Genomic characterization for familial cases with urothelial carcinoma
In this report, we present familial cases of urothelial carcinoma. To investigate the possibility of hereditary urothelial cancer, we performed semiconductor-based next-generation DNA sequencing. A woman in her 80s who had bladder and left ureteral cancer was hospitalized in Sapporo Shirakaba-dai Hospital due to consciousness disturbance. Radiographic evaluation revealed multiple liver metastases and she died 38  days later. Needle necropsy was done for a left ureteral tumor that continued to her bladder tumor and for liver metastases. At the same time, her son in his 60s, who also had muscle-invasive bladder cancer, ...
Source: International Cancer Conference Journal - June 27, 2019 Category: Cancer & Oncology Source Type: research

Remarkable effect of presurgical nivolumab on originally inoperable papillary renal cell carcinoma with tumor thrombus in inferior vena cava
AbstractFor the long-term survival of a patient with renal cell carcinoma and a vena cava tumor thrombus, total resection is desired: inoperable patients are sometimes treated with drugs. The effect of the presurgical use of nivolumab, an anti-programmed cell death 1 (PD-1) antibody drug, has been described. Our patient had inoperable renal cancer with an inferior vena cava tumor thrombus. We were able to downsize the tumor to operable size by administrating nivolumab. The patient underwent a nephrectomy and thrombectomy safely. Pathological findings revealed papillary renal cell carcinoma type 2. No viable cells were iden...
Source: International Cancer Conference Journal - June 18, 2019 Category: Cancer & Oncology Source Type: research

Hair regrowth using a properly fitted scalp cooling cap during adjuvant chemotherapy for breast cancer
AbstractPatients with breast cancer desire to avoid chemotherapy-induced alopecia because it induces mental stress during treatment. Scalp cooling can suppress chemotherapy-induced alopecia without increasing the risk of scalp metastasis; however, in certain cases, alopecia cannot be prevented. The use of properly fitted scalp cooling caps has not yet been explored in Asian patients. Here, we report a case of hair regrowth using a properly fitted scalp cooling cap during adjuvant chemotherapy for breast cancer. A 51-year-old Japanese woman who was recalled by screening mammography for grouped amorphous calcifications and a...
Source: International Cancer Conference Journal - June 17, 2019 Category: Cancer & Oncology Source Type: research

Testicular rhabdomyosarcoma after chemotherapy for metastatic germ cell tumors
AbstractA 36-year-old male was referred to our hospital with left scrotal swelling. Computed tomography revealed a massive tumor in his left scrotum. The tumor extended along the gonadal vein extraperitoneally forming a massive tumor. Pathological examination showed a mixed-type germ cell tumor. Despite several chemotherapeutic treatments, the tumor continued to grow, and the patient died 28  months later after his first presentation at our institution. Autopsy revealed that the tumor comprised rhabdomyosarcoma and mature teratoma. We could not find useful tumor markers to facilitate the diagnosis of rhabdomyosarcoma....
Source: International Cancer Conference Journal - June 15, 2019 Category: Cancer & Oncology Source Type: research

Simultaneous robotic surgery with low anterior resection and prostatectomy/hysterectomy
AbstractCooperation with multiple departments is essential for the treatment of patients with rectal cancer and other pelvic cancers. In our department, we experienced two cases of rectal cancer that underwent robotic low anterior resection (LAR) and simultaneous resection of other pelvic organs (case 1 with prostatectomy and case 2 with hysterectomy) using the da Vinci Xi system. Here, we show the precise procedures of these two robotic surgeries. Under general anesthesia and lithotomy position, five da Vinci ports were symmetrically placed along the umbilical horizontal line with a 7  cm interval, and a 5 mm Ai...
Source: International Cancer Conference Journal - June 3, 2019 Category: Cancer & Oncology Source Type: research

