How ceramides affect the development of colon cancer: from normal colon to carcinoma
Pflugers Arch. 2024 Apr 18. doi: 10.1007/s00424-024-02960-x. Online ahead of print.ABSTRACTThe integrity of the colon and the development of colon cancer depend on the sphingolipid balance in colon epithelial cells. In this review, we summarize the current knowledge on how ceramides and their complex derivatives influence normal colon development and colon cancer development. Ceramides, glucosylceramides and sphingomyelin are essential membrane components and, due to their biophysical properties, can influence the activation of membrane proteins, affecting protein-protein interactions and downstream signalling pathways. He...
Source: Pflugers Archiv : European Journal of Physiology - April 18, 2024 Category: Physiology Authors: Nadine Merz Jennifer Christina Hartel Sabine Gr ösch Source Type: research
Mining and exploration of rehabilitation nursing targets for colorectal cancer
CONCLUSIONS: High MYC and NCAPG2 expression has been observed in colorectal cancer, and increased MYC and NCAPG2 expression correlates with worse prognosis.PMID:38637125 | DOI:10.18632/aging.205739 (Source: Aging)
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Ruipu Li Jie He Zhijie Ni Jie Zhang Xiaoqian Chi Chunbo Kang Zhongbo Li Xubin Li Source Type: research
How ceramides affect the development of colon cancer: from normal colon to carcinoma
Pflugers Arch. 2024 Apr 18. doi: 10.1007/s00424-024-02960-x. Online ahead of print.ABSTRACTThe integrity of the colon and the development of colon cancer depend on the sphingolipid balance in colon epithelial cells. In this review, we summarize the current knowledge on how ceramides and their complex derivatives influence normal colon development and colon cancer development. Ceramides, glucosylceramides and sphingomyelin are essential membrane components and, due to their biophysical properties, can influence the activation of membrane proteins, affecting protein-protein interactions and downstream signalling pathways. He...
Source: Pflugers Archiv : European Journal of Physiology - April 18, 2024 Category: Physiology Authors: Nadine Merz Jennifer Christina Hartel Sabine Gr ösch Source Type: research
Correction: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation
Oncogene, Published online: 18 April 2024; doi:10.1038/s41388-024-03037-wCorrection: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation (Source: Oncogene)
Source: Oncogene - April 18, 2024 Category: Cancer & Oncology Authors: E. Grassilli F. Pisano A. Cialdella S. Bonomo C. Missaglia M. G. Cerrito L. Masiero L. Ianzano F. Giordano V. Cicirelli R. Narloch F. D ’Amato B. Noli G. L. Ferri B. E. Leone G. Stanta S. Bonin K. Helin R. Giovannoni M. Lavitrano Source Type: research
Cancers, Vol. 16, Pages 1552: Systematic Review and Meta-Analysis of Laparoscopic versus Robotic-Assisted Surgery for Colon Cancer: Efficacy, Safety, and Outcomes & mdash;A Focus on Studies from 2020 & ndash;2024
Conclusions: The choice of surgical method should be individualized, considering factors such as surgeon expertise, medical facilities, and patient-specific considerations. Future research should aim to elucidate long-term outcomes to further guide the clinical decision-making. (Source: Cancers)
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Roxana Loriana Negrut Adrian Cote Vasile Aurel Caus Adrian Marius Maghiar Tags: Systematic Review Source Type: research
Upfront laparotomy versus conversion from minimally invasive surgery to open surgery in colon cancer: Is there a difference in outcomes?
In this study, we aimed to assess the implications of transitioning from minimally invasive surgery to laparotomy in patients with colon cancer compared with patients undergoing upfront laparotomy. (Source: Surgery)
Source: Surgery - April 18, 2024 Category: Surgery Authors: Nir Horesh, Sameh Hany Emile, Zoe Garoufalia, Rachel Gefen, Peige Zhou, Steven D. Wexner Source Type: research
Chlordiazepoxide against signalling, receptor and regulatory proteins of breast cancer: a structure-based in-silico approach
In this study, we included four crucial proteins that perform signalling, receptor, and regulatory action, namely- NUDIX Hydrolases, Dihydrofolate Reductase, HER2/neu Kinase and EGFR and performed multitargeted molecular docking studies against human-approved drugs using HTVS, SP and extra precise algorithms and filtered the poses with MM\GBSA, suggested a benzodiazepine derivative chlordiazepoxide, used as an anxiolytic agent, can be a multitargeted inhibitor with docking and MM\GBSA score ranging from - 4.628 to - 7.877 and - 18.59 to - 135.86 kcal/mol, respectively, and the most interacted residues were 6ARG, 6GLU, 3TRP...
