C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
Functionalized liposomes as a potential drug delivery systems for colon cancer treatment: A systematic review
Int J Biol Macromol. 2024 Apr 30;269(Pt 1):132023. doi: 10.1016/j.ijbiomac.2024.132023. Online ahead of print.ABSTRACTColon cancer is one of the lethal diseases in the world with approximately 700,000 fatalities annually. Nowadays, due to the side effects of existing methods in the treatment of colon cancer such as radiotherapy and chemotherapy, the use of targeted nanocarriers in cancer treatment has received wide attention, and among them, especially liposomes have been studied a lot. Based on this, anti-tumor drugs hidden in targeted active liposomes can selectively act on cancer cells. In this systematic review, the us...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Eskandar Moghimipour Somayeh Handali Source Type: research
Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
CONCLUSION: The results indicated that the 5-FU + DOX combination therapy induces apoptosis and renders 5-FU and DOX more effective at lower concentrations compared to their alone use. This study reveals promising results in reducing the potential side effects of treatment by enabling the use of lower drug doses.PMID:38698270 | DOI:10.1007/s11033-024-09562-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 2, 2024 Category: Molecular Biology Authors: Sema Bilgin Source Type: research
Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
CONCLUSION: The results indicated that the 5-FU + DOX combination therapy induces apoptosis and renders 5-FU and DOX more effective at lower concentrations compared to their alone use. This study reveals promising results in reducing the potential side effects of treatment by enabling the use of lower drug doses.PMID:38698270 | DOI:10.1007/s11033-024-09562-x (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 2, 2024 Category: Molecular Biology Authors: Sema Bilgin Source Type: research
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4
Pharmacol Rev. 2024 May 2;76(3):388-413. doi: 10.1124/pharmrev.123.000901.ABSTRACTThe involvement of the prostaglandin E2 (PGE2) system in cancer progression has long been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with pleiotropic effects in the human body. High levels of intratumoral PGE2 and overexpression of the key metabolic enzymes of PGE2 have been observed and suggested to contribute to tumor progression. This has been claimed for different types of solid tumors, including, but not limited to, lung, breast, and colon cancer. PGE2 has direct effects on tumor cells and angiogenesis th...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Ana Santiso Akos Heinemann Julia Kargl Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
The transcriptional landscape of coding and non-coding RNAs in recurrent and non-recurrent colon cancer
A considerable number of colon cancer patients with local or local advanced disease suffer from recurrence and there is an urgent need for better prognostic biomarkers in this setting. Here, the transcriptomic landscape of messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs), small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), small Cajal body-specific RNAs (scaRNAs), pseudogenes and circular RNAs (circRNAs), as well as RNAs denoted as miscellaneous RNAs, was profiled by total RNA sequencing. (Source: American Journal of Pathology)
Source: American Journal of Pathology - May 2, 2024 Category: Pathology Authors: Ulrik Korsgaard, Juan L. Garc ía-Rodríguez, Theresa Jakobsen, Ulvi Ahmadov, Kim-Gwendolyn Dietrich, Stine Mary Vissing, Thea Petersen Paasch, Jan Lindebjerg, Jørgen Kjems, Henrik Hager, Lasse Sommer Kristensen Tags: Regular Article Source Type: research
Addressing Colorectal Cancer Disparities in Unhoused Populations: A Call for Equitable Access and Compassionate Care
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786531Housing is essential for health. Unhoused individuals have markedly worse health status than the general population culminating in higher rates of premature mortality. Cancer is a leading cause of death in older unhoused adults. Caring for unhoused patients at risk for or with colorectal cancer poses challenges at every stage of oncologic care: prevention, screening, diagnosis, treatment, and follow-up. These challenges result in later stages at diagnosis and worse overall survival. Health systems can work to advance health equity in colorectal cancer in unhoused patients b...
Source: Clinics in Colon and Rectal Surgery - May 2, 2024 Category: Surgery Authors: Decker, Hannah Erickson, Caroline Wick, Elizabeth Tags: Review Article Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Breast Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Genitourinary Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors: A decade-apart study of two nationwide cohorts
CONCLUSION: Colon cancer survivors hospitalized 10 years apart in the United States showed an increased CVD risk with an increased risk of acute cardiovascular events (stroke 28%, PE 47%, arrhythmia 41%, and cardiac arrest 63%). It is vital to regularly screen colon cancer survivors with concomitant CVD risk factors to curtail long-term cardiovascular complications.PMID:38689632 | PMC:PMC11056864 | DOI:10.5306/wjco.v15.i4.548 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Rupak Desai Avilash Mondal Vivek Patel Sandeep Singh Shaylika Chauhan Akhil Jain Source Type: research
Impact of the thyroid hormone T3 and its nuclear receptor TRalpha1 on colon cancer stem cell phenotypes and response to chemotherapies
Cell Death Dis. 2024 May 1;15(5):306. doi: 10.1038/s41419-024-06690-x.ABSTRACTColorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization, with cancer stem cells (CSCs) responsible for tumor development, maintenance, and drug resistance. Our previous studies showed the importance of thyroid hormone-dependent signaling on intestinal tumor development and progression through action on stem cells. These results have a translational value, given that the thyroid hormone nuclear receptor TRα1 is upregulated in human CRCs, including in the molecular subtypes associated with CSC features. We used an e...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Maria Virginia Giolito Serguei Bodoirat Theo La Rosa Mathieu Reslinger Gabriela D A Guardia Jana Mourtada Leo Claret Alain Joung Pedro A F Galante Luiz O F Penalva Michelina Plateroti Source Type: research
Zinc Suppresses Colorectal Cancer Development through Cell-mediated Immunity
Yakugaku Zasshi. 2024;144(5):475-481. doi: 10.1248/yakushi.23-00154-1.ABSTRACTZinc is one of the essential trace elements, and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, then the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number ...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Keigo Nishida Naoya Nakagawa Source Type: research
