Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC)
CONCLUSIONS: Our results demonstrated that TPM2 knockdown suppressed the proliferation of CAC IECs, enhanced immune suppression on CAC IECs, and inhibited the JNK signaling pathway within the framework of CAC. These findings suggest TPM2 can serve as a potential therapeutic target for CAC treatment.PMID:38665026 | DOI:10.24976/Discov.Med.202436183.73 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Aixi Sun Jian Ge Kaixin Ding Zhiyang Gao Yun Zhang Source Type: research
The Impact of the Pandemic on the Quality of Colorectal and Anal Cancer Care, and 2-Year Clinical Outcomes
Curr Oncol. 2024 Apr 19;31(4):2328-2340. doi: 10.3390/curroncol31040173.ABSTRACTWe undertook a retrospective study to compare the quality of care delivered to a cohort of newly diagnosed adults with colon, rectal or anal cancer during the early phase of COVID-19 (02/20-12/20) relative to the same period in the year prior (the comparator cohort), and examine the impact of the pandemic on 2-year disease progression and all-cause mortality. We observed poorer performance on a number of quality measures, such as approximately three times as many patients in the COVID-19 cohort experienced 30-day post-surgical readmission (10.5...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Melanie Powis Rinku Sutradhar Simron Singh Shabbir Alibhai Saidah Hack Abed Baiad Kevin Chen Huaqi Li Zuhal Mohmand Monika K Krzyzanowska Source Type: research
The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review
Curr Oncol. 2024 Apr 3;31(4):1994-2023. doi: 10.3390/curroncol31040149.ABSTRACTMelatonin is a multifunctional hormone regulator that maintains homeostasis through circadian rhythms, and desynchronization of these rhythms can lead to gastrointestinal disorders and increase the risk of cancer. Preliminary clinical studies have shown that exogenous melatonin alleviates the harmful effects of anticancer therapy and improves quality of life, but the results are still inconclusive due to the heterogeneity of the studies. A personalized approach to testing clinical parameters and response to integrative treatment with nontoxic an...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Eugeniy Smorodin Valentin Chuzmarov Toomas Veidebaum Source Type: research
Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1
Oncol Rep. 2024 Jun;51(6):82. doi: 10.3892/or.2024.8741. Epub 2024 Apr 26.ABSTRACTColorectal cancer (CRC) is one of the most common malignancies worldwide. The 5‑year survival rate of patients diagnosed with the early stages of the disease is markedly higher than that of patients in the advanced stages. Therefore, identifying novel biomarkers and drug targets for CRC is critical for clinical practice. Zinc finger protein 169 (ZNF169) is a crucial transcription factor, and its role in CRC remains to be explored. The present study aimed to investigate the clinical relevance, function and underlying mechanisms of ZNF169 in ...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Jie Zhang Ye Wang Shiyang Hou Xiaoqian Chi Danyang Ding Mei Xue Mengqiao Zhang Jing Wang Junfang Shuai Haiying Sun Qiang Gao Chunbo Kang Source Type: research
Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models
In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. The MTT assay was used to determine the cannabinoids' ability to induce colon cancer cell death. All cannabinoids were cytotoxic at the lowest concentration (3 μg/mL). The half maximal inhibitory concentration (IC50) ranged from 3.90 to 8.24 μg/mL, depending on the substance. Cytotoxicity was confirmed in a 3D spheroidal cell...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Dorota B ęben Oliwia Siwiela Anna Szyjka Micha ł Graczyk Daniel Rzepka Ewa Barg Helena Moreira Source Type: research
Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC)
CONCLUSIONS: Our results demonstrated that TPM2 knockdown suppressed the proliferation of CAC IECs, enhanced immune suppression on CAC IECs, and inhibited the JNK signaling pathway within the framework of CAC. These findings suggest TPM2 can serve as a potential therapeutic target for CAC treatment.PMID:38665026 | DOI:10.24976/Discov.Med.202436183.73 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Aixi Sun Jian Ge Kaixin Ding Zhiyang Gao Yun Zhang Source Type: research
The Impact of the Pandemic on the Quality of Colorectal and Anal Cancer Care, and 2-Year Clinical Outcomes
Curr Oncol. 2024 Apr 19;31(4):2328-2340. doi: 10.3390/curroncol31040173.ABSTRACTWe undertook a retrospective study to compare the quality of care delivered to a cohort of newly diagnosed adults with colon, rectal or anal cancer during the early phase of COVID-19 (02/20-12/20) relative to the same period in the year prior (the comparator cohort), and examine the impact of the pandemic on 2-year disease progression and all-cause mortality. We observed poorer performance on a number of quality measures, such as approximately three times as many patients in the COVID-19 cohort experienced 30-day post-surgical readmission (10.5...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Melanie Powis Rinku Sutradhar Simron Singh Shabbir Alibhai Saidah Hack Abed Baiad Kevin Chen Huaqi Li Zuhal Mohmand Monika K Krzyzanowska Source Type: research
The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review
