A review on the advances and challenges of immunotherapy for head and neck cancer
Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide. Due to the interaction of tumor cells... (Source: Cancer Cell International)
Source: Cancer Cell International - July 31, 2021 Category: Cancer & Oncology Authors: Gang Cheng, Hui Dong, Chen Yang, Yang Liu, Yi Wu, Lifen Zhu, Xiangmin Tong and Shibing Wang Tags: Review Source Type: research

Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese
WNT1-inducible signaling pathway protein 1 (WISP1) is a member of the CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression may be involved in carcinogenesis. To date, no studies h... (Source: Cancer Cell International)
Source: Cancer Cell International - July 30, 2021 Category: Cancer & Oncology Authors: Yanqiong Liu, Weijuan Qin, Fuyong Zhang, Jian Wang, Xi Li, Shan Li, Xue Qin and Yuefeng Lu Tags: Primary research Source Type: research

Analysis of therapeutic targets and prognostic biomarkers of CXC chemokines in cervical cancer microenvironment
The tumor microenvironment (TME) has received an increasing amount of attention. CXC chemokines can regulate immune cell transport and tumor cell activity to exert anti-tumor immunity. However, studies on the ... (Source: Cancer Cell International)
Source: Cancer Cell International - July 28, 2021 Category: Cancer & Oncology Authors: Weina Kong, Gang Zhao, Haixia Chen, Weina Wang, Xiaoqian Shang, Qiannan Sun, Fan Guo and Xiumin Ma Tags: Primary research Source Type: research

LncRNA HOTAIR promotes proliferation and inhibits apoptosis by sponging miR-214-3p in HPV16 positive cervical cancer cells
Cervical cancer (CC) is one of the most common gynaecological malignancies all around the world. The mechanisms of cervical carcinoma formation remain under close scrutiny. The long non-coding RNAs (lncRNA) an... (Source: Cancer Cell International)
Source: Cancer Cell International - July 28, 2021 Category: Cancer & Oncology Authors: Yu Zhou, Yuqing Wang, Mingying Lin, Daiqian Wu and Min Zhao Tags: Primary research Source Type: research

Midazolam increases cisplatin-sensitivity in non-small cell lung cancer (NSCLC) via the miR-194-5p/HOOK3 axis
As previously reported, midazolam anesthesia exerts tumor-suppressing effects in non-small cell lung cancer (NSCLC), but the regulating effects of this drug on cisplatin-resistance in NSCLC have not been studi... (Source: Cancer Cell International)
Source: Cancer Cell International - July 28, 2021 Category: Cancer & Oncology Authors: Tingting Sun, Jing Chen, Xuechao Sun and Guonian Wang Tags: Primary research Source Type: research

Expression and prognostic significance of CBX2 in colorectal cancer: database mining for CBX family members in malignancies and vitro analyses
The Chromobox (CBX) domain protein family, a core component of polycomb repressive complexes 1, is involved in transcriptional repression, cell differentiation, and program development by binding to methylated... (Source: Cancer Cell International)
Source: Cancer Cell International - July 28, 2021 Category: Cancer & Oncology Authors: He Zhou, Yong Xiong, Zuoliang Liu, Songlin Hou, Tong Zhou and Yongfu Xiong Tags: Primary research Source Type: research

Correction to: Synergism between the phosphatidylinositol 3-kinase p110 β isoform inhibitor AZD6482 and the mixed lineage kinase 3 inhibitor URMC-099 on the blockade of glioblastoma cell motility and focal adhesion formation
(Source: Cancer Cell International)
Source: Cancer Cell International - July 28, 2021 Category: Cancer & Oncology Authors: Hua ‑fu Zhao, Chang‑peng Wu, Xiu‑ming Zhou, Peng‑yu Diao, Yan‑wen Xu, Jing Liu, Jing Wang, Xian‑jian Huang, Wen‑lan Liu, Zhong‑ping Chen, Guo‑dong Huang and Wei‑ping Li Tags: Correction Source Type: research