Systemic steroid treatment can desensitize the skin reaction due to regorafenib in a recurrence colorectal cancer patient
We report the case of a 59-year-old Japanese woman diagnosed with recurrence after curative operation for sigmoid colon cancer (T3N2aM0, Stage IIIC). Despite undergoing multiple lines of standard chemotherapy, disease control could not be maintained. Consequently, regorafenib was started as a late-line treatment. However, after 2  weeks, the patient experienced regorafenib-induced serious erythema multiforme; thus, regorafenib was discontinued and oral prednisolone was started. Regorafenib administration was resumed when the adverse effects resolved and prednisolone was stopped, but skin rash rapidly reappeared. Predn...
Source: International Cancer Conference Journal - May 24, 2019 Category: Cancer & Oncology Source Type: research

Primary signet ring cell carcinoma of uterine cervix and related disease: two case reports and a review
We present two cases of primary SRCCC that were treated with robot-assisted laparoscopic radical hysterectomy (RALRH). Case 1 had stage IB2 cervical adenocarcinoma, in which signet ring cell (SRC) was predominant. As adjuvant chemotherapy was not successful, she twice underwent surgical excision of recurrent tumors in pararectal lymph node and periureteral space 11  months and 27 months after RALRH, respectively. There were only SRCs observed in recurrent tumors. Case 2 had stage IB1 cervical adenocarcinoma, in which SRCs were detected only in the biopsy specimen, and no relapse occurred at 15 months after R...
Source: International Cancer Conference Journal - May 17, 2019 Category: Cancer & Oncology Source Type: research

A case of medial pterygoid muscle metastasis of lung cancer presenting with trismus
AbstractA man in his 60s with severe trismus was referred to our hospital. Based on computed tomography (CT), positron emission tomography/computed tomography (PET/CT), and biopsy, his initial diagnosis at another hospital was oropharyngeal cancer with cervical lymph node and distant metastases. After the review of the contrast-enhanced CT and reevaluated PET/CT images, we updated his diagnosis to left primary lung cancer that had metastasized to the cervical lymph nodes, bones, and skeletal muscles including the right medial pterygoid muscle. Since metastasis from primary lung cancer to the contralateral cervical lymph no...
Source: International Cancer Conference Journal - May 4, 2019 Category: Cancer & Oncology Source Type: research

Durable clinical benefit of letrozole in leptomeningeal metastasis of breast cancer
AbstractA case of a woman in her 60s with breast cancer, whose leptomeningeal metastasis (LM) of breast cancer improved remarkably with letrozole monotherapy, is reported. The patient complained of numbness of her left hand and hoarseness, followed by progressive asymmetric extremity weakness and a bladder and rectal disturbance. The patient had undergone surgery for left breast cancer 18  years earlier and was concerned about recurrence of breast cancer, but there were no typical findings with some imaging modalities. The third lumbar puncture showed the malignant cytology of breast cancer, and the patient was diagno...
Source: International Cancer Conference Journal - April 19, 2019 Category: Cancer & Oncology Source Type: research

A case of leptomeningeal carcinomatosis in advanced gastric adenocarcinoma with controlled peritoneal dissemination
AbstractA 48-year-old man with unresectable gastric cancer and widespread peritoneal dissemination received concentrated ascites reinfusion therapy, followed by systemic chemotherapy. However, leptomeningeal carcinomatosis (LMC) was diagnosed 1  year later. Spinal drainage and ventriculoperitoneal shunting improved the patient’s neurological functions for approximately 2 weeks. The patient died 2 months after LMC diagnosis, but these treatments temporarily improved the quality of life during end-of-life care. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - April 13, 2019 Category: Cancer & Oncology Source Type: research

The rapid improvement in visual field defect observed with weekly perimetry during intensity-modulated radiotherapy for optic nerve sheath meningioma
AbstractDuring precision radiotherapy to treat optic nerve sheath meningioma, early improvement in visual function has been seen. This has been difficult to explain biologically. In the present study, we aimed to investigate this rapid improvement in visual function. To this end, we prospectively tested a single patient ’s visual field (VF) using Humphrey automated perimetry at weekly intervals. The patient exhibited significant stepwise improvement in VF during an intensity-modulated radiotherapy course. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - April 6, 2019 Category: Cancer & Oncology Source Type: research

