Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Survival trends for left and right sided colon cancer using population ‐based SEER database: A forty‐five‐year analysis from 1975 to 2019
ConclusionLSCC was associated with superior survival compared to right sided tumors. With the adoption of modern chemotherapy regimens, prognosis between LSCC and RSCC became more divergent in favor of LSCC. Colon cancer clinical trials should strongly consider tumor sidedness as an enrollment factor. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Mark B. Ulanja,
Kwabena Oppong Asafo ‐Agyei,
Vijay Neelam,
Bryce D. Beutler,
Daniel Antwi‐Amoabeng,
Samuel B. Governor,
Ganiyu A. Rahman,
Francis T. Djankpa,
Reginald N. Ulanja,
Grace B. Nteim,
Tarig Mabrouk,
Millicent Amankwah,
Olatunji B Tags: RESEARCH ARTICLE Source Type: research
N-methyl-D-aspartate receptors and thymoquinone induce apoptosis and alteration in mitochondria in colorectal cancer cells
This study aimed to determine the roles of N-Methyl-D-Aspartate agonists and Thymoquinone on mitochondria and apoptosis. HT-29 cells were treated with different TQ and MK-801 concentrations. We analyzed cell viability, apoptosis, and alteration of mitochondria. Cell viability significantly decreased depending on doses of TQ and MK-801. Apoptosis and mitochondrial dysfunctions induced by low and high doses of TQ and MK-801. Our study emphasizes the need for further safety evaluation of MK-801 due to the potential toxicity risk of TQ and MK-801. Optimal and toxic doses of TQ and MK-801 were determined for the treatment of co...
Source: Medical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Isolated Inguinal Lymph Node Metastasis from Colon Cancer: A Case Report
We reported a rare case of isolated metachronous inguinal lymph node metastasis from colon cancer with a round ligament route of spread as the hypothesized mechanism. Surgical resection with inguinal LN dissection is the preferred treatment option for isolated inguinal lymph node metastasis from colon cancer followed by adjuvant chemotherapy, yet long term follow-up data is needed to support this strategy. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Promising anticancer activity of cromolyn in colon cancer: in vitro and in vivo analysis
CONCLUSION: Our study showed that cromolyn is a selective and strong drug in inhibiting the proliferation of colon cancer cells. Based on our results, the efficacy of C in vitro analysis (MTT assays and apoptosis), as well as animal studies is competitive with the FDA-approved drug doxorubicin. C is very promising as a low-complication and good-efficacy drug for cancer drug repositioning. This requires clinical research study designs to comprehensively evaluate its anti-cancer effects.PMID:38647571 | DOI:10.1007/s00432-024-05741-2 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Amin Aliabadi Mohammad Reza Haghshenas Razie Kiani Mohammad Reza Panjehshahin Nasrollah Erfani Source Type: research
Successful curative treatment for a ruptured pancreatic acinar cell carcinoma by radical resection following modified FOLFIRINOX: a case report and literature review
AbstractPancreatic acinar cell carcinoma (PACC) is a rare pancreatic tumor type, and ruptured pancreatic tumors are rarer. Computed tomography (CT) in a 48-year-old man incidentally revealed a raptured pancreatic tail tumor. The patient was treated conservatively because he was asymptomatic, and his general condition was stable. After a detailed examination, the pancreatic tumor was diagnosed as raptured PACC. Considering the potential infiltration of tumor cells into the hematoma within the omental sac, our decision is to initiate chemotherapy as the primary course of action. A liquid biopsy was performed, and comprehensi...
