The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
A convenient method for the relative and absolute quantification of lipid components in liposomes by < sup > 1 < /sup > H- and < sup > 31 < /sup > P-NMR-spectroscopy
CONCLUSION: Liposome preparations containing POPC, POPE, DOPC, DPPC, TACH, and PEG-ceramide can be reliably characterized and quantified by 1H-NMR and 31P-NMR spectroscopy at 600MHz in the μmol range.PMID:38615786 | DOI:10.1016/j.chemphyslip.2024.105395 (Source: Chemistry and Physics of Lipids)
Source: Chemistry and Physics of Lipids - April 14, 2024 Category: Lipidology Authors: Andreas H Franz Nataliya M Samoshina Vyacheslav V Samoshin Source Type: research
Comparison of structural effects of cholesterol, lanosterol, and oxysterol on phospholipid (POPC) bilayers
Chem Phys Lipids. 2024 Mar;259:105376. doi: 10.1016/j.chemphyslip.2024.105376. Epub 2024 Feb 6.ABSTRACTMembrane sterols contribute to the function of biomembranes by regulating the physical properties of the lipid bilayers. Cholesterol, a typical mammalian sterol, is biosynthesized by oxidation of lanosterol. From a molecular evolutionary perspective, lanosterol is considered the ancestral molecule of cholesterol. Here, we studied whether cholesterol is superior to lanosterol in regulating the physical properties of the lipid bilayer in terms of the structural effect on model biomembranes composed of a phospholipid. For co...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Ayumi Okayama Tatsuya Hoshino Kohei Wada Hiroshi Takahashi Source Type: research
Micelle formation of sodium taurolithocholate
This study investigated the aggregate properties of the NaTLC using surface tension measurements, light scattering, small-angle X-ray scattering (SAXS), and cryo-transmission electron microscopy (cryo-TEM). Surface tension measurement showed that the surface tension of the NaTLC solution decreased to 54 mN m-1. The concentration that showed the minimum surface tension corresponded to the critical micelle concentration (CMC: 0.6 mmol L-1, 308 K) determined by the change in light scattering intensity. On the other hand, the degree of counterion (sodium ions) binding to the micelles increased with increasing NaTLC concentrati...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Keisuke Matsuoka Rina Sekiguchi Tomokazu Yoshimura Source Type: research
Non-lamellar lyotropic liquid crystalline nanoparticles as nanocarriers for enhanced drug encapsulation of atorvastatin calcium and proanthocyanidins
Chem Phys Lipids. 2024 May;260:105377. doi: 10.1016/j.chemphyslip.2024.105377. Epub 2024 Feb 5.ABSTRACTAtorvastatin calcium (ATV) and proanthocyanidins (PAC) have a strong antioxidant activity, that can benefit to reduce the atherosclerotic plaque progression. Unfortunately, the bioavailability of ATV is greatly reduced due to its limited drug solubility while the PAC drug is unstable upon exposure to the atmospheric oxygen. Herein, the lyotropic liquid crystalline nanoparticles (LLCNPs) constructed by a binary mixture of soy phosphatidylcholine (SPC) and citric acid ester of monoglyceride (citrem) at different weight rati...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Mardhiah Maslizan Muhammad Salahuddin Haris Mokrish Ajat Siti Nurul Ain Md Jamil Shah Christirani Azhar N Idayu Zahid Intan Diana Mat Azmi Source Type: research
Comparison of structural effects of cholesterol, lanosterol, and oxysterol on phospholipid (POPC) bilayers
Chem Phys Lipids. 2024 Mar;259:105376. doi: 10.1016/j.chemphyslip.2024.105376. Epub 2024 Feb 6.ABSTRACTMembrane sterols contribute to the function of biomembranes by regulating the physical properties of the lipid bilayers. Cholesterol, a typical mammalian sterol, is biosynthesized by oxidation of lanosterol. From a molecular evolutionary perspective, lanosterol is considered the ancestral molecule of cholesterol. Here, we studied whether cholesterol is superior to lanosterol in regulating the physical properties of the lipid bilayer in terms of the structural effect on model biomembranes composed of a phospholipid. For co...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Ayumi Okayama Tatsuya Hoshino Kohei Wada Hiroshi Takahashi Source Type: research
Micelle formation of sodium taurolithocholate
This study investigated the aggregate properties of the NaTLC using surface tension measurements, light scattering, small-angle X-ray scattering (SAXS), and cryo-transmission electron microscopy (cryo-TEM). Surface tension measurement showed that the surface tension of the NaTLC solution decreased to 54 mN m-1. The concentration that showed the minimum surface tension corresponded to the critical micelle concentration (CMC: 0.6 mmol L-1, 308 K) determined by the change in light scattering intensity. On the other hand, the degree of counterion (sodium ions) binding to the micelles increased with increasing NaTLC concentrati...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Keisuke Matsuoka Rina Sekiguchi Tomokazu Yoshimura Source Type: research
Non-lamellar lyotropic liquid crystalline nanoparticles as nanocarriers for enhanced drug encapsulation of atorvastatin calcium and proanthocyanidins
Chem Phys Lipids. 2024 May;260:105377. doi: 10.1016/j.chemphyslip.2024.105377. Epub 2024 Feb 5.ABSTRACTAtorvastatin calcium (ATV) and proanthocyanidins (PAC) have a strong antioxidant activity, that can benefit to reduce the atherosclerotic plaque progression. Unfortunately, the bioavailability of ATV is greatly reduced due to its limited drug solubility while the PAC drug is unstable upon exposure to the atmospheric oxygen. Herein, the lyotropic liquid crystalline nanoparticles (LLCNPs) constructed by a binary mixture of soy phosphatidylcholine (SPC) and citric acid ester of monoglyceride (citrem) at different weight rati...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Mardhiah Maslizan Muhammad Salahuddin Haris Mokrish Ajat Siti Nurul Ain Md Jamil Shah Christirani Azhar N Idayu Zahid Intan Diana Mat Azmi Source Type: research
Comparison of structural effects of cholesterol, lanosterol, and oxysterol on phospholipid (POPC) bilayers
Chem Phys Lipids. 2024 Mar;259:105376. doi: 10.1016/j.chemphyslip.2024.105376. Epub 2024 Feb 6.ABSTRACTMembrane sterols contribute to the function of biomembranes by regulating the physical properties of the lipid bilayers. Cholesterol, a typical mammalian sterol, is biosynthesized by oxidation of lanosterol. From a molecular evolutionary perspective, lanosterol is considered the ancestral molecule of cholesterol. Here, we studied whether cholesterol is superior to lanosterol in regulating the physical properties of the lipid bilayer in terms of the structural effect on model biomembranes composed of a phospholipid. For co...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Ayumi Okayama Tatsuya Hoshino Kohei Wada Hiroshi Takahashi Source Type: research
Micelle formation of sodium taurolithocholate
This study investigated the aggregate properties of the NaTLC using surface tension measurements, light scattering, small-angle X-ray scattering (SAXS), and cryo-transmission electron microscopy (cryo-TEM). Surface tension measurement showed that the surface tension of the NaTLC solution decreased to 54 mN m-1. The concentration that showed the minimum surface tension corresponded to the critical micelle concentration (CMC: 0.6 mmol L-1, 308 K) determined by the change in light scattering intensity. On the other hand, the degree of counterion (sodium ions) binding to the micelles increased with increasing NaTLC concentrati...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Keisuke Matsuoka Rina Sekiguchi Tomokazu Yoshimura Source Type: research
Non-lamellar lyotropic liquid crystalline nanoparticles as nanocarriers for enhanced drug encapsulation of atorvastatin calcium and proanthocyanidins
Chem Phys Lipids. 2024 May;260:105377. doi: 10.1016/j.chemphyslip.2024.105377. Epub 2024 Feb 5.ABSTRACTAtorvastatin calcium (ATV) and proanthocyanidins (PAC) have a strong antioxidant activity, that can benefit to reduce the atherosclerotic plaque progression. Unfortunately, the bioavailability of ATV is greatly reduced due to its limited drug solubility while the PAC drug is unstable upon exposure to the atmospheric oxygen. Herein, the lyotropic liquid crystalline nanoparticles (LLCNPs) constructed by a binary mixture of soy phosphatidylcholine (SPC) and citric acid ester of monoglyceride (citrem) at different weight rati...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Mardhiah Maslizan Muhammad Salahuddin Haris Mokrish Ajat Siti Nurul Ain Md Jamil Shah Christirani Azhar N Idayu Zahid Intan Diana Mat Azmi Source Type: research
Comparison of structural effects of cholesterol, lanosterol, and oxysterol on phospholipid (POPC) bilayers
Chem Phys Lipids. 2024 Mar;259:105376. doi: 10.1016/j.chemphyslip.2024.105376. Epub 2024 Feb 6.ABSTRACTMembrane sterols contribute to the function of biomembranes by regulating the physical properties of the lipid bilayers. Cholesterol, a typical mammalian sterol, is biosynthesized by oxidation of lanosterol. From a molecular evolutionary perspective, lanosterol is considered the ancestral molecule of cholesterol. Here, we studied whether cholesterol is superior to lanosterol in regulating the physical properties of the lipid bilayer in terms of the structural effect on model biomembranes composed of a phospholipid. For co...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Ayumi Okayama Tatsuya Hoshino Kohei Wada Hiroshi Takahashi Source Type: research
Micelle formation of sodium taurolithocholate
This study investigated the aggregate properties of the NaTLC using surface tension measurements, light scattering, small-angle X-ray scattering (SAXS), and cryo-transmission electron microscopy (cryo-TEM). Surface tension measurement showed that the surface tension of the NaTLC solution decreased to 54 mN m-1. The concentration that showed the minimum surface tension corresponded to the critical micelle concentration (CMC: 0.6 mmol L-1, 308 K) determined by the change in light scattering intensity. On the other hand, the degree of counterion (sodium ions) binding to the micelles increased with increasing NaTLC concentrati...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Keisuke Matsuoka Rina Sekiguchi Tomokazu Yoshimura Source Type: research
Non-lamellar lyotropic liquid crystalline nanoparticles as nanocarriers for enhanced drug encapsulation of atorvastatin calcium and proanthocyanidins
Chem Phys Lipids. 2024 May;260:105377. doi: 10.1016/j.chemphyslip.2024.105377. Epub 2024 Feb 5.ABSTRACTAtorvastatin calcium (ATV) and proanthocyanidins (PAC) have a strong antioxidant activity, that can benefit to reduce the atherosclerotic plaque progression. Unfortunately, the bioavailability of ATV is greatly reduced due to its limited drug solubility while the PAC drug is unstable upon exposure to the atmospheric oxygen. Herein, the lyotropic liquid crystalline nanoparticles (LLCNPs) constructed by a binary mixture of soy phosphatidylcholine (SPC) and citric acid ester of monoglyceride (citrem) at different weight rati...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Mardhiah Maslizan Muhammad Salahuddin Haris Mokrish Ajat Siti Nurul Ain Md Jamil Shah Christirani Azhar N Idayu Zahid Intan Diana Mat Azmi Source Type: research
