The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target
Cancer chemoresistance is a problematic dilemma that significantly restrains numerous cancer management protocols. It can promote cancer recurrence, spreading of cancer, and finally, mortality. Accordingly, en... (Source: Cancer Cell International)
Source: Cancer Cell International - February 28, 2024 Category: Cancer & Oncology Authors: Samar Sami Alkafaas, Mohamed I. Elsalahaty, Doha F. Ismail, Mustafa Ali Radwan, Sara Samy Elkafas, Samah A. Loutfy, Rami M. Elshazli, Narjes Baazaoui, Ahmed Ezzat Ahmed, Wael Hafez, Mohanad Diab, Mohamed Sakran, Mohamed T. El-Saadony, Khaled A. El-Tarabil Tags: Review Source Type: research
Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib
Apatinib was the first anti-angiogenic agent approved for treatment of metastatic gastric cancer (GC). However, the emergence of resistance was inevitable. Thus investigating new and valuable off-target effect... (Source: Cancer Cell International)
Source: Cancer Cell International - February 24, 2024 Category: Cancer & Oncology Authors: Bei Zhang, Yan Chen, Xinqi Chen, Zhiyao Ren, Hong Xiang, Lipeng Mao and Guodong Zhu Tags: Research Source Type: research
Emerging trends in the coexistence of primary lung Cancer and hematologic malignancy: a comprehensive analysis of clinicopathological features and genetic abnormalities
This study aims to analyze clinicopathological features, g... (Source: Cancer Cell International)
Source: Cancer Cell International - February 24, 2024 Category: Cancer & Oncology Authors: Mengchen Lyu, Lifeng Luo, Ling Zhou, Xiangran Feng, Jin Yang, Ziwei Xu, Xianwen Sun, Zhiyao Bao, Xiaofei Wang, Beili Gao and Yi Xiang Tags: Research Source Type: research
SLC25A17 inhibits autophagy to promote triple-negative breast cancer tumorigenesis by ROS-mediated JAK2/STAT3 signaling pathway
SLC25A17, a peroxisomal solute carrier, has been implicated in various physiological and pathological processes. However, its precise roles and underlying mechanisms in triple-negative breast cancer (TNBC) rem... (Source: Cancer Cell International)
Source: Cancer Cell International - February 24, 2024 Category: Cancer & Oncology Authors: Haiting Zhou, Jiahao Li, Yi He, Xiaohui Xia, Junxia Liu and Huihua Xiong Tags: Research Source Type: research
ACADL-YAP axis activity in non-small cell lung cancer carcinogenicity
The role of Acyl-CoA dehydrogenase long chain (ACADL) in different tumor types had different inhibiting or promoting effect. However, its role in non-small cell lung cancer (NSCLC) carcinogenicity is not clear. (Source: Cancer Cell International)
Source: Cancer Cell International - February 24, 2024 Category: Cancer & Oncology Authors: Kegong Chen, Chunqiao Hong, Weibo Kong, Guanghua Li, Zhuang Liu, Kechao Zhu, Chen Lu, Panpan Si, Pan Gao, Guangyao Ning and Renquan Zhang Tags: Research Source Type: research
Super enhancer related gene ANP32B promotes the proliferation of acute myeloid leukemia by enhancing MYC through histone acetylation
Acute myeloid leukemia (AML) is a malignancy of the hematopoietic system, and childhood AML accounts for about 20% of pediatric leukemia. ANP32B, an important nuclear protein associated with proliferation, has... (Source: Cancer Cell International)
Source: Cancer Cell International - February 22, 2024 Category: Cancer & Oncology Authors: Xiaomei Wan, Jianwei Wang, Fang Fang, Yixin Hu, Zimu Zhang, Yanfang Tao, Yongping Zhang, Juanjuan Yu, Yumeng Wu, Bi Zhou, Hongli Yin, Li Ma, Xiaolu Li, Ran Zhuo, Wei Cheng, Shuqi Zhang & hellip; Tags: Research Source Type: research
Retraction Note: GPX8 is transcriptionally regulated by FOXC1 and promotes the growth of gastric cancer cells through activating the Wnt signaling pathway
(Source: Cancer Cell International)
Source: Cancer Cell International - February 22, 2024 Category: Cancer & Oncology Authors: Hong Chen, Lu Xu, Zhi-li Shan, Shu Chen and Hao Hu Tags: Retraction Note Source Type: research
RNA-binding proteins signature is a favorable biomarker of prognosis, immunotherapy and chemotherapy response for cervical cancer
Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) still present a huge threaten to women ’s health, especially the local advanced patients. Hence, developing more effectiveness prognostic ... (Source: Cancer Cell International)
Source: Cancer Cell International - February 21, 2024 Category: Cancer & Oncology Authors: Xiaomei Chen, Xunhu Dong, Hong Li, Tingting Wu, Haoyin Liu, Jie Wu, Wei Ge, Lingji Hao and Zhe Zhang Tags: Research Source Type: research
Signature construction and molecular subtype identification based on liver-specific genes for prediction of prognosis, immune activity, and anti-cancer drug sensitivity in hepatocellular carcinoma
Liver specific genes (LSGs) are crucial for hepatocyte differentiation and maintaining normal liver function. A deep understanding of LSGs and their heterogeneity in hepatocellular carcinoma (HCC) is necessary... (Source: Cancer Cell International)
Source: Cancer Cell International - February 19, 2024 Category: Cancer & Oncology Authors: Xiuzhi Zhang, Zhefeng Xiao, Xia Zhang, Ningning Li, Tao Sun, JinZhong Zhang, Chunyan Kang, Shasha Fan, Liping Dai and Xiaoli liu Tags: Research Source Type: research
Platycodin D2 enhances P21/CyclinA2-mediated senescence of HCC cells by regulating NIX-induced mitophagy
Hepatocellular carcinoma (HCC) cells usually show strong resistance to chemotherapy, which not only reduces the efficacy of chemotherapy but also increases the side effects. Regulation of autophagy plays an im... (Source: Cancer Cell International)
Source: Cancer Cell International - February 19, 2024 Category: Cancer & Oncology Authors: Lili Sun, Yaru Li, Renshuang Zhao, Qinlei Fan, Fei Liu, Yilong Zhu, Jicheng Han, Yunyun Liu, Ningyi Jin, Xiao Li and Yiquan Li Tags: Research Source Type: research
The clustering status of detached gastric cancer cells inhibits anoikis-induced ferroptosis to promote metastatic colonization
In this study, we aimed to investigate the potential involvement... (Source: Cancer Cell International)
Source: Cancer Cell International - February 18, 2024 Category: Cancer & Oncology Authors: Juan Sun, Jie Li, Kostas Pantopoulos, Yuqin Liu, Yixuan He, Weiming Kang and Xin Ye Tags: Research Source Type: research
Correction: A novel mechanism by which ACTA2-AS1 promotes cervical cancer progression: acting as a ceRNA of miR-143-3p to regulate SMAD3 expression
(Source: Cancer Cell International)
Source: Cancer Cell International - February 17, 2024 Category: Cancer & Oncology Authors: Lingli Luo, Min Wang, Xianping Li, Can Luo, Shan Tan, Sheng Yin, Lei Liu and Xiaolin Zhu Tags: Correction Source Type: research
RhoB expression associated with chemotherapy response and prognosis in colorectal cancer
To examine the role of RhoB expression in relation to chemotherapy response, clinical outcomes and associated signaling pathways in colorectal cancer patients. (Source: Cancer Cell International)
Source: Cancer Cell International - February 15, 2024 Category: Cancer & Oncology Authors: Maria Kopsida, Na Liu, Angeliki Kotti, Jing Wang, Lasse Jensen, Ganesan Jothimani, Camilla Hildesjo, Staffan Haapaniemi, Wen Zhong, Surajit Pathak and Xiao-Feng Sun Tags: Research Source Type: research
PLK1 phosphorylates RhoGDI1 and promotes cancer cell migration and invasion
Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1) plays an important role in diverse cellular processes by regulating Rho guanosine triphosphate (GTP)ases activity. RhoGDI1 phosphorylation regulates th... (Source: Cancer Cell International)
Source: Cancer Cell International - February 14, 2024 Category: Cancer & Oncology Authors: Jeewon Lim, Yo Sep Hwang, Hyang Ran Yoon, Jiyun Yoo, Suk Ran Yoon, Haiyoung Jung, Hee Jun Cho and Hee Gu Lee Tags: Research Source Type: research
Icariin exerts anti-tumor activity by inducing autophagy via AMPK/mTOR/ULK1 pathway in triple-negative breast cancer
Breast cancer is the most prevalent female tumor, of which triple-negative breast cancer (TNBC) accounts for about 15%. Characterized by its aggressive nature and limited treatment options, TNBC currently stan... (Source: Cancer Cell International)
Source: Cancer Cell International - February 14, 2024 Category: Cancer & Oncology Authors: Mei Zhao, Panling Xu, Wenjing Shi, Juan Wang, Ting Wang and Ping Li Tags: Research Source Type: research
