Cancer stem cells: Recent trends in cancer therapy
Nucleosides Nucleotides Nucleic Acids. 2024 Feb 6:1-32. doi: 10.1080/15257770.2024.2311789. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subset of tumor cells that were first identified in blood cancers (leukemia) and are considered promising therapeutic targets in cancer treatment. These cells are the cause of many malignancies including metastasis, heterogeneity, drug resistance, and tumor recurrence. They carry out these activities through multiple transcriptional programs and signaling pathways. This review summarizes the characteristics of cancer stem cells, explains their key signaling pathways and fa...
Source: Nucleosides, Nucleotides and Nucleic Acids - February 6, 2024 Category: Biochemistry Authors: Maryam Amiri-Farsani Zahra Taheri Somayeh Tirbakhsh Gouran Omid Chabok Maryam Safarpour-Dehkordi Mahsa Kazemi Roudsari Source Type: research

Genetic insights into bladder cancer: the impact of SIRT1 gene polymorphism
This study investigates the association between BC and the Sirtuin 1 (SIRT1) gene polymorphism rs369274325 in the Turkish population. Genomic DNA was isolated from peripheral blood samples and genotyping of rs369274325 polymorphism in SIRT 1 was investigated in 200 individuals (in 100 Turkish bladder cancer patients and 100 healthy individuals as the control group.) by real-time PCR. Demographic information, smoking and alcohol consumption status was analyzed by statistical analysis. Statistical analysis was performed by Pearson's Chi-square test. Smoking and alcohol consumption were significantly higher in BC patients com...
Source: Nucleosides, Nucleotides and Nucleic Acids - February 2, 2024 Category: Biochemistry Authors: Emre Bostanci Duygu Kirkik Sevgi Kalkanli Tas Ugur Uyeturk Source Type: research

Tuberculosis and lung cancer: metabolic pathways play a key role
Nucleosides Nucleotides Nucleic Acids. 2024 Feb 2:1-20. doi: 10.1080/15257770.2024.2308522. Online ahead of print.ABSTRACTDespite the fact that some cases of tuberculosis (TB) are undiagnosed and untreated, it remains a serious global public health issue. In the diagnosis, treatment, and control of latent and active TB, there may be a lack of effectiveness. An understanding of metabolic pathways can be fundamental to treat latent TB infection and active TB disease. Rather than targeting Mycobacterium tuberculosis, the control strategies aim to strengthen host responses to infection and reduce chronic inflammation by effect...
Source: Nucleosides, Nucleotides and Nucleic Acids - February 2, 2024 Category: Biochemistry Authors: Kianoosh Ferdosnejad Mohammad Saber Zamani Erfan Soroush Abolfazl Fateh Seyed Davar Siadat Samira Tarashi Source Type: research

Naphthyl cyanoketene < em > N < /em > , < em > S < /em > -acetals in glycoside synthesis: a new preparative route to a new class of < em > N < /em > -naphthylcyanoacrylamide thioglycosides and their conversions to naphthyl-pyrazole hybrids
Nucleosides Nucleotides Nucleic Acids. 2024 Jan 24:1-11. doi: 10.1080/15257770.2024.2305247. Online ahead of print.ABSTRACTThe novel N-naphthylcyanoacrylamide thioglycosides 4 were readily prepared by the reaction of N-napthylcyanoacetamide 1 with aryl isothiocyanates in the presence of potassium hydroxide, followed by coupling of the produced salts 2 with 2,3,4,6-tetra-O-acetyl-α-d-gluco- and galacto-pyranosyl bromides 3. The N-naphthyl acrylamide thioglycoside 12 was prepared by the reaction of N-napthylcyanoacetamide 1 with glucose isothiocyante 10 in the presence of potassium hydroxide, followed by alkylation of the p...
Source: Nucleosides, Nucleotides and Nucleic Acids - January 24, 2024 Category: Biochemistry Authors: Galal H Elgemeie Nahed M Fathy Sayed I Shaarawi Source Type: research

Evaluation of the 18-bp deletion/insertion variant of the VEGF gene in athletes
In this study, the athletes and the controls showed a statistically significant difference in the genotype and allele distribution of the VEGF I/D variant. The athletes had a more prevalent D allele and D/D genotype than the controls (p = 0.008 and p = 0.034, respectively). There was a statistically significant association between the patients and the controls in terms of D/D vs. I/I + I/D genotypes (p = 0.018). There was no significant difference in VEGF I/D genotype distribution according to sports branches. Athletic performance is a complex trait influenced by genetic and environmental factors. As far as we know, this i...
Source: Nucleosides, Nucleotides and Nucleic Acids - January 19, 2024 Category: Biochemistry Authors: Saban Unver Ayse Feyda Nursal Serbulent Yigit Tulin Atan Source Type: research

< em > HLAB27 < /em > may confer protection to COVID-19 in generalized vitiligo patients from South Gujarat population
Nucleosides Nucleotides Nucleic Acids. 2024 Jan 19:1-15. doi: 10.1080/15257770.2024.2303710. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), while generalized vitiligo(GV) is an autoimmune disease that causes the loss of functional melanocytes, resulting in white patches all over the body. Human Leukocyte Antigen (HLA) plays a crucial role in immune response to pathogens. Studies assessing the link between GV and COVID-19 are lacking; therefore, our current study was aimed to establish the association between GV and HLAB27 by genot...
Source: Nucleosides, Nucleotides and Nucleic Acids - January 19, 2024 Category: Biochemistry Authors: Prashant S Giri Radhika Bhimani Naresh C Laddha Mitesh Dwivedi Source Type: research

