NXPH4 can be used as a biomarker for pan-cancer and promotes colon cancer progression
Aging (Albany NY). 2024 Apr 12;16. doi: 10.18632/aging.205648. Online ahead of print.ABSTRACTNXPH4 promotes cancer proliferation and invasion. However, its specific role and mechanism in cancer remain unclear. Transcriptome and clinical data for pan-cancer were derived from the TCGA database. K-M survival curve and univariate Cox were used for prognostic analysis. CIBERSORT and TIMER algorithms were employed to calculate immune cell infiltration. Gene set enrichment analysis (GSEA) was employed for investigating the function of NXPH4. Western blot verified differential expression of NXPH4 in colon cancer. Functional assays...
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Zhipeng Zhang Pengfei Wang Siwen Chen Dezhi Xiang Jinzhen Chen Wanchang Huang Xiao Liu Tongwen Yi Dawei Wang Yunfei Pu Longfu He Hao Zhang Source Type: research
NXPH4 can be used as a biomarker for pan-cancer and promotes colon cancer progression
Aging (Albany NY). 2024 Apr 12;16. doi: 10.18632/aging.205648. Online ahead of print.ABSTRACTNXPH4 promotes cancer proliferation and invasion. However, its specific role and mechanism in cancer remain unclear. Transcriptome and clinical data for pan-cancer were derived from the TCGA database. K-M survival curve and univariate Cox were used for prognostic analysis. CIBERSORT and TIMER algorithms were employed to calculate immune cell infiltration. Gene set enrichment analysis (GSEA) was employed for investigating the function of NXPH4. Western blot verified differential expression of NXPH4 in colon cancer. Functional assays...
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Zhipeng Zhang Pengfei Wang Siwen Chen Dezhi Xiang Jinzhen Chen Wanchang Huang Xiao Liu Tongwen Yi Dawei Wang Yunfei Pu Longfu He Hao Zhang Source Type: research
Impact of surgical proximal and distal margins on the recurrence of resectable colon cancer: a single-center observational cohort study
ConclusionA resection margin of at least 7 cm should be maintained for patients with pT4 colon cancer. (Source: Surgery Today)
Source: Surgery Today - April 13, 2024 Category: Surgery Source Type: research
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Clin Colon Rectal Surg. 2023 Jul 19;37(3):133-139. doi: 10.1055/s-0043-1770381. eCollection 2024 May.ABSTRACTThe field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those with the highest likelihood of testing positive. In addition, we have learned that the criteria developed to determine who has the highest likelihood of testing positive are neither sensitive nor specific. As a result, the field is moving from testing only the highest risk patients id...
Source: Clinical Breast Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Lauren Gima Ilana Solomon Heather Hampel Source Type: research
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Clin Colon Rectal Surg. 2023 Jul 19;37(3):133-139. doi: 10.1055/s-0043-1770381. eCollection 2024 May.ABSTRACTThe field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those with the highest likelihood of testing positive. In addition, we have learned that the criteria developed to determine who has the highest likelihood of testing positive are neither sensitive nor specific. As a result, the field is moving from testing only the highest risk patients id...
Source: Clinical Genitourinary Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Lauren Gima Ilana Solomon Heather Hampel Source Type: research
