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Evaluation of miR-130b-3p and miR-375 levels and telomere length with telomerase activity in prostate cancer
Nucleosides Nucleotides Nucleic Acids. 2024 Apr 9:1-12. doi: 10.1080/15257770.2024.2334896. Online ahead of print.ABSTRACTProstate cancer (PC) is the most frequent cancer in males, as well as the second highest cause of cancer-related deaths in men. Differences in expression levels of miRNAs were linked with prostat cancer pathogenesis. qPCR was used to evaluate the expression of miR-130b-3p and miR-375 in Benign Prostate Hyperplasia (BPH (n = 20) and PC (n = 22, pre- and post-operative) patients plasma. Relative telomere lengths (RLTs) in genomic DNA isolated from plasma were measured with qPCR, and telomerase activity an...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 9, 2024 Category: Biochemistry Authors: Abdullah Karada ğ Ebubekir Dirican Çağdaş Gökhun Özmerdiven Ata Özen Semih Ayan Selda Kabadere Source Type: research

Association of rs11081062 polymorphism of DLGAP1 gene and levels of SLC1A1 protein with obsessive-compulsive disorder
This study suggests that rs11081062 in DLGAP1 may be associated with OCD and that SLC1A1 protein levels may be involved in the occurrence of OCD. We believe that our research can contribute to the understanding of the importance of glutamate in OCD.PMID:38593060 | DOI:10.1080/15257770.2024.2336213 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 9, 2024 Category: Biochemistry Authors: Efruz İrem Akkuş Burcu Bayo ğlu Ne şe Kocabaşoğlu Jansed Berfin Y ıldız M üjgan Cengiz Source Type: research

Long noncoding RNAs and their possible roles in tumorigenesis and drug resistance in cancer chemotherapy
Nucleosides Nucleotides Nucleic Acids. 2024 Apr 4:1-15. doi: 10.1080/15257770.2024.2336210. Online ahead of print.ABSTRACTCancer is still one of the most important diseases that have a high mortality rate around the world. The management of cancer involves many procedures, which include surgery, radiotherapy, and chemotherapy. Drug resistance in cancer chemotherapy is considered one of the most important problems in clinical oncology. A good understanding of the tumorigenesis process and the mechanisms of developing chemotherapy resistance in cancer cells will help achieve significant advances in cancer treatment protocols...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 4, 2024 Category: Biochemistry Authors: Ehsan Sayed Ali Ali Erdin ç Yalın Serap Yal ın Source Type: research

Bioinformatics and meta-analysis of the clinical significance of RECK expression and its genetic polymorphisms in cancer
In conclusion, these findings suggest that RECK expression levels may serve as a valuable indicator for assessing cancer prognosis in some cancers as well as drug sensitivity in pan-cancer, and its rs10814325 polymorphism may be used to assess cancer risk.PMID:38557395 | DOI:10.1080/15257770.2024.2336222 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 1, 2024 Category: Biochemistry Authors: Weichao Zhang Xueren Gao Source Type: research

Anticancer sensitivity and biological aspect of 5-fluorouracil-resistant human colorectal cancer HCT116 cells in three-dimensional culture under high- and low-glucose conditions
We examined the sensitivity to 5-FU and the formation of tumor spheres in parental HCT116 cells and 5-FU-resistant HCT116RF10 cells under 3D culture conditions at high-glucose (HG 25 mM) and low-glucose (LG 5.5 mM) concentrations. These results suggested that the tumor spheres of parental HCT116 cells displayed higher sensitivity to 5-FU under LG conditions than under HG conditions. HCT116RF10 tumor spheres exhibited comparable sensitivity to 5-FU under HG and LG conditions. Furthermore, under HG conditions, there was a marked decrease in extracellular lactate in the HCT116RF10 tumor sphere compared to that in the LG tumor...
Source: Nucleosides, Nucleotides and Nucleic Acids - March 31, 2024 Category: Biochemistry Authors: Chinatsu Kurasaka Nana Nishizawa Yoko Ogino Akira Sato Source Type: research

Construction of a novel mRNA-miRNA-lncRNA/circRNA triple subnetwork associated with immunity and aging in intervertebral disc degeneration
CONCLUSION: We established a novel immune-related and aging-related triple regulatory network of mRNA-miRNA-lncRNA/circRNA ceRNA, among which all RNAs may be utilized as the pathogenesis biomarker of NP cells in IVDD.PMID:38555595 | DOI:10.1080/15257770.2024.2334353 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - March 31, 2024 Category: Biochemistry Authors: Wei Liu Hui-Min Li Guangchao Bai Source Type: research