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Unusual effects of PCSK9 E670G (rs505151) variation in patients with in-stent restenosis: Variable effects on restenosis risk according to concomitant chronic conditions
This study evaluated for the first time the association of the E670G variation with the serum lipids, PCSK9 levels and concomitant diseases on the ISR risk. The study included 109 ISR, and 82 Non-ISR patients, based on the results of coronary angiography. Genotypes were determined using the real-time PCR and serum PCSK9 levels were measured by ELISA technique. The rare G allele of PCSK9 E670G (p < 0.05), hyperlipidemia (HL) (p < 0.001), and type 2 diabetes (T2DM) (p < 0.01) were associated with increased risk for ISR. In hyperlipidemic conditions, the E670G-G allele was associated with hypercholesterolemia and a h...
Source: Nucleosides, Nucleotides and Nucleic Acids - February 15, 2024 Category: Biochemistry Authors: Gulcin Ozkara Ezgi Irmak Aslan Ayse Begum Ceviz Gonca Candan Fidan Malikova Allison Pinar Eronat Ozgur Selim Ser Onur K ılıcarslan Ozlem Kucukhuseyin Cem Bostan Ahmet Yildiz Oguz Ozturk Hulya Yilmaz-Aydogan Source Type: research

Risk association of the nitric oxide synthase VNTR intron 4 a/b variant with diabetic nephropathy - a pilot study
This study evaluated whether the VNTR intron 4 a/b and rs1799983 polymorphisms of endothelial-derived nitric oxide synthase (eNOS) gene modulated the risk of developing DN in Asian Indian patients. The eNOS variants were genotyped in 200 patients, 100 with DN and 100 without DN. A significant risk association was observed for the VNTR intron 4 a/b (p < 0.05). Haplotype analysis revealed that the allele combination of rs1799983894 G/Intron 4b and rs1799983894 T/Intron 4b had a statistically significant inverse association with DN.PMID:38359337 | DOI:10.1080/15257770.2024.2317411 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - February 15, 2024 Category: Biochemistry Authors: Swathy Moorthy Teena Koshy Source Type: research

Evaluation and normalization of a set of reliable reference genes for quantitative sgk-1 gene expression analysis in Caenorhabditis elegans -focused cancer research
Nucleosides Nucleotides Nucleic Acids. 2024 Feb 15:1-20. doi: 10.1080/15257770.2024.2317413. Online ahead of print.ABSTRACTMultiple signaling pathways have been discovered to play a role in aging and longevity, including the insulin/IGF-1 signaling system, AMPK pathway, TOR signaling, JNK pathway, and germline signaling. Mammalian serum and glucocorticoid-inducible kinase 1 (sgk-1), which has been associated with various disorders including hypertension, obesity, and tumor growth, limits survival in C. elegans by reducing DAF-16/FoxO activity while suppressing FoxO3 activity in human cell culture. C. elegans provides signi...
Source: Nucleosides, Nucleotides and Nucleic Acids - February 15, 2024 Category: Biochemistry Authors: Özgür Ülkü Özdemir K übra Yurt Ay şe Nur Pektaş Şeyda Berk Source Type: research

DNA three-way junction structures with amino acid side chains prepared via post-synthetic amide condensation
Nucleosides Nucleotides Nucleic Acids. 2024 Feb 15:1-14. doi: 10.1080/15257770.2024.2314645. Online ahead of print.ABSTRACTDNA three-way junction (3WJ) structures with three amino acid side chains in the core have been synthesized via post-synthetic DNA modification. Amide condensation reactions of oligonucleotides containing 2'-aminouridine with activated esters yielded DNA strands modified with His, Cys and Asp side chains to form modified 3WJs. Even a 3WJ with three negatively charged Asp side chains formed stably at room temperature. Furthermore, DNA hybridization alone placed two (His and Asp) and three (His, Cys, and...
Source: Nucleosides, Nucleotides and Nucleic Acids - February 15, 2024 Category: Biochemistry Authors: Yusuke Takezawa Naofumi Kudo Nobuyuki Fuse Mitsuhiko Shionoya Source Type: research