A simple manual method to estimate water-equivalent diameter for calculating size-specific dose estimate in chest computed tomography.
CONCLUSIONS: A simple, quick manual method to estimate CT patient radiation dose in terms of SSDE was proposed as an alternative where sophisticated computer programming is not available. It can be readily used during any clinical chest CT scanning. ADVANCES IN KNOWLEDGE: The paper is novel as it presents simple, quick manual method to estimate CT patient radiation dose in chest imaging. The process can be used as alternative in cases no sophisticated computer programming is available. PMID: 33058736 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - October 15, 2020 Category: Radiology Authors: Mihailidis D, Tsapaki V, Tomara P Tags: Br J Radiol Source Type: research

Reporting incidental coronary, aortic valve and cardiac calcification on non-gated thoracic computed tomography, a consensus statement from the BSCI/BSCCT and BSTI.
Abstract Incidental coronary and cardiac calcification are frequent findings on non-gated thoracic computed tomography (CT). We recommend that the heart is reviewed on all CT scans where it is visualised. Coronary artery calcification is a marker of coronary artery disease and it is associated with an adverse prognosis on dedicated cardiac imaging and on non-gated thoracic CT performed for non-cardiac indications, both with and without contrast. We recommend that CAC is reported on all non-gated thoracic CT using a simple patient-based score (none, mild, moderate, severe). Furthermore, we recommend that reports in...
Source: The British Journal of Radiology - October 14, 2020 Category: Radiology Authors: Williams MC, Abbas A, Tirr E, Alam S, Nicol E, Shambrook J, Schmitt M, Hughes GM, Stirrup J, Holloway B, Gopalan D, Deshpande A, Weir-McCall J, Agrawal B, Rodrigues JCL, Brady AJB, Roditi G, Robinson G, Bull R Tags: Br J Radiol Source Type: research

Background parenchymal enhancement and breast cancer: a review of the emerging evidences about its potential use as imaging biomarker.
CONCLUSIONS: BPE of the contralateral breast is associated with breast cancer in several aspects, therefore it has been proposed as a tool to refine breast cancer decision-making process. ADVANCES IN KNOWLEDGE: additional researches with standardized BPE assessment are needed to translate this emerging biomarker into clinical practice in the era of personalized medicine. PMID: 33035073 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - October 9, 2020 Category: Radiology Authors: Rella R, Contegiacomo A, Bufi E, Mercogliano S, Belli P, Manfredi R Tags: Br J Radiol Source Type: research

Brain metastases from primary colorectal cancer: is radiosurgery an effective treatment approach? results of a multicenter study of the radiation and clinical oncology italian association (AIRO).
CONCLUSIONS: SRS/HSRS have proven to be an effective local treatment for BMCRC. A careful evaluation of prognostic factors as well as a multidisciplinary evaluation is a valid aid to manage the optimal therapeutic strategy for CTC patients with BMs. ADVANCES IN KNOWLEDGE: The prognosis of brain metastatic colorectal cancer patients (BMCRC) is poor. Several local treatments was used, but optimal treatment choice remains undefined. Radiosurgery has proven to be an effective local treatment for BMCRC. A careful evaluation of prognostic factors and a multidisciplinary evaluation needed. PMID: 33035077 [PubMed - as su...
Source: The British Journal of Radiology - October 9, 2020 Category: Radiology Authors: Navarria P, Minniti G, Clerici E, Comito T, Cozzi S, Pinzi V, Fariselli L, Ciammella P, Scoccianti S, Borzillo V, Anselmo P, Maranzano E, Dell'acqua V, Jereczek-Fossa B, Giaj Levra N, Podlesko AM, Giudice E, Buglione di Monale E Bastia M, Pedretti S, Brