Possible prognostic impact of PKC ι genetic variants in prostate cancer
Single nucleotide polymorphisms (SNPs) have been linked with prostate cancer (PCa) and have shown potential as prognostic markers for advanced stages. Loss of function mutations in PKC ι have been linked with i... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2024 Category: Cancer & Oncology Authors: Amna Hafeez, Maria Shabbir, Khushbukhat Khan, Janeen H. Trembley, Yasmin Badshah, Sameen Zafar, Kanza Shahid, Hania Shah, Naeem Mahmood Ashraf, Arslan Hamid, Tayyaba Afsar, Ali Almajwal, Afifa Marium and Suhail Razak Tags: Research Source Type: research
DNA mismatch repair system regulates the expression of PD-L1 through DNMTs in cervical cancer
Cervical cancer (CC) is a potential clinical application of PD-1/PD-L1 inhibitor. We aimed to study the mechanism of DNA mismatch repair (MMR) system regulating the expression of PD-L1 in CC through DNA methyl... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2024 Category: Cancer & Oncology Authors: Fan Guo, Ruijiao Lu, Weina Kong, Miyessar Anwar and Yangchun Feng Tags: Research Source Type: research
Non-coding RNAs as potential therapeutic targets for receptor tyrosine kinase signaling in solid tumors: current status and future directions
This review article presents an in-depth analysis of the current state of research on receptor tyrosine kinase regulatory non-coding RNAs (RTK-RNAs) in solid tumors. RTK-RNAs belong to a class of non-coding RN... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2024 Category: Cancer & Oncology Authors: Aysan Moeinafshar, Mohammad Nouri, Nima Shokrollahi, Mahdi Masrour, Amirmohammad Behnam, Sahand Tehrani Fateh, Hossein Sadeghi, Mohammad Miryounesi and Mohammad-Reza Ghasemi Tags: Review Source Type: research
Targeting cholesterol impairs cell invasion of all breast cancer types
Breast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose mechanism remains unclear. We recently revealed the specific contribution o... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2024 Category: Cancer & Oncology Authors: Mauriane Maja, Marie Verfaillie, Patrick Van Der Smissen, Patrick Henriet, Christophe E. Pierreux, Nor Eddine Sounni and Donatienne Tyteca Tags: Research Source Type: research
A serum panel of three microRNAs may serve as possible biomarkers for kidney renal clear cell carcinoma
Although non-invasive radiological techniques are widely applied in kidney renal clear cell carcinoma (KIRC) diagnosis, more than 50% of KIRCs are detected incidentally during the diagnostic procedures to iden... (Source: Cancer Cell International)
Source: Cancer Cell International - January 8, 2024 Category: Cancer & Oncology Authors: Zhenyu Wen, Yingqi Li, Zhengping Zhao, Rongkang Li, Xinji Li, Chong Lu, Chen Sun, Wenkang Chen, Zhenjian Ge, Liangchao Ni and Yongqing Lai Tags: Research Source Type: research
Interplay of miRNAs and lncRNAs in STAT3 signaling pathway in colorectal cancer progression
In recent decades, colorectal cancer (CRC) has turned into one of the most widespread malignancies, and the incidence of this malignancy is expected to increase. Despite considerable improvements in therapeuti... (Source: Cancer Cell International)
Source: Cancer Cell International - January 7, 2024 Category: Cancer & Oncology Authors: Omid Rahbar Farzam, Souzan Najafi, Mohammad Amini, Zohreh Rahimi, Reza Dabbaghipour, Omid Zohdi, Ghazale Asemani Shahgoli, Behzad Baradaran and Bahman Akbari Tags: Review Source Type: research
Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma
Oleanolic acid (3 β-hydroxyolean-12-en-28-oic acid, OA) is a kind of pentacyclic triterpene, which widely distributes in nature. OA possesses a powerful anti-cancer effect; however, its low solubility limits it... (Source: Cancer Cell International)
Source: Cancer Cell International - January 7, 2024 Category: Cancer & Oncology Authors: Jiaqi Wang, Chuchu Ma, Zhongyuan Tang, Zhengwu Sun, Eskandar Qaed, Xinming Chi, Jun Wang, Yazeed Jamalat, Zhaohong Geng, Zeyao Tang and Qiying Yao Tags: Research Source Type: research
