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Exercise-induced cardiac mitochondrial reorganization and enhancement in spontaneously hypertensive rats
Pflugers Arch. 2024 Apr 16. doi: 10.1007/s00424-024-02956-7. Online ahead of print.ABSTRACTThe myocardium is a highly oxidative tissue in which mitochondria are essential to supply the energy required to maintain pump function. When pathological hypertrophy develops, energy consumption augments and jeopardizes mitochondrial capacity. We explored the cardiac consequences of chronic swimming training, focusing on the mitochondrial network, in spontaneously hypertensive rats (SHR). Male adult SHR were randomized to sedentary or trained (T: 8-week swimming protocol). Blood pressure and echocardiograms were recorded, and hearts...
Source: Pflugers Archiv : European Journal of Physiology - April 16, 2024 Category: Physiology Authors: Joshua Godoy Coto Erica V Pereyra Fiorella A Cavalli Carlos A Valverde Claudia I Caldiz Sabina M Mat é Alejandra M Yeves Irene L Ennis Source Type: research

Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BK < sub > Ca < /sub > channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells
In this study, using RT-qPCR, whole-cell patch clamp, and Ca2+-imaging, we uncovered several ion channels and a G protein-coupled receptor, which were regulated directly or indirectly by low extracellular pH in DAOY and UW228 medulloblastoma cells. Acidification directly activated acid-sensing ion channel 1a (ASIC1a), the proton-activated Cl- channel (PAC, ASOR, or TMEM206), and the proton-activated G protein-coupled receptor OGR1. The resulting Ca2+ signal secondarily activated the large conductance calcium-activated potassium channel (BKCa). Our analyses uncover a complex relationship of these transmembrane proteins in D...
Source: Pflugers Archiv : European Journal of Physiology - April 16, 2024 Category: Physiology Authors: Karolos-Philippos Pissas Stefan Gr ünder Yuemin Tian Source Type: research

Are you sometimes lost? Read our new Concept Articles!
Pflugers Arch. 2024 Apr 16. doi: 10.1007/s00424-024-02963-8. Online ahead of print.NO ABSTRACTPMID:38622293 | DOI:10.1007/s00424-024-02963-8 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - April 15, 2024 Category: Physiology Authors: Andreas Draguhn Armin Kurtz Source Type: research

Membrane potential dynamics of C5a-stimulated neutrophil granulocytes
Pflugers Arch. 2024 Apr 13. doi: 10.1007/s00424-024-02947-8. Online ahead of print.ABSTRACTNeutrophil granulocytes play a crucial role in host defense against invading pathogens and in inflammatory diseases. The aim of this study was to elucidate membrane potential dynamics during the initial phase of neutrophil activation and its relation to migration and production of reactive oxygen species (ROS). We performed ROS production measurements of neutrophils from healthy C57BL/6J mice after TNFα-priming and/or C5a stimulation. The actin cytoskeleton was visualized with fluorescence microscopy. Furthermore, we combined migrat...
Source: Pflugers Archiv : European Journal of Physiology - April 13, 2024 Category: Physiology Authors: Stina Becker Aljoscha Swoboda Henrik Siemer Sandra Schimmelpfennig Sarah Sargin Victor Shahin Albrecht Schwab Karolina Najder Source Type: research

Tribute to Andrea Huwiler (1966-2023)
Pflugers Arch. 2024 Apr 9. doi: 10.1007/s00424-024-02958-5. Online ahead of print.NO ABSTRACTPMID:38592461 | DOI:10.1007/s00424-024-02958-5 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - April 9, 2024 Category: Physiology Authors: Josef Pfeilschifter Erich Gulbins Source Type: research

The role of soluble adenylyl cyclase in sensing and regulating intracellular pH
Pflugers Arch. 2024 Apr;476(4):457-465. doi: 10.1007/s00424-024-02952-x. Epub 2024 Apr 6.ABSTRACTSoluble adenylyl cyclase (sAC) differs from transmembrane adenylyl cyclases (tmAC) in many aspects. In particular, the activity of sAC is not regulated by G-proteins but by the prevailing bicarbonate concentrations inside cells. Therefore, sAC serves as an exquisite intracellular pH sensor, with the capacity to translate pH changes into the regulation of localization and/or activity of cellular proteins involved in pH homeostasis. In this review, we provide an overview of literature describing the regulation of sAC activity by ...
Source: Pflugers Archiv : European Journal of Physiology - April 6, 2024 Category: Physiology Authors: Hang Lam Li Arthur Verhoeven Ronald Oude Elferink Source Type: research

Piezo1, the new actor in cell volume regulation
Pflugers Arch. 2024 Apr 6. doi: 10.1007/s00424-024-02951-y. Online ahead of print.ABSTRACTAll animal cells control their volume through a complex set of mechanisms, both to counteract osmotic perturbations of the environment and to enable numerous vital biological processes, such as proliferation, apoptosis, and migration. The ability of cells to adjust their volume depends on the activity of ion channels and transporters which, by moving K+, Na+, and Cl- ions across the plasma membrane, generate the osmotic gradient that drives water in and out of the cell. In 2010, Patapoutian's group identified a small family of evoluti...
Source: Pflugers Archiv : European Journal of Physiology - April 6, 2024 Category: Physiology Authors: A Michelucci L Catacuzzeno Source Type: research

The role of soluble adenylyl cyclase in sensing and regulating intracellular pH
Pflugers Arch. 2024 Apr 6. doi: 10.1007/s00424-024-02952-x. Online ahead of print.ABSTRACTSoluble adenylyl cyclase (sAC) differs from transmembrane adenylyl cyclases (tmAC) in many aspects. In particular, the activity of sAC is not regulated by G-proteins but by the prevailing bicarbonate concentrations inside cells. Therefore, sAC serves as an exquisite intracellular pH sensor, with the capacity to translate pH changes into the regulation of localization and/or activity of cellular proteins involved in pH homeostasis. In this review, we provide an overview of literature describing the regulation of sAC activity by bicarbo...
Source: Pflugers Archiv : European Journal of Physiology - April 6, 2024 Category: Physiology Authors: Hang Lam Li Arthur Verhoeven Ronald Oude Elferink Source Type: research

Phosphatidylserine externalization as immune checkpoint in cancer
Pflugers Arch. 2024 Apr 4. doi: 10.1007/s00424-024-02948-7. Online ahead of print.ABSTRACTCancer is the second leading cause of mortality worldwide. Despite recent advances in cancer treatment including immunotherapy with immune checkpoint inhibitors, new unconventional biomarkers and targets for the detection, prognosis, and treatment of cancer are still in high demand. Tumor cells are characterized by mutations that allow their unlimited growth, program their local microenvironment to support tumor growth, and spread towards distant sites. While a major focus has been on altered tumor genomes and proteomes, crucial signa...
Source: Pflugers Archiv : European Journal of Physiology - April 4, 2024 Category: Physiology Authors: Ivan-Maximiliano Kur Andreas Weigert Source Type: research