A cuproptosis-related gene expression signature predicting clinical prognosis and immune responses in intrahepatic cholangiocarcinoma detected by single-cell RNA sequence analysis
Cholangiocarcinoma represents a malignant neoplasm originating from the hepatobiliary tree, with a subset of tumors developing inside the liver. Intrahepatic cholangiocarcinomas (ICC) commonly exhibit an asymp... (Source: Cancer Cell International)
Source: Cancer Cell International - March 2, 2024 Category: Cancer & Oncology Authors: Hefei Ren, Chang Liu, Cheng Zhang, Hongkun Wu, Jiafeng Zhang, Zhenhua Wang, Lei Chen, Huiquan Wang, Chenghao Shao and Lin Zhou Tags: Research Source Type: research
RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway
Novel therapeutic targets are urgently needed for treating drug-resistant non-small cell lung cancer (NSCLC) and overcoming drug resistance to molecular-targeted therapies. Regulator of G protein signaling 20 ... (Source: Cancer Cell International)
Source: Cancer Cell International - March 2, 2024 Category: Cancer & Oncology Authors: Xiaoyan Ding, Xiaoxia Li, Yanxia Jiang, Yujun Li, Hong Li, Lipeng Shang, Guilin Feng, Huhu Zhang, Ziyuan Xu, Lina Yang, Bing Li and Robert Chunhua Zhao Tags: Research Source Type: research
Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways
Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, includi... (Source: Cancer Cell International)
Source: Cancer Cell International - March 2, 2024 Category: Cancer & Oncology Authors: Hadeel Kheraldine, Ishita Gupta, Farhan Sachal Cyprian, Semir Vranic, Halema F. Al-Farsi, Maysaloun Merhi, Said Dermime and Ala-Eddin Al Moustafa Tags: Research Source Type: research
PPP2R1B abolishes colorectal cancer liver metastasis and sensitizes Oxaliplatin by inhibiting MAPK/ERK signaling pathway
Patients with colorectal cancer (CRC) with liver metastasis or drug resistance have a poor prognosis. Previous research has demonstrated that PPP2R1B inactivation results in the development of CRC. However, th... (Source: Cancer Cell International)
Source: Cancer Cell International - March 1, 2024 Category: Cancer & Oncology Authors: Wei Liu, Jingtong Tang, Wei Gao, Jian Sun, Gang Liu and Jianping Zhou Tags: Research Source Type: research
The circRNA hsa-circ-0013561 regulates head and neck squamous cell carcinoma development via the miR-7-5p/PDK3 axis
Circular RNAs (circRNAs) belong to a class of covalently closed single stranded RNAs that have been implicated in cancer progression. Former investigations showed that hsa-circ-0013561 is abnormally expressed ... (Source: Cancer Cell International)
Source: Cancer Cell International - March 1, 2024 Category: Cancer & Oncology Authors: Kaisai Tian, Liying Zheng, Tailei Yuan, Xiaoping Chen, Qun Chen, Xiaocheng Xue, Shuixian Huang, Weining He, Mingming Jin and Yi Zhang Tags: Research Source Type: research
LASS2 suppresses metastasis in multiple cancers by regulating the ferroptosis signalling pathway through interaction with TFRC
As a key enzyme in ceramide synthesis, longevity assurance homologue 2 (LASS2) has been indicated to act as a tumour suppressor in a variety of cancers. Ferroptosis is involved in a variety of tumour processes... (Source: Cancer Cell International)
Source: Cancer Cell International - February 28, 2024 Category: Cancer & Oncology Authors: Yunfei Huang, Jie Du, Dan Li, Wei He, Zhouheng Liu, Li Liu, Xiaoli Yang, Xiaoming Cheng, Rui Chen and Yan Yang Tags: Research Source Type: research
Dormancy of cutaneous melanoma
Many cancer-related deaths including melanoma result from metastases that develop months or years after the initial cancer therapy. Even the most effective drugs and immune therapies rarely eradicate all tumor... (Source: Cancer Cell International)
Source: Cancer Cell International - February 28, 2024 Category: Cancer & Oncology Authors: Kathrin Singvogel and Birgit Schittek Tags: Review Source Type: research
The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target
Cancer chemoresistance is a problematic dilemma that significantly restrains numerous cancer management protocols. It can promote cancer recurrence, spreading of cancer, and finally, mortality. Accordingly, en... (Source: Cancer Cell International)
