Interplay of miRNAs and lncRNAs in STAT3 signaling pathway in colorectal cancer progression
In recent decades, colorectal cancer (CRC) has turned into one of the most widespread malignancies, and the incidence of this malignancy is expected to increase. Despite considerable improvements in therapeuti... (Source: Cancer Cell International)
Source: Cancer Cell International - January 7, 2024 Category: Cancer & Oncology Authors: Omid Rahbar Farzam, Souzan Najafi, Mohammad Amini, Zohreh Rahimi, Reza Dabbaghipour, Omid Zohdi, Ghazale Asemani Shahgoli, Behzad Baradaran and Bahman Akbari Tags: Review Source Type: research
Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma
Oleanolic acid (3 β-hydroxyolean-12-en-28-oic acid, OA) is a kind of pentacyclic triterpene, which widely distributes in nature. OA possesses a powerful anti-cancer effect; however, its low solubility limits it... (Source: Cancer Cell International)
Source: Cancer Cell International - January 7, 2024 Category: Cancer & Oncology Authors: Jiaqi Wang, Chuchu Ma, Zhongyuan Tang, Zhengwu Sun, Eskandar Qaed, Xinming Chi, Jun Wang, Yazeed Jamalat, Zhaohong Geng, Zeyao Tang and Qiying Yao Tags: Research Source Type: research
Altering phosphorylation in cancer through PP2A modifiers
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase integral to the regulation of many cellular processes. Due to the deregulation of PP2A in cancer, many of these processes are turned toward promo... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Hannah Johnson, Satya Narayan and Arun K. Sharma Tags: Review Source Type: research
ROR α inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity
Glycolysis is critical for harvesting abundant energy to maintain the tumor microenvironment in malignant tumors. Retinoic acid-related orphan receptor α (RORα) has been identified as a circadian gene. However... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Xiaoshan Wang, Junyi Zhang, Yuwei Wu, Yuqing Zhang, Siyuan Zhang, Angqing Li, Jian Wang and Zhengguang Wang Tags: Research Source Type: research
Clinical applications and perspectives of circulating tumor DNA in gastric cancer
Gastric cancer remains a leading cause of cancer-related death worldwide, largely due to inadequate screening methods, late diagnosis, and limited treatment options. Liquid biopsy has emerged as a promising no... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Jing-Han Li, Dan-Ying Zhang, Ji-Min Zhu and Ling Dong Tags: Review Source Type: research
Identification of TNFRSF21 as an inhibitory factor of osteosarcoma based on a necroptosis-related prognostic gene signature and molecular experiments
Osteosarcoma is one of the most common malignant bone tumors with bad prognosis. Necroptosis is a form of programmed cell death. Recent studies showed that targeting necroptosis was a new promising approach fo... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Xiang Li, Zhenqian Sun, Jinlong Ma, Miaomiao Yang, Hongxin Cao and Guangjun Jiao Tags: Research Source Type: research
Role of long non-coding RNAs in metabolic reprogramming of gastrointestinal cancer cells
Metabolic reprogramming, which is recognized as a hallmark of cancer, refers to the phenomenon by which cancer cells change their metabolism to support their increased biosynthetic demands. Tumor cells undergo... (Source: Cancer Cell International)
Source: Cancer Cell International - January 6, 2024 Category: Cancer & Oncology Authors: Kang Wang, Yan Lu, Haibin Li, Jun Zhang, Yongle Ju and Manzhao Ouyang Tags: Review Source Type: research
ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy
Despite advancements in treating metastatic melanoma, many patients exhibit resistance to targeted therapies. Our study focuses on ATP1A1, a sodium pump subunit associated with cancer development. We aimed to ... (Source: Cancer Cell International)
