Immune-related gene signature for predicting the prognosis of head and neck squamous cell carcinoma
This study aimed to identify the effects of an immune-related gene signature (IRGS) that can predict t... (Source: Cancer Cell International)
Source: Cancer Cell International - January 17, 2020 Category: Cancer & Oncology Authors: Yangyang She, Xiangbo Kong, Yaping Ge, Ping Yin, Zhiyong Liu, Jieyu Chen, Feng Gao and Silian Fang Tags: Primary research Source Type: research

Correction to: The predictive value of dynamic monitoring of peripheral blood lymphocyte to monocyte ratio in patients with extranodal NK/T cell lymphoma
After publication of our article [1] it was highlighted by the authors that the type of this article was primary research, instead of review. (Source: Cancer Cell International)
Source: Cancer Cell International - January 16, 2020 Category: Cancer & Oncology Authors: Shengnan Zhang, Mengjuan Li, Fangfang Yuan, Lin Chen, Ruihua Mi, Xudong Wei, Yongping Song and Qingsong Yin Tags: Correction Source Type: research

Microsatellite instability: a review of what the oncologist should know
The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) tumors recently have been reported that can benefit from immunotherapy, and MSI can be used as a genetic instability o... (Source: Cancer Cell International)
Source: Cancer Cell International - January 13, 2020 Category: Cancer & Oncology Authors: Kai Li, Haiqing Luo, Lianfang Huang, Hui Luo and Xiao Zhu Tags: Review Source Type: research

MAP7 promotes migration and invasion and progression of human cervical cancer through modulating the autophagy
Microtubule-associated proteins 7(MAP7) was reported to be engaged into the function of neuronal function. The function of MAP7 in human cervical cancer (CC) was unknown. We aimed to uncover the function and m... (Source: Cancer Cell International)
Source: Cancer Cell International - January 13, 2020 Category: Cancer & Oncology Authors: Li Zhang, Xudong Liu, Lina Song, Hui Zhai and Chaohua Chang Tags: Primary research Source Type: research

Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis
There are different treatments for breast cancer and melanoma that mostly have some side effects. One of the therapeutic strategies is the use of natural components. Phenol components are a class of antioxidan... (Source: Cancer Cell International)
Source: Cancer Cell International - January 13, 2020 Category: Cancer & Oncology Authors: Khatereh Khorsandi, Zahra Kianmehr, Zohreh hosseinmardi and Reza Hosseinzadeh Tags: Primary research Source Type: research

CircZDHHC20 represses the proliferation, migration and invasion in trophoblast cells by miR-144/GRHL2 axis
Preeclampsia (PE) is a prevalent pregnancy disorder that has been one of the leading causes of maternal and perinatal mortality worldwide. Circular RNAs (circRNAs) have recently considered as important regulat... (Source: Cancer Cell International)
Source: Cancer Cell International - January 13, 2020 Category: Cancer & Oncology Authors: Bing Zhou, Xia Zhang, Ting Li, Rongping Xie, Jianbin Zhou, Yu Luo and Chunfen Yang Tags: Primary research Source Type: research

EphA5 knockdown enhances the invasion and migration ability of esophageal squamous cell carcinoma via epithelial-mesenchymal transition through activating Wnt/ β-catenin pathway
The erythropoietin-producing hepatocellular (Eph) receptor A5 (EphA5) has been found to be overexpressed in some malignant tumors and is associated with disease prognosis. However, the role of EphA5 in esophag... (Source: Cancer Cell International)
Source: Cancer Cell International - January 13, 2020 Category: Cancer & Oncology Authors: Rui Zhang, Jing Liu, Wei Zhang, Lei Hua, Li-Ting Qian and Shao-Bing Zhou Tags: Primary research Source Type: research

LncRNA MEG3 promotes melanoma growth, metastasis and formation through modulating miR-21/E-cadherin axis
Melanoma is the most aggressive type of skin cancer with high mortality rate and poor prognosis. lncRNA MEG3, a tumor suppressor, is closely related to the development of various cancers. However, the role of ... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2020 Category: Cancer & Oncology Authors: Liangcai Wu, Lifei Zhu, Yanchang Li, Zhixin Zheng, Xi Lin and Chaoying Yang Tags: Primary research Source Type: research

