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Identification of autophagy and angiogenesis modulators in colorectal cancer based on bioinformatics analysis
In conclusion, our findings suggest that downregulation of ADIPOQ and upregulation of SLC7A5 in tumor cells lead to increased mTORC1 activity, reduced autophagy, enhanced angiogenesis, and ultimately contribute to cancer progression and decreased survival in CRC patients.PMID:37791824 | DOI:10.1080/15257770.2023.2259431 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 4, 2023 Category: Biochemistry Authors: Fariba Shakeri Parisa Mohamadynejad Mehdi Moghanibashi Source Type: research

Expression of GRP78 and its copartners in HEK293 and pancreatic cancer cell lines (BxPC-3/PANC-1) exposed to MRI and CT contrast agents
Nucleosides Nucleotides Nucleic Acids. 2023 Oct 3:1-26. doi: 10.1080/15257770.2023.2263496. Online ahead of print.ABSTRACTEndoplasmic reticulum (ER) stress-associated chaperones trigger a defense mechanism called as unfolded protein response (UPR) which can manage apoptosis and be determinative in cell fate. Both anticancer drug effects and potential toxicity effects of magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents were aimed to be evaluated. For this purpose, we investigated expression profiles of endoplasmic reticulum stress-associated chaperone molecules in human pancreatic tumor lines Bx...
Source: Nucleosides, Nucleotides and Nucleic Acids - October 3, 2023 Category: Biochemistry Authors: Ali Ahmed Azzawri Ibrahim Halil Yildirim Zeynep Yegin Abdurrahim Dusak Source Type: research

Evaluating interleukin-6 levels and the rs1800795 variant in Turkish patients with COVID-19: a prospective cohort study
CONCLUSIONS: These findings suggest that IL6 rs1800795 may contribute to the susceptibility of COVID-19 in people to Turkish origin.LIMITATIONS: Further large-scale studies in different genetic populations are needed as this is a single-center, prospective study.PMID:37787093 | DOI:10.1080/15257770.2023.2263490 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - October 3, 2023 Category: Biochemistry Authors: Ozlem Sezer Ayse Feyda Nursal Ozgur Gunal Selim Gorgun Akin Tekcan Goksenin Unluguzel Ustun Serbulent Yigit Source Type: research

Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6 : an in silico approach
Nucleosides Nucleotides Nucleic Acids. 2023 Sep 25:1-21. doi: 10.1080/15257770.2023.2262519. Online ahead of print.ABSTRACTGenetic variations in the human cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and cytochrome P450 family 2 subfamily D member 6 (CYP2D6) genes may affect drug metabolism and lead to alterations in phenotypes. Genetic variations are associated with toxicity, adverse drug reactions, inefficient treatment. Various in silico tools were combined to investigate the deleterious effects of missense non-synonymous single nucleotide polymorphisms (nsSNPs) of the human CYP2C9 and CYP2D6. The structural a...
Source: Nucleosides, Nucleotides and Nucleic Acids - September 25, 2023 Category: Biochemistry Authors: Orcun Avsar Source Type: research