterogeneity of the tumors, an in vitro cell line model is required. However, t...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Multikinase inhibitor motesanib enhances the antitumor effect of cisplatin in cisplatin ‑resistant human bladder cancer cells via apoptosis and the PI3K/Akt pathway.
In conclusion, combination treatment with motesanib and cisplatin revealed a synergistically enhanced anticancer effect on cisplatin‑resistant human bladder cancer cells, accompanied with induced apoptosis and cell cycle arrest. Thus, the multikinase inhibitor motesanib could be developed as possible therapeutic agent for bladder cancer. PMID: 30816494 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Myristoylated alanine rich protein kinase  C substrate is a potential cancer prognostic factor that regulates cell migration and invasion in glioblastoma.
Myristoylated alanine rich protein kinase C substrate is a potential cancer prognostic factor that regulates cell migration and invasion in glioblastoma. Oncol Rep. 2019 Feb 13;: Authors: Xiang W, Peng T, Ming Y, Li S, Wang K, Wang H, Chen L, Zhou J Abstract Myristoylated alanine‑rich C‑kinase substrate (MARCKS) serves an important role in various pathological processes in several malignancies. However, little is known about the specific role and molecular mechanism of MARCKS in glioblastoma (GBM). In the present study, it was found that the expression of MARCKS was significantly upregulated i...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Chlorophyllin  e6‑mediated photodynamic therapy inhibits proliferation and induces apoptosis in human bladder cancer cells.
Chlorophyllin e6‑mediated photodynamic therapy inhibits proliferation and induces apoptosis in human bladder cancer cells. Oncol Rep. 2019 Feb 14;: Authors: Zhuo Z, Song Z, Ma Z, Zhang Y, Xu G, Chen G Abstract Patients with non‑muscle invasive bladder cancer (NMIBC) frequently relapse following surgery due to incomplete resection and chemoresistance, highlighting the importance of developing novel therapeutic strategies that mechanistically assist in eradicating the residual tumor. The aim of the present study was to evaluate the anticancer effect of chlorophyllin e6‑mediated photodynamic th...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of BHLHE41, correlated with DNA hypomethylation in 3'UTR region, promotes the growth of human clear cell renal cell carcinoma.
Authors: Shen Z, Zhu L, Zhang C, Cui X, Lu J Abstract Basic helix‑loop‑helix family member e41 (BHLHE41) serves an important role in regulating cell differentiation, circadian rhythms and the response to hypoxia. However, the roles of BHLHE41 in clear cell renal cell carcinoma (ccRCC) remain unclear. The aim of the present study was to analyze the expression of BHLHE41 in ccRCC and investigate the effect of downregulated BHLHE41 on the growth and migration of ccRCC cells. The expression of BHLHE41 in ccRCC was demonstrated to be significantly increased in gene expression microarray datasets and RNA sequenc...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Adipose ‑derived mesenchymal stem cells exhibit tumor tropism and promote tumorsphere formation of breast cancer cells.
Adipose‑derived mesenchymal stem cells exhibit tumor tropism and promote tumorsphere formation of breast cancer cells. Oncol Rep. 2019 Feb 15;: Authors: Chen Y, He Y, Wang X, Lu F, Gao J Abstract Mesenchymal stem cells reportedly have a marked effect on tumor growth or suppression. However, it remains uncertain whether adipose‑derived mesenchymal stem cells (ADSCs) from grafted fat can contribute to breast cancer growth and recurrence. In the present study, interactions between ADSCs and MCF‑7 breast cancer cells were evaluated in a Matrigel co‑culture system and in an in vivo nude mouse model....
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer.
MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer. Oncol Rep. 2019 Feb 21;: Authors: Jiang Y, Cai Y, Shao W, Li F, Guan Z, Zhou Y, Tang C, Feng S Abstract The aim of the present study was to research the mechanism of action of microRNA‑144 (miR‑144) in colorectal cancer (CRC) and its role in tumor progression. It was demonstrated that miR‑144 was downregulated and anoctamin 1 (ANO1) expression was upregulated in CRC. The expression of ANO1 was negatively associated with that of miR‑144 in CRC. The present study indicated that upregulated ...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The role of GDF15 in bone metastasis of lung adenocarcinoma cells.