Over-expression of CDX2 alleviates breast cancer by up-regulating microRNA let-7b and inhibiting COL11A1 expression
microRNA Let-7 serves as a tumor suppressor by targeting various oncogenic pathways in cancer cells. However, the underlying mechanism of its involvement in breast cancer remains largely unknown. With our rese... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2020 Category: Cancer & Oncology Authors: Hongbin Wang, Yanlv Ren, Cheng Qian, Jiaxin Liu, Ge Li and Zhigao Li Tags: Primary research Source Type: research

Silencing of miR-17-5p suppresses cell proliferation and promotes cell apoptosis by directly targeting PIK3R1 in laryngeal squamous cell carcinoma
Increasing evidence has suggested that microRNAs (miRNAs) act as key post-transcriptional regulators in tumor progression. Previous studies have confirmed that miR-17-5p functions as an oncogene in multiple ca... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2020 Category: Cancer & Oncology Authors: Jian-Xing Wang, Xin-Ju Jia, Yan Liu, Jin-Hui Dong, Xiu-Min Ren, Ou Xu, Sheng-Hui Liu and Chun-Guang Shan Tags: Primary research Source Type: research

Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis
To evaluate the prognostic value of pretreatment lymphocyte counts with respect to clinical outcomes in patients with solid tumors. (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2020 Category: Cancer & Oncology Authors: Jiawen Zhao, Weijia Huang, Yongxian Wu, Yihuan Luo, Bo Wu, Jiwen Cheng, Junqiang Chen, Deyun Liu and Chengyang Li Tags: Primary research Source Type: research

LINC00908 negatively regulates microRNA-483-5p to increase TSPYL5 expression and inhibit the development of prostate cancer
This study aimed to explore the role of LINC00908 in prostate cancer (PCa) and its possible underlying m... (Source: Cancer Cell International)
Source: Cancer Cell International - January 9, 2020 Category: Cancer & Oncology Authors: Li Fan, Hai Li and Yun Zhang Tags: Primary research Source Type: research

Adaptor protein LNK promotes anaplastic thyroid carcinoma cell growth via 14-3-3 ε/γ binding
Rapid progression contributes to treatment failure in anaplastic thyroid carcinoma (ATC) patients. In a preliminary study, we demonstrated that some hematopoietic factors may be involved in the progression of ... (Source: Cancer Cell International)
Source: Cancer Cell International - January 9, 2020 Category: Cancer & Oncology Authors: Zhao-Ming Zhong, Xue Chen, Xiao Qi, Xue-Min Wang, Chun-Yan Li, Ru-Jia Qin, Shi-Qi Wang, Jin Liang, Mu-Sheng Zeng and Chuan-Zheng Sun Tags: Primary research Source Type: research

Long non-coding RNA TUG1 promotes cell progression in hepatocellular carcinoma via regulating miR-216b-5p/DLX2 axis
Accumulating evidence indicates that the long noncoding RNA taurine upregulated gene 1(TUG1) plays a critical role in cancer progression and metastasis. However, the overall biological role and clinical signif... (Source: Cancer Cell International)
Source: Cancer Cell International - January 7, 2020 Category: Cancer & Oncology Authors: Qun Dai, Jingyi Deng, Jinrong Zhou, Zhuhong Wang, Xiao-feng Yuan, Shunwen Pan and Hong-bin Zhang Tags: Primary research Source Type: research

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells
Aurora kinase A (AURKA) has been implicated in the regulation of cell cycle progression, mitosis and a key number of oncogenic signaling pathways in various malignancies including neuroblastoma. Small molecule... (Source: Cancer Cell International)
Source: Cancer Cell International - January 7, 2020 Category: Cancer & Oncology Authors: Yan Yang, Lili Ding, Qi Zhou, Li Fen, Yuhua Cao, Junjie Sun, Xuefeng Zhou and Aiguo Liu Tags: Primary research Source Type: research

