An arresten-derived anti-angiogenic peptide triggers apoptotic cell death in endothelial cells

CONCLUSIONS: It might be suggested that Ars induced apoptosis in endothelial cells through the mitochondrial pathway and had no effect on the cell cycle. Besides, Ars induced apoptosis significantly in vivo. However, further studies are required to confirm the detailed molecular mechanism of Ars, this peptide has the potential to be optimized for clinical translations.PMID:38622345 | DOI:10.1007/s11033-024-09448-y
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Source Type: research