Source: Cancer Cell International - January 4, 2024 Category: Cancer & Oncology Authors: Laura Soumoy, Aline Genbauffe, Lena Mouchart, Alexandra Sperone, Anne Trelcat, L éa Mukeba-Harchies, Mathilde Wells, Bertrand Blankert, Ahmad Najem, Ghanem Ghanem, Sven Saussez and Fabrice Journe Tags: Research Source Type: research
Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, with a high mortality rate and poor prognosis. Mutated or dysregulated transcription factors (TFs) are significantly associated with c... (Source: Cancer Cell International)
Source: Cancer Cell International - January 4, 2024 Category: Cancer & Oncology Authors: Meixia Wang, Hanyao Guo, Bo Zhang, Yanan Shang, Sidi Zhang, Xiaoyu Liu, Pengxiu Cao, Yumei Fan and Ke Tan Tags: Research Source Type: research
Abnormal arginine synthesis confers worse prognosis in patients with middle third gastric cancer
Gastric cancer at different locations has distinct prognoses and biological behaviors, but the specific mechanism is unclear. (Source: Cancer Cell International)
Source: Cancer Cell International - January 3, 2024 Category: Cancer & Oncology Authors: Lianlian Hong, Xi Tang, Jing Han, Jiaqi Wang, Qianqian Xu and Xin Zhu Tags: Research Source Type: research
KCNA1 promotes the growth and invasion of glioblastoma cells through ferroptosis inhibition via upregulating SLC7A11
This study aimed to investigate the role of KCNA1 in GBM progression. (Source: Cancer Cell International)
Source: Cancer Cell International - January 3, 2024 Category: Cancer & Oncology Authors: Weichao Wang, Yang Zhang, Xuetao Li, Qinzi E, Zuoyu Jiang, Qikun Shi, Yu Huang, Jian Wang and Yulun Huang Tags: Research Source Type: research
Development and validation of a disulfidptosis and disulfide metabolism-related risk index for predicting prognosis in lung adenocarcinoma
Disulfidptosis is a recently proposed novel cell death mode in which cells with high SLC7A11 expression induce disulfide stress and cell death in response to glucose deficiency. The purpose of the research was to... (Source: Cancer Cell International)
Source: Cancer Cell International - January 2, 2024 Category: Cancer & Oncology Authors: Leqi Zhong, Wuguang Chang, Bin Luo, Wuyou Gao, Huanhuan He, Mouxiang Fang, Hongmu Li, Zhesheng Wen and Youfang Chen Tags: Research Source Type: research
TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC)
This study aimed to explore the potential snoRNAs in TEP as biomarkers for dia... (Source: Cancer Cell International)
Source: Cancer Cell International - January 2, 2024 Category: Cancer & Oncology Authors: Xuan Zhao, Guanxuan Chen, Yawen Wu, Xiao Li, Zhe Zhang, Li Xie, Xianrang Song and Xingguo Song Tags: Research Source Type: research
LncRNA FOXD1-AS1 regulates pancreatic cancer stem cell properties and 5-FU resistance by regulating the miR-570-3p/SPP1 axis as a ceRNA
Cancer stem cells (CSCs) play a pivotal role in the pathogenesis of human cancers. Previous studies have highlighted the role of long non-coding RNA (lncRNA) in modulating the stemness of CSCs. In our investig... (Source: Cancer Cell International)
Source: Cancer Cell International - January 2, 2024 Category: Cancer & Oncology Authors: Liu Ouyang, Min-min Sun, Ping-sheng Zhou, Yi-wei Ren, Xin-yu Liu, Wan-ying Wei, Zhen-shun Song, Kai Lu and Li-xue Yang Tags: Research Source Type: research
PDGF-BB accelerates TSCC via fibroblast lactates limiting miR-26a-5p and boosting mitophagy
The tumor microenvironment and cancer-associated fibroblasts (CAFs) play crucial roles in tumor development, and their metabolic coupling remains unclear. Clinical data showed a positive correlation between PD... (Source: Cancer Cell International)
Source: Cancer Cell International - January 2, 2024 Category: Cancer & Oncology Authors: Jianguo Xu, Li Bian, Dingyun You, Ziliang Li, Tingting Wang, Yiting Li, Xiaobin Ren and Yongwen He Tags: Research Source Type: research