Primary small cell neuroendocrine carcinoma of adrenal gland
AbstractNeuroendocrine tumors are an extremely rare form of retroperitoneum tumor. A 79-year-old man presented with abdominal pain. Computed tomography and magnetic resonance imaging revealed a 51  × 36 mm mass in the left adrenal gland. Gastrofiberscopy, colonfiberscopy and positron emission tomography were performed and showed no lesions or other malignancies. Endocrine tests were normal. Two months later, the mass had grown to 68 × 52 mm. Suspecting a malignant tumor, we perfor med laparoscopic adrenalectomy. Histopathological diagnosis revealed the tumor was small cell ...
Source: International Cancer Conference Journal - March 27, 2019 Category: Cancer & Oncology Source Type: research

Primary tumor of the ureteral stump after a radical nephrectomy for renal cell carcinoma: case report and literature review
We report a case of ureteral stump carcinoma following a radical nephrectomy for renal cell carcinoma. A 76-year-old man was diagnosed as having ascending colon cancer and a right renal carcinoma. He was treated with partial colon resection and radical nephrectomy without lymphadenectomy. The histology was renal cell carcinoma. Three years after that surgery, he complained of intermittent macrohematuria. Abdominal computed tomography (CT) suggested a solid mass in the pelvis. We then performed a biopsy with CT guidance. An epithelial tumor was suspected by immunohistochemistry. A total excision of ureter was then performed...
Source: International Cancer Conference Journal - March 20, 2019 Category: Cancer & Oncology Source Type: research

Cancer-associated cerebral infarction during direct oral anticoagulant treatment in cancer patients: a case series
We present the clinical course of 20 consecutive patients with cancer-associated CI that developed during treatment with DOACs. The incidence rate of cancer-associated CI during the treatment with DOACs was 3.4%. The median modified Rankin scale (mRS) and Karnofsky performance status (KPS) after CI were 5 and 30, respectively. The median survival time after CI was 1  month. In the group in which the thrombus due to venous thromboembolism (VTE) was reduced before CI, the median mRS, KPS, and prognosis after CI were significantly better than in those of the group with unchanged thrombus. Cancer-associated CI also develo...
Source: International Cancer Conference Journal - March 19, 2019 Category: Cancer & Oncology Source Type: research

Radiation myelitis after durvalumab administration following chemoradiotherapy for locally advanced non-small cell lung cancer: an illustrative case report and review of the literature
AbstractA 69-year-old man with stage IIIB lung adenocarcinoma received durvalumab following chemoradiotherapy. The prescribed dose was 50  Gy in 2 Gy fractions, and the maximum spinal cord dose was 40 Gy. After three cycles of durvalumab, he experienced bladder and rectal disturbance, muscle weakness in the lower limbs, and sensory loss in the lower body. Magnetic resonance imaging revealed T2 signal hyperintensity involving the th oracic spinal cord. As the thoracic spinal cord with T2 signal hyperintensity matched with the irradiated site, the patient was diagnosed with radiation myelitis. This case report...
Source: International Cancer Conference Journal - March 13, 2019 Category: Cancer & Oncology Source Type: research

Small-cell lung carcinoma with ovarian metastasis 4  years after the first-line treatment
AbstractSmall-cell lung carcinoma rarely metastasizes to the ovary. Only few cases of this condition have been reported to date. A 42-year-old female nonsmoker was an outpatient after receiving treatment for small-cell lung carcinoma. Approximately 45  months after the first-line treatment, the pro-gastrin-releasing peptide level exhibited a gradual increase. Positron emission tomography-computed tomography revealed abnormal accumulation in the left ovary. Accordingly, we performed laparoscopic salpingo-oophorectomy. Both pathological and immuno histochemical examinations (thyroid transcription factor-1, synaptophysin...
Source: International Cancer Conference Journal - March 7, 2019 Category: Cancer & Oncology Source Type: research

Simultaneous chylous ascites and chylothorax during ramucirumab plus docetaxel chemotherapy in a patient with non-small lung cell cancer
AbstractA 69-year-old woman was diagnosed as having non-small cell lung cancer (adenocarcinoma, T1aN3M1b). She had no history of surgery or abdominal trauma. She was treated with ramucirumab (10  mg/kg) plus docetaxel (60 mg/m2) intravenously (RAM  + DTX) every 3 weeks. Although an enhanced CT examination showed a partial tumor response after eight courses of RAM + DTX, she gradually began to experience abdominal fullness with severe peripheral pitching edema. Her body weight increased by 18 kg in 2 months and RAM + DTX chemoth erapy was discontinued. An en...
Source: International Cancer Conference Journal - February 25, 2019 Category: Cancer & Oncology Source Type: research

