USP29 activation mediated by FUBP1 promotes AURKB stability and oncogenic functions in gastric cancer
Gastric cancer is a highly prevalent cancer type and the underlying molecular mechanisms are not fully understood. Ubiquitin-specific peptidase (USP) 29 has been suggested to regulate cell fate in several type... (Source: Cancer Cell International)
Source: Cancer Cell International - January 17, 2024 Category: Cancer & Oncology Authors: Rongfu Tu, Ye Kang, Yiwen Pan, Yanyan Da, Doudou Ren, Ru Zhang, Zeqiong Cai, Yijia Liu, Jiao Xu, Junpeng Ma, Zhiyong Zhou, Shupeng Yin, Xiaozhuang Li, Peng Zhang, Qi Zhang, Jingchao Wang & hellip; Tags: Research Source Type: research
TIPARP as a prognostic biomarker and potential immunotherapeutic target in male papillary thyroid carcinoma
Male patients with papillary thyroid carcinoma (PTC) tend to have poorer prognosis compared to females, partially attributable to a higher rate of lymph node metastasis (LNM). Developing a precise predictive m... (Source: Cancer Cell International)
Source: Cancer Cell International - January 17, 2024 Category: Cancer & Oncology Authors: Jianlin Zhang, Xumin Zhou, Fan Yao, JiaLi Zhang and Qiang Li Tags: Research Source Type: research
USP5 facilitates bladder cancer progression by stabilizing the c-Jun protein
Bladder cancer is the second most common genitourinary malignancy worldwide. The death rate of bladder cancer has increased every year. However, the molecular mechanism of bladder cancer is not sufficiently st... (Source: Cancer Cell International)
Source: Cancer Cell International - January 16, 2024 Category: Cancer & Oncology Authors: Hui-hui Zhang, An-qi Zhang, Peng Peng, Liang Huang, Cai-ying Liu, Xin-rui Nie, De-fu Hou, Xia Zhang and Shang-ze Li Tags: Research Source Type: research
Platinum-based drugs induce phenotypic alterations in nucleoli and Cajal bodies in prostate cancer cells
Platinum-based drugs are cytotoxic drugs commonly used in cancer treatment. They cause DNA damage, effects of which on chromatin and cellular responses are relatively well described. Yet, the nuclear stress re... (Source: Cancer Cell International)
Source: Cancer Cell International - January 13, 2024 Category: Cancer & Oncology Authors: Enkhzaya Batnasan, Minttu K ärkkäinen, Sonja Koivukoski, Nithin Sadeesh, Sylvain Tollis, Pekka Ruusuvuori, Mauro Scaravilli and Leena Latonen Tags: Research Source Type: research
Integrating bioinformatics and experimental validation to unveil disulfidptosis-related lncRNAs as prognostic biomarker and therapeutic target in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) stands as a prevalent malignancy globally, characterized by significant morbidity and mortality. Despite continuous advancements in the treatment of HCC, the prognosis of patient... (Source: Cancer Cell International)
Source: Cancer Cell International - January 13, 2024 Category: Cancer & Oncology Authors: Lixia Xu, Shu Chen, Qiaoqiao Li, Xinyi Chen, Yuan Xu, Yongjian Zhou, Juan Li, Zhixian Guo, Jiyuan Xing and Di Chen Tags: Research Source Type: research
What role does GPR65 play in the progression of osteosarcoma? Its mechanism and clinical significance
GPR65 is a pH-sensing G-protein-coupled receptor that acts as a key innate immune checkpoint in the human tumor microenvironment, inhibiting the release of inflammatory factors and inducing significant upregul... (Source: Cancer Cell International)
Source: Cancer Cell International - January 13, 2024 Category: Cancer & Oncology Authors: Jin Qi, Sihang Liu and Zhirui Zhang Tags: Research Source Type: research
Navigating challenges: optimising methods for primary cell culture isolation
Primary cell lines are invaluable for exploring cancer biology and investigating novel treatments. Despite their numerous advantages, primary cultures are laborious to obtain and maintain in culture. Hence, es... (Source: Cancer Cell International)
Source: Cancer Cell International - January 11, 2024 Category: Cancer & Oncology Authors: Oliwia Piwocka, Marika Musielak, Karolina Ampu ła, Igor Piotrowski, Beata Adamczyk, Magdalena Fundowicz, Wiktoria Maria Suchorska and Julian Malicki Tags: Research Source Type: research
Identification of a new gene signature for prognostic evaluation in cervical cancer: based on cuproptosis-associated angiogenesis and multi-omics analysis
