Investigation of MIF gene promoter variations and their haplotypes in the Alzheimer disease in Turkish population
Nucleosides Nucleotides Nucleic Acids. 2023 Sep 4:1-15. doi: 10.1080/15257770.2023.2253282. Online ahead of print.ABSTRACTIn Alzheimer's disease, which is characterized by amyloid plaques and neurofibrillary tangles in the brain tissue, many components such as acute phase proteins, cytokines, and proteases contribute to the progression of the disease or are part of the pathological process. The macrophage migration inhibitory factor (MIF) gene encodes a cytokine, which is secreted by lymphocytes, and has a role in the pathogenesis of autoimmune/inflammatory diseases such as rheumatoid arthritis. The purpose of this study t...
Source: Nucleosides, Nucleotides and Nucleic Acids - September 4, 2023 Category: Biochemistry Authors: Kubra Sahin Ayd ın Rustemoglu Source Type: research

Investigation of virulence factors in < em > Pseudomonas aeruginosa < /em > isolates by phenotypic and genotypic methods
CONCLUSIONS: The relationship between antibiotic resistance and virulence factors is controversial. There are studies demonstrating the relationship between virulence factors and antibiotic resistance, as well as studies that indicate the absence of such a relationship. Investigating virulence and antibiotic resistance rates may be important for identifying potential drug targets for subsequent research.PMID:37665184 | DOI:10.1080/15257770.2023.2254346 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - September 4, 2023 Category: Biochemistry Authors: Erhan Özsoy Umut Safiye Şay Coşkun Yelda Dagc ıoğlu Osman Demir Source Type: research

Investigation of MIF gene promoter variations and their haplotypes in the Alzheimer disease in Turkish population
Nucleosides Nucleotides Nucleic Acids. 2023 Sep 4:1-15. doi: 10.1080/15257770.2023.2253282. Online ahead of print.ABSTRACTIn Alzheimer's disease, which is characterized by amyloid plaques and neurofibrillary tangles in the brain tissue, many components such as acute phase proteins, cytokines, and proteases contribute to the progression of the disease or are part of the pathological process. The macrophage migration inhibitory factor (MIF) gene encodes a cytokine, which is secreted by lymphocytes, and has a role in the pathogenesis of autoimmune/inflammatory diseases such as rheumatoid arthritis. The purpose of this study t...
Source: Nucleosides, Nucleotides and Nucleic Acids - September 4, 2023 Category: Biochemistry Authors: Kubra Sahin Ayd ın Rustemoglu Source Type: research

Investigation of virulence factors in < em > Pseudomonas aeruginosa < /em > isolates by phenotypic and genotypic methods
CONCLUSIONS: The relationship between antibiotic resistance and virulence factors is controversial. There are studies demonstrating the relationship between virulence factors and antibiotic resistance, as well as studies that indicate the absence of such a relationship. Investigating virulence and antibiotic resistance rates may be important for identifying potential drug targets for subsequent research.PMID:37665184 | DOI:10.1080/15257770.2023.2254346 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - September 4, 2023 Category: Biochemistry Authors: Erhan Özsoy Umut Safiye Şay Coşkun Yelda Dagc ıoğlu Osman Demir Source Type: research

SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2
Nucleosides Nucleotides Nucleic Acids. 2023 Sep 3:1-15. doi: 10.1080/15257770.2023.2253279. Online ahead of print.ABSTRACTSALL4 is a transcription factor highly expressed in diverse cancers and is implicated in the development of cancer. SALL4 has been implied to play a cancer-promoting role in colon cancer (CC), but the molecular mechanism remains unclear. Chromatin immunoprecipitation assay and dual-luciferase assay were conducted to verify the binding relationship of SALL4 and ROBO2. qRT-PCR detected the mRNA expression levels of SALL4 and ROBO2, and the flow cytometry analyzed the cell cycle distribution. Western blot ...
Source: Nucleosides, Nucleotides and Nucleic Acids - September 3, 2023 Category: Biochemistry Authors: Yahui Jiang Yunhao Tang Source Type: research