Successful treatment of advanced gastric cancer with liver metastasis by S-1  + CDDP and S-1 therapy without surgery
AbstractIt is generally reported that prognosis of patients who have unresectable gastric cancer is from 3 to 5  months with best supportive care. Despite the improvement of survival after the appearance of S-1, the outcome of treatment for advanced gastric cancer is still unfavorable. Here we present a valuable case of advanced gastric cancer with synchronous liver metastasis, which was treated by S-1 +  CDDP and S-1 therapy without surgery. A 58-year-old man was referred to our hospital with a diagnosis of advanced gastric cancer with liver metastasis at stage of cT3N0M1. He underwent first-line chemot...
Source: International Cancer Conference Journal - February 25, 2019 Category: Cancer & Oncology Source Type: research

Systematic review of case reports of Japanese esophageal neuroendocrine cell carcinoma in the Japanese literature
AbstractEsophageal neuroendocrine cell carcinoma (NEC) is extremely rare, and its treatment strategy has not been established. Systematic review and meta-analysis were carried out to assess the treatment and prognosis of patients with esophageal NEC in Japan. The Ichushi-Web database was searched from January 1964 to May 2018. In total, 141 cases of esophageal NEC were included in the analysis. The survival of the chemotherapy group with stage II/III esophageal NEC was better than that of the surgery group. Meanwhile, the survival of the adjuvant treatment group with stage II/III esophageal NEC was significantly better tha...
Source: International Cancer Conference Journal - February 18, 2019 Category: Cancer & Oncology Source Type: research

Hematogenous intestinal metastases from sigmoid colon cancer presenting as iliopsoas abscess and bowel obstruction
We report a case of intestinal metastases from sigmoid colon cancer that presented as iliopsoas abscess and ileus. A 78-year-old man who had undergone sigmoidectomy for sigmoid colon cancer 5  years ago was referred to our hospital with recurrent ileus and fever. Abdominal computed tomography showed a left iliopsoas abscess and a mass near the abscess that had ostensibly caused ileus. The patient underwent segmental resection of the jejunum including the mass. Histopathological examinat ion of the resected specimen revealed moderately differentiated adenocarcinoma proliferating mainly in the submucosal and muscular la...
Source: International Cancer Conference Journal - February 18, 2019 Category: Cancer & Oncology Source Type: research

Adenocarcinoma of intestinal type of the vulva
We report a case of adenocarcinoma of intestinal type of the vulva occurring in a 63-year-old female. The tumor was found near the urethra, and biopsy specimen showed a proliferation of signet ring cells embedded in an abundant myxoid stroma and irregular tubular structures of atypical columnar epithelium. An extensive workup showed no metastases. Local excision with a 2-cm lesion in the vulva side , bilateral superficial inguinal lymph node dissection and Cloquet lymph node biopsy were performed. Cancer cells contained mucinous materials in the cytoplasm, which exhibited diffuse positive staining for cytokeratin 20 and CD...
Source: International Cancer Conference Journal - February 14, 2019 Category: Cancer & Oncology Source Type: research

Pazopanib maintenance therapy after tandem high-dose chemotherapy for disseminated Ewing sarcoma
AbstractThe dismal prognosis of patients with disseminated Ewing sarcoma necessitates the development of novel treatment strategies. Pazopanib is an oral multi-targeted tyrosine kinase inhibitor that is active against advanced soft tissue sarcoma. However, the clinical activity and feasibility of pazopanib for treating Ewing sarcoma remain poorly understood. Moreover, clinical information on the use of tandem high-dose chemotherapy for Ewing sarcoma is limited. A 14-year-old boy with Ewing sarcoma was transferred to our hospital for treatment. Magnetic resonance imaging, computed tomography scans, and bone scintigraphy rev...
Source: International Cancer Conference Journal - February 14, 2019 Category: Cancer & Oncology Source Type: research

