A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression
Gamma-butyrobetaine hydroxylase 1 antisense RNA 1 (BBOX1-AS1), located on human chromosome 11 p14, emerges as a critical player in tumorigenesis with diverse oncogenic effects. Aberrant expression of BBOX1-AS1... (Source: Cancer Cell International)
Source: Cancer Cell International - November 5, 2023 Category: Cancer & Oncology Authors: Juan Hu, Jipeng Liu, Siwei Zhou and Hongliang Luo Tags: Review Source Type: research
Determining the prognosis of Lung cancer from mutated genes using a deep learning survival model: a large multi-center study
Gene status has become the focus of prognosis prediction. Furthermore, deep learning has frequently been implemented in medical imaging to diagnose, prognosticate, and evaluate treatment responses in patients ... (Source: Cancer Cell International)
Source: Cancer Cell International - November 4, 2023 Category: Cancer & Oncology Authors: Jie Peng, Lushan Xiao, Hongbo Zhu, Lijie Han and Honglian Ma Tags: Research Source Type: research
Exosomal circRNA RHOT1 promotes breast cancer progression by targeting miR-204-5p/ PRMT5 axis
Circular RNA RHOT1 (circRHOT1) plays crucial roles in tumorigenesis by competing with microRNAs. It is largely abundant in tumor cell-derived exosomes. Meanwhile, cancer-derived exosomes participate in diverse... (Source: Cancer Cell International)
Source: Cancer Cell International - November 3, 2023 Category: Cancer & Oncology Authors: Weihua Jiang, YinPing Yu, Jianghua Ou, Yongtao Li and Ning Zhu Tags: Research Source Type: research
Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms
There is a growing interest to understand the role and mechanism of action of microRNAs (miRNAs) in cancer. The miRNAs are defined as short non-coding RNAs (18-22nt) that regulate fundamental cellular processe... (Source: Cancer Cell International)
Source: Cancer Cell International - November 3, 2023 Category: Cancer & Oncology Authors: Ali Ameri, Hani Moslem Ahmed, Renzon Daniel Cosme Pecho, Hesamoddin Arabnozari, Hoda Sarabadani, Romina Esbati, Seyedsaber Mirabdali and Omid Yazdani Tags: Review Source Type: research
Comparative clinical significance and biological roles of PFKFB family members in oral squamous cell carcinoma
Cancer cells promote glycolysis, which supports rapid cell growth and proliferation. Phosphofructokinase-fructose bisphosphatases (PFKFBs), a family of bidirectional glycolytic enzymes, play key roles in the r... (Source: Cancer Cell International)
Source: Cancer Cell International - November 2, 2023 Category: Cancer & Oncology Authors: Kai-Fang Hu, Chih-Wen Shu, Cheng-Hsin Lee, Ching-Jiunn Tseng, Yu-Hsiang Chou and Pei-Feng Liu Tags: Research Source Type: research
NUAK1 promotes tumor metastasis through upregulating slug transcription in esophageal squamous cell carcinoma
Metastasis is still a major cause of poor pathological outcome and prognosis in esophageal squamous cell carcinoma (ESCC) patients. NUAK1 has been reported highly expressed in many human cancers and is associa... (Source: Cancer Cell International)
Source: Cancer Cell International - November 2, 2023 Category: Cancer & Oncology Authors: Huiru Yang, Zhen Wei, Yifan Song, Kexin Du, Nannan Yin, Hong Lu, Bingbing Li, Lili Hou, Panfei Xing, Liang Chen, Chaojie Wang and Songqiang Xie Tags: Research Source Type: research
Exploring the role of the disulfidptosis-related gene SLC7A11 in adrenocortical carcinoma: implications for prognosis, immune infiltration, and therapeutic strategies
Disulfidptosis and the disulfidptosis-related gene SLC7A11 have recently attracted significant attention for their role in tumorigenesis and tumour management. However, its association with adrenocortical carc... (Source: Cancer Cell International)
Source: Cancer Cell International - November 2, 2023 Category: Cancer & Oncology Authors: Tonghu Liu, Yilin Ren, Qixin Wang, Yu Wang, Zhiyuan Li, Weibo Sun, Dandan Fan, Yongkun Luan, Yukui Gao and Zechen Yan Tags: Research Source Type: research
Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis
