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Investigation of circadian rhythm gene Per3 in diabetic neuropathy
CONCLUSIONS: In conclusion, first in the world, the relationship between PER3 gene VNTR polymorphism and diabetic neuropathy and diabetes, was investigated. Our results showed that PER3 may be associated with diabetes but not with diabetic neuropathy.PMID:38037954 | DOI:10.1080/15257770.2023.2286996 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - December 1, 2023 Category: Biochemistry Authors: H üsniye Rüstemoğlu Recai Aci S üheyla Uzun Serb ülent Yiğit Ayd ın Rüstemoğlu Source Type: research

Lack of association between VNTR variant of the circadian gene (PER3) and major depressive disorder in a sample of a Turkish population
Nucleosides Nucleotides Nucleic Acids. 2023 Nov 24:1-10. doi: 10.1080/15257770.2023.2282572. Online ahead of print.ABSTRACTMajor depressive disorder (MDD), which is a prevalent psychiatric disorder, is characterized by sleep-wake disturbances. An underlying circadian rhythm disorder mainly may cause these disturbances. The study presented here was designed to investigate the existence of Period Circadian Regulator 3 (PER3) gene VNTR variant in MDD patients in Turkish population. A sample of 118 patients with MDD and 150 healthy volunteers were included in the study. The PER3 VNTR genotyping was performed on DNA by polymera...
Source: Nucleosides, Nucleotides and Nucleic Acids - November 25, 2023 Category: Biochemistry Authors: Serbulent Yigit Ayse Feyda Nursal Filiz Ozsoy Esra Duman Melih Sercan Ustaoglu Source Type: research

 VEGF I/D variant and preeclampsia risk in Turkish women: a case-control study
In conclusion, for the first time, our results supported that the VEGF I/D variant is not a risk factor for the development of PE in a group of Turkish populations. But VEGF I/D variant D/D genotype associated with low gestational week and birth weight while I/D genotype seems to be protective from high systolic blood pressure.PMID:37991450 | DOI:10.1080/15257770.2023.2283621 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - November 22, 2023 Category: Biochemistry Authors: Mehmet Can Nacar Serbulent Yigit Adem Keskin Pinar Kirici Talip Karacor Source Type: research

The effect of HLA-DP gene polymorphisms in Plasmodium Vivax -induced malaria susceptibility
Nucleosides Nucleotides Nucleic Acids. 2023 Nov 19:1-13. doi: 10.1080/15257770.2023.2283620. Online ahead of print.ABSTRACTPlasmodium vivax is the second most common Plasmodium parasite causing clinically serious symptoms and death from malaria. It is an important cause of morbidity and mortality, especially in Asia, the Middle East, and South America. Human leukocyte antigen molecules are responsible for presenting foreign antigens to T cells. Polymorphisms in HLA genes affect antigen presentation. HLA alleles involved in the presentation of P. vivax antigens affect the antibody response. The present study aimed to reveal...
Source: Nucleosides, Nucleotides and Nucleic Acids - November 19, 2023 Category: Biochemistry Authors: Ersin Akg öllü Mehtap Demirkaz ık Ramazan Bilgin Source Type: research

Development of low-cost in-house tetra-ARMS-PCR assay for the screening of five CBS mutations found in Pakistani homocystinuria patients
CONCLUSION: T-ARMS-PCR has wide applications for low-income countries for the screening and early diagnosis of asymptomatic patients and carriers in the homocystinuria affected families as well as other inherited diseases.PMID:37971987 | DOI:10.1080/15257770.2023.2280013 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - November 16, 2023 Category: Biochemistry Authors: Adila Khalil Haq Nawaz Khan Muhammad Wasim Hina Ayesha Fazli Rabbi Awan Source Type: research

Interaction studies of water-soluble Zn(II) complex with calf thymus DNA using biophysical and molecular docking methods"
Nucleosides Nucleotides Nucleic Acids. 2023 Nov 14:1-24. doi: 10.1080/15257770.2023.2280001. Online ahead of print.ABSTRACTThe binding between a fluorescent water-soluble Zn(II) complex of {2-[N-(2-hydroxyethylammonioethyl) imino methyl] phenol} and calf thymus DNA (ct-DNA) was investigated using spectroscopic techniques. The complex was prepared and identified by FT-IR, and 1H NMR spectroscopies. The significant changes in the absorption and the circular dichroism spectra of ct-DNA in the presence of the Zn(II) complex implied the interaction between the Zn(II) complex and ct-DNA. Upon addition of ct-DNA, the fluorescence...
Source: Nucleosides, Nucleotides and Nucleic Acids - November 14, 2023 Category: Biochemistry Authors: Nahid Shahabadi Lida Ghaffari Zahra Mardani Farshad Shiri Source Type: research