MINDY1 promotes bladder cancer progression by stabilizing YAP
Bladder cancer is one of the most commonly diagnosed urological malignant tumor. The Hippo tumor suppressor pathway is highly conserved in mammals and plays an important role in carcinogenesis. YAP is one of m... (Source: Cancer Cell International)
Source: Cancer Cell International - July 27, 2021 Category: Cancer & Oncology Authors: Yongwen Luo, Jun Zhou, Jianing Tang, Fengfang Zhou, Zhiwen He, Tongzu Liu and Tao Liu Tags: Primary research Source Type: research

Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma
Protopine is an isoquinoline alkaloid that possesses various biological activities including the anti-tumour activity. However, the effects of protopine on liver carcinoma cells are still elusive. The aim of t... (Source: Cancer Cell International)
Source: Cancer Cell International - July 27, 2021 Category: Cancer & Oncology Authors: Chunhui Nie, Bei Wang, Baoquan Wang, Ning Lv, Rui Yu and Enfan Zhang Tags: Primary research Source Type: research

IGHG1 upregulation promoted gastric cancer malignancy via AKT/GSK-3 β/β-Catenin pathway
Despite current advances in gastric cancer treatment, disease metastasis and chemo-resistance remain as major hurdles against better overall prognosis. Previous studies indicated that IGHG1 as well as -Catenin... (Source: Cancer Cell International)
Source: Cancer Cell International - July 27, 2021 Category: Cancer & Oncology Authors: Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang and Lifeng Xie Tags: Primary research Source Type: research

A pancreas tumor derived organoid study: from drug screen to precision medicine
Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality has shown no appreciable change, ... (Source: Cancer Cell International)
Source: Cancer Cell International - July 27, 2021 Category: Cancer & Oncology Authors: Jia Yao, Man Yang, Lawrence Atteh, Pinyan Liu, Yongcui Mao, Wenbo Meng and Xun Li Tags: Review Source Type: research

Significance of initial, interim and end-of-therapy 18F-FDG PET/CT for predicting transformation risk in follicular lymphoma
Histological transformation (HT) of follicular lymphoma to a more aggressive lymphoma is a serious event affecting patients ’ outcomes. To date, no strong clinical HT predictors present at diagnosis have yet be... (Source: Cancer Cell International)
Source: Cancer Cell International - July 26, 2021 Category: Cancer & Oncology Authors: Mixue Xie, Lulu Wang, Qi Jiang, Xuxia Luo, Xin Zhao, Xueying Li, Jie Jin, Xiujin Ye and Kui Zhao Tags: Primary research Source Type: research

HOXB7 acts as an oncogenic biomarker in head and neck squamous cell carcinoma
The homeobox gene Homeobox B7 (HOXB7) is overexpressed across a range of cancers and promotes tumorigenesis through varying effects on proliferation, survival, migration and invasion. However, its expression p... (Source: Cancer Cell International)
Source: Cancer Cell International - July 24, 2021 Category: Cancer & Oncology Authors: Xiang Wu, Jin Li, Tingyuan Yan, Xueping Ke, Xin Li, Yumin Zhu, Jianrong Yang and Zhongwu Li Tags: Primary research Source Type: research

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers
Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsibl... (Source: Cancer Cell International)
Source: Cancer Cell International - July 21, 2021 Category: Cancer & Oncology Authors: Zeeshan Javed, Khushbukhat Khan, Jes ús Herrera-Bravo, Sajid Naeem, Muhammad Javed Iqbal, Haleema Sadia, Qamar Raza Qadri, Shahid Raza, Asma Irshad, Ali Akbar, Željko Reiner, Ahmed Al-Harrasi, Ahmed Al-Rawahi, Dinara Satmbekova, Monica Butnariu, Iulia C Tags: Review Source Type: research