Altering phosphorylation in cancer through PP2A modifiers
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase integral to the regulation of many cellular processes. Due to the deregulation of PP2A in cancer, many of these processes are turned toward promo... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Hannah Johnson, Satya Narayan and Arun K. Sharma Tags: Review Source Type: research
ROR α inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity
Glycolysis is critical for harvesting abundant energy to maintain the tumor microenvironment in malignant tumors. Retinoic acid-related orphan receptor α (RORα) has been identified as a circadian gene. However... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Xiaoshan Wang, Junyi Zhang, Yuwei Wu, Yuqing Zhang, Siyuan Zhang, Angqing Li, Jian Wang and Zhengguang Wang Tags: Research Source Type: research
Clinical applications and perspectives of circulating tumor DNA in gastric cancer
Gastric cancer remains a leading cause of cancer-related death worldwide, largely due to inadequate screening methods, late diagnosis, and limited treatment options. Liquid biopsy has emerged as a promising no... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Jing-Han Li, Dan-Ying Zhang, Ji-Min Zhu and Ling Dong Tags: Review Source Type: research
Identification of TNFRSF21 as an inhibitory factor of osteosarcoma based on a necroptosis-related prognostic gene signature and molecular experiments
Osteosarcoma is one of the most common malignant bone tumors with bad prognosis. Necroptosis is a form of programmed cell death. Recent studies showed that targeting necroptosis was a new promising approach fo... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Xiang Li, Zhenqian Sun, Jinlong Ma, Miaomiao Yang, Hongxin Cao and Guangjun Jiao Tags: Research Source Type: research
Role of long non-coding RNAs in metabolic reprogramming of gastrointestinal cancer cells
Metabolic reprogramming, which is recognized as a hallmark of cancer, refers to the phenomenon by which cancer cells change their metabolism to support their increased biosynthetic demands. Tumor cells undergo... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Kang Wang, Yan Lu, Haibin Li, Jun Zhang, Yongle Ju and Manzhao Ouyang Tags: Review Source Type: research
ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy
Despite advancements in treating metastatic melanoma, many patients exhibit resistance to targeted therapies. Our study focuses on ATP1A1, a sodium pump subunit associated with cancer development. We aimed to ... (Source: Cancer Cell International)
Source: Cancer Cell International - January 4, 2024 Category: Cancer & Oncology Authors: Laura Soumoy, Aline Genbauffe, Lena Mouchart, Alexandra Sperone, Anne Trelcat, L éa Mukeba-Harchies, Mathilde Wells, Bertrand Blankert, Ahmad Najem, Ghanem Ghanem, Sven Saussez and Fabrice Journe Tags: Research Source Type: research
Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, with a high mortality rate and poor prognosis. Mutated or dysregulated transcription factors (TFs) are significantly associated with c... (Source: Cancer Cell International)
Source: Cancer Cell International - January 4, 2024 Category: Cancer & Oncology Authors: Meixia Wang, Hanyao Guo, Bo Zhang, Yanan Shang, Sidi Zhang, Xiaoyu Liu, Pengxiu Cao, Yumei Fan and Ke Tan Tags: Research Source Type: research
Abnormal arginine synthesis confers worse prognosis in patients with middle third gastric cancer
Gastric cancer at different locations has distinct prognoses and biological behaviors, but the specific mechanism is unclear. (Source: Cancer Cell International)
Source: Cancer Cell International - January 3, 2024 Category: Cancer & Oncology Authors: Lianlian Hong, Xi Tang, Jing Han, Jiaqi Wang, Qianqian Xu and Xin Zhu Tags: Research Source Type: research