Authors: Duan L, Pang HL, Chen WJ, Shen WW, Cao PP, Wang SM, Liu LL, Zhang HL Abstract Lung cancer is the most common malignant tumor in China. It often metastasizes to bone, thereby significantly shortening the lives of patients, and reducing their quality of life. However, the efficacy of treatment for bone metastasis of lung cancer at this stage is very limited. The development and clinical application of molecular‑targeted drugs for the effective targeted therapy of bone metastasis of lung cancer are urgently required. The growth differentiation factor 15 (GDF15) gene which may be associated with bone metasta...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Organic anion ‑transporting polypeptides contribute to the uptake of curcumin and its main metabolites by human breast cancer cells: Impact on antitumor activity.
In conclusion, our data revealed that OATPs act as cellular uptake transporters for curcumin and its major metabolites, and this may also be applicable to patients undergoing cancer therapy. PMID: 30816509 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia.
Authors: Pang Y, Li H, Gong Y, Jing S, Peng C, Liu W, Zhao Y, Wang H, Kaushik D, Rodriguez R, Wang Z Abstract Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, the aim was to evaluate the association of three polymorphisms in chemokine genes, namely C‑C motif chemokine ligand (CCL)2 rs1024611, CC chemokine receptor 2 (CCR2) rs1799864 and CCL5 rs2107...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tripartite motif ‑containing 11 regulates the proliferation and apoptosis of breast cancer cells.
Tripartite motif‑containing 11 regulates the proliferation and apoptosis of breast cancer cells. Oncol Rep. 2019 Feb 14;: Authors: Dai X, Geng F, Li M, Liu M Abstract Breast cancer, an increasing health problem worldwide, is the second major cause of cancer‑associated mortality in females. Studies have focused on the pathogenesis of breast cancer for decades, but the underlying mechanisms have not been fully elucidated. Tripartite motif‑containing 11 (TRIM11), a novel oncogene that was recently identified, was reported to function in various types of cancer, including ovarian and lung cancer...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of apoptosis by miR ‑122‑5p in α‑fetoprotein‑producing gastric cancer.
In conclusion, miR‑122‑5p inhibited apoptosis and facilitated tumor progression by targeting FOXO3 in AFPGC, which indicates the possibility of miR‑122‑5p as a potential therapeutic target in AFPGC. PMID: 30816512 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Genome ‑wide DNA methylation profile of thymomas and potential epigenetic regulation of thymoma subtypes.
Genome‑wide DNA methylation profile of thymomas and potential epigenetic regulation of thymoma subtypes. Oncol Rep. 2019 Feb 28;: Authors: Bi Y, Meng Y, Niu Y, Li S, Liu H, He J, Zhang Y, Liang N, Liu L, Mao X, Yan J, Long B, Liang Z, Wu Z Abstract The aim of the present study was to examine the whole‑genome DNA methylation status of thymomas and identify differences in thymoma DNA methylation profiles. DNA methylation profiles of tissues (n=12) were studied using the Infinium MethylationEPIC BeadChip microarray (850K) and analyzed in relation to gene expression data. Functional annotation analysis...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

IL22 furthers malignant transformation of rat mesenchymal stem cells, possibly in association with IL22RA1/STAT3 signaling.
Authors: Cui X, Jing X, Yi Q, Xiang Z, Tian J, Tan B, Zhu J Abstract Mesenchymal stem cells (MSCs) hold great promise as potential therapies for tumors through the delivery of various anticancer agents. However, exogenous tissue‑derived MSCs, such as those of bone marrow, have exhibited a tendency for malignant transformation in the tumor microenvironment. This issue remains controversial and is poorly understood. In the present study, the role of interleukin 22 (IL22)/IL22 receptor subunit α 1 (IL22RA1) and signal transducer and activator of transcription 3 (STAT3) signaling in the malignant transformation...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anti ‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer.
Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer. Oncol Rep. 2019 Feb 14;: Authors: Sugyo A, Aung W, Tsuji AB, Sudo H, Takashima H, Yasunaga M, Matsumura Y, Saga T, Higashi T Abstract Tissue factor (TF) has emerged as a critical factor in oncogenic events, leading to the development of TF‑targeted diagnostic and therapeutic approaches. A non‑invasive imaging method to evaluate target molecule expression with high sensitivity and high quantitative ability is imperative for selecting the appropriate patients for TF‑targ...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Analysis of gene co ‑expression network reveals prognostic significance of CNFN in patients with head and neck cancer.
In conclusion, CNFN, identified via the WGCNA algorithm, may contribute to the prediction of lymph node metastases and prognosis, probably by regulating the pathways associated with P53, and the early and late estrogen response. PMID: 30816522 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of IL ‑6 and TNF‑α.
LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of IL‑6 and TNF‑α. Oncol Rep. 2019 Feb 26;: Authors: Xu J, Qian J, Zhang W, Chen E, Zhang G, Cao G, Wang F, Shen X, Zhou W, Song Z Abstract Ly6/Plaur domain‑containing 8 (LYPD8) contributes to the segregation of intestinal microbiota and intestinal epithelia and is critical for the prevention of intestinal inflammation. However, its relevance in cancer biology remains to be fully elucidated. The present study aimed to clarify the biological effects of LYPD8 on colon cancer tissue from...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma.
Authors: Gao Z, Man X, Li Z, Bi J, Liu X, Li Z, Zhu Y, Zhang Z, Kong C Abstract Adrenocortical carcinoma (ACC) is a rare disease associated with a poor prognosis. Furthermore, the underlying molecular mechanism of carcinogenesis is poorly understood, and prognostic prediction of ACC has low accuracy. In the present study, a bioinformatics approach was used to investigate the molecular mechanisms and prognosis of ACC. Samples of adrenal tumors were collected from patients undergoing adrenalectomy at the Department of Urology, the First Hospital of China Medical University. The analyzed gene datasets were downloaded ...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑92a promotes cell proliferation, migration and survival by directly targeting the tumor suppressor gene NF2 in colorectal and lung cancer cells.
MicroRNA‑92a promotes cell proliferation, migration and survival by directly targeting the tumor suppressor gene NF2 in colorectal and lung cancer cells. Oncol Rep. 2019 Feb 19;: Authors: Alcantara KMM, Garcia RL Abstract Inactivation of the tumor suppressor protein Merlin leads to the development of benign nervous system tumors in neurofibromatosis type2 (NF2). Documented causes of Merlin inactivation include deleterious mutations in the encoding neurofibromin2 gene (NF2) and aberrant Merlin phosphorylation leading to proteasomal degradation. Rare somatic NF2 mutations have also been detected in com...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The underlying molecular mechanism and potential drugs for treatment in papillary renal cell carcinoma: A study based on TCGA and Cmap datasets.
Authors: Pang JS, Li ZK, Lin P, Wang XD, Chen G, Yan HB, Li SH Abstract Papillary renal cell carcinoma (PRCC) accounts for 15‑20% of all kidney neoplasms and continually attracts attention due to the increase in the incidents in which it occurs. The molecular mechanism of PRCC remains unclear and the efficacy of drugs that treat PRCC lacks sufficient evidence in clinical trials. Therefore, it is necessary to investigate the underlying mechanism in the development of PRCC and identify additional potential anti‑PRCC drugs for its treatment. The differently expressed genes (DEGs) of PRCC were identified, followed ...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

In  silico analysis identified miRNA‑based therapeutic agents against glioblastoma multiforme.
In silico analysis identified miRNA‑based therapeutic agents against glioblastoma multiforme. Oncol Rep. 2019 Feb 19;: Authors: Xiong DD, Xu WQ, He RQ, Dang YW, Chen G, Luo DZ Abstract MicroRNAs (miRNAs or miRs) contribute to the development of various malignant neoplasms, including glioblastoma multiforme (GBM). The present study aimed to explore the pathogenesis of GBM and to identify latent therapeutic agents for patients with GBM, based on an in silico analysis. Gene chips that provide miRNA expression profiling in GBM were obtained from the Gene Expression Omnibus (GEO) database. Differenti...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research