Gastrointestinal stromal tumors (GIST) represent a significant clinical challenge due to their metastatic potential and limited treatment options. Raf kinase inhibitor protein (RKIP), a suppressor of the MAPK ... (Source: Cancer Cell International)
Source: Cancer Cell International - October 31, 2023 Category: Cancer & Oncology Authors: Nath ália Cristina Campanella, Izabela Natalia Faria Gomes, Ana Laura Vieira Alves, Leticia Ferro Leal, Adriane Feijó Evangelista, Marcela Nunes Rosa, Matias Eliseo Melendez, Viviane Aline Oliveira Silva, Richard Lucas Konichi Dias, Lucas Faria Abrahão Tags: Research Source Type: research
GAD1 contributes to the progression and drug resistance in castration resistant prostate cancer
Prostate cancer is currently the second most lethal malignancy in men worldwide due to metastasis and invasion in advanced stages. Studies have revealed that androgen deprivation therapy can induce stable remi... (Source: Cancer Cell International)
Source: Cancer Cell International - October 30, 2023 Category: Cancer & Oncology Authors: Lilin Wan, Yifan Liu, Ruiji Liu and Weipu Mao Tags: Research Source Type: research
Systematic analysis of integrated bioinformatics to identify upregulated THBS2 expression in colorectal cancer cells inhibiting tumour immunity through the HIF1A/Lactic Acid/GPR132 pathway
This study aimed to investigate the biological role of THBS2 in various types of cancers... (Source: Cancer Cell International)
Source: Cancer Cell International - October 27, 2023 Category: Cancer & Oncology Authors: Ye Liu, Chunhui Jiang, Chunjie Xu and Lei Gu Tags: Research Source Type: research
The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS signaling enhances cell proli... (Source: Cancer Cell International)
Source: Cancer Cell International - October 27, 2023 Category: Cancer & Oncology Authors: Bahareh Hassani, Zeinab Attar and Negar Firouzabadi Tags: Review Source Type: research
Canine diffuse large b-cell lymphoma downregulates the activity of CD8 + T-cells through tumor-derived extracellular vesicles
Tumor-derived extracellular vesicles (EVs) have been proposed as the essential mediator between host immunity and cancer development. These EVs conduct cellular communication to facilitate tumor growth, enable... (Source: Cancer Cell International)
Source: Cancer Cell International - October 26, 2023 Category: Cancer & Oncology Authors: Hsin-Pei Weng, Chiao-Hsu Ke, Chun-Wei Tung, Akiyoshi Tani, Chia-Chi Wang, Wen-Yuan Yang, Yu-Shan Wang, Winston Han, Chi-Hsun Liao, Hirotaka Tomiyasu and Chen-Si Lin Tags: Research Source Type: research
The role of oncolytic virotherapy and viral oncogenes in the cancer stem cells: a review of virus in cancer stem cells
Cancer Stem Cells (CSCs) are the main “seeds” for the initiation, growth, metastasis, and recurrence of tumors. According to many studies, several viral infections, including the human papillomaviruses, hepati... (Source: Cancer Cell International)
Source: Cancer Cell International - October 25, 2023 Category: Cancer & Oncology Authors: Amirhosein Faghihkhorasani, Alaleh Dalvand, Ehsan Derafsh, Farnaz Tavakoli, Nada Khairi Younis, Saman Yasamineh, Omid Gholizadeh and Pooria Shokri Tags: Review Source Type: research
Bladder cancer: therapeutic challenges and role of 3D cell culture systems in the screening of novel cancer therapeutics
Bladder cancer (BC) is the sixth most common worldwide urologic malignancy associated with elevated morbidity and mortality rates if not well treated. The muscle-invasive form of BC develops in about 25% of pa... (Source: Cancer Cell International)
Source: Cancer Cell International - October 25, 2023 Category: Cancer & Oncology Authors: Sameh M. Farouk, Asmaa F. Khafaga and Ahmed M. Abdellatif Tags: Review Source Type: research
The role of alternative pre-mRNA splicing in cancer progression
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of spec... (Source: Cancer Cell International)
Source: Cancer Cell International - October 24, 2023 Category: Cancer & Oncology Authors: Sunkyung Choi, Namjoon Cho, Eun-Mi Kim and Kee K. Kim Tags: Review Source Type: research
