Serum exosomal hsa-circ-0004771 modulates the resistance of colorectal cancer to 5-fluorouracil via regulating miR-653/ZEB2 signaling pathway
Drug resistance is a major obstacle causing chemotherapy failure, and enabling cancer progression. Exosome excreted by cancer cells is participated in cancer progression and chemoresistance, and can be used as... (Source: Cancer Cell International)
Source: Cancer Cell International - October 16, 2023 Category: Cancer & Oncology Authors: Xiao-Xue Qiao, Hui-Bo Shi and Li Xiao Tags: Research Source Type: research
Epigallocatechin-3-gallate and cancer: focus on the role of microRNAs
MicroRNAs (miRNAs) are a group of small non-coding RNAs that affect gene expression. The role of miRNAs in different types of cancers has been published and it was shown that several miRNAs are inappropriately... (Source: Cancer Cell International)
Source: Cancer Cell International - October 14, 2023 Category: Cancer & Oncology Authors: Chunguang Wang, Meiling Bai, Zhiguang Sun, Nan Yao, Aiting Zhang, Shengyu Guo and Zatollah Asemi Tags: Review Source Type: research
EGCG inhibits the inflammation and senescence inducing properties of MDA-MB-231 triple-negative breast cancer (TNBC) cells-derived extracellular vesicles in human adipose-derived mesenchymal stem cells
Triple-negative breast cancer (TNBC) cells ’ secretome can induce a pro-inflammatory phenotype in human adipose-derived mesenchymal stem cells (hADMSC). This can be prevented by the green tea polyphenol epigall... (Source: Cancer Cell International)
Source: Cancer Cell International - October 13, 2023 Category: Cancer & Oncology Authors: Narjara Gonzalez Suarez, Yuniel Fernandez-Marrero, Mathieu P. A. H ébert, Marie-Eve Roy, Luc H. Boudreau and Borhane Annabi Tags: Research Source Type: research
Urinary biomarkers for hepatocellular carcinoma: current knowledge for clinicians
Hepatocellular carcinoma (HCC) is the most predominant primary liver cancer, causing many illnesses and deaths worldwide. The insidious clinical presentation, difficulty in early diagnosis, and the highly mali... (Source: Cancer Cell International)
Source: Cancer Cell International - October 13, 2023 Category: Cancer & Oncology Authors: Kaige Deng, Jiali Xing, Gang Xu, Bao Jin, Xueshuai Wan, Yongchang Zheng, Shunda Du and Xinting Sang Tags: Review Source Type: research
AP4M1 as a prognostic biomarker associated with cell proliferation, migration and immune regulation in hepatocellular carcinoma
AP4M1 is a protein-coding gene that plays a crucial role in transporter activity, recognition, and hereditary-associated diseases, but it ’s largely unknown in cancers. (Source: Cancer Cell International)
Source: Cancer Cell International - October 11, 2023 Category: Cancer & Oncology Authors: Yuanhao Peng, Xuanxuan Li, Kuo Kang and Yangying Zhou Tags: Research Source Type: research
Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in breast cancer among Indian population
Breast cancer (BC) is the most common malignancy with very high incidence and relatively high mortality in women. The PIK3CA gene plays a pivotal role in the pathogenicity of breast cancer. Despite this, the m... (Source: Cancer Cell International)
Source: Cancer Cell International - October 11, 2023 Category: Cancer & Oncology Authors: Rahul Kumar, Rakesh Kumar, Harsh Goel, Sonu Kumar, Somorjit Singh Ningombam, Imran Haider, Usha Agrawal, Svs Deo, Ajay Gogia, Atul Batra, Ashok Sharma, Sandeep Mathur, Amar Ranjan, Anita Chopra, Showket Hussain and Pranay Tanwar Tags: Research Source Type: research
A novel STAT3/ NF κB p50 axis regulates stromal-KDM2A to promote M2 macrophage-mediated chemoresistance in breast cancer
Lysine Demethylase 2A (KDM2A) plays a crucial role in cancer cell growth, differentiation, metastasis, and the maintenance of cancer stemness. Our previous study found that cancer-secreted IL-6 can upregulate ... (Source: Cancer Cell International)
Source: Cancer Cell International - October 11, 2023 Category: Cancer & Oncology Authors: Jia-Shing Chen, Yu-Ning Teng, Cheng-Yi Chen and Jing-Yi Chen Tags: Research Source Type: research
Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics
Glioma is the most aggressive and malignant type of primary brain tumor, comprises the majority of central nervous system deaths, and is categorized into different subgroups according to its histological chara... (Source: Cancer Cell International)
