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The role of miRNA134 in pathogenesis and treatment of intractable epilepsy: a review article
Nucleosides Nucleotides Nucleic Acids. 2024 Mar 26:1-16. doi: 10.1080/15257770.2024.2331046. Online ahead of print.ABSTRACTMicroRNA-134 (miRNA134) has emerged as a critical regulator in the pathogenesis of epilepsy, particularly in intractable cases resistant to conventional therapies. This review explores the multifaceted roles of miRNA134 in epileptogenesis, focusing on its influence on dendritic spine morphology and synaptic plasticity. Through its interactions with proteins such as LIM kinase 1 (LIMK1), Pumilio 2 (PUM2), and Tubby-like protein 1 (TULP1), miRNA134 modulates various molecular pathways implicated in epile...
Source: Nucleosides, Nucleotides and Nucleic Acids - March 26, 2024 Category: Biochemistry Authors: Maniya Kasaiyan Mohsen Basiri Sara Pajouhanfar Source Type: research

The critical role and functional mechanism of microRNA-146a in doxorubicin-induced apoptosis in breast cancer cells
CONCLUSION: Considering the role of doxorubicin in inducing apoptosis and increasing the expression of miR-146a, it can be suggested that this miR is involved in inducing apoptosis in BC cells. In addition, miR-146a can be considered a therapeutic candidate.PMID:38531028 | DOI:10.1080/15257770.2024.2330592 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - March 26, 2024 Category: Biochemistry Authors: Sara Tutunchi Parisa Nourmohammadi Roghayeh Tofigh Saeedeh Akhavan Mina Zare Sadra Samavarchi Tehrani Ghodratollah Panahi Source Type: research

Integrated bioinformatics analysis of ferroptosis-related gene signature in inflammation and immunity in intervertebral disc degeneration
The objective of this work was to use stringent bioinformatic techniques to clarify the crucial roles played by genes associated with ferroptosis in the emergence of IDD. For additional study, the microarray data pertinent to the IDD were acquired from the Gene Expression Omnibus database. The ferroptosis-related and IDD-related genes (FIDDRGs) were identified using a variety of bioinformatic techniques, which were also used to carry out function enrichment analysis, protein-protein correlation analysis, build the correlation regulatory network, and examine the potential connections between ferroptosis and immune abnormali...
Source: Nucleosides, Nucleotides and Nucleic Acids - March 26, 2024 Category: Biochemistry Authors: Wei Liu Hui-Min Li Guangchao Bai Source Type: research

Molecular characterization of < em > Drosophila melanogaster < /em > thymidylate kinase
This study has laid a solid foundation for future study of TMPK function in Drosophila.PMID:38518117 | DOI:10.1080/15257770.2024.2332410 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - March 22, 2024 Category: Biochemistry Authors: Junmei Hu Frisk Liya Wang Source Type: research

Causal relationship between irritability and asthma: a bidirectional two-sample Mendelian randomization study
CONCLUSION: The causal relationship between irritability and asthma was analyzed through MR analysis. Irritability increased the risk of asthma. GERD might play an important mediating role in this relationship.PMID:38506573 | DOI:10.1080/15257770.2024.2330594 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - March 20, 2024 Category: Biochemistry Authors: Xiaoying Lu Xu Hu Ling Wang Source Type: research

MiRNA-miRNA interaction network in peripheral blood of patients with myocardial infarction: a gene expression meta-analysis
Nucleosides Nucleotides Nucleic Acids. 2024 Mar 18:1-18. doi: 10.1080/15257770.2024.2330597. Online ahead of print.ABSTRACTIn recent years, investigations have revealed that microRNAs (miRNAs) can bind together and form a miRNA-miRNA-mRNA regulatory network that alters the consequence of miRNA-mRNA interaction. If we consider the miRNA that binds to mRNA as the primary miRNA and the miRNA that binds to the primary miRNA as the secondary one, secondry miRNAs can act as master regulators upstream of primary miRNAs and their target mRNAs. One of the distinguishing characteristics of secondary miRNAs as master regulators withi...
Source: Nucleosides, Nucleotides and Nucleic Acids - March 18, 2024 Category: Biochemistry Authors: Setareh Zahedian Morteza Hadizadeh Mohammad Mojtaba Farazi Saeideh Jafarinejad-Farsangi Source Type: research

Protective effect of FKBP12 on dextran sulfate sodium-induced ulcerative colitis in mice as a tacrolimus receptor
In conclusion, our study revealed that FKBP12 may act as a TAC receptor to have anti-inflammatory and protective effects on DSS-induced UC in mice, which will provide a new option for the treatment of UC.PMID:38466901 | DOI:10.1080/15257770.2024.2320817 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - March 11, 2024 Category: Biochemistry Authors: Birong Wang Tingzan Li Liqin Xu Yuxi Cai Source Type: research