CTLA-4 correlates with immune and clinical characteristics of glioma
CTLA-4 is a well-studied immune checkpoint protein that negatively regulates T cell-mediated immune responses. However, the expression of CTLA-4 in glioma and the effects of CTLA-4 on prognosis in patients wit... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2020 Category: Cancer & Oncology Authors: Fangkun Liu, Jing Huang, Xuming Liu, Quan Cheng, Chengke Luo and Zhixiong Liu Tags: Primary research Source Type: research

Up-regulation of circ_LARP4 suppresses cell proliferation and migration in ovarian cancer by regulating miR-513b-5p/LARP4 axis
Ovarian cancer (OC) is a common fatal malignant tumor of female reproductive system worldwide. Growing studies have proofed that circular RNAs (circRNAs) engage in the regulation of various types of cancers. H... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2020 Category: Cancer & Oncology Authors: Wumei Lin, Haiyan Ye, Keli You and Le Chen Tags: Primary research Source Type: research

LncRNA BCYRN1/miR-490-3p/POU3F2, served as a ceRNA network, is connected with worse survival rate of hepatocellular carcinoma patients and promotes tumor cell growth and metastasis
LncRNA Brain Cytoplasmic RNA 1 (BCYRN1) has been certified to modulate cancer cells growth and aggressiveness in several tumors. However, research about function of BCYRN1 in hepatocellular carcinoma (HCC) is ... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2020 Category: Cancer & Oncology Authors: Shichao Ding, Yanfeng Jin, Qingzhi Hao, Yanmeng Kang and Ruiping Ma Tags: Primary research Source Type: research

UBQLN4 promotes progression of HCC via activating wnt- β-catenin pathway and is regulated by miR-370
Ubiquilin-4 (UBQLN4) is a member of the ubiquitin –proteasome system that is usually upregulated in many tumor cells. Its overexpression has been associated with poor disease outcomes in various cancer diseases... (Source: Cancer Cell International)
Source: Cancer Cell International - January 3, 2020 Category: Cancer & Oncology Authors: Yan Yu, Penglin Xu, Guangying Cui, Xiaodong Xu, Kongfei Li, Xiaolong Chen and Jie Bao Tags: Primary research Source Type: research

TSPAN9 suppresses the chemosensitivity of gastric cancer to 5-fluorouracil by promoting autophagy
The issue of drug resistance in gastric cancer has attracted global attention. TSPAN9, a 4-transmembrane protein that plays an important role in tumor progression and signal transduction, has been found to be ... (Source: Cancer Cell International)
Source: Cancer Cell International - January 3, 2020 Category: Cancer & Oncology Authors: Yaoyue Qi, Weiwei Qi, Shihai Liu, Libin Sun, Aiping Ding, Guohong Yu, Hui Li, Yixuan Wang, Wensheng Qiu and Jing Lv Tags: Primary research Source Type: research

Patient-derived xenografts of different grade gliomas retain the heterogeneous histological and genetic features of human gliomas
Gliomas account for the major part of primary brain tumors. Based on their histology and molecular alternations, adult gliomas have been classified into four grades, each with distinct biology and outcome. Pre... (Source: Cancer Cell International)
Source: Cancer Cell International - January 3, 2020 Category: Cancer & Oncology Authors: Wenxin Zeng, Zhaohua Tang, Yongguo Li, Guangnian Yin, Zili Liu, Jie Gao, Yan Chen and Feilan Chen Tags: Primary research Source Type: research

Circ-SOX4 drives the tumorigenesis and development of lung adenocarcinoma via sponging miR-1270 and modulating PLAGL2 to activate WNT signaling pathway
Lung adenocarcinoma (LUAD), a widespread histopathological subtype of lung cancer, is deemed as a malignant tumor with a peak risk of mortality. Emerged as RNA with a loop structure that depleted protein codin... (Source: Cancer Cell International)
Source: Cancer Cell International - January 3, 2020 Category: Cancer & Oncology Authors: Nan Gao and Baoguo Ye Tags: Primary research Source Type: research

Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma
In this study, we sought to construct a high-specific and superior microRNAs si... (Source: Cancer Cell International)
Source: Cancer Cell International - December 30, 2019 Category: Cancer & Oncology Authors: Rong Ma, Yanyun Zhao, Miao He, Hongliang Zhao, Yifan Zhang, Shuqi Zhou, Mengcong Gao, Di Di, Jue Wang, Jian Ding and Minjie Wei Tags: Primary research Source Type: research

Retraction Note to: IL ‑2 augments the sorafenib‑induced apoptosis in liver cancer by promoting mitochondrial fission and activating the JNK/TAZ pathway
The editor has retracted this article [1] because Figures 2 and 4 contain duplicated and modified figures from [2 –4]. The data reported in this article are therefore unreliable. (Source: Cancer Cell International)
Source: Cancer Cell International - December 30, 2019 Category: Cancer & Oncology Authors: Xiaoyan Ding, Wei Sun and Jinglong Chen Tags: Retraction Note Source Type: research

Retraction Note to: LATS2 overexpression attenuates the therapeutic resistance of liver cancer HepG2 cells to sorafenib ‑mediated death via inhibiting the AMPK–Mfn2 signaling pathway
The editor has retracted this article [1] because Fig. 2f has been duplicated from Fig. 6j in a previously published article [2]. In addition, the article contains sections that substantially overlap with a pr... (Source: Cancer Cell International)
Source: Cancer Cell International - December 30, 2019 Category: Cancer & Oncology Authors: Jie Song, Wei Zhao, Chang Lu and Xue Shao Tags: Retraction Note Source Type: research

HAND2-AS1 inhibits invasion and metastasis of cervical cancer cells via microRNA-330-5p-mediated LDOC1
Cervical cancer is a serious disease with complicated pathogenesis and thus there is an urgent need to find novel targets for the treatment. Recently, long non-coding RNAs (lncRNAs) have emerged as critical fa... (Source: Cancer Cell International)
Source: Cancer Cell International - December 27, 2019 Category: Cancer & Oncology Authors: Shengcai Chen and Jing Wang Tags: Primary research Source Type: research

miR-100-3p inhibits cell proliferation and induces apoptosis in human gastric cancer through targeting to BMPR2
In this study, we intend to s... (Source: Cancer Cell International)
Source: Cancer Cell International - December 27, 2019 Category: Cancer & Oncology Authors: Chun-Wei Peng, Ling-Xiao Yue, Yuan-Qin Zhou, Sai Tang, Chen Kan, Lei-Ming Xia, Fan Yang and Si-Ying Wang Tags: Primary research Source Type: research

Prognostic nomograms for predicting cause-specific survival and overall survival of stage I –III colon cancer patients: a large population-based study
The purpose of this study was to build functional nomograms based on significant clinicopathological features to predict cause-specific survival (CSS) and overall survival (OS) in patients with stage I –III col... (Source: Cancer Cell International)
Source: Cancer Cell International - December 27, 2019 Category: Cancer & Oncology Authors: Zheng Zhou, Shaobo Mo, Weixing Dai, Wenqiang Xiang, Lingyu Han, Qingguo Li, Renjie Wang, Lu Liu, Long Zhang, Sanjun Cai and Guoxiang Cai Tags: Primary research Source Type: research

RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer
The DNA damage and repair pathway is considered a promising target for developing strategies against cancer. RAD51, also known as RECA, is a recombinase that performs the critical step in homologous recombinat... (Source: Cancer Cell International)
Source: Cancer Cell International - December 27, 2019 Category: Cancer & Oncology Authors: Xiaomeng Zhang, Ningyi Ma, Weiqiang Yao, Shuo Li and Zhigang Ren Tags: Primary research Source Type: research

miR-149 inhibits cell proliferation and enhances chemosensitivity by targeting CDC42 and BCL2 in neuroblastoma
Neuroblastoma (NB) is one of most common childhood tumors with high mortality among children worldwide. microRNAs (miRNAs) have been reported to play essential roles in the pathogenesis and therapeutics of NB.... (Source: Cancer Cell International)
Source: Cancer Cell International - December 27, 2019 Category: Cancer & Oncology Authors: Fengxia Mao, Ju Zhang, Xinru Cheng and Qianya Xu Tags: Primary research Source Type: research

