Preclinical imaging evaluation of a bispecific antibody targeting hPD1/CTLA4 using humanized mice
CONCLUSIONS: The results demonstrated the potential of translating 124I-AK104 into a method for screening patients who benefit from immunotherapy and the efficacy, as well as the feasibility, of this method was verified by immuno-PET imaging of humanized mice.PMID:38677243 | DOI:10.1016/j.biopha.2024.116669 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 27, 2024 Category: Drugs & Pharmacology Authors: Xingguo Hou Song Liu Ziqing Zeng Zilei Wang Jin Ding Yan Chen Xiangyu Gao Jianghua Wang Guanxi Xiao Baiyong Li Hua Zhu Zhi Yang Source Type: research

Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives
This study found that while both exogenous β-hydroxybutyrate and BD-AcAc 2 produced the same levels of plasma β-hydroxybutyrate, BD-AcAc 2 demonstrated superior effectiveness in mitigating dextran sodium sulfate-induced UC in rats. The mechanism of action involves modulating the NF-κB signaling, inhibiting the NLRP3 inflammasome, regulating antioxidant capacity, controlling tight junction protein expression and a potential to inhibit apoptosis and pyroptosis. Certainly, BD-AcAc 2's anti-inflammatory effects require more than just increasing plasma β-hydroxybutyrate levels and other factors contribute to its efficacy. L...
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Osama A Mohammed Sameh Saber Mustafa Ahmed Abdel-Reheim Mohannad Mohammad S Alamri Jaber Alfaifi Masoud I E Adam Muffarah Hamid Alharthi Ali M S Eleragi Hanan B Eltahir Mohamed Osama Abdalla Emad Bahashwan Elwathiq Khalid Ibrahim Assad Ali Rezigalla Sameh Source Type: research

The Impact of the Pandemic on the Quality of Colorectal and Anal Cancer Care, and 2-Year Clinical Outcomes
Curr Oncol. 2024 Apr 19;31(4):2328-2340. doi: 10.3390/curroncol31040173.ABSTRACTWe undertook a retrospective study to compare the quality of care delivered to a cohort of newly diagnosed adults with colon, rectal or anal cancer during the early phase of COVID-19 (02/20-12/20) relative to the same period in the year prior (the comparator cohort), and examine the impact of the pandemic on 2-year disease progression and all-cause mortality. We observed poorer performance on a number of quality measures, such as approximately three times as many patients in the COVID-19 cohort experienced 30-day post-surgical readmission (10.5...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Melanie Powis Rinku Sutradhar Simron Singh Shabbir Alibhai Saidah Hack Abed Baiad Kevin Chen Huaqi Li Zuhal Mohmand Monika K Krzyzanowska Source Type: research

The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review
Curr Oncol. 2024 Apr 3;31(4):1994-2023. doi: 10.3390/curroncol31040149.ABSTRACTMelatonin is a multifunctional hormone regulator that maintains homeostasis through circadian rhythms, and desynchronization of these rhythms can lead to gastrointestinal disorders and increase the risk of cancer. Preliminary clinical studies have shown that exogenous melatonin alleviates the harmful effects of anticancer therapy and improves quality of life, but the results are still inconclusive due to the heterogeneity of the studies. A personalized approach to testing clinical parameters and response to integrative treatment with nontoxic an...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Eugeniy Smorodin Valentin Chuzmarov Toomas Veidebaum Source Type: research

Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1
Oncol Rep. 2024 Jun;51(6):82. doi: 10.3892/or.2024.8741. Epub 2024 Apr 26.ABSTRACTColorectal cancer (CRC) is one of the most common malignancies worldwide. The 5‑year survival rate of patients diagnosed with the early stages of the disease is markedly higher than that of patients in the advanced stages. Therefore, identifying novel biomarkers and drug targets for CRC is critical for clinical practice. Zinc finger protein 169 (ZNF169) is a crucial transcription factor, and its role in CRC remains to be explored. The present study aimed to investigate the clinical relevance, function and underlying mechanisms of ZNF169 in ...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Jie Zhang Ye Wang Shiyang Hou Xiaoqian Chi Danyang Ding Mei Xue Mengqiao Zhang Jing Wang Junfang Shuai Haiying Sun Qiang Gao Chunbo Kang Source Type: research

Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC)
CONCLUSIONS: Our results demonstrated that TPM2 knockdown suppressed the proliferation of CAC IECs, enhanced immune suppression on CAC IECs, and inhibited the JNK signaling pathway within the framework of CAC. These findings suggest TPM2 can serve as a potential therapeutic target for CAC treatment.PMID:38665026 | DOI:10.24976/Discov.Med.202436183.73 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Aixi Sun Jian Ge Kaixin Ding Zhiyang Gao Yun Zhang Source Type: research

(Sialyl)Lewis antigen expression on glycosphingolipids, N- and O-glycans in colorectal cancer cell lines is linked to a colon-like differentiation program
In conclusion, our study provides insights into the possible regulation of glycans in CRC and can serve as a guide for the development of diagnostic and therapeutic biomarkers.PMID:38670309 | DOI:10.1016/j.mcpro.2024.100776 (Source: Molecular and Cellular Proteomics : MCP)
Source: Molecular and Cellular Proteomics : MCP - April 26, 2024 Category: Molecular Biology Authors: Di Wang Katarina Maduni ć Oleg A Mayboroda Guinevere S M Lageveen-Kammeijer Manfred Wuhrer Source Type: research

Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models
In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. The MTT assay was used to determine the cannabinoids' ability to induce colon cancer cell death. All cannabinoids were cytotoxic at the lowest concentration (3 μg/mL). The half maximal inhibitory concentration (IC50) ranged from 3.90 to 8.24 μg/mL, depending on the substance. Cytotoxicity was confirmed in a 3D spheroidal cell...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Dorota B ęben Oliwia Siwiela Anna Szyjka Micha ł Graczyk Daniel Rzepka Ewa Barg Helena Moreira Source Type: research

Coordination environment dependence of anticancer activity in cyclometalated bismuth(III) complexes with C,O-chelating ligands
J Inorg Biochem. 2024 Apr 21;256:112571. doi: 10.1016/j.jinorgbio.2024.112571. Online ahead of print.ABSTRACTIn this paper, a series of cyclometalated bismuth(III) complexes bearing C,O-bidentate ligands were synthesized and characterized by techniques such as UV-vis, NMR, HRMS, and single crystal X-ray diffraction. Meanwhile, their cytotoxicities against various human cell lines, including colon cancer cells (HCT-116), breast cancer cells (MDA-MB-231), lung cancer cells (A549), gastric cancer cells (SGC-7901), and normal embryonic kidney cells (HEK-293) were assessed in vitro. Compared with the clinical cisplatin, most of...
Source: Journal of Inorganic Biochemistry - April 26, 2024 Category: Biochemistry Authors: Jian Lei Yongping Liu Mingming Yin Shan Li Zixiu Wang Yi Chen Source Type: research

Ginsenoside Rg1 Induces Autophagy in Colorectal Cancer through Inhibition of the Akt/mTOR/p70S6K Pathway
This study aimed to elucidate the anti-colon cancer mechanism of ginsenoside Rg1 in vitro and in vivo. Cell viability rate was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tetrazolium assay. The inhibitory effect of ginsenoside Rg1 against CT26 cell proliferation gradually increased with increasing concentration. The in vivo experiments also demonstrated an antitumor effect. The monodansylcadaverine (MDC), transmission electron microscopy (TEM), and expression of autophagy marker proteins confirmed that ginsenoside Rg1 induced autophagy in vitro. Ginsenoside Rg1 induced autophagy de...
Source: Journal of Microbiology and Biotechnology - April 26, 2024 Category: Biotechnology Authors: Ruiqi Liu Bin Zhang Shuting Zou Li Cui Lin Lin Lingchang Li Source Type: research

Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models
In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. The MTT assay was used to determine the cannabinoids' ability to induce colon cancer cell death. All cannabinoids were cytotoxic at the lowest concentration (3 μg/mL). The half maximal inhibitory concentration (IC50) ranged from 3.90 to 8.24 μg/mL, depending on the substance. Cytotoxicity was confirmed in a 3D spheroidal cell...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Dorota B ęben Oliwia Siwiela Anna Szyjka Micha ł Graczyk Daniel Rzepka Ewa Barg Helena Moreira Source Type: research

Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC)
CONCLUSIONS: Our results demonstrated that TPM2 knockdown suppressed the proliferation of CAC IECs, enhanced immune suppression on CAC IECs, and inhibited the JNK signaling pathway within the framework of CAC. These findings suggest TPM2 can serve as a potential therapeutic target for CAC treatment.PMID:38665026 | DOI:10.24976/Discov.Med.202436183.73 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Aixi Sun Jian Ge Kaixin Ding Zhiyang Gao Yun Zhang Source Type: research

The Impact of the Pandemic on the Quality of Colorectal and Anal Cancer Care, and 2-Year Clinical Outcomes
Curr Oncol. 2024 Apr 19;31(4):2328-2340. doi: 10.3390/curroncol31040173.ABSTRACTWe undertook a retrospective study to compare the quality of care delivered to a cohort of newly diagnosed adults with colon, rectal or anal cancer during the early phase of COVID-19 (02/20-12/20) relative to the same period in the year prior (the comparator cohort), and examine the impact of the pandemic on 2-year disease progression and all-cause mortality. We observed poorer performance on a number of quality measures, such as approximately three times as many patients in the COVID-19 cohort experienced 30-day post-surgical readmission (10.5...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Melanie Powis Rinku Sutradhar Simron Singh Shabbir Alibhai Saidah Hack Abed Baiad Kevin Chen Huaqi Li Zuhal Mohmand Monika K Krzyzanowska Source Type: research

The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review
Curr Oncol. 2024 Apr 3;31(4):1994-2023. doi: 10.3390/curroncol31040149.ABSTRACTMelatonin is a multifunctional hormone regulator that maintains homeostasis through circadian rhythms, and desynchronization of these rhythms can lead to gastrointestinal disorders and increase the risk of cancer. Preliminary clinical studies have shown that exogenous melatonin alleviates the harmful effects of anticancer therapy and improves quality of life, but the results are still inconclusive due to the heterogeneity of the studies. A personalized approach to testing clinical parameters and response to integrative treatment with nontoxic an...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Eugeniy Smorodin Valentin Chuzmarov Toomas Veidebaum Source Type: research

Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1
Oncol Rep. 2024 Jun;51(6):82. doi: 10.3892/or.2024.8741. Epub 2024 Apr 26.ABSTRACTColorectal cancer (CRC) is one of the most common malignancies worldwide. The 5‑year survival rate of patients diagnosed with the early stages of the disease is markedly higher than that of patients in the advanced stages. Therefore, identifying novel biomarkers and drug targets for CRC is critical for clinical practice. Zinc finger protein 169 (ZNF169) is a crucial transcription factor, and its role in CRC remains to be explored. The present study aimed to investigate the clinical relevance, function and underlying mechanisms of ZNF169 in ...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Jie Zhang Ye Wang Shiyang Hou Xiaoqian Chi Danyang Ding Mei Xue Mengqiao Zhang Jing Wang Junfang Shuai Haiying Sun Qiang Gao Chunbo Kang Source Type: research