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Ahad Amer Alsaiari Amal F Gharib Maha Mahfouz Bakhuraysah Amani A Alrehaili Shatha M Algethami Hayfa Ali Alsaif Norah Al Harthi Mohammed Ageeli Hakami Source Type: research
LP-184, a novel acylfulvene molecule, exhibits anti-cancer activity against diverse solid tumors with homologous recombination deficiency
Cancer Res Commun. 2024 Apr 17. doi: 10.1158/2767-9764.CRC-23-0554. Online ahead of print.ABSTRACTHomologous recombination (HR) related gene alterations are present in a significant subset of prostate, breast, ovarian, pancreatic, lung and colon cancers rendering these tumors as potential responders to specific DNA damaging agents. A small molecule acylfulvene prodrug, LP-184, metabolizes to an active compound by the oxidoreductase activity of enzyme Prostaglandin Reductase 1 (PTGR1), which is frequently elevated in multiple solid tumor types. Prior work demonstrated that cancer cell lines deficient in a spectrum of (DNA d...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Aditya Kulkarni Jianli Zhou Neha Biyani Umesh Kathad Partha P Banerjee Shiv Srivastava Zsombor Prucsi Kamil Solarczyk Kishor Bhatia Reginald B Ewesuedo Panna Sharma Source Type: research
Tumor Lysis Syndrome in a Patient with BRAF < sup > V600E < /sup > Mutated Colon Cancer Treated with Cetuximab and Encorafenib
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.2925-23. Online ahead of print.ABSTRACTTumor lysis syndrome (TLS) is a fatal complication associated with chemotherapy. We herein report a case of TLS in a 73-year-old woman with metastatic BRAFV600E mutated colon cancer after she received combined treatment with cetuximab and encorafenib. The serum uric acid, urea nitrogen, and creatinine levels were elevated on day four of the first cycle. The fibrin degradation product (FDP) and D-dimer levels were also high. Diuresis and rasburicase were initiated for TLS, and the laboratory data all normalized on day 8. Thus, the ...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Shunsuke Kasai Etsuko Sato Chikara Sakaguchi Yasutsuna Sasaki Source Type: research
Four sulfur-containing compounds with effect from marine-derived fungus aspergillus terreus
In this study, four previously undescribed sulfur-containing compounds asperteretals L and M, terreins A and B, together with 17 known compounds were obtained from a culture of marine fungus A. terreus supplemented with inorganic sulfur source Na2SO4. Their planar structures and absolute configurations were elucidated by NMR, HRESIMS, and ECD experiments. The in vitro cytotoxicities of compounds 1-21 against HCT-116 and Caco-2 were evaluated by SRB assay. Asperteretal M (2) exhibited activity against HCT-116 with the IC50 value at 30 μM. The antiproliferative effect of asperteretal M was confirmed by colony formation assa...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Guang-Yu Zhang Bei-Jia Liu Hui-Lin Pan Hou-Jin Li Zi-Feng Huang Taifo Mahmud Wen-Zhe Ma Wen-Jian Lan Source Type: research
Chlordiazepoxide against signalling, receptor and regulatory proteins of breast cancer: a structure-based in-silico approach
In this study, we included four crucial proteins that perform signalling, receptor, and regulatory action, namely- NUDIX Hydrolases, Dihydrofolate Reductase, HER2/neu Kinase and EGFR and performed multitargeted molecular docking studies against human-approved drugs using HTVS, SP and extra precise algorithms and filtered the poses with MM\GBSA, suggested a benzodiazepine derivative chlordiazepoxide, used as an anxiolytic agent, can be a multitargeted inhibitor with docking and MM\GBSA score ranging from - 4.628 to - 7.877 and - 18.59 to - 135.86 kcal/mol, respectively, and the most interacted residues were 6ARG, 6GLU, 3TRP...