Acute arteritis after G-CSF administration
AbstractGranulocyte colony-stimulating factor (G-CSF) is commonly used in clinical practice to accelerate neutropenia recovery after chemotherapy. G-CSF is a myeloid growth factor produced by monocytes, macrophages, fibroblasts and endothelial cells. Generally, aortitis and arteritis are not a known side effect of G-CSF and is thought to be extremely rare. Here, we present a case of a 77-year-old woman who underwent adjuvant chemotherapy (combined paclitaxel and carboplatin) for ovarian cancer, and then developed acute arteritis after receiving G-CSF. She developed grade 4 neutropenia on day 7 of the third chemotherapy cyc...
Source: International Cancer Conference Journal - February 13, 2019 Category: Cancer & Oncology Source Type: research

Re-introducing the same chemotherapy after exposure to anti-PD-1 therapy
AbstractCytotoxic chemotherapy after exposure to nivolumab (nivo), an anti-programmed death-1 (PD-1) antibody, has been associated with good response compared with historical data in various cancers including head and neck squamous cell carcinoma (HNSCC). In a previous report, different chemotherapy regimens were used before and after treatment with nivo. This HNSCC case is the first report of a good response when the same cytotoxic chemotherapy regimen was used before and after nivo. In addition, the efficacy of anti-epidermal growth factor receptor antibody after nivo treatment may be better than without exposure to nivo...
Source: International Cancer Conference Journal - February 12, 2019 Category: Cancer & Oncology Source Type: research

A case of pulmonary artery intimal sarcoma successfully treated using concurrent chemoradiotherapy and subsequent chemotherapy
AbstractPulmonary artery intimal sarcoma (PAIS) is a rare malignancy with an extremely poor prognosis. A 43-year-old man visited our hospital with shortness of breath and suddenly experienced cardiopulmonary arrest before he could be examined. After prompt resuscitation, we diagnosed PAIS, but the patient refused to undergo surgery because of the high perioperative mortality risk. Thus, the patient was treated using concurrent chemoradiotherapy with weekly paclitaxel therapy, as well as subsequent chemotherapy. The patient continued chemotherapy for 36  months until he elected to discontinue treatment. To the best of ...
Source: International Cancer Conference Journal - January 25, 2019 Category: Cancer & Oncology Source Type: research

Primary retroperitoneal squamous cell carcinoma: a case report with review of the literature
AbstractSquamous cell carcinoma originating in the retroperitoneal cavity is an exceedingly rare disease, and little is known about it. Here, we report the case of primary retroperitoneal squamous cell carcinoma. A 76-year-old gravida four para two woman with a history of hysterectomy for unknown reasons was referred to our hospital for an infant-head-sized multicystic pelvic mass. She was initially diagnosed with ovarian cancer Stage IIB, poorly differentiated carcinoma by exploratory laparotomy in which only a tumor biopsy was performed due to severe adhesion. She underwent 5 courses of combination chemotherapy with pacl...
Source: International Cancer Conference Journal - January 23, 2019 Category: Cancer & Oncology Source Type: research

Spontaneous regression of a carcinoid tumor that required resection owing to its reappearance and subsequent enlargement after 2  years: a case report
We present a rare case of spontaneous regression in a typical lung carcinoid. A 20-year-old woman with an abnormal shadow on a chest radiograph was admitted to our hospital. Computed tomography revealed a smooth nodule in the left S1  + 2 segment. At the 6-month follow-up, the nodule had regressed without treatment. At the 2-year follow-up, the tumor reappeared in the same place as before. We performed left upper lobectomy via 4-port thoracoscopic surgery. A pathological examination revealed a typical carcinoid. Lung carcino ids can spontaneously regress; long-term follow-up is important for timely detection ...
Source: International Cancer Conference Journal - January 23, 2019 Category: Cancer & Oncology Source Type: research

