YY1: a key regulator inhibits gastric cancer ferroptosis and mediating apatinib-resistance
Gastric cancer (GC) stands as a prevalent and deadly global malignancy. Despite its role as a preoperative neoadjuvant therapy, Apatinib ’s effectiveness is curtailed among GC patients exhibiting elevated YY1 e... (Source: Cancer Cell International)
Source: Cancer Cell International - February 12, 2024 Category: Cancer & Oncology Authors: Zi-Han Geng, Jun-Xian Du, Yue-Da Chen, Pei-Yao Fu, Ping-Hong Zhou, Wen-Zheng Qin and Yi-Hong Luo Tags: Research Source Type: research
Extracellular vesicles produced by irradiated endothelial or Glioblastoma stem cells promote tumor growth and vascularization modulating tumor microenvironment
Glioblastoma (GBM) is the most lethal primary brain tumor in adult, characterized by highly aggressive and infiltrative growth. The current therapeutic management of GBM includes surgical resection followed by... (Source: Cancer Cell International)
Source: Cancer Cell International - February 12, 2024 Category: Cancer & Oncology Authors: Giorgia Castellani, Mariachiara Buccarelli, Quintino Giorgio D ’Alessandris, Ramona Ilari, Andrea Cappannini, Francesca Pedini, Alessandra Boe, Valentina Lulli, Isabella Parolini, Stefano Giannetti, Mauro Biffoni, Vincenzo Zappavigna, Giovanna Marziali, Tags: Research Source Type: research
Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies
Targeted drug delivery is one of the attractive ways in which cancer treatment can significantly reduce side effects. In the last two decades, the use of antibodies as a tool for accurate detection of cancer h... (Source: Cancer Cell International)
Source: Cancer Cell International - February 10, 2024 Category: Cancer & Oncology Authors: Mohadeseh Haji Abdolvahab, Pegah Karimi, Nasrin Mohajeri, Mohammad Abedini and Hamed Zare Tags: Review Source Type: research
A cuproptosis score model and prognostic score model can evaluate clinical characteristics and immune microenvironment in NSCLC
In this study, we aimed to develop two cuproptosi... (Source: Cancer Cell International)
Source: Cancer Cell International - February 10, 2024 Category: Cancer & Oncology Authors: Yijie Tang, Tianyi Wang, Qixuan Li and Jiahai Shi Tags: Research Source Type: research
AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway
Glioblastoma (GBM) is the most common brain tumor with the worst prognosis. Temozolomide is the only first-line drug for GBM. Unfortunately, the resistance issue is a classic problem. Therefore, it is essentia... (Source: Cancer Cell International)
Source: Cancer Cell International - February 10, 2024 Category: Cancer & Oncology Authors: Yizhi Zhang, Wan Li, Yihui Yang, Sen Zhang, Hong Yang, Yue Hao, Xu Fang, Guanhua Du, Jianyou Shi, Lianqiu Wu and Jinhua Wang Tags: Research Source Type: research
Retraction Note: Down-regulation of LINC00472 promotes osteosarcoma tumorigenesis by reducing FOXO1 expressions via miR-300
(Source: Cancer Cell International)
Source: Cancer Cell International - February 10, 2024 Category: Cancer & Oncology Authors: Jingwei Zhang, Jieyuan Zhang, Dong Zhang, Weifeng Ni, Haijun Xiao and Bizeng Zhao Tags: Retraction Note Source Type: research
Melanoma biology and treatment: a review of novel regulated cell death-based approaches
The incidence of melanoma, the most lethal form of skin cancer, has increased due to ultraviolet exposure. The treatment of advanced melanoma, particularly metastatic cases, remains challenging with poor outco... (Source: Cancer Cell International)
Source: Cancer Cell International - February 9, 2024 Category: Cancer & Oncology Authors: Ming-yun Hsieh, Sheng-Kai Hsu, Tzu-Yu Liu, Chang-Yi Wu and Chien-Chih Chiu Tags: Review Source Type: research
NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route
Esophageal cancer (EC) is a global canker notorious for causing high mortality due to its relentless incidence rate, convoluted with unyielding recurrence and metastasis. However, these intricacies of EC are a... (Source: Cancer Cell International)