Vitamin D receptor (VDR) variants are risk factors for ovarian cancer: a meta-analysis and trial sequential analysis
Nucleosides Nucleotides Nucleic Acids. 2024 Jan 19:1-15. doi: 10.1080/15257770.2024.2302525. Online ahead of print.ABSTRACTThe importance of Vitamin D in ovarian cancer (OC) has been well documented, and lower levels have been associated with susceptibility to OC. Vitamin D exerts its effect through the vitamin D receptor (VDR). Common genetic variants in the VDR gene (Fok I, TaqI, BamI and ApaI) have been linked with the susceptibility to the development of OC; however, the reports remain contradictory. To draw a valid conclusion, we performed a meta-analysis of the earlier published reports in the present study. The lite...
Source: Nucleosides, Nucleotides and Nucleic Acids - January 19, 2024 Category: Biochemistry Authors: Juan Chen Chunyan Hu Guiying Chen Yi Zhang Source Type: research

Comparison of interaction between antimiR and microRNA versus HDO-antimiR and microRNA by molecular dynamics simulation
Nucleosides Nucleotides Nucleic Acids. 2024 Jan 11:1-16. doi: 10.1080/15257770.2024.2302526. Online ahead of print.ABSTRACTRecently, we found DNA/RNA heteroduplex oligonucleotide-based antimiR (HDO-antimiR) can more efficiently inhibit the target miRNA than conventional antimiR after its cellular uptake. But the mechanism of HDO-antimiR about the target-silencing is unknown. We here tried to elucidate the interaction mechanism of HDO-antimiR to miRNA using molecular dynamics (MD) simulation. When interaction of the conventional antimiR or HDO-antimiR and the target miRNA was simulated, they combined with each other in vari...
Source: Nucleosides, Nucleotides and Nucleic Acids - January 11, 2024 Category: Biochemistry Authors: Kazutaka Nishina Kotaro Yoshioka Takanori Yokota Rintaro Iwata Hara Source Type: research

Evaluation of the association COMT Val158Met variant and childhood trauma on aggression in Turkish SCZ patients
This study included 89 patients diagnosed with SCZ. Childhood Trauma Questionnaire (CTS) and Overt Aggression Scale (OAS) were used to assess childhood trauma and aggression. COMT Val158Met variant was analyzed by PCR-RFLP method from isolated DNAs.There was no statistically significant difference in comparing the COMT genotype distribution and clinical characteristics including suicide attempts, self-destructive behavior, crime history, substance, alcohol and tobacco use. When we evaluate Spearman's rank correlation coefficients between CTQ and OAS, the correlation between the OAS and CTQ scores of the patients was statis...
Source: Nucleosides, Nucleotides and Nucleic Acids - January 11, 2024 Category: Biochemistry Authors: P ınar Çetinay Aydın Yusuf Ezel Y ıldırım Ay şe Erol Ayse Feyda Nursal Ay ça Öngel Atar Yasemin Oyac ı Ye şim Ayar Sati Ki şioğlu Sacide Pehlivan Source Type: research

Integrative bioinformatics analysis reveals ECM and nicotine-related genes in both LUAD and LUSC, but different lung fibrosis-related genes are involved in LUAD and LUSC
In this study, we have combined both types of data to identify differentially expressed genes (DEGs) specific to lung cancer subtypes. We obtained six microarray datasets from the GEO and also the expression matrix of LUSC and LUAD from TCGA, which were analyzed by GEO2R tool and GEPIA2, respectively. Enrichment analyses of DEGs were performed using the Enrichr database. Protein module identification was done by MCODE plugin in cytoscape software. We identified 30 LUAD-specific, 17 LUSC-specific, and 17 DEGs shared between LUAD and LUSC. Enrichment analyses revealed that LUSC-specific DEGs are involved in lung fibrosis. In...
Source: Nucleosides, Nucleotides and Nucleic Acids - January 10, 2024 Category: Biochemistry Authors: Marzyeh Alipour Mehdi Moghanibashi Sirous Naeimi Parisa Mohamadynejad Source Type: research

< em > MMP-9 < /em > gene polymorphisms on cancer risk: an updated systematic review and meta-analysis
Nucleosides Nucleotides Nucleic Acids. 2024 Jan 3:1-24. doi: 10.1080/15257770.2023.2299710. Online ahead of print.ABSTRACTTo provide a comprehensive account of the association of MMP-9 gene polymorphisms (rs3918242) with susceptibility to cancer. A literature search for eligible candidate gene studies published before May 27, 2022 was conducted in PubMed, Medline, Google Scholar and Web of Science. Potential sources of heterogeneity were sought out across subgroups and sensitivity analysis. Publication bias were also estimated. Overall, a total of 37 articles with 7616 cases and 8165 controls for rs3918242 gene polymorphis...
Source: Nucleosides, Nucleotides and Nucleic Acids - January 3, 2024 Category: Biochemistry Authors: Zhihai Teng Song Wang Hao Yuan Hu Wang Jingdong Li Xueliang Chang Yanping Zhang Zhenwei Han Yaxuan Wang Source Type: research