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Ahad Amer Alsaiari Amal F Gharib Maha Mahfouz Bakhuraysah Amani A Alrehaili Shatha M Algethami Hayfa Ali Alsaif Norah Al Harthi Mohammed Ageeli Hakami Source Type: research
Role of the 3-mercaptopyruvate sulfurtransferase in colon/colorectal cancers
Eur J Cell Biol. 2024 Apr 15;103(2):151415. doi: 10.1016/j.ejcb.2024.151415. Online ahead of print.ABSTRACTThe 3-mercaptopyruvate sulfurtransferase (MPST) is a protein persulfidase, occurring mainly in mitochondria. Although function of this protein in cancer cells has been already studied, no clear outcome can be postulated up to now. Therefore, we focused on the determination of function of MPST in colon (HCT116 cells)/colorectal (DLD1 cells) cancers. In silico analysis revealed that in gastrointestinal cancers, MPST together with its binding partners can be either of a high risk or might have a protective effect. Silenc...
Source: European Journal of Cell Biology - April 17, 2024 Category: Cytology Authors: Katarina Matyasova Andrea Soltysova Petr Babula Olga Krizanova Veronika Liskova Source Type: research
Tumor Lysis Syndrome in a Patient with BRAF < sup > V600E < /sup > Mutated Colon Cancer Treated with Cetuximab and Encorafenib
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.2925-23. Online ahead of print.ABSTRACTTumor lysis syndrome (TLS) is a fatal complication associated with chemotherapy. We herein report a case of TLS in a 73-year-old woman with metastatic BRAFV600E mutated colon cancer after she received combined treatment with cetuximab and encorafenib. The serum uric acid, urea nitrogen, and creatinine levels were elevated on day four of the first cycle. The fibrin degradation product (FDP) and D-dimer levels were also high. Diuresis and rasburicase were initiated for TLS, and the laboratory data all normalized on day 8. Thus, the ...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Shunsuke Kasai Etsuko Sato Chikara Sakaguchi Yasutsuna Sasaki Source Type: research
Four sulfur-containing compounds with effect from marine-derived fungus aspergillus terreus
In this study, four previously undescribed sulfur-containing compounds asperteretals L and M, terreins A and B, together with 17 known compounds were obtained from a culture of marine fungus A. terreus supplemented with inorganic sulfur source Na2SO4. Their planar structures and absolute configurations were elucidated by NMR, HRESIMS, and ECD experiments. The in vitro cytotoxicities of compounds 1-21 against HCT-116 and Caco-2 were evaluated by SRB assay. Asperteretal M (2) exhibited activity against HCT-116 with the IC50 value at 30 μM. The antiproliferative effect of asperteretal M was confirmed by colony formation assa...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Guang-Yu Zhang Bei-Jia Liu Hui-Lin Pan Hou-Jin Li Zi-Feng Huang Taifo Mahmud Wen-Zhe Ma Wen-Jian Lan Source Type: research
Tumor Lysis Syndrome in a Patient with BRAF < sup > V600E < /sup > Mutated Colon Cancer Treated with Cetuximab and Encorafenib
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.2925-23. Online ahead of print.ABSTRACTTumor lysis syndrome (TLS) is a fatal complication associated with chemotherapy. We herein report a case of TLS in a 73-year-old woman with metastatic BRAFV600E mutated colon cancer after she received combined treatment with cetuximab and encorafenib. The serum uric acid, urea nitrogen, and creatinine levels were elevated on day four of the first cycle. The fibrin degradation product (FDP) and D-dimer levels were also high. Diuresis and rasburicase were initiated for TLS, and the laboratory data all normalized on day 8. Thus, the ...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Shunsuke Kasai Etsuko Sato Chikara Sakaguchi Yasutsuna Sasaki Source Type: research