New insights into M1/M2 macrophages: key modulators in cancer progression
Infiltration of macrophages in and around tumor nest represents one of the most crucial hallmarks during tumor progression. The mutual interactions with tumor cells and stromal microenvironment contribute to p... (Source: Cancer Cell International)
Source: Cancer Cell International - July 21, 2021 Category: Cancer & Oncology Authors: Jiuyang Liu, Xiafei Geng, Jinxuan Hou and Gaosong Wu Tags: Review Source Type: research

miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5
miR-198 is involved in the formation, migration, invasion, and metastasis of various malignant cancers. However, the function and mechanism of action of miR-198 in the tumorigenesis of renal cell carcinoma (RC... (Source: Cancer Cell International)
Source: Cancer Cell International - July 21, 2021 Category: Cancer & Oncology Authors: Chao Yuan, Zhenhong Su, Shengjie Liao, Duanzhuo Li, Zhiwen Zhou, Yawen Wang, Mingchun Quan, Lingling Zeng, Cai Lv, Chenyi Shen, Weida Gong, Jianfeng Wu, Xiaogang Chen, Wenbing Hu, Xu Lv, Wenxia Si & hellip; Tags: Primary research Source Type: research

Therapeutic potentials of resveratrol in combination with radiotherapy and chemotherapy during glioblastoma treatment: a mechanistic review
Glioblastoma, WHO grade IV astrocytoma, is the most aggressive type of brain tumors. These cancerous cells have a rapid growth rate, tendency to penetrate vital brain structures, molecular heterogeneity, etc. ... (Source: Cancer Cell International)
Source: Cancer Cell International - July 21, 2021 Category: Cancer & Oncology Authors: AmirAhmad Arabzadeh, Tohid Mortezazadeh, Tayebeh Aryafar, Esmaeil Gharepapagh, Mehrsa Majdaeen and Bagher Farhood Tags: Review Source Type: research

Long noncoding RNA FER1L4 promotes the malignant processes of papillary thyroid cancer by targeting the miR-612/ Cadherin 4 axis
This study aims ... (Source: Cancer Cell International)
Source: Cancer Cell International - July 21, 2021 Category: Cancer & Oncology Authors: Luyao Wu, Yu Ding, Houchao Tong, Xi Zhuang, Jingsheng Cai, Yan Si, Hao Zhang, Xiaoting Wang and Meiping Shen Tags: Primary research Source Type: research

The immune landscape of the microenvironment of thyroid cancer is closely related to differentiation status
We have read with great interest the article entitled “Identification of an immune-related signature indicating the dedifferentiation of thyroid cells” by Wang et al. Their data reinforce our own previous resu... (Source: Cancer Cell International)
Source: Cancer Cell International - July 20, 2021 Category: Cancer & Oncology Authors: Lucas Leite Cunha, Guilherme Augusto Barcelos Domingues, Elaine Cristina Morari, Fernando Augusto Soares, Jos é Vassallo and Laura Sterian Ward Tags: Commentary Source Type: research

Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment
Malignant tumor has become one of the major diseases that seriously endangers human health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely associated with patient prognosis. Tu... (Source: Cancer Cell International)
Source: Cancer Cell International - July 20, 2021 Category: Cancer & Oncology Authors: Yanming Luo, Shuangshuang Yin, Jia Lu, Shiyue Zhou, Yingying Shao, Xiaomei Bao, Tao Wang, Yuling Qiu and Haiyang Yu Tags: Review Source Type: research

Pseudoginsengenin DQ exerts antitumour activity against hypopharyngeal cancer cells by targeting the HIF-1 α-GLUT1 pathway
Ginsenosides have been reported to possess a variety of biological activities. Synthesized from the ginsenoside protopanaxadiol (PPD), the octanone pseudoginsengenin DQ (PDQ) may have robust pharmacological ef... (Source: Cancer Cell International)
Source: Cancer Cell International - July 19, 2021 Category: Cancer & Oncology Authors: Sanchun Wang, Yu Cai, Qingjie Feng, Jing Gao and Bo Teng Tags: Primary research Source Type: research

