Looking for the unexpected in purine and pyrimidine metabolism
Nucleosides Nucleotides Nucleic Acids. 2023 Oct 24:1-9. doi: 10.1080/15257770.2023.2272647. Online ahead of print.ABSTRACTIn June 2023, the Purine and Pyrimidine Society (PPS) organized the 20th biennial symposium on Purine and Pyrimidine metabolism (PP23). The symposium was organized in Los Angeles, California, USA, by Pr Caius Radu affiliated to UCLA. The scientific program covered various topics such as inborn errors, cancer, immunity, enzymatic reactions, drug development etc and was presented at 9 sessions over three days. The current issue of Nucleosides, Nucleotides & Nucleic Acids is a special issue covering pr...
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Lars Petter Jordheim Caius G Radu Godefridus J Peters Source Type: research

Association between interferon-gamma ( < em > IFN- γ < /em > ) gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-analysis
In conclusion, this meta-analysis suggests that two SNPs in IFN-γ may be associated with TB susceptibility in non-Asian populations. However, for Asians, there is no evidence to support a conclusive relationship between these SNPs and the risk of TB.PMID:37874649 | DOI:10.1080/15257770.2023.2272641 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Xu Hu Xiaoying Lu Source Type: research

Clinical use of biomarkers in the field of cytotoxic nucleoside analogues
CONCLUSION: There is still much to do in the field of outcome-prediction with nucleoside analogues. The use of multiparametric methods could increase the success rate but at the cost of a poorer understanding of molecular mechanisms.PMID:37874211 | DOI:10.1080/15257770.2023.2272640 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Lars Petter Jordheim Source Type: research

Looking for the unexpected in purine and pyrimidine metabolism
Nucleosides Nucleotides Nucleic Acids. 2023 Oct 24:1-9. doi: 10.1080/15257770.2023.2272647. Online ahead of print.ABSTRACTIn June 2023, the Purine and Pyrimidine Society (PPS) organized the 20th biennial symposium on Purine and Pyrimidine metabolism (PP23). The symposium was organized in Los Angeles, California, USA, by Pr Caius Radu affiliated to UCLA. The scientific program covered various topics such as inborn errors, cancer, immunity, enzymatic reactions, drug development etc and was presented at 9 sessions over three days. The current issue of Nucleosides, Nucleotides & Nucleic Acids is a special issue covering pr...
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Lars Petter Jordheim Caius G Radu Godefridus J Peters Source Type: research

Association between interferon-gamma ( < em > IFN- γ < /em > ) gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-analysis
In conclusion, this meta-analysis suggests that two SNPs in IFN-γ may be associated with TB susceptibility in non-Asian populations. However, for Asians, there is no evidence to support a conclusive relationship between these SNPs and the risk of TB.PMID:37874649 | DOI:10.1080/15257770.2023.2272641 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Xu Hu Xiaoying Lu Source Type: research

Clinical use of biomarkers in the field of cytotoxic nucleoside analogues
CONCLUSION: There is still much to do in the field of outcome-prediction with nucleoside analogues. The use of multiparametric methods could increase the success rate but at the cost of a poorer understanding of molecular mechanisms.PMID:37874211 | DOI:10.1080/15257770.2023.2272640 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Lars Petter Jordheim Source Type: research

Looking for the unexpected in purine and pyrimidine metabolism
Nucleosides Nucleotides Nucleic Acids. 2023 Oct 24:1-9. doi: 10.1080/15257770.2023.2272647. Online ahead of print.ABSTRACTIn June 2023, the Purine and Pyrimidine Society (PPS) organized the 20th biennial symposium on Purine and Pyrimidine metabolism (PP23). The symposium was organized in Los Angeles, California, USA, by Pr Caius Radu affiliated to UCLA. The scientific program covered various topics such as inborn errors, cancer, immunity, enzymatic reactions, drug development etc and was presented at 9 sessions over three days. The current issue of Nucleosides, Nucleotides & Nucleic Acids is a special issue covering pr...
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Lars Petter Jordheim Caius G Radu Godefridus J Peters Source Type: research

Association between interferon-gamma ( < em > IFN- γ < /em > ) gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-analysis
In conclusion, this meta-analysis suggests that two SNPs in IFN-γ may be associated with TB susceptibility in non-Asian populations. However, for Asians, there is no evidence to support a conclusive relationship between these SNPs and the risk of TB.PMID:37874649 | DOI:10.1080/15257770.2023.2272641 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Xu Hu Xiaoying Lu Source Type: research

