Isolated Inguinal Lymph Node Metastasis from Colon Cancer: A Case Report
We reported a rare case of isolated metachronous inguinal lymph node metastasis from colon cancer with a round ligament route of spread as the hypothesized mechanism. Surgical resection with inguinal LN dissection is the preferred treatment option for isolated inguinal lymph node metastasis from colon cancer followed by adjuvant chemotherapy, yet long term follow-up data is needed to support this strategy. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
C6orf15 promotes liver metastasis via WNT/ β-catenin signalling in colorectal cancer
Colon cancer ranks third among global tumours and second in cancer-related mortality, prompting an urgent need to explore new therapeutic targets. C6orf15 is a novel gene that has been reported only in Sjogren... (Source: Cancer Cell International)
Source: Cancer Cell International - April 23, 2024 Category: Cancer & Oncology Authors: Jiankang Yu, Jian Sun, Jingtong Tang, Jiayu Xu, Guanru Qian and Jianping Zhou Tags: Research Source Type: research
Promising anticancer activity of cromolyn in colon cancer: in vitro and in vivo analysis
CONCLUSION: Our study showed that cromolyn is a selective and strong drug in inhibiting the proliferation of colon cancer cells. Based on our results, the efficacy of C in vitro analysis (MTT assays and apoptosis), as well as animal studies is competitive with the FDA-approved drug doxorubicin. C is very promising as a low-complication and good-efficacy drug for cancer drug repositioning. This requires clinical research study designs to comprehensively evaluate its anti-cancer effects.PMID:38647571 | DOI:10.1007/s00432-024-05741-2 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Amin Aliabadi Mohammad Reza Haghshenas Razie Kiani Mohammad Reza Panjehshahin Nasrollah Erfani Source Type: research
Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review)
Oncol Lett. 2024 Apr 9;27(6):256. doi: 10.3892/ol.2024.14389. eCollection 2024 Jun.ABSTRACTCluster of differentiation 47 (CD47) is a transmembrane protein that is widely and moderately expressed on the surface of various cells and can have an essential role in mediating cell proliferation, migration, phagocytosis, apoptosis, immune homeostasis and other related responses by binding to its ligands, integrins, thrombospondin-1 and signal regulatory protein α. The poor prognosis of cancer patients is closely associated with high expression of CD47 in glioblastoma, ovarian cancer, breast cancer, bladder cancer, colon cancer a...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Fan Wu Hongyuan Pang Fan Li Mengqing Hua Chuanwang Song Jie Tang Source Type: research
Imaging in the era of risk-adapted treatment in Colon cancer
Br J Radiol. 2024 Apr 22:tqae061. doi: 10.1093/bjr/tqae061. Online ahead of print.ABSTRACTThe treatment landscape for patients with colon cancer is continuously evolving. Risk-adapted treatment strategies, including neoadjuvant chemotherapy and immunotherapy, are slowly finding their way into clinical practice and guidelines. Radiologists are pivotal in guiding clinicians toward the most optimal treatment for each colon cancer patient. This review provides an overview of recent and upcoming advances in the diagnostic management of colon cancer and the radiologist's role in the multidisciplinary approach to treating colon c...
Source: The British Journal of Radiology - April 22, 2024 Category: Radiology Authors: Max J Lahaye Doenja M J Lambregts Arend G J Aalbers Petur Snaebjornsson R G H Beets-Tan Niels F M Kok Source Type: research
Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review)
Oncol Lett. 2024 Apr 9;27(6):256. doi: 10.3892/ol.2024.14389. eCollection 2024 Jun.ABSTRACTCluster of differentiation 47 (CD47) is a transmembrane protein that is widely and moderately expressed on the surface of various cells and can have an essential role in mediating cell proliferation, migration, phagocytosis, apoptosis, immune homeostasis and other related responses by binding to its ligands, integrins, thrombospondin-1 and signal regulatory protein α. The poor prognosis of cancer patients is closely associated with high expression of CD47 in glioblastoma, ovarian cancer, breast cancer, bladder cancer, colon cancer a...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Fan Wu Hongyuan Pang Fan Li Mengqing Hua Chuanwang Song Jie Tang Source Type: research
Imaging in the era of risk-adapted treatment in Colon cancer
Br J Radiol. 2024 Apr 22:tqae061. doi: 10.1093/bjr/tqae061. Online ahead of print.ABSTRACTThe treatment landscape for patients with colon cancer is continuously evolving. Risk-adapted treatment strategies, including neoadjuvant chemotherapy and immunotherapy, are slowly finding their way into clinical practice and guidelines. Radiologists are pivotal in guiding clinicians toward the most optimal treatment for each colon cancer patient. This review provides an overview of recent and upcoming advances in the diagnostic management of colon cancer and the radiologist's role in the multidisciplinary approach to treating colon c...
Source: The British Journal of Radiology - April 22, 2024 Category: Radiology Authors: Max J Lahaye Doenja M J Lambregts Arend G J Aalbers Petur Snaebjornsson R G H Beets-Tan Niels F M Kok Source Type: research
Successful curative treatment for a ruptured pancreatic acinar cell carcinoma by radical resection following modified FOLFIRINOX: a case report and literature review
AbstractPancreatic acinar cell carcinoma (PACC) is a rare pancreatic tumor type, and ruptured pancreatic tumors are rarer. Computed tomography (CT) in a 48-year-old man incidentally revealed a raptured pancreatic tail tumor. The patient was treated conservatively because he was asymptomatic, and his general condition was stable. After a detailed examination, the pancreatic tumor was diagnosed as raptured PACC. Considering the potential infiltration of tumor cells into the hematoma within the omental sac, our decision is to initiate chemotherapy as the primary course of action. A liquid biopsy was performed, and comprehensi...
