In silico analysis of prognostic and diagnostic significance of target genes from prostate cancer cell lines derived exomicroRNAs
Cancer-secreted exovesicles are important for cell-to-cell communication by altering cancer-related signalling pathways. Exovesicles-derived miRNAs (exomiRNAs)-target genes can be useful for diagnostic and pro... (Source: Cancer Cell International)
Source: Cancer Cell International - November 17, 2023 Category: Cancer & Oncology Authors: Antonio Altuna-Coy, Xavier Ruiz-Plazas, Ver ónica Arreaza-Gil, José Segarra-Tomás and Matilde R. Chacón Tags: Research Source Type: research
Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells
Despite therapeutic advances, the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Metabolic reprogramming is increasingly recognized as a key contributor to tumor progression and t... (Source: Cancer Cell International)
Source: Cancer Cell International - November 17, 2023 Category: Cancer & Oncology Authors: Yuchuan Li, Manoj Amrutkar, Anette Vefferstad Finstadsveen, Knut Tomas Dalen, Caroline S. Verbeke and Ivar P. Gladhaug Tags: Research Source Type: research
The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection
Helicobacter pylori (H. pylori) infection is a major risk factor for gastric diseases, including gastritis and gastric cancer. Heat shock protein 60 (HSP60) is a chaperone protein involved in various cellular pro... (Source: Cancer Cell International)
Source: Cancer Cell International - November 16, 2023 Category: Cancer & Oncology Authors: Yujie Li, Hui Cao, Dewen Qiu, Nan Wang, Yan Wang, Tingting Wen, Jianjun Wang and Hong Zhu Tags: Research Source Type: research
A novel autoantibody signatures for enhanced clinical diagnosis of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease that requires precise diagnosis for effective treatment. However, the diagnostic value of carbohydrate antigen 19 − 9 (CA19-9) is limited. There... (Source: Cancer Cell International)
Source: Cancer Cell International - November 16, 2023 Category: Cancer & Oncology Authors: Tiandong Li, Junfen Xia, Huan Yun, Guiying Sun, Yajing Shen, Peng Wang, Jianxiang Shi, Keyan Wang, Hongwei Yang and Hua Ye Tags: Research Source Type: research
Circulating memory PD-1+CD8+ T cells and PD-1+CD8+T/PD-1+CD4+T cell ratio predict response and outcome to immunotherapy in advanced gastric cancer patients
Limited benefit population of immunotherapy makes it urgent to select effective biomarkers for screening appropriate treatment population. Herein, we have investigated the predictive values of circulating CD8+ T ... (Source: Cancer Cell International)
Source: Cancer Cell International - November 16, 2023 Category: Cancer & Oncology Authors: Jiang Liu, Degan Liu, Guangyin Hu, Jingjing Wang, Dadong Chen, Chuanjun Song, Yin Cai, Chentong Zhai and Wenjing Xu Tags: Research Source Type: research
Development of dendritic cell loaded MAGE-A2 long peptide; a potential target for tumor-specific T cell-mediated prostate cancer immunotherapy
Prostate cancer (PCa) is the second leading cause of cancer-related deaths among men worldwide. Immunotherapy is an emerging treatment modality for cancers that harnesses the immune system ’s ability to elimina... (Source: Cancer Cell International)
Source: Cancer Cell International - November 11, 2023 Category: Cancer & Oncology Authors: Parisa Bakhshi, Maryam Nourizadeh, Laleh Sharifi, Mohammad M. Farajollahi and Monireh Mohsenzadegan Tags: Research Source Type: research
Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering
Recent developments in sequencing technology and analytical approaches have allowed researchers to show that the healthy gut microbiome is very varied and capable of performing a wide range of tasks. The impor... (Source: Cancer Cell International)
Source: Cancer Cell International - November 11, 2023 Category: Cancer & Oncology Authors: Fatemehsadat Mousavinasab, Ronika karimi, Sima Taheri, Fatemeh Ahmadvand, Saameh Sanaaee, Sajad Najafi, Masood Soltani Halvaii, Alireza Haghgoo, Marzieh Zamany, Jamal Majidpoor, Mina Khosravifar, Mohammad Baniasadi, Mehrdad Talebi, Abolfazl Movafagh, Seye Tags: Review Source Type: research
The impact of gut bacteria producing long chain homologs of vitamin K2 on colorectal carcinogenesis
