Light-regulated RNA interference induced by p-hydroxyphenacyl-modified siRNA in mammalian cells
This study will open new doors for optochemical regulation of a variety of genes by pHP caging group in mammalian cell culture.PMID:37700699 | DOI:10.1080/15257770.2023.2258171 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - September 13, 2023 Category: Biochemistry Authors: Swati Arora Chengde Mao Source Type: research

Elevated programmed cell death-1 protein/ligand (PD-1/PD-L1) and variants are associated with susceptibility to multiple myeloma: a case-control study in the Chinese cohort
Nucleosides Nucleotides Nucleic Acids. 2023 Sep 9:1-19. doi: 10.1080/15257770.2023.2253276. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a malignant disorder characterised by progressive immune dysregulation. The importance of programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) in MM has been documented in various populations, but studies have been limited to the Chinese cohort. In the present study, we examined the role of PD-1/PDL-1 in large cohorts of Chinese patients with MM and healthy controls to reveal a possible association with MM. Three hundred thirty-four MM patients and 202 h...
Source: Nucleosides, Nucleotides and Nucleic Acids - September 9, 2023 Category: Biochemistry Authors: Jing Yang Ling Meng Yongxin Yang Hongwei Gao Honggang Jiang Source Type: research

Association between CTLA4  + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis
In conclusion, the current meta-analysis shows that the CTLA4 + 49 A/G polymorphism is not significantly associated with the risk of developing HCC.PMID:37679967 | DOI:10.1080/15257770.2023.2255626 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - September 8, 2023 Category: Biochemistry Authors: Xiujuan Tan Chunfeng Liu Lingling Sun Source Type: research

Investigation of MIF gene promoter variations and their haplotypes in the Alzheimer disease in Turkish population
Nucleosides Nucleotides Nucleic Acids. 2023 Sep 4:1-15. doi: 10.1080/15257770.2023.2253282. Online ahead of print.ABSTRACTIn Alzheimer's disease, which is characterized by amyloid plaques and neurofibrillary tangles in the brain tissue, many components such as acute phase proteins, cytokines, and proteases contribute to the progression of the disease or are part of the pathological process. The macrophage migration inhibitory factor (MIF) gene encodes a cytokine, which is secreted by lymphocytes, and has a role in the pathogenesis of autoimmune/inflammatory diseases such as rheumatoid arthritis. The purpose of this study t...
Source: Nucleosides, Nucleotides and Nucleic Acids - September 4, 2023 Category: Biochemistry Authors: Kubra Sahin Ayd ın Rustemoglu Source Type: research