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Angiotensin-converting enzyme I/D gene polymorphism and risk of type 2 diabetes mellitus in Iranian individuals
This study aimed to examine the relationship between type 2 diabetes mellitus (T2DM) and renin-angiotensin system gene polymorphisms in the Iranian population. Additionally, we performed a straightforward meta-analysis of the present articles to better understand this role. A total of 100 Iranian individuals, 50 patients with T2DM, and 50 age-matched healthy individuals were included in this study. DNA was extracted using the salting-out approach, polymerase chain reaction was used to amplify the angiotensin-converting enzyme (ACE) gene, electrophoresis techniques were used, and genotyping was performed. We also searched P...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 23, 2024 Category: Biochemistry Authors: Mohammad Amin Momeni-Moghaddam Hanieh Chahkandi Narges Amini Beidokhti Marziye Rahmani Davoud Salarbashi Milad Khorasani Source Type: research

Promoter of lncRNA < em > MORT < /em > is aberrantly methylated in colorectal cancer
In conclusion, based on our results, promoter hypermethylation of MORT might be considered as a potential biomarker for CRC detection.PMID:38619194 | DOI:10.1080/15257770.2024.2328732 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 15, 2024 Category: Biochemistry Authors: Aylar Nazari Tayyebeh Ghasemi Mohammad Khalaj-Kondori Ramin Fathi Source Type: research

Correlation of BARD1 gene polymorphisms with risk of neuroblastoma: a meta-analysis
Nucleosides Nucleotides Nucleic Acids. 2024 Apr 15:1-19. doi: 10.1080/15257770.2024.2336215. Online ahead of print.ABSTRACTBRCA1-associated RING domain protein 1 (BARD1) gene polymorphisms may be associated with neuroblastoma (NB) susceptibility. However, the results remain controversial. Relevant studies were identified by searching PubMed, Web of Science, Embase, China National Knowledge Infrastructure databases up to March 5, 2023. The strength of the association between BARD1 polymorphisms and susceptibility of NB was assessed by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs) through the fixed- or...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 15, 2024 Category: Biochemistry Authors: Shan Chen Di Xu Rongdong Huang Yang Lin Lizhi Li Source Type: research

Effects of nucleoside analogues, lipophilic prodrugs and elaidic acids on core signaling pathways in cancer cells
CONCLUSIONS: The findings suggest that both parent drugs, prodrugs, and the EA chain influence cell survival and signaling pathways.PMID:38619266 | DOI:10.1080/15257770.2024.2339952 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 15, 2024 Category: Biochemistry Authors: Marika A Fra ńczak Claudine van der Sande Elisa Giovannetti Godefridus J Peters Source Type: research

Difluoroacetic acid: an alternative acid in the detritylation reaction for the solid-phase synthesis of oligonucleotides
Nucleosides Nucleotides Nucleic Acids. 2024 Apr 11:1-9. doi: 10.1080/15257770.2024.2337145. Online ahead of print.ABSTRACTDichloroacetic acid or trichloroacetic acid are commonly used in the detritylation reaction of the automated solid-phase synthesis of oligonucleotides. Dichloroacetic acid, however, is often contaminated with trichloroacetaldehyde (chloral), leading to the formation of inseparable impurities in the final oligonucleotide product. In this work, three different sequences, namely T18, d(TAA)6, and an 18-mer mixed sequence, were used as models to compare the deprotection efficiency of three acids: trichloroa...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 11, 2024 Category: Biochemistry Authors: Quanjian Li Dhruval Joshi Yogesh S Sanghvi Hongbin Yan Source Type: research