LncRNA HCG11 promotes proliferation and migration in gastric cancer via targeting miR-1276/CTNNB1 and activating Wnt signaling pathway
Gastric cancer (GC) is one common cancer which occurs in the stomach leading to high mortality around the world. Long non-coding RNAs (lncRNAs) were found overexpressed or silenced in the occurrence and progre... (Source: Cancer Cell International)
Source: Cancer Cell International - December 26, 2019 Category: Cancer & Oncology Authors: Hua Zhang, Haitao Huang, Xiaomei Xu, Haiying Wang, Jianxiang Wang, Zuoyi Yao, Xiaoyan Xu, Qian Wu and Fenlan Xu Tags: Primary research Source Type: research

LINC00511 accelerated the process of gastric cancer by targeting miR-625-5p/NFIX axis
Gastric cancer (GC) is a common-sighted cancer which is hard to cure over the world. Substantial researches revealed that long non-coding RNAs (lncRNAs) were fundamental regulators in the process of cancers. N... (Source: Cancer Cell International)
Source: Cancer Cell International - December 26, 2019 Category: Cancer & Oncology Authors: Zhaosheng Chen, Honglei Wu, Zhen Zhang, Guangchun Li and Bin Liu Tags: Primary research Source Type: research

Comprehensive analysis of DNA methylation and gene expression profiles in cholangiocarcinoma
The incidence of cholangiocarcinoma (CCA) has risen in recent years, and it has become a significant health burden worldwide. However, the mechanisms underlying tumorigenesis and progression of this disease re... (Source: Cancer Cell International)
Source: Cancer Cell International - December 26, 2019 Category: Cancer & Oncology Authors: Cheng Zhang, Bingye Zhang, Di Meng and Chunlin Ge Tags: Primary research Source Type: research

Degradation of long non-coding RNA-CIR decelerates proliferation, invasion and migration, but promotes apoptosis of osteosarcoma cells
Over the years, long non-coding RNAs (lncRNAs) have been clarified in malignancies, this research was focused on the role of lncRNA cartilage injury-related (lncRNA-CIR) in osteosarcoma cells. (Source: Cancer Cell International)
Source: Cancer Cell International - December 23, 2019 Category: Cancer & Oncology Authors: Shiwei Liu, Jingchao Li, Liang Kang, Yueyang Tian and Yuan Xue Tags: Primary research Source Type: research

Cancer-associated fibroblast-derived exosomal microRNA-98-5p promotes cisplatin resistance in ovarian cancer by targeting CDKN1A
Ovarian cancer (OC) is a gynecological malignancy with a high mortality. Cisplatin-based treatment is the typical treatment regimen for OC patients; however, it may cause unfavorable resistance. The current st... (Source: Cancer Cell International)
Source: Cancer Cell International - December 21, 2019 Category: Cancer & Oncology Authors: Hua Guo, Chunfang Ha, Hui Dong, Zhijuan Yang, Yuan Ma and Yonghui Ding Tags: Primary research Source Type: research

Casticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase
Casticin, an isoflavone compound extracted from the herb Fructus Viticis, has demonstrated anti-inflammatory and anticancer activities and properties. The aim of this study was to investigate the effects and m... (Source: Cancer Cell International)
Source: Cancer Cell International - December 21, 2019 Category: Cancer & Oncology Authors: Jingxian Liu, Jinghong Yang, Yuhe Hou, Zhenwei Zhu, Jie He, Hao Zhao, Xidong Ye, Dengke Li, Zhaohui Wu, Zhongxi Huang, Bingtao Hao and Kaitai Yao Tags: Primary research Source Type: research