METTL7B is a novel prognostic biomarker of lower-grade glioma based on pan-cancer analysis
Methyltransferase-like 7B (METTL7B) is a member of the methyltransferase-like protein family that plays an important role in the development and progression of tumors. However, its prognostic value and the cor... (Source: Cancer Cell International)
Source: Cancer Cell International - July 19, 2021 Category: Cancer & Oncology Authors: Zhipeng Jiang, Wen Yin, Hecheng Zhu, Jun Tan, Youwei Guo, Zhaoqi Xin, Quanwei Zhou, Yudong Cao, Zhaoping Wu, Yirui Kuang, Can Li, Dongcheng Xie, Hailong Huang, Ming Zhao, Xingjun Jiang, Lei Wang & hellip; Tags: Primary research Source Type: research

CircFBXL5 promotes the 5-FU resistance of breast cancer via modulating miR-216b/HMGA2 axis
Circular RNAs (circRNAs) have been confirmed to be relevant to the 5-fluorouracil (5-FU) resistance of breast cancer. Nevertheless, how and whether circRNA F-box and leucine-rich repeat protein 5 (circFBXL5) r... (Source: Cancer Cell International)
Source: Cancer Cell International - July 19, 2021 Category: Cancer & Oncology Authors: Mingzhi Zhu, Yanyan Wang, Fang Wang, Lin Li and Xinguang Qiu Tags: Primary research Source Type: research

The functions and prognostic values of m6A RNA methylation regulators in thyroid carcinoma
N6-Methyladenosine (m6A) is the most common RNA modification and regulates RNA splicing, translation, translocation, and stability. Aberrant expression of m6A has been reported in various types of human cancers..... (Source: Cancer Cell International)
Source: Cancer Cell International - July 19, 2021 Category: Cancer & Oncology Authors: Zhi-Hao Yu, Shao-Ting Feng, Di Zhang, Xu-Chen Cao, Yue Yu and Xin Wang Tags: Primary research Source Type: research

β-Catenin/LEF-1 transcription complex is responsible for the transcriptional activation of LINC01278
Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating the miR-376c-3p/DNM3 axis. However, the regulation mechanism o... (Source: Cancer Cell International)
Source: Cancer Cell International - July 17, 2021 Category: Cancer & Oncology Authors: Shaojian Lin, Weiwei Zhang, Ziwen Shi, Langping Tan, Yue Zhu, Honghao Li and Xinzhi Peng Tags: Primary research Source Type: research

PODN is a prognostic biomarker and correlated with immune infiltrates in osteosarcoma
This study was aimed to identify potential ... (Source: Cancer Cell International)
Source: Cancer Cell International - July 17, 2021 Category: Cancer & Oncology Authors: Feng Yao, Zhao Feng Zhu, Jun Wen, Fu Yong Zhang, Zheng Zhang, Lun Qing Zhu, Guang Hao Su, Quan Wen Yuan, Yun Fang Zhen and Xiao Dong Wang Tags: Review Source Type: research

Circular RNA-DPP4 serves an oncogenic role in prostate cancer progression through regulating miR-195/cyclin D1 axis
Recently, more and more studies have highlighted the critical regulatory roles of circular RNAs (circRNAs), a class of non-coding RNAs, in the progression of many human cancers, including prostate cancer (PCa)... (Source: Cancer Cell International)
Source: Cancer Cell International - July 16, 2021 Category: Cancer & Oncology Authors: Deping Yang, Bo Yang, Yanjun Zhu, Qianlin Xia, Yan Zhang, Xin Zhu, Jianming Guo, Tao Ding and Jianghua Zheng Tags: Primary research Source Type: research

Identification and validation of an immune-related prognostic signature and key gene in papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer. The effect of traditional anti-tumor therapy is not ideal for the patients with recurrence, metastasis and radioiodine ... (Source: Cancer Cell International)
Source: Cancer Cell International - July 15, 2021 Category: Cancer & Oncology Authors: Rujia Qin, Chunyan Li, Xuemin Wang, Zhaoming Zhong and Chuanzheng Sun Tags: Primary research Source Type: research

Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9
This study aimed to identify novel targets in the carcinogenesis, therapy and prognosis of osteosarcoma from genomic level, together with screening ideal lead compounds with potential inhibition regarding MMP-9. (Source: Cancer Cell International)
Source: Cancer Cell International - July 14, 2021 Category: Cancer & Oncology Authors: Weihang Li, Ziyi Ding, Dong Wang, Chengfei Li, Yikai Pan, Yingjing Zhao, Hongzhe Zhao, Tianxing Lu, Rui Xu, Shilei Zhang, Bin Yuan, Yunlong Zhao, Yanjiang Yin, Yuan Gao, Jing Li and Ming Yan Tags: Primary research Source Type: research