Erlotinib and bevacizumab combination therapy for afatinib-refractory leptomeningeal carcinomatosis from EGFR-mutated lung cancer
AbstractAcquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors remains the main hurdle in treating EGFR-mutated lung cancer. Besides, when leptomeningeal carcinomatosis occurs during treatment, it often leads to treatment failure. We herein report a case of lung adenocarcinoma involving a patient with an EGFR exon 19 deletion mutation who developed leptomeningeal carcinomatosis after afatinib treatment for post-operative recurrence. He received right lower lobectomy, followed by four cycles of cisplatin and pemetrexed treatment. Follow-up CT/MRI revealed multiple pulmonary metastases and brain m...
Source: International Cancer Conference Journal - January 18, 2019 Category: Cancer & Oncology Source Type: research

Mass-forming mucosa-associated lymphoid tissue lymphoma of the cecum treated by laparoscopy-assisted bowel resection
AbstractColonic mucosa-associated lymphoid tissue (MALT) lymphoma is very rare, especially those which form a mass. Although the characteristics and treatment methods of gastric MALT lymphomas are well established, those of colonic MALT lymphomas have been insufficiently described. Here, we report a case of mass-forming cecal MALT lymphoma that was successfully treated by laparoscopy-assisted bowel resection. A 60-year-old woman with right lower abdominal pain and a palpable tumor was referred to our hospital. Colonoscopy showed a smooth elevated submucosal tumor-like lesion in the cecum. Histological and immunochemical fi...
Source: International Cancer Conference Journal - January 3, 2019 Category: Cancer & Oncology Source Type: research

Epithelioid hemangioendothelioma of the parotid gland: a case report
We present the case of a patient with epithelioid hemangioendothelioma of the parotid gland. A 70-year-old female developed swelling and pain in the lower part of the left ear 18  months previously and had visited a local hospital. Fine-needle aspiration cytology revealed no definitive diagnosis, but incisional biopsy under local anesthesia suggested epithelioid hemangioendothelioma. She was then transferred to our hospital, where she underwent total extirpation of the left parotid gland, left cervical lymph node dissection, and postoperative radiation therapy. However, she died from distant metastases 13 months ...
Source: International Cancer Conference Journal - November 29, 2018 Category: Cancer & Oncology Source Type: research

A case of acute perforated cholecystitis with intracystic tumor thrombus of hepatocellular carcinoma
AbstractA 72-year-old man with hepatocellular carcinoma (HCC) was diagnosed with acute perforated cholecystitis requiring emergency surgery. Unexpectedly, a bile duct tumor thrombus was found to have spread into the intracystic space, mimicking a gall stone and presumably causing the severe acute cholecystitis. We herein report an extremely rare subtype of bile duct tumor thrombus of HCC. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - November 24, 2018 Category: Cancer & Oncology Source Type: research

Uterine leiomyosarcoma well-controlled with eribulin mesylate
We report a case of uterine progressive leiomyosarcoma that responded to eribulin. A 57-year-old woman was suspected of having leiomyosarcoma based on an endometrial biopsy and imaging examinations. Although the tumor grew toward the uterine artery on the right side of the uterine cervix, we performed a total abdominal hysterectomy and bilateral salpingo-oophorectomy to obtain an outcome of no gross residual disease. However, the margin of the right side of the uterine cervix was histologically positive, so leiomyosarcoma stage IIB (pT2bcN0cM0, FIGO2008) was diagnosed. Gemcitabine and docetaxel therapy was administered pos...
Source: International Cancer Conference Journal - November 12, 2018 Category: Cancer & Oncology Source Type: research

Marked response to nivolumab combined with external radiation therapy for metastatic renal cell carcinoma: report of two cases
AbstractAlthough nivolumab has been regarded as a standard agent for patients with previously treated advanced renal cell carcinoma (RCC), a significant proportion of these patients fail to achieve a response to nivolumab. In recent years, several studies have reported the favorable therapeutic impact of combined therapy with immune checkpoint inhibitors and radiotherapy on a wide variety of advanced malignant tumors, such as melanoma and lung cancer; however, the significance of this combined treatment for advanced RCC patients has not been well characterized. Here, we report two patients with metastatic RCC showing a mar...
Source: International Cancer Conference Journal - November 9, 2018 Category: Cancer & Oncology Source Type: research