Source: Cancer Cell International - February 28, 2024 Category: Cancer & Oncology Authors: Samar Sami Alkafaas, Mohamed I. Elsalahaty, Doha F. Ismail, Mustafa Ali Radwan, Sara Samy Elkafas, Samah A. Loutfy, Rami M. Elshazli, Narjes Baazaoui, Ahmed Ezzat Ahmed, Wael Hafez, Mohanad Diab, Mohamed Sakran, Mohamed T. El-Saadony, Khaled A. El-Tarabil Tags: Review Source Type: research
Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib
Apatinib was the first anti-angiogenic agent approved for treatment of metastatic gastric cancer (GC). However, the emergence of resistance was inevitable. Thus investigating new and valuable off-target effect... (Source: Cancer Cell International)
Source: Cancer Cell International - February 24, 2024 Category: Cancer & Oncology Authors: Bei Zhang, Yan Chen, Xinqi Chen, Zhiyao Ren, Hong Xiang, Lipeng Mao and Guodong Zhu Tags: Research Source Type: research
Emerging trends in the coexistence of primary lung Cancer and hematologic malignancy: a comprehensive analysis of clinicopathological features and genetic abnormalities
This study aims to analyze clinicopathological features, g... (Source: Cancer Cell International)
Source: Cancer Cell International - February 24, 2024 Category: Cancer & Oncology Authors: Mengchen Lyu, Lifeng Luo, Ling Zhou, Xiangran Feng, Jin Yang, Ziwei Xu, Xianwen Sun, Zhiyao Bao, Xiaofei Wang, Beili Gao and Yi Xiang Tags: Research Source Type: research
SLC25A17 inhibits autophagy to promote triple-negative breast cancer tumorigenesis by ROS-mediated JAK2/STAT3 signaling pathway
SLC25A17, a peroxisomal solute carrier, has been implicated in various physiological and pathological processes. However, its precise roles and underlying mechanisms in triple-negative breast cancer (TNBC) rem... (Source: Cancer Cell International)
Source: Cancer Cell International - February 24, 2024 Category: Cancer & Oncology Authors: Haiting Zhou, Jiahao Li, Yi He, Xiaohui Xia, Junxia Liu and Huihua Xiong Tags: Research Source Type: research
ACADL-YAP axis activity in non-small cell lung cancer carcinogenicity
The role of Acyl-CoA dehydrogenase long chain (ACADL) in different tumor types had different inhibiting or promoting effect. However, its role in non-small cell lung cancer (NSCLC) carcinogenicity is not clear. (Source: Cancer Cell International)
Source: Cancer Cell International - February 24, 2024 Category: Cancer & Oncology Authors: Kegong Chen, Chunqiao Hong, Weibo Kong, Guanghua Li, Zhuang Liu, Kechao Zhu, Chen Lu, Panpan Si, Pan Gao, Guangyao Ning and Renquan Zhang Tags: Research Source Type: research
Super enhancer related gene ANP32B promotes the proliferation of acute myeloid leukemia by enhancing MYC through histone acetylation
Acute myeloid leukemia (AML) is a malignancy of the hematopoietic system, and childhood AML accounts for about 20% of pediatric leukemia. ANP32B, an important nuclear protein associated with proliferation, has... (Source: Cancer Cell International)
Source: Cancer Cell International - February 22, 2024 Category: Cancer & Oncology Authors: Xiaomei Wan, Jianwei Wang, Fang Fang, Yixin Hu, Zimu Zhang, Yanfang Tao, Yongping Zhang, Juanjuan Yu, Yumeng Wu, Bi Zhou, Hongli Yin, Li Ma, Xiaolu Li, Ran Zhuo, Wei Cheng, Shuqi Zhang & hellip; Tags: Research Source Type: research
Retraction Note: GPX8 is transcriptionally regulated by FOXC1 and promotes the growth of gastric cancer cells through activating the Wnt signaling pathway
(Source: Cancer Cell International)
Source: Cancer Cell International - February 22, 2024 Category: Cancer & Oncology Authors: Hong Chen, Lu Xu, Zhi-li Shan, Shu Chen and Hao Hu Tags: Retraction Note Source Type: research
RNA-binding proteins signature is a favorable biomarker of prognosis, immunotherapy and chemotherapy response for cervical cancer
Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) still present a huge threaten to women ’s health, especially the local advanced patients. Hence, developing more effectiveness prognostic ... (Source: Cancer Cell International)
Source: Cancer Cell International - February 21, 2024 Category: Cancer & Oncology Authors: Xiaomei Chen, Xunhu Dong, Hong Li, Tingting Wu, Haoyin Liu, Jie Wu, Wei Ge, Lingji Hao and Zhe Zhang Tags: Research Source Type: research