Source: International Cancer Conference Journal - April 22, 2024 Category: Cancer & Oncology Source Type: research
Promising anticancer activity of cromolyn in colon cancer: in vitro and in vivo analysis
ConclusionOur study showed that cromolyn is a selective and strong drug in inhibiting the proliferation of colon cancer cells. Based on our results, the efficacy of C in vitro analysis (MTT assays and apoptosis), as well as animal studies is competitive with the FDA-approved drug doxorubicin. C is very promising as a low-complication and good-efficacy drug for cancer drug repositioning. This requires clinical research study designs to comprehensively evaluate its anti-cancer effects. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Targeted delivery of HSP90 inhibitors for efficient therapy of CD44-positive acute myeloid leukemia and solid tumor-colon cancer
Heat shock protein 90 (HSP90) is overexpressed in numerous cancers, promotes the maturation of numerous oncoproteins and facilitates cancer cell growth. Certain HSP90 inhibitors have entered clinical trials. A... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 22, 2024 Category: Nanotechnology Authors: Lejiao Jia, Huatian Yang, Yue Liu, Ying Zhou, Guosheng Li, Qian Zhou, Yan Xu, Zhiping Huang, Feng Ye, Jingjing Ye, Anchang Liu and Chunyan Ji Tags: Research Source Type: research
The Role of miR-132-3p in Inhibiting the Proliferation, Invasion and Metastasis of Colon Cancer by Targeted Regulation of PDGF
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - April 20, 2024 Category: Nanotechnology Authors: Li, Chaobin Lu, Kemei Lang, Cuicui Li, Min Yang, Chenggang Tags: research-article Source Type: research
Identification of the Immune-related lncRNA SNHG14/ miR-200a-3p/ PCOLCE2 Axis in Colorectal Cancer
CONCLUSIONS: The current study revealed for the first time that a novel regulatory axis-long noncoding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14)/ miR-200a-3p/ PCOLCE2- can act as the oncogenic axis of CRC cells and that clinicians can use it to predict the OS of colon-cancer patients. Additionally, differences in the protein expression of PCOLCE2 between normal and adenocarcinoma-colorectal tissues suggest its potential as a prognostic biomarker for CRC.PMID:38639631 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Na Li Jiangli Shen Ximin Qiao Qiang Liu Xiaoqiang Dai Xiongwen Jiao Source Type: research
Identification of the Immune-related lncRNA SNHG14/ miR-200a-3p/ PCOLCE2 Axis in Colorectal Cancer
CONCLUSIONS: The current study revealed for the first time that a novel regulatory axis-long noncoding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14)/ miR-200a-3p/ PCOLCE2- can act as the oncogenic axis of CRC cells and that clinicians can use it to predict the OS of colon-cancer patients. Additionally, differences in the protein expression of PCOLCE2 between normal and adenocarcinoma-colorectal tissues suggest its potential as a prognostic biomarker for CRC.PMID:38639631 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Na Li Jiangli Shen Ximin Qiao Qiang Liu Xiaoqiang Dai Xiongwen Jiao Source Type: research
Conditional survival analysis and real-time prognosis prediction in stage III T3 –T4 colon cancer patients after surgical resection: a SEER database analysis
ConclusionsOur study developed nomograms and predictive models for postoperative stage III survival in T3 –T4 colon cancer with the aim of accurately estimating conditional survival. Survival bias in our analyses may lead to overestimation of survival outcomes, which may limit the applicability of our findings. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 19, 2024 Category: Gastroenterology Source Type: research
Nonfistulizing Perianal Crohn's Disease
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786198Perianal Crohn's disease (CD) includes a wide range of nonfistulizing sequela, including fissures and ulcers, skin tags, anal stricture, and anal cancer. Symptoms related to perianal manifestations of CD are often disabling and have a significant impact on patients' quality of life. They include pain, drainage, bleeding, difficulty with hygiene and may cause secondary difficulties with sexual and defecatory dysfunction. The care of patients with perianal CD requires a thoughtful approach, including detailed history taking, physical examination, and often multidisciplinary c...
Source: Clinics in Colon and Rectal Surgery - April 19, 2024 Category: Surgery Authors: Simon, Emily Steinhagen, Emily Tags: Review Article Source Type: research
How ceramides affect the development of colon cancer: from normal colon to carcinoma
Pflugers Arch. 2024 Apr 18. doi: 10.1007/s00424-024-02960-x. Online ahead of print.ABSTRACTThe integrity of the colon and the development of colon cancer depend on the sphingolipid balance in colon epithelial cells. In this review, we summarize the current knowledge on how ceramides and their complex derivatives influence normal colon development and colon cancer development. Ceramides, glucosylceramides and sphingomyelin are essential membrane components and, due to their biophysical properties, can influence the activation of membrane proteins, affecting protein-protein interactions and downstream signalling pathways. He...
Source: Pflugers Archiv : European Journal of Physiology - April 18, 2024 Category: Physiology Authors: Nadine Merz Jennifer Christina Hartel Sabine Gr ösch Source Type: research
Mining and exploration of rehabilitation nursing targets for colorectal cancer
CONCLUSIONS: High MYC and NCAPG2 expression has been observed in colorectal cancer, and increased MYC and NCAPG2 expression correlates with worse prognosis.PMID:38637125 | DOI:10.18632/aging.205739 (Source: Aging)
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Ruipu Li Jie He Zhijie Ni Jie Zhang Xiaoqian Chi Chunbo Kang Zhongbo Li Xubin Li Source Type: research