Source: Cancer Cell International - October 11, 2023 Category: Cancer & Oncology Authors: Peyman Tabnak, Aysa Hasanzade Bashkandi, Mohammad Ebrahimnezhad and Mahdieh Soleimani Tags: Review Source Type: research
FOXA1/MND1/TKT axis regulates gastric cancer progression and oxaliplatin sensitivity via PI3K/AKT signaling pathway
Drug resistance is a main factor affecting the chemotherapy efficacy of gastric cancer (GC), in which meiosis plays an important role. Therefore, it is urgent to explore the effect of meiosis related genes on ... (Source: Cancer Cell International)
Source: Cancer Cell International - October 10, 2023 Category: Cancer & Oncology Authors: Xiaosi Hu, Shuai Zhou, Haohao Li, Zehui Wu, Ye Wang, Lei Meng, Zhangming Chen, Zhijian Wei, Qing Pang and Aman Xu Tags: Research Source Type: research
PRC2 mediated KLF2 down regulation: a therapeutic and diagnostic axis during tumor progression
Surgery and chemo-radiotherapy are used as the common first-line treatment options in many cancers. However, tumor relapse is observed in many cancer patients following such first-line treatments. Therefore, t... (Source: Cancer Cell International)
Source: Cancer Cell International - October 8, 2023 Category: Cancer & Oncology Authors: Negin Taghehchian, Amirhosein Maharati, Iman Akhlaghipour, Amir Sadra Zangouei and Meysam Moghbeli Tags: Review Source Type: research
Clinical significance and immune infiltration analyses of a novel coagulation-related signature in ovarian cancer
Ovarian cancer (OV) is the most lethal gynecological malignancies worldwide. The coagulation cascade could induce tumor cell infiltration and contribute to OV progression. However, coagulation-related gene (CR... (Source: Cancer Cell International)
Source: Cancer Cell International - October 6, 2023 Category: Cancer & Oncology Authors: Jiani Yang, Chao Wang, Yue Zhang, Shanshan Cheng, Meixuan Wu, Sijia Gu, Shilin Xu, Yongsong Wu, Jindan Sheng, Dominic Chih-Cheng Voon and Yu Wang Tags: Research Source Type: research
Hsa_circRNA_102051 regulates colorectal cancer proliferation and metastasis by mediating Notch pathway
The purpose of this study was to investigate the role of hsa_circRNA_102051 in colorectal cancer (CRC) and its effect on the stemness of tumor cells. (Source: Cancer Cell International)
Source: Cancer Cell International - October 5, 2023 Category: Cancer & Oncology Authors: Zhongsheng Chen, Haiyu Cheng, Jiandong Zhang, Dongbing Jiang, Gang Chen, Shunkang Yan, Wen Chen and Wei Zhan Tags: Research Source Type: research
RAD51 is a poor prognostic marker and a potential therapeutic target for oral squamous cell carcinoma
This study aimed to survey the role of RAD51 in oral squamous cell carcinoma and whether RAD51 could be a ... (Source: Cancer Cell International)
Source: Cancer Cell International - October 5, 2023 Category: Cancer & Oncology Authors: Yu-Fen Tsai, Leong-Perng Chan, Yuk-Kwan Chen, Chang-Wei Su, Ching-Wei Hsu, Yen-Yun Wang and Shyng-Shiou F. Yuan Tags: Research Source Type: research
It is not all about the alpha: elevated expression of p53 β variants is associated with lower probability of survival in a retrospective melanoma cohort
Melanoma is the deadliest type of skin cancer and despite improvements in treatment outcomes, melanoma claimed 57,043 lives in 2020. In most malignancies, p53 mutation rates are above 50% and provide prognosti... (Source: Cancer Cell International)
Source: Cancer Cell International - October 4, 2023 Category: Cancer & Oncology Authors: Kira Groen, Luiza Steffens Reinhardt, Jean-Christophe Bourdon and Kelly A. Avery-Kiejda Tags: Research Source Type: research
Pan-cancer analysis of NFE2L2 mutations identifies a subset of lung cancers with distinct genomic and improved immunotherapy outcomes
Mutations in the KEAP1-NFE2L2 signaling pathway were linked to increased tumorigenesis and aggressiveness. Interestingly, not all hotspot mutations on NFE2L2 were damaging; some even were activating. However, ... (Source: Cancer Cell International)
Source: Cancer Cell International - October 4, 2023 Category: Cancer & Oncology Authors: Kewei Wang, Zixi Li, Ying Xuan, Yong Zhao, Chao Deng, Meidan Wang, Chenjun Xie, Fenglai Yuan, Qingfeng Pang, Wenjun Mao, Dongyan Cai, Zhangfeng Zhong and Jie Mei Tags: Research Source Type: research