A case of advanced pancreatic neuroendocrine tumor in which octreotide long-acting repeatable was effective after failure of everolimus and sunitinib
We report a 71-year-old man with multiple liver metastases of pancreatic neuroendocrine tumor. He was treated with everolimus 10  mg daily and sunitinib 25 mg daily on days 1–14 every 3 weeks at the physician’s discretion. However, these molecular targeted drugs were discontinued due to disease progression or severe adverse effects. Octreotide long-acting repeatable was administered continuously from the initiation of e verolimus treatment. The tumor marker level markedly decreased and the metastatic liver lesions showed shrinkage with octreotide treatment. Immunohistochemistry of tumor specimens obta...
Source: International Cancer Conference Journal - November 7, 2018 Category: Cancer & Oncology Source Type: research

Double primary recurrent human epidermal growth factor receptor 2-positive breast cancer and esophageal cancer that responded well to chemotherapy
We report a case of double primary recurrent HER2-positive breast cancer and esophageal cancer that responded well to radiotherapy and chemotherapy. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Reiter ’s syndrome following intravesical Bacillus Calmette-Guerin therapy for bladder carcinoma: a report of five cases
We report five cases of patients with Reiter’s syndrome following intravesical BCG therapy for bladder carcinoma, and review the clinical characteristics, treatments, and outcomes of these patients. Each patient developed polyarthritis after urinary tract symptoms, and developed conjunctivitis anywhere from the third to the eighth BCG induction cycle. One case presented a slight elevation of inflammatory responses in blood analysis, and the other four cases had a higher level of white blood cell (WB C) counts and C-reactive protein (CRP) values. WBC counts at the diagnosis of Reiter’s syndrome had a positive co...
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Definitive concurrent chemoradiotherapy in a patient with stage IV non-small cell lung cancer due to cervical lymph node metastases
In conclusion, our patient with stage IV NSCLC due to CLNM achieved long-term disease-free survival by concurrent CRT as with patients with locally advanced NSCLC. Patient subgroups should be explored to achieve long-term disease-free survival after definitive CRT in patients with s tage IV NSCLC due to CLNM. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

A case of angiosarcomas which occurred in an adrenal gland and spleen synchronously
We report a case of a 56-year-old woman who simultaneously presented adrenal and spleen tumors. Computed tomography imaging revealed a 7-cm enhancing adrenal and 2-cm solitary spleen masses. The patient simultaneously underwent left adrenalectomy and splenectomy. The pathological findings revealed the presence of synchronous adrenal and spleen angiosarcomas. Remarkably, she is disease-free since postoperative 18  months. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Double primary recurrent human epidermal growth factor receptor 2-positive breast cancer and esophageal cancer that responded well to chemotherapy
We report a case of double primary recurrent HER2-positive breast cancer and esophageal cancer that responded well to radiotherapy and chemotherapy. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