Colorectal cancer (CRC) is one of the foremost causes of cancer-related deaths. Lately, a close connection between the course of CRC and the intestinal microbiota has been revealed. Vitamin K2 (VK2) is a bacteria... (Source: Cancer Cell International)
Source: Cancer Cell International - November 10, 2023 Category: Cancer & Oncology Authors: Joanna Smajdor, Katarzyna Jedli ńska, Radosław Porada, Anna Górska-Ratusznik, Aleksandra Policht, Małgorzata Śróttek, Grażyna Więcek, Bogusław Baś and Magdalena Strus Tags: Research Source Type: research
Novel biomarker genes for the prediction of post-hepatectomy survival of patients with NAFLD-related hepatocellular carcinoma
This study aimed to identify biomarker genes for prognostic predi... (Source: Cancer Cell International)
Source: Cancer Cell International - November 10, 2023 Category: Cancer & Oncology Authors: Yuting Song, Ying Wang, Xin Geng, Xianming Wang, Huisi He, Youwen Qian, Yaping Dong, Zhecai Fan, Shuzhen Chen, Wen Wen and Hongyang Wang Tags: Research Source Type: research
Leveraging a disulfidptosis/ferroptosis-based signature to predict the prognosis of lung adenocarcinoma
Disulfidptosis and Ferroptosis are two novel forms of cell death. Although their mechanisms differ, research has shown that there is a relationship between the two. Investigating the connection between these t... (Source: Cancer Cell International)
Source: Cancer Cell International - November 9, 2023 Category: Cancer & Oncology Authors: Xiaoqing Ma, Zilin Deng, Zhen Li, Ting Ma, Guiqing Li, Cuijia Zhang, Wentao Zhang and Jin Chang Tags: Research Source Type: research
Interplay between lncRNA RP11-367G18.1 variant 2 and YY1 plays a vital role in hypoxia-mediated gene expression and tumorigenesis
The hypoxia-responsive long non-coding RNA, RP11-367G18.1, has recently been reported to induce histone 4 lysine 16 acetylation (H4K16Ac) through its variant 2; however, the underlying molecular mechanism remains... (Source: Cancer Cell International)
Source: Cancer Cell International - November 8, 2023 Category: Cancer & Oncology Authors: Pei-Hua Peng, Ji-Lin Chen, Heng-Hsiung Wu, Wen-Hao Yang, Li-Jie Lin, Joseph Chieh-Yu Lai, Jeng-Shou Chang, Jia-Ling Syu, Han-Tsang Wu, Fei-Ting Hsu, Wei-Chung Cheng and Kai-Wen Hsu Tags: Research Source Type: research
Epigenetic and metabolic reprogramming in inflammatory bowel diseases: diagnostic and prognostic biomarkers in colorectal cancer
"Inflammatory bowel disease" (IBD) is a chronic, relapsing inflammatory disease of the intestinal tract that typically begins at a young age and might transit to colorectal cancer (CRC). In this manuscript, we... (Source: Cancer Cell International)
Source: Cancer Cell International - November 7, 2023 Category: Cancer & Oncology Authors: Zeinab Deris Zayeri, Abazar Parsi, Saeid Shahrabi, Masoud Kargar, Nader Davari and Najmaldin Saki Tags: Review Source Type: research
VISTA and its ligands: the next generation of promising therapeutic targets in immunotherapy
V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel negative checkpoint receptor (NCR) primarily involved in maintaining immune tolerance. It has a role in the pathogenesis of autoimmune... (Source: Cancer Cell International)
Source: Cancer Cell International - November 7, 2023 Category: Cancer & Oncology Authors: Najibeh Shekari, Dariush Shanehbandi, Tohid Kazemi, Habib Zarredar, Behzad Baradaran and Seyed Amir Jalali Tags: Review Source Type: research
A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression
Gamma-butyrobetaine hydroxylase 1 antisense RNA 1 (BBOX1-AS1), located on human chromosome 11 p14, emerges as a critical player in tumorigenesis with diverse oncogenic effects. Aberrant expression of BBOX1-AS1... (Source: Cancer Cell International)
Source: Cancer Cell International - November 5, 2023 Category: Cancer & Oncology Authors: Juan Hu, Jipeng Liu, Siwei Zhou and Hongliang Luo Tags: Review Source Type: research
Determining the prognosis of Lung cancer from mutated genes using a deep learning survival model: a large multi-center study
Gene status has become the focus of prognosis prediction. Furthermore, deep learning has frequently been implemented in medical imaging to diagnose, prognosticate, and evaluate treatment responses in patients ... (Source: Cancer Cell International)
Source: Cancer Cell International - November 4, 2023 Category: Cancer & Oncology Authors: Jie Peng, Lushan Xiao, Hongbo Zhu, Lijie Han and Honglian Ma Tags: Research Source Type: research