Source: Cancer Cell International - February 9, 2024 Category: Cancer & Oncology Authors: Obed Boadi Amissah, Wenfang Chen, Jean de Dieu Habimana, Yirong Sun, Lihui Lin, Yujie Liu, Ling Wang, Zhaoming Liu, Omar Mukama, Rajesh Basnet, Hohua Liu, Junyi Li, Xuanyan Ding, Lingshuang Lv, Min Chen, Yalin Liang & hellip; Tags: Research Source Type: research
Novel lncRNAs LINC01221, RP11-472G21.2 and CRNDE are markers of differential expression in pediatric patients with T cell acute lymphoblastic leukemia
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) poses significant challenges due to its aggressive nature and resistance to standard treatments. Long non-coding RNAs (lncRNAs) have emerged as potential b... (Source: Cancer Cell International)
Source: Cancer Cell International - February 9, 2024 Category: Cancer & Oncology Authors: Pankaj Sharma, Parminder kaur, Prateek Bhatia, Amita Trehan, Sreejesh Sreedharanunni and Minu Singh Tags: Research Source Type: research
PHF6 loss reduces leukemia stem cell activity in an acute myeloid leukemia mouse model
Acute myeloid leukemia (AML) is a malignant hematologic disease caused by gene mutations and genomic rearrangements in hematologic progenitors. The PHF6 (PHD finger protein 6) gene is highly conserved and loca... (Source: Cancer Cell International)
Source: Cancer Cell International - February 9, 2024 Category: Cancer & Oncology Authors: Shengnan Yuan, Mingming Gao, Yizhou Wang, Yanjie Lan, Mengrou Li, Yuwei Du, Yue Li, Wen Ju, Yujin Huang, Ke Yuan and Lingyu Zeng Tags: Research Source Type: research
Insulin receptor alternative splicing in breast and prostate cancer
Cancer etiology represents an intricate, multifactorial orchestration where metabolically associated insulin-like growth factors (IGFs) and insulin foster cellular proliferation and growth throughout tumorigen... (Source: Cancer Cell International)
Source: Cancer Cell International - February 8, 2024 Category: Cancer & Oncology Authors: Jinyu Li and Gena Huang Tags: Review Source Type: research
IGFBP3 induces PD-L1 expression to promote glioblastoma immune evasion
Glioblastoma (GBM) characterized by immune escape is the most malignant primary brain tumors, which has strong immunosuppressive effect. Programmed death ligand-1 (PD-L1) is a recognized immunosuppressive memb... (Source: Cancer Cell International)
Source: Cancer Cell International - February 7, 2024 Category: Cancer & Oncology Authors: Leilei Zhao, Yudi Wang, Peizheng Mu, Xuehua Zhang, Ruomei Qi, Yurui Zhang, He Zhang, Xiao Zhu, Zhouyan Dong and Yucui Dong Tags: Research Source Type: research
METTL14 enhances the m6A modification level of lncRNA MSTRG.292666.16 to promote the progression of non-small cell lung cancer
This study aimed to explore the roles of m6A modification and its related mechanisms in non-small cell lung canc... (Source: Cancer Cell International)
Source: Cancer Cell International - February 7, 2024 Category: Cancer & Oncology Authors: Xianxiu Ji, Xiaoying Wan, Hui Sun, Qinfang Deng, Shuyan Meng, Boxiong Xie and Songwen Zhou Tags: Research Source Type: research
Spatial and single-cell analyses uncover links between ALKBH1 and tumor-associated macrophages in gastric cancer
AlkB homolog 1, histone H2A dioxygenase (ALKBH1), a crucial enzyme involved in RNA demethylation in humans, plays a significant role in various cellular processes. While its role in tumor progression is well-e... (Source: Cancer Cell International)
Source: Cancer Cell International - February 6, 2024 Category: Cancer & Oncology Authors: Renin Chang, Kuan-Hao Tsui, Li-Fei Pan and Chia-Jung Li Tags: Research Source Type: research
Integrated bioinformatics analysis of SEMA3C in tongue squamous cell carcinoma using machine-learning strategies
Tongue squamous cell carcinoma (TSCC) is an aggressive oral cancer with a high incidence of metastasis and poor prognosis. We aim to identify and verify potential biomarkers for TSCC using bioinformatics analy... (Source: Cancer Cell International)
Source: Cancer Cell International - February 6, 2024 Category: Cancer & Oncology Authors: Huixin Dou, Can Song, Xiaoyan Wang, Zhien Feng, Yingying Su and Hao Wang Tags: Research Source Type: research