Clinical use of biomarkers in the field of cytotoxic nucleoside analogues
CONCLUSION: There is still much to do in the field of outcome-prediction with nucleoside analogues. The use of multiparametric methods could increase the success rate but at the cost of a poorer understanding of molecular mechanisms.PMID:37874211 | DOI:10.1080/15257770.2023.2272640 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Lars Petter Jordheim Source Type: research

Looking for the unexpected in purine and pyrimidine metabolism
Nucleosides Nucleotides Nucleic Acids. 2023 Oct 24:1-9. doi: 10.1080/15257770.2023.2272647. Online ahead of print.ABSTRACTIn June 2023, the Purine and Pyrimidine Society (PPS) organized the 20th biennial symposium on Purine and Pyrimidine metabolism (PP23). The symposium was organized in Los Angeles, California, USA, by Pr Caius Radu affiliated to UCLA. The scientific program covered various topics such as inborn errors, cancer, immunity, enzymatic reactions, drug development etc and was presented at 9 sessions over three days. The current issue of Nucleosides, Nucleotides & Nucleic Acids is a special issue covering pr...
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Lars Petter Jordheim Caius G Radu Godefridus J Peters Source Type: research

Association between interferon-gamma ( < em > IFN- γ < /em > ) gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-analysis
In conclusion, this meta-analysis suggests that two SNPs in IFN-γ may be associated with TB susceptibility in non-Asian populations. However, for Asians, there is no evidence to support a conclusive relationship between these SNPs and the risk of TB.PMID:37874649 | DOI:10.1080/15257770.2023.2272641 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Xu Hu Xiaoying Lu Source Type: research

Clinical use of biomarkers in the field of cytotoxic nucleoside analogues
CONCLUSION: There is still much to do in the field of outcome-prediction with nucleoside analogues. The use of multiparametric methods could increase the success rate but at the cost of a poorer understanding of molecular mechanisms.PMID:37874211 | DOI:10.1080/15257770.2023.2272640 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Lars Petter Jordheim Source Type: research

Looking for the unexpected in purine and pyrimidine metabolism
Nucleosides Nucleotides Nucleic Acids. 2023 Oct 24:1-9. doi: 10.1080/15257770.2023.2272647. Online ahead of print.ABSTRACTIn June 2023, the Purine and Pyrimidine Society (PPS) organized the 20th biennial symposium on Purine and Pyrimidine metabolism (PP23). The symposium was organized in Los Angeles, California, USA, by Pr Caius Radu affiliated to UCLA. The scientific program covered various topics such as inborn errors, cancer, immunity, enzymatic reactions, drug development etc and was presented at 9 sessions over three days. The current issue of Nucleosides, Nucleotides & Nucleic Acids is a special issue covering pr...
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Lars Petter Jordheim Caius G Radu Godefridus J Peters Source Type: research

Association between interferon-gamma ( < em > IFN- γ < /em > ) gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-analysis
In conclusion, this meta-analysis suggests that two SNPs in IFN-γ may be associated with TB susceptibility in non-Asian populations. However, for Asians, there is no evidence to support a conclusive relationship between these SNPs and the risk of TB.PMID:37874649 | DOI:10.1080/15257770.2023.2272641 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 24, 2023 Category: Biochemistry Authors: Xu Hu Xiaoying Lu Source Type: research

6-azido and 6-azidomethyl uracil nucleosides
Nucleosides Nucleotides Nucleic Acids. 2023 Oct 19:1-19. doi: 10.1080/15257770.2023.2271023. Online ahead of print.ABSTRACTAzido nucleosides have been utilized for click reactions, metabolic incorporation into cellular DNA, and fluorescent imaging of live cells. Two classes of 6-azido modified uracil nucleosides; one with azido group directly attached to uracil ring and second with azido group attached via methylene linker are described. The 6-azido-2'-deoxyuridine (6-AdU) was prepared in 55% overall yield by lithiation-based regioselective C6-iodination of silyl protected 2'-deoxyuridine followed by treatment with sodium ...
Source: Nucleosides, Nucleotides and Nucleic Acids - October 20, 2023 Category: Biochemistry Authors: Yahaira Reyes Alexander Mebel Stanislaw F Wnuk Source Type: research