Source: International Cancer Conference Journal - April 22, 2024 Category: Cancer & Oncology Source Type: research
Promising anticancer activity of cromolyn in colon cancer: in vitro and in vivo analysis
ConclusionOur study showed that cromolyn is a selective and strong drug in inhibiting the proliferation of colon cancer cells. Based on our results, the efficacy of C in vitro analysis (MTT assays and apoptosis), as well as animal studies is competitive with the FDA-approved drug doxorubicin. C is very promising as a low-complication and good-efficacy drug for cancer drug repositioning. This requires clinical research study designs to comprehensively evaluate its anti-cancer effects. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Targeted delivery of HSP90 inhibitors for efficient therapy of CD44-positive acute myeloid leukemia and solid tumor-colon cancer
Heat shock protein 90 (HSP90) is overexpressed in numerous cancers, promotes the maturation of numerous oncoproteins and facilitates cancer cell growth. Certain HSP90 inhibitors have entered clinical trials. A... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 22, 2024 Category: Nanotechnology Authors: Lejiao Jia, Huatian Yang, Yue Liu, Ying Zhou, Guosheng Li, Qian Zhou, Yan Xu, Zhiping Huang, Feng Ye, Jingjing Ye, Anchang Liu and Chunyan Ji Tags: Research Source Type: research
The Role of miR-132-3p in Inhibiting the Proliferation, Invasion and Metastasis of Colon Cancer by Targeted Regulation of PDGF
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - April 20, 2024 Category: Nanotechnology Authors: Li, Chaobin Lu, Kemei Lang, Cuicui Li, Min Yang, Chenggang Tags: research-article Source Type: research
Valuing the health benefits of nature-based recreational physical activity in England
Environ Int. 2024 Apr 16;187:108667. doi: 10.1016/j.envint.2024.108667. Online ahead of print.ABSTRACTPhysical activity (PA) reduces the risk of several non-communicable diseases (NCDs). Natural environments support recreational PA. Using data including a representative cross-sectional survey of the English population, we estimated the annual value of nature-based PA conducted in England in 2019 in terms of avoided healthcare and societal costs of disease. Population-representative data from the Monitor of Engagement with the Natural Environment (MENE) survey (n = 47,580; representing 44,386,756) were used to estimate the ...
Source: Environment International - April 20, 2024 Category: Environmental Health Authors: James Grellier Mathew P White Si ân de Bell Oscar Brousse Lewis R Elliott Lora E Fleming Clare Heaviside Charles Simpson Tim Taylor Benedict W Wheeler Rebecca Lovell Source Type: research
Effects of p-coumaric acid on probiotic properties of Lactobacillus acidophilus LA-5 and lacticaseibacillus rhamnosus GG
Arch Microbiol. 2024 Apr 20;206(5):223. doi: 10.1007/s00203-024-03957-x.ABSTRACTProbiotics are defined as "live microorganisms that provide health benefits to the host when administered in adequate amounts." Probiotics have beneficial effects on human health, including antibacterial activity against intestinal pathogens, regulation of blood cholesterol levels, reduction of colitis and inflammation incidence, regulation of the immune system, and prevention of colon cancer. In addition to probiotic bacteria, some phenolic compounds found in foods we consume (both food and beverages) have positive effects on human health. p-c...
Source: Archives of Microbiology - April 20, 2024 Category: Microbiology Authors: Buse Nur Derebasi Sena Davran Bulut Busra Aksoy Erden Nastaran Sadeghian Parham Taslimi Hasan Ufuk Celebioglu Source Type: research
Identification of the Immune-related lncRNA SNHG14/ miR-200a-3p/ PCOLCE2 Axis in Colorectal Cancer
CONCLUSIONS: The current study revealed for the first time that a novel regulatory axis-long noncoding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14)/ miR-200a-3p/ PCOLCE2- can act as the oncogenic axis of CRC cells and that clinicians can use it to predict the OS of colon-cancer patients. Additionally, differences in the protein expression of PCOLCE2 between normal and adenocarcinoma-colorectal tissues suggest its potential as a prognostic biomarker for CRC.PMID:38639631 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Na Li Jiangli Shen Ximin Qiao Qiang Liu Xiaoqiang Dai Xiongwen Jiao Source Type: research
Identification of the Immune-related lncRNA SNHG14/ miR-200a-3p/ PCOLCE2 Axis in Colorectal Cancer
CONCLUSIONS: The current study revealed for the first time that a novel regulatory axis-long noncoding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14)/ miR-200a-3p/ PCOLCE2- can act as the oncogenic axis of CRC cells and that clinicians can use it to predict the OS of colon-cancer patients. Additionally, differences in the protein expression of PCOLCE2 between normal and adenocarcinoma-colorectal tissues suggest its potential as a prognostic biomarker for CRC.PMID:38639631 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Na Li Jiangli Shen Ximin Qiao Qiang Liu Xiaoqiang Dai Xiongwen Jiao Source Type: research
