Effects of nucleoside analogues, lipophilic prodrugs and elaidic acids on core signaling pathways in cancer cells
CONCLUSIONS: The findings suggest that both parent drugs, prodrugs, and the EA chain influence cell survival and signaling pathways.PMID:38619266 | DOI:10.1080/15257770.2024.2339952 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 15, 2024 Category: Biochemistry Authors: Marika A Fra ńczak Claudine van der Sande Elisa Giovannetti Godefridus J Peters Source Type: research
Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon
J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361.ABSTRACTInvasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel. We reviewed endoscopic colon biopsie...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Malte Gronewold Isabel Grote Stephan Bartels Henriette Christgen Leonie D Kandt Maria Jose Brito G àbor Cserni Maximilian E Daemmrich Franz Fogt Burkhard M Helmke Natalie Ter Hoeve Corinna Lang-Schwarz Michael Vieth Axel Wellmann Elna Kuehnle Ulf Kulik G Source Type: research
The prognostic biomarker TPGS2 is correlated with immune infiltrates in pan-cancer: a bioinformatics analysis
CONCLUSIONS: TPGS2 is aberrantly expressed in most cancer tissues and might be associated with immune cell infiltration in the tumor microenvironment. TPGS2 could serve not only as a biomarker for predicting clinical outcomes, but also as a promising biomarker for evaluating and developing new approaches to immunotherapy in many types of cancers, especially colon adenocarcinoma and stomach adenocarcinoma.PMID:38617524 | PMC:PMC11009813 | DOI:10.21037/tcr-23-113 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Zujun Ding Qing Ding Hang Li Source Type: research
Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon
J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361.ABSTRACTInvasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel. We reviewed endoscopic colon biopsie...
Source: Clinical Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Malte Gronewold Isabel Grote Stephan Bartels Henriette Christgen Leonie D Kandt Maria Jose Brito G àbor Cserni Maximilian E Daemmrich Franz Fogt Burkhard M Helmke Natalie Ter Hoeve Corinna Lang-Schwarz Michael Vieth Axel Wellmann Elna Kuehnle Ulf Kulik G Source Type: research
Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon
J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361.ABSTRACTInvasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel. We reviewed endoscopic colon biopsie...
Source: Clinical Genitourinary Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Malte Gronewold Isabel Grote Stephan Bartels Henriette Christgen Leonie D Kandt Maria Jose Brito G àbor Cserni Maximilian E Daemmrich Franz Fogt Burkhard M Helmke Natalie Ter Hoeve Corinna Lang-Schwarz Michael Vieth Axel Wellmann Elna Kuehnle Ulf Kulik G Source Type: research
Precision Medicine in the Era of Genetic Testing: Microsatellite Instability Evolved
Clin Colon Rectal Surg. 2023 Jul 25;37(3):157-171. doi: 10.1055/s-0043-1770385. eCollection 2024 May.ABSTRACTThe recognized importance of microsatellite instability (MSI) in cancer has evolved considerably in the past 30 years. From its beginnings as a molecular predictor for Lynch syndrome, MSI first transitioned to a universal screening test in all colorectal and endometrial cancers, substantially increasing the identification of patients with Lynch syndrome among cancer patients. More recently, MSI has been shown to be a powerful biomarker of response to immune checkpoint blockade therapy across a diversity of tumor typ...
Source: Clinical Colorectal Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Dina Ioffe Michelle McSweeny Michael J Hall Source Type: research
Surgical Decision-Making in Familial Adenomatous Polyposis
Clin Colon Rectal Surg. 2023 Aug 10;37(3):191-197. doi: 10.1055/s-0043-1770732. eCollection 2024 May.ABSTRACTFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostom...
Source: Clinical Colorectal Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Allie E Steinberger Maggie L Westfal Paul E Wise Source Type: research
Banxia Xiexin Decoction inhibiting colitis-associated colorectal cancer infected with Fusobacterium nucleatum by regulating Wnt/beta-catenin pathway
In conclusion, BXD can inhibit CAC infected with Fn, and its potential mechanism may be related to the inhibition of Fn binding to E-cadherin, the decrease in annexin A1 protein level, and the regulation of the Wnt/β-catenin pathway.PMID:38621974 | DOI:10.19540/j.cnki.cjcmm.20231114.701 (Source: Cancer Control)
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Yi-Fang Jiang Yu-Qing Huang Yan-E Hu Yi Yang Chuan Zheng Feng-Ming You Zi-Yi Zhao Source Type: research
Surgical Decision-Making in Familial Adenomatous Polyposis
Clin Colon Rectal Surg. 2023 Aug 10;37(3):191-197. doi: 10.1055/s-0043-1770732. eCollection 2024 May.ABSTRACTFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostom...
Source: Hand Surgery - April 15, 2024 Category: Surgery Authors: Allie E Steinberger Maggie L Westfal Paul E Wise Source Type: research
An arresten-derived anti-angiogenic peptide triggers apoptotic cell death in endothelial cells
CONCLUSIONS: It might be suggested that Ars induced apoptosis in endothelial cells through the mitochondrial pathway and had no effect on the cell cycle. Besides, Ars induced apoptosis significantly in vivo. However, further studies are required to confirm the detailed molecular mechanism of Ars, this peptide has the potential to be optimized for clinical translations.PMID:38622345 | DOI:10.1007/s11033-024-09448-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Reyhane Chamani Omid Saberi Fatemeh Fathinejad Source Type: research
An arresten-derived anti-angiogenic peptide triggers apoptotic cell death in endothelial cells
CONCLUSIONS: It might be suggested that Ars induced apoptosis in endothelial cells through the mitochondrial pathway and had no effect on the cell cycle. Besides, Ars induced apoptosis significantly in vivo. However, further studies are required to confirm the detailed molecular mechanism of Ars, this peptide has the potential to be optimized for clinical translations.PMID:38622345 | DOI:10.1007/s11033-024-09448-y (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 15, 2024 Category: Molecular Biology Authors: Reyhane Chamani Omid Saberi Fatemeh Fathinejad Source Type: research
The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
Effects of nucleoside analogues, lipophilic prodrugs and elaidic acids on core signaling pathways in cancer cells
CONCLUSIONS: The findings suggest that both parent drugs, prodrugs, and the EA chain influence cell survival and signaling pathways.PMID:38619266 | DOI:10.1080/15257770.2024.2339952 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 15, 2024 Category: Biochemistry Authors: Marika A Fra ńczak Claudine van der Sande Elisa Giovannetti Godefridus J Peters Source Type: research
The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
Effects of nucleoside analogues, lipophilic prodrugs and elaidic acids on core signaling pathways in cancer cells
CONCLUSIONS: The findings suggest that both parent drugs, prodrugs, and the EA chain influence cell survival and signaling pathways.PMID:38619266 | DOI:10.1080/15257770.2024.2339952 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 15, 2024 Category: Biochemistry Authors: Marika A Fra ńczak Claudine van der Sande Elisa Giovannetti Godefridus J Peters Source Type: research