Curr Oncol. 2024 Apr 3;31(4):1994-2023. doi: 10.3390/curroncol31040149.ABSTRACTMelatonin is a multifunctional hormone regulator that maintains homeostasis through circadian rhythms, and desynchronization of these rhythms can lead to gastrointestinal disorders and increase the risk of cancer. Preliminary clinical studies have shown that exogenous melatonin alleviates the harmful effects of anticancer therapy and improves quality of life, but the results are still inconclusive due to the heterogeneity of the studies. A personalized approach to testing clinical parameters and response to integrative treatment with nontoxic an...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Eugeniy Smorodin Valentin Chuzmarov Toomas Veidebaum Source Type: research
Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models
In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. The MTT assay was used to determine the cannabinoids' ability to induce colon cancer cell death. All cannabinoids were cytotoxic at the lowest concentration (3 μg/mL). The half maximal inhibitory concentration (IC50) ranged from 3.90 to 8.24 μg/mL, depending on the substance. Cytotoxicity was confirmed in a 3D spheroidal cell...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Dorota B ęben Oliwia Siwiela Anna Szyjka Micha ł Graczyk Daniel Rzepka Ewa Barg Helena Moreira Source Type: research
Preparation, quality control, and absorbed dose estimation of 89Zr-DFO-Cetuximab for imaging of EGFR-expressing tumors
In this study,89Zr-DFO-Cetuximab was prepared under the optimized conditions with a radiochemical purity > 99%, and a specific activity of 185 GBq g−1. Cellular studies on EGFR + SW480 colon cancer and EGFR-CHO cell lines were performed, indicating the remarkable capability of89Zr-DFO-Cetuximab for binding to the low EGFR-expressing cells. High accumulation was observed in tumors of nude mice-bearing SW480 cell lines. Human absorbed dose estimation showed the liver receives the highest absorbed dose (0.94 mGy MBq−1). This radiopharmaceutical is the suitable PET agent for imaging of EGFR-expressing tu...
Source: Journal of Radioanalytical and Nuclear Chemistry - April 26, 2024 Category: Nuclear Medicine Source Type: research
Cancers, Vol. 16, Pages 1686: Digital Pathology for Better Clinical Practice
Conclusion: The ongoing progress in DP holds the potential to revolutionize pathology practices, emphasizing the need to incorporate powerful AI technologies, including IS, into clinical settings to enhance personalized cancer therapy. (Source: Cancers)
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Assia Hijazi Carlo Bifulco Pamela Baldin J érôme Galon Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1676: Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project)
Conclusions: There were no differences in the surgical outcomes between the centers performing <50 and ≥50 hepatectomies/year. Further analysis evaluating factors associated with clinical outcomes and determining the best candidates for this approach will be subsequently conducted. (Source: Cancers)
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Mario Serradilla-Mart ín Celia Villodre Laia Falgueras-Verdaguer Natalia Zambudio-Carroll Jos é T. Castell-Gómez Juan L. Blas-Laina Vicente Borrego-Estella Carlos Domingo-del-Pozo Gabriel Garc ía-Plaza Francisco J. Gonz ález-Rodríguez Eva M. Montalv Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1678: Proteins Involved in Focal Cell Adhesion and Podosome Formation Are Differentially Expressed during Colorectal Tumorigenesis in AOM-Treated Rats
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Colorectal tumorigenesis involves the development of aberrant crypt foci (ACF) or preneoplastic lesions, representing the earliest morphological lesion visible in colon cancer. The purpose of this study was to determine changes in protein expression in carcinogen-induced ACF as they mature and transform into adenomas. Protein expression profiles of azoxymethane (AOM)-induced F344 rat colon ACF and adenomas were compared at four time points, 4 (control), 8, 16, and 24 weeks post AOM administration (n = 9/group), with time points correlating with induction and transformation events. At each time point, micro-dissecte...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Ian X. Swain Adam M. Kresak Tags: Article Source Type: research
Fasting hyperglycaemia and fatty liver drive colorectal cancer: a retrospective analysis in 1145 patients
ConclusionMASLD and increased FPG may play a role in the clinical background of CRC, bringing to light the fascinating possibility of a reversed gut –liver axis communication in the pathogenesis of CRC. Thus, the use of non-invasive scores of fatty liver may be helpful to predict the risk of CRC and serve as novel prognostic factors for prevention and therapeutic strategies. (Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - April 26, 2024 Category: Emergency Medicine Source Type: research
UViT-Seg: An Efficient ViT and U-Net-Based Framework for Accurate Colorectal Polyp Segmentation in Colonoscopy and WCE Images
AbstractColorectal cancer (CRC) stands out as one of the most prevalent global cancers. The accurate localization of colorectal polyps in endoscopy images is pivotal for timely detection and removal, contributing significantly to CRC prevention. The manual analysis of images generated by gastrointestinal screening technologies poses a tedious task for doctors. Therefore, computer vision-assisted cancer detection could serve as an efficient tool for polyp segmentation. Numerous efforts have been dedicated to automating polyp localization, with the majority of studies relying on convolutional neural networks (CNNs) to learn ...
Source: Journal of Digital Imaging - April 26, 2024 Category: Radiology Source Type: research