TGF- β1 stimulates epithelial–mesenchymal transition and cancer-associated myoepithelial cell during the progression from in situ to invasive breast cancer
The progression of ductal carcinoma in situ (DCIS) into invasive ductal carcinoma (IDC) is prevented by normal breast myoepithelial cells. Studies have suggested that EMT-associated genes were enriched in IDC ... (Source: Cancer Cell International)
Source: Cancer Cell International - December 19, 2019 Category: Cancer & Oncology Authors: Li Wang, Cong Xu, Xia Liu, Yang Yang, Lu Cao, Guomin Xiang, Fang Liu, Shuling Wang, Jing Liu, Qingxiang Meng, Jiao Jiao and Yun Niu Tags: Primary research Source Type: research

Hyperglycemia promotes Snail-induced epithelial –mesenchymal transition of gastric cancer via activating ENO1 expression
Gastric cancer (GC) is one of the most common gastrointestinal malignancies worldwide. Emerging evidence indicates that hyperglycemia promotes tumor progression, especially the processes of migration, invasion... (Source: Cancer Cell International)
Source: Cancer Cell International - December 19, 2019 Category: Cancer & Oncology Authors: Xin Xu, Bang Chen, Shaopu Zhu, Jiawei Zhang, Xiaobo He, Guodong Cao and Bo Chen Tags: Primary research Source Type: research

SNHG29 regulates miR-223-3p/CTNND1 axis to promote glioblastoma progression via Wnt/ β-catenin signaling pathway
Glioblastoma has been seen as the most common malignancy of brain tumor. Emerging reports has claimed that SNHG29 (LRRC75A-AS1) was involved in several biological processes via modulation of signaling pathway,... (Source: Cancer Cell International)
Source: Cancer Cell International - December 19, 2019 Category: Cancer & Oncology Authors: Lizhang Han, Zhonggang Li, Yuquan Jiang, Zheng Jiang and Ling Tang Tags: Primary research Source Type: research

AGI-134: a fully synthetic α-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 antibody in mouse melanoma models
Treatments that generate T cell-mediated immunity to a patient ’s unique neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that do not require cumbersome and individualiz... (Source: Cancer Cell International)
Source: Cancer Cell International - December 19, 2019 Category: Cancer & Oncology Authors: Stephen M. Shaw, Jenny Middleton, Kim Wigglesworth, Amber Charlemagne, Oliver Schulz, Melanie S. Glossop, Giles F. Whalen, Robert Old, Mike Westby, Chris Pickford, Rinat Tabakman, Irit Carmi-Levy, Abi Vainstein, Ella Sorani, Arik A. Zur and Sascha A. Kris Tags: Primary research Source Type: research

Sulforaphene induces apoptosis and inhibits the invasion of esophageal cancer cells through MSK2/CREB/Bcl-2 and cadherin pathway in vivo and in vitro
As a novel type of isothiocyanate derived from radish seeds from cruciferous vegetables, sulforaphene (SFE, 4-methylsufinyl-3-butenyl isothiocyanate) has various important biological effects, such as anti-oxid... (Source: Cancer Cell International)
Source: Cancer Cell International - December 19, 2019 Category: Cancer & Oncology Authors: Chengjuan Zhang, Junxia Zhang, Qiong Wu, Benling Xu, Guoguo Jin, Yan Qiao, Simin Zhao, Yang Yang, Jinwen Shang, Xiaofang Li and Kangdong Liu Tags: Primary research Source Type: research

Circulating tumor cells in precision oncology: clinical applications in liquid biopsy and 3D organoid model
Circulating tumor cells (CTCs) are a rare subset of cells found in the blood of patients with solid tumors, which function as a seed for metastases. Cancer cells metastasize through the bloodstream either as s... (Source: Cancer Cell International)
Source: Cancer Cell International - December 18, 2019 Category: Cancer & Oncology Authors: Chang Yang, Bai-Rong Xia, Wei-Lin Jin and Ge Lou Tags: Review Source Type: research