Downregulation of tumor ‐derived exosomal miR-34c induces cancer‐associated fibroblast activation to promote cholangiocarcinoma progress
This study aimed to investigate the exact regulatory mechanisms of exosomal miR-34c in mediating communication between cholangiocarcinoma cells and fibroblasts. (Source: Cancer Cell International)
Source: Cancer Cell International - July 14, 2021 Category: Cancer & Oncology Authors: Xinglei Qin, Min Lu, Gang Li, Yajun Zhou and Zhaoyang Liu Tags: Primary research Source Type: research

Molecular mechanism study of HGF/c-MET pathway activation and immune regulation for a tumor diagnosis model
Hepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Gi... (Source: Cancer Cell International)
Source: Cancer Cell International - July 14, 2021 Category: Cancer & Oncology Authors: Zhibo Shen, Wenhua Xue, Yuanyuan Zheng, Qishun Geng, Le Wang, Zhirui Fan, Wenbin Wang, Ying Yue, Yunkai Zhai, Lifeng Li and Jie Zhao Tags: Primary research Source Type: research

JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4
Deubiquitinating enzymes (DUBs) play critical roles in various cancers by modulating functional proteins post-translationally. Previous studies have demonstrated that DUB Josephin Domain Containing 1 (JOSD1) i... (Source: Cancer Cell International)
Source: Cancer Cell International - July 14, 2021 Category: Cancer & Oncology Authors: Chao Jing, Dandan Liu, Qingchuan Lai, Linqi Li, Mengqian Zhou, Beibei Ye, Yue Wu, Hong Li, Kai Yue, Yansheng Wu, Yuansheng Duan and Xudong Wang Tags: Primary research Source Type: research

lncRNA DLEU2 promotes gastric cancer progression through ETS2 via targeting miR-30a-5p
Gastric cancer (GC) remains an important cancer worldwide. Further understanding of the molecular mechanisms of gastric carcinogenesis will enhance the diagnosis and treatment of GC. (Source: Cancer Cell International)
Source: Cancer Cell International - July 14, 2021 Category: Cancer & Oncology Authors: Shuyi Han, Yan Qi, Yihui Xu, Min Wang, Jun Wang, Jing Wang, Mingjie Yuan, Yanfei Jia, Xiaoli Ma, Yunshan Wang and Xiangdong Liu Tags: Primary research Source Type: research

New insight into long non-coding RNAs associated with bone metastasis of breast cancer based on an integrated analysis
This study aimed to explore bone metastasis-related long non-coding RNAs (lncRNAs) in breast ... (Source: Cancer Cell International)
Source: Cancer Cell International - July 13, 2021 Category: Cancer & Oncology Authors: Yu Zhang, Xiaofeng Huang, Jin Liu, Guo Chen, Chengjun Liu, Sen Zhang and Jiaxin Li Tags: Primary research Source Type: research

NCK1-AS1 promotes the progression of melanoma by accelerating cell proliferation and migration via targeting miR-526b-5p/ADAM15 axis
Long non-coding RNAs (lncRNAs) are vital regulators of gene expression and cellular processes in multiple cancers, including melanoma. Nevertheless, the function of lncRNA NCK1-antisense 1 (NCK1-AS1) in melano... (Source: Cancer Cell International)
Source: Cancer Cell International - July 12, 2021 Category: Cancer & Oncology Authors: Quan Lin, Yan Jia, Duo Zhang and Hongjuan Jin Tags: Primary research Source Type: research

Identification of differential proteomics in Epstein-Barr virus-associated gastric cancer and related functional analysis
Epstein-Barr virus-associated gastric cancer (EBVaGC) is the most common EBV-related malignancy. A comprehensive research for the protein expression patterns in EBVaGC established by high-throughput assay rema... (Source: Cancer Cell International)
Source: Cancer Cell International - July 12, 2021 Category: Cancer & Oncology Authors: Zeyang Wang, Zhi Lv, Qian Xu, Liping Sun and Yuan Yuan Tags: Primary research Source Type: research