A young female case of primary renal carcinoid tumor mimicking fat-poor angiomyolipoma
AbstractRenal mass biopsy is useful for the pathological diagnosis of a small renal mass difficult to distinguish fat-poor angiomyolipoma from renal cell carcinoma radiologically. Here, we report a young female case of a small renal mass suspected as fat-poor angiomyolipoma in imaging studies. The patient received a renal mass biopsy to obtain the correct pathological information. Unexpectedly, the pathological diagnosis was neuroendocrine tumor. She, finally, underwent a right radical nephrectomy as a curative treatment. This case indicates that the radiological findings of primary renal carcinoid tumor can be similar to ...
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Severe adverse events due to dihydropyrimidine dehydrogenase deficiency in a Japanese patient with colon cancer taking capecitabine: a case report
This report describes the case of a Japanese patient with colon cancer who experienced severe side effects while taking capecitabine, due to DPD deficiency. A 68-year-old man with ascending colon cancer underwent curative laparoscopic right hemicolectomy. Because final pathologic staging was Stage IIIa, standard adjuvant chemotherapy with capecitabine (3600  mg/body/day, days 1–14, every 3 weeks) was started on postoperative day 50. After 2 weeks, he started to experience Grade 3 diarrhea and was admitted to the hospital on postoperative day 66. On day 70, the patient had Grade 4 febrile neutropenia. A...
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Mesenteric excision for esophageal cancer surgery: based on the concept of mesotracheoesophagus
AbstractThe fundamental principle of surgery for intestinal cancer is mesenteric excision. It has been widely accepted as radical surgery for colorectal cancer, and it comprises procedures such as complete mesocolic excision for colon cancer and total mesorectal excision for rectal cancer. So far, the concept of mesenteric excision of the esophagus has not been well documented, but our surgical experience with a magnified view using a thoracoscope and understanding of the surgical anatomy based on embryologic foregut development has led us to introduce the concept of mesotracheoesophagus. Using this concept, our technique ...
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Locally advanced pancreatic cancer successfully treated with high-dose helical tomotherapy
AbstractComplete surgical resection is the potentially curative treatment for pancreatic cancer, but only fewer than 20% of those individuals will be found to be eligible for surgery. Here we report a 49-year-old man with locally advanced pancreatic cancer successfully treated with high-dose radiotherapy using helical tomotherapy (66  Gy/33 fractions, 2 Gy per day over 6.5 weeks). To our knowledge, this is the first reported case of locally advanced pancreatic cancer curatively treated with helical tomotherapy alone. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Two case reports of fair lower limb function after sciatic nerve sacrifice for the treatment of a malignant peripheral nerve sheath tumor
In this report, we describe our surgical management of two cases of malignant peripheral nerve sheath tumor, a 58-year-old man and a 10-year-old girl, requiring a limb salvage procedure with sacrifice of the sciatic nerve. Although both patients required a short-leg brace for walking, because of a drop foot, both patients reported satisfactory functional results and were able to perform their activities of daily living with only slight difficulties. Based on our experience, limb salvage surgery can be considered for the treatment of malignancies involving the sciatic nerve, with fair functional outcomes expected. (Source: ...
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Tamoxifen withdrawal in women with progressive metastatic breast cancer: a case series of six patients
AbstractEstrogen receptor (ER)-positive metastatic breast cancers after a period of response to tamoxifen develop resistance, and the disease progresses clinically. Domination of partial agonistic activity of tamoxifen over its antagonist activity has been implicated as one of the mechanisms for acquired tamoxifen resistance. Six patients with ER-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer who were treated with tamoxifen withdrawal were retrospectively reviewed. Three patients were premenopausal and three were postmenopausal at the beginning of this treatment. Three patients ...
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

A case of uterine carcinosarcoma which was strongly suspected to have metastases to the psoas and gluteus muscles
We report a case which was strongly suspected to have psoas and gluteus muscle metastases from uterine carcinosarcoma. A 68-year-old woman (gravida, 2; para, 0) underwent retroperitoneal endoscopic paraaortic lymphadenectomy, laparoscopic modified radical hysterectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy for uterine carcinosarcoma, suspected to be stage IB. Metastasis to one right pelvic lymph node was observed. Ascites fluid cytology was negative. Postoperative pathological examination revealed stage IIIC1 (pT1bN1M0) disease. Five cycles of chemotherapy with paclitaxel  + carboplatin w...
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Publisher Correction to: Severe adverse events due to dihydropyrimidine dehydrogenase deficiency in a Japanese patient with colon cancer taking capecitabine: a case report
The publisher regrets that in the original version of this article, unfortunately the word “phosphate” in Fig. 1 has been misspelt as “phosohate”. The original article has now been corrected. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Primary adrenal lymphoma: three case reports and review of Japanese cases
The original article can be found online. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - October 1, 2018 Category: Cancer & Oncology Source Type: research

Hepatocellular carcinoma producing granulocyte colony-stimulating factor: diagnosis and treatment
AbstractGranulocyte colony-stimulating factor (G-CSF) is a naturally occurring glycoprotein that is synthesized by stromal cells in bone marrow. Several cases of G-CSF-producing malignant tumors in various organs have been reported, but it is extremely rare in hepatocellular carcinoma (HCC). Here, we report a rare case of HCC producing G-CSF. The patient presented with a continuous fever and had a huge liver mass in the right lobe with portal vein tumor thrombus (PVTT) in the right first branch. He had marked granulocytosis, and his serum level of G-CSF was elevated. A complete curative liver resection was performed after ...
Source: International Cancer Conference Journal - September 24, 2018 Category: Cancer & Oncology Source Type: research