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MEFV gene pathogenic variants: a risk factor for dysmenorrhea in the Turkish population
CONCLUSION: Our findings suggest that MEFV variations may be a risk factor for patients with dysmenorrhea in a Turkish cohort.HighlightsThere are very few studies in the literature regarding the relationship between pathological variants of MEFV and dysmenorrhea disease.The common MEFV mutations/variants were evaluated in primary dysmenorrhea patients.Family history was statistically higher in the patient group (p <.001).MEFV gene variations were found 52 (35.9%) in patients and 29 (21.5%2) in controls.MEFV gene allele frequency was significantly higher in-patient group than control (p =.005).PMID:38133485 | DOI:10.1080...
Source: Nucleosides, Nucleotides and Nucleic Acids - December 22, 2023 Category: Biochemistry Authors: Mehmet Can Nacar Serbulent Yigit Asker Zeki Ozsoy Fazli Demirturk Ayse Feyda Nursal Nevin Karakus Source Type: research

Insights on the nuclear shuttling of H2A-H2B histone chaperones
This article sheds light on the crucial aspect that in addition of being directly engaged in nucleosome synthesis and disassembly in vivo, histone chaperone also performs various specific roles via histone binding activity.PMID:38133493 | DOI:10.1080/15257770.2023.2296616 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - December 22, 2023 Category: Biochemistry Authors: Rasanpreet Kaur Pramod Kumar Anuj Kumar Source Type: research

"Difficult" deoxyribonucleotide sequences in the solid-phase synthesis by the phosphoramidite chemistry
Nucleosides Nucleotides Nucleic Acids. 2023 Dec 20:1-9. doi: 10.1080/15257770.2023.2295478. Online ahead of print.ABSTRACTThis work catalogued oligonucleotide sequences and sequence compositions based on the overall yield of full-length product obtained by the phosphoramidite chemistry-based solid phase synthesis. In total, 76 sequences with different dinucleotide and trinucleotide repeats were synthesized, and the fully-deprotected products were analyzed by denaturing anion exchange HPLC. Overall, sequences containing more 2'-deoxyadenosine residues were obtained in relatively lower yields, likely due to the relative ease...
Source: Nucleosides, Nucleotides and Nucleic Acids - December 20, 2023 Category: Biochemistry Authors: Quanjian Li Hongbin Yan Source Type: research

Identification of common genes and pathways underlying imatinib and nilotinib treatment in CML: a Bioinformatics Study
Nucleosides Nucleotides Nucleic Acids. 2023 Dec 20:1-21. doi: 10.1080/15257770.2023.2296021. Online ahead of print.ABSTRACTImatinib (IMA) and nilotinib are the first and second generations of BCR-ABL tyrosine kinase inhibitors, which widely applied in chronic myeloid leukemia (CML) treatment. Here we aimed to provide new targets for CML treatment by transcriptome analysis. Microarray data GSE19567 was downloaded and analyzed from Gene Expression Omnibus (GEO) to identify common genes, which are downregulated or upregulated in K562-imatinib and K562-nilotinib treated cells. The differentially expressed genes (DEGs) were ass...
Source: Nucleosides, Nucleotides and Nucleic Acids - December 20, 2023 Category: Biochemistry Authors: Yalda Hekmatshoar Yalda Rahbar Saadat Tulin Ozkan Sureyya Bozkurt Aynur Karadag Gurel Source Type: research

Clinical significance of BTLA gene expression and rs1982809 polymorphism in pan-cancer
In conclusion, BTLA is expected to serve as a prognostic marker and therapeutic target for certain cancers, and the rs1982809 polymorphism is expected to serve as a cancer susceptibility marker in Polish and Tunisian populations.PMID:38117093 | DOI:10.1080/15257770.2023.2296615 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - December 20, 2023 Category: Biochemistry Authors: Xueren Gao Yichang Gao Shiyu Pan Lin Yang Source Type: research

Synthesis of novel 5-[3-(4-chlorophenyl)-substituted-1,3-dimethylpyrimidine-2,4,6(1 H ,3 H ,5 H )-trione derivatives as potential anti-diabetic and anticancer agents
Nucleosides Nucleotides Nucleic Acids. 2023 Dec 6:1-24. doi: 10.1080/15257770.2023.2289479. Online ahead of print.ABSTRACTIn this work, we developed a series of novel 5-[3-(4-chlorophenyl)-substituted-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione derivatives 4(a-e) via a one-pot multicomponent reaction. The structures of the compounds were confirmed using analytical and spectroscopic techniques. Also, the synthesized compounds were screened for their anti-diabetic activity, cytotoxicity and in silico studies. The activity results suggested that the compound 4e exhibited least IC50 values of 0.055 ± 0.002 µM, 0.050 ± 0.0...
Source: Nucleosides, Nucleotides and Nucleic Acids - December 6, 2023 Category: Biochemistry Authors: S H Sukanya Talavara Venkatesh H Shanavaz Source Type: research