Correlations between chromobox homolog 8 and key factors of epithelial –mesenchymal transition in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, especially in China, with high metastasis and poor prognosis. Recently, as the core component of the polycomb repressive complex... (Source: Cancer Cell International)
Source: Cancer Cell International - December 17, 2019 Category: Cancer & Oncology Authors: Xiaonian Zhu, Wei Luo, Chunhua Bei, Juan Kong, Shidong Zhang, Yuanyuan Fu, Di Li and Shengkui Tan Tags: Primary research Source Type: research

Systematic analysis of gene expression profiles reveals prognostic stratification and underlying mechanisms for muscle-invasive bladder cancer
Muscle-invasive bladder cancer (MIBC) is originated in the muscle wall of the bladder, and is the ninth most common malignancy worldwide. However, there are no reliable, accurate and robust gene signatures for... (Source: Cancer Cell International)
Source: Cancer Cell International - December 16, 2019 Category: Cancer & Oncology Authors: Ping-Bao Zhang, Zi-Li Huang, Yong-Hua Xu, Jin Huang, Xin-Yu Huang and Xiu-Yan Huang Tags: Primary research Source Type: research

Circular RNA ABCB10 promotes hepatocellular carcinoma progression by increasing HMG20A expression by sponging miR-670-3p
The dysregulation of circABCB10 may play an critical role in tumor progression. However, its function in liver cancer (HCC) is still unclear. Therefore, this experimental design is based on circABCB10 to explo... (Source: Cancer Cell International)
Source: Cancer Cell International - December 16, 2019 Category: Cancer & Oncology Authors: Yu Fu, Limin Cai, Xuexue Lei and Dunwei Wang Tags: Primary research Source Type: research

Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1)
Ovarian cancer is one of the leading causes of female death worldwide, with a poor prognosis of advanced patients. Sevoflurane, a volatile anesthetic commonly used in clinical operations, has been reported to ... (Source: Cancer Cell International)
Source: Cancer Cell International - December 16, 2019 Category: Cancer & Oncology Authors: Chuanfeng Zhang, Baosheng Wang, Xiuqin Wang, Xiugui Sheng and Yongchun Cui Tags: Primary research Source Type: research

Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth
Autophagy is an evolutionarily conserved process through which cells degrade and recycle cytoplasm. The relation among autophagy, apoptosis and tumor is highly controversial until now and the molecular mechani... (Source: Cancer Cell International)
Source: Cancer Cell International - December 13, 2019 Category: Cancer & Oncology Authors: Jing Liu, Shuaiyu Long, Huanan Wang, Nannan Liu, Chuchu Zhang, Lingling Zhang and Yingjie Zhang Tags: Primary research Source Type: research

hnRNPK promotes gastric tumorigenesis through regulating CD44E alternative splicing
The high prevalence of alternative splicing among genes implies the importance of genomic complexity in regulating normal physiological processes and diseases such as gastric cancer (GC). The standard form of ... (Source: Cancer Cell International)
Source: Cancer Cell International - December 12, 2019 Category: Cancer & Oncology Authors: Wei-zhao Peng, Ji-xi Liu, Chao-feng Li, Ren Ma and Jian-zheng Jie Tags: Primary research Source Type: research

MiR-566 mediates cell migration and invasion in colon cancer cells by direct targeting of PSKH1
Colorectal cancer (CRC), a common malignancy worldwide, and microRNAs (miRs) have been suggested to play roles in the disease. MiR-566 expression has been shown to be reduced in CRC, but its functions and mech... (Source: Cancer Cell International)
Source: Cancer Cell International - December 11, 2019 Category: Cancer & Oncology Authors: Ying Zhang, Siqi Zhang, Jian Yin and Ruisi Xu Tags: Primary research Source Type: research

Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region
In this study, ... (Source: Cancer Cell International)
Source: Cancer Cell International - December 11, 2019 Category: Cancer & Oncology Authors: Abdul K. Siraj, Sandeep Kumar Parvathareddy, Rong Bu, Kaleem Iqbal, Sarah Siraj, Tariq Masoodi, Rica Micaela Concepcion, Laila Omar Ghazwani, Ismail AlBadawi, Fouad Al-Dayel and Khawla S. Al-Kuraya Tags: Primary research Source Type: research