The potential oncogenic and MLN4924-resistant effects of CSN5 on cervical cancer cells
CSN5, a member of Cop9 signalosome, is essential for protein neddylation. It has been supposed to serve as an oncogene in some cancers. However, the role of CSN5 has not been investigated in cervical cancer yet. (Source: Cancer Cell International)
Source: Cancer Cell International - July 12, 2021 Category: Cancer & Oncology Authors: Huilin Zhang, Ping He, Qing Zhou, Yan Lu and Bingjian Lu Tags: Primary research Source Type: research

PCAT6 may be a new prognostic biomarker in various cancers: a meta-analysis and bioinformatics analysis
LncRNA prostate cancer-associated transcript 6 (PCAT6) has been reported to be dysregulated in several cancers and is associated with tumor progression. Here, we have performed a meta-analysis to assess the ge... (Source: Cancer Cell International)
Source: Cancer Cell International - July 12, 2021 Category: Cancer & Oncology Authors: Song-bo Shi, Qing-hao Cheng, Shi-yi Gong, Ting-ting Lu, Shi-fang Guo, Shao-ming Song, Yu-ping Yang, Qi Cui, Ke-hu Yang and Yao-wen Qian Tags: Review Source Type: research

Relationship between PD-L1 expression, CD8+ T-cell infiltration and prognosis in intrahepatic cholangiocarcinoma patients
Programmed death- ligand 1 (PD-L1) seems to be associated with the immune escape of tumors, and immunotherapy may be a favorable treatment for PD-L1-positive patients. We evaluated intrahepatic cholangiocarcin... (Source: Cancer Cell International)
Source: Cancer Cell International - July 12, 2021 Category: Cancer & Oncology Authors: Min Deng, Shao-Hua Li, Xu Fu, Xiao-Peng Yan, Jun Chen, Yu-Dong Qiu and Rong-Ping Guo Tags: Primary research Source Type: research

Identification of methylation-driven genes prognosis signature and immune microenvironment in uterus corpus endometrial cancer
Uterus corpus endometrial cancer (UCEC) is the main malignant tumor in gynecology, with a high degree of heterogeneity, especially in terms of prognosis and immunotherapy efficacy. DNA methylation is one of th... (Source: Cancer Cell International)
Source: Cancer Cell International - July 10, 2021 Category: Cancer & Oncology Authors: JinHui Liu, ChengJian Ji, Yichun Wang, Cheng Zhang and HongJun Zhu Tags: Primary research Source Type: research

Integrative analysis the characterization of peroxiredoxins in pan-cancer
Peroxiredoxins (PRDXs) are an antioxidant enzymes protein family involved in several biological functions such as differentiation, cell growth. In addition, previous studies report that PRDXs play critical rol... (Source: Cancer Cell International)
Source: Cancer Cell International - July 10, 2021 Category: Cancer & Oncology Authors: Lei Gao, Jialin Meng, Chuang Yue, Xingyu Wu, Quanxin Su, Hao Wu, Ze Zhang, Qinzhou Yu, Shenglin Gao, Song Fan and Li Zuo Tags: Primary research Source Type: research

The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer
Exosomes are single-membrane, secreted organelles with a diameter of 30 –200 nm, containing diverse bioactive constituents, including DNAs, RNAs, proteins, and lipids, with prominent molecular heterogeneity. Ex... (Source: Cancer Cell International)
Source: Cancer Cell International - July 9, 2021 Category: Cancer & Oncology Authors: Zheng Zhao, Guiping Zhao, Shuyue Yang, Shengtao Zhu, Shutian Zhang and Peng Li Tags: Review Source Type: research