In this study, a novel prognostic gene signature was discovered by utilizing cupr... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2024 Category: Cancer & Oncology Authors: Jiawen Kang, Jingwen Jiang, Xiaoqing Xiang, Yong Zhang, Jie Tang and Lesai Li Tags: Research Source Type: research
Possible prognostic impact of PKC ι genetic variants in prostate cancer
Single nucleotide polymorphisms (SNPs) have been linked with prostate cancer (PCa) and have shown potential as prognostic markers for advanced stages. Loss of function mutations in PKC ι have been linked with i... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2024 Category: Cancer & Oncology Authors: Amna Hafeez, Maria Shabbir, Khushbukhat Khan, Janeen H. Trembley, Yasmin Badshah, Sameen Zafar, Kanza Shahid, Hania Shah, Naeem Mahmood Ashraf, Arslan Hamid, Tayyaba Afsar, Ali Almajwal, Afifa Marium and Suhail Razak Tags: Research Source Type: research
DNA mismatch repair system regulates the expression of PD-L1 through DNMTs in cervical cancer
Cervical cancer (CC) is a potential clinical application of PD-1/PD-L1 inhibitor. We aimed to study the mechanism of DNA mismatch repair (MMR) system regulating the expression of PD-L1 in CC through DNA methyl... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2024 Category: Cancer & Oncology Authors: Fan Guo, Ruijiao Lu, Weina Kong, Miyessar Anwar and Yangchun Feng Tags: Research Source Type: research
Non-coding RNAs as potential therapeutic targets for receptor tyrosine kinase signaling in solid tumors: current status and future directions
This review article presents an in-depth analysis of the current state of research on receptor tyrosine kinase regulatory non-coding RNAs (RTK-RNAs) in solid tumors. RTK-RNAs belong to a class of non-coding RN... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2024 Category: Cancer & Oncology Authors: Aysan Moeinafshar, Mohammad Nouri, Nima Shokrollahi, Mahdi Masrour, Amirmohammad Behnam, Sahand Tehrani Fateh, Hossein Sadeghi, Mohammad Miryounesi and Mohammad-Reza Ghasemi Tags: Review Source Type: research
Targeting cholesterol impairs cell invasion of all breast cancer types
Breast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose mechanism remains unclear. We recently revealed the specific contribution o... (Source: Cancer Cell International)
Source: Cancer Cell International - January 10, 2024 Category: Cancer & Oncology Authors: Mauriane Maja, Marie Verfaillie, Patrick Van Der Smissen, Patrick Henriet, Christophe E. Pierreux, Nor Eddine Sounni and Donatienne Tyteca Tags: Research Source Type: research
A serum panel of three microRNAs may serve as possible biomarkers for kidney renal clear cell carcinoma
Although non-invasive radiological techniques are widely applied in kidney renal clear cell carcinoma (KIRC) diagnosis, more than 50% of KIRCs are detected incidentally during the diagnostic procedures to iden... (Source: Cancer Cell International)
Source: Cancer Cell International - January 8, 2024 Category: Cancer & Oncology Authors: Zhenyu Wen, Yingqi Li, Zhengping Zhao, Rongkang Li, Xinji Li, Chong Lu, Chen Sun, Wenkang Chen, Zhenjian Ge, Liangchao Ni and Yongqing Lai Tags: Research Source Type: research
Interplay of miRNAs and lncRNAs in STAT3 signaling pathway in colorectal cancer progression
In recent decades, colorectal cancer (CRC) has turned into one of the most widespread malignancies, and the incidence of this malignancy is expected to increase. Despite considerable improvements in therapeuti... (Source: Cancer Cell International)
Source: Cancer Cell International - January 7, 2024 Category: Cancer & Oncology Authors: Omid Rahbar Farzam, Souzan Najafi, Mohammad Amini, Zohreh Rahimi, Reza Dabbaghipour, Omid Zohdi, Ghazale Asemani Shahgoli, Behzad Baradaran and Bahman Akbari Tags: Review Source Type: research
Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma
Oleanolic acid (3 β-hydroxyolean-12-en-28-oic acid, OA) is a kind of pentacyclic triterpene, which widely distributes in nature. OA possesses a powerful anti-cancer effect; however, its low solubility limits it... (Source: Cancer Cell International)
Source: Cancer Cell International - January 7, 2024 Category: Cancer & Oncology Authors: Jiaqi Wang, Chuchu Ma, Zhongyuan Tang, Zhengwu Sun, Eskandar Qaed, Xinming Chi, Jun Wang, Yazeed Jamalat, Zhaohong Geng, Zeyao Tang and Qiying Yao Tags: Research Source Type: research