LINC00115 promotes stemness and inhibits apoptosis of ovarian cancer stem cells by upregulating SOX9 and inhibiting the Wnt/ β-catenin pathway through competitively binding to microRNA-30a
This study intended to explore the underlying roles of LINC00115 and ... (Source: Cancer Cell International)
Source: Cancer Cell International - July 8, 2021 Category: Cancer & Oncology Authors: Rui Hou and Luo Jiang Tags: Primary research Source Type: research

LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146
Growing evidence has shown that long noncoding RNA: microRNA: mRNA is implicated in tumor initiation, development, and progression. Long noncoding RNA HAND2-AS1 exhibits anti-cancer effects in diverse cancers.... (Source: Cancer Cell International)
Source: Cancer Cell International - July 8, 2021 Category: Cancer & Oncology Authors: Liping Shan, Wei Liu and Yunhong Zhan Tags: Primary research Source Type: research

Identification of autophagy-related risk signatures for the prognosis, diagnosis, and targeted therapy in cervical cancer
To rummage autophagy-related prognostic, diagnostic, and therapeutic biomarkers in cervical cancer (CC). (Source: Cancer Cell International)
Source: Cancer Cell International - July 8, 2021 Category: Cancer & Oncology Authors: Dan Meng, Hua Jin, Xing Zhang, Wenjing Yan, Qianqian Xia, Siyuan Shen, Shuqian Xie, Mengjing Cui, Bo Ding, Yun Gu and Shizhi Wang Tags: Primary research Source Type: research

Identification and validation of lncRNAs involved in m6A regulation for patients with ovarian cancer
Both N6-methyladenosine (m6A) modification and lncRNAs play an important role in the carcinogenesis and cancer inhibition of ovarian cancer (OC). However, lncRNAs involved in m6A regulation (LI-m6As) have neve... (Source: Cancer Cell International)
Source: Cancer Cell International - July 8, 2021 Category: Cancer & Oncology Authors: Jianfeng Zheng, Jialu Guo, Benben Cao, Ying Zhou and Jinyi Tong Tags: Primary research Source Type: research

Retraction Note to: Circ-DENND4C up-regulates TCF4 expression to modulate hepatocellular carcinoma cell proliferation and apoptosis via activating Wnt/ β-catenin signal pathway
(Source: Cancer Cell International)
Source: Cancer Cell International - July 7, 2021 Category: Cancer & Oncology Authors: Xialei Liu, Lewei Yang, Dong Jiang, Wuzhu Lu and Yongyu Zhang Tags: Retraction Note Source Type: research

Post treatment NLR is a predictor of response to immune checkpoint inhibitor therapy in patients with esophageal squamous cell carcinoma
In view of the fact that peripheral blood parameters have been reported as predictors of immunotherapy to various cancers, this study aimed to determine the predictors of response to anti-programmed death-1 (a... (Source: Cancer Cell International)
Source: Cancer Cell International - July 7, 2021 Category: Cancer & Oncology Authors: Xianbin Wu, Runkun Han, Yanping Zhong, Nuoqing Weng and Ao Zhang Tags: Primary research Source Type: research

Prognostic signature composed of transcription factors accurately predicts the prognosis of gastric cancer patients
Transcription factors (TFs) are involved in important molecular biological processes of tumor cells and play an essential role in the occurrence and development of gastric cancer (GC). (Source: Cancer Cell International)
Source: Cancer Cell International - July 7, 2021 Category: Cancer & Oncology Authors: Liqiang Zhou, Zhiqing Chen, You Wu, Hao Lu and Lin Xin Tags: Primary research Source Type: research

Development and clinical validation of a novel six-gene signature for accurately predicting the recurrence risk of patients with stage II/III colorectal cancer
A large number of patients with stage II/III colorectal cancer (CRC) have a high recurrence rate after radical resection. We aimed to develop a novel tool to stratify patients with different recurrence-risk fo... (Source: Cancer Cell International)
Source: Cancer Cell International - July 7, 2021 Category: Cancer & Oncology Authors: Zaoqu Liu, Taoyuan Lu, Jing Li, Libo Wang, Kaihao Xu, Qin Dang, Chunguang Guo, Long Liu, Dechao Jiao, Zhenqiang Sun and Xinwei Han Tags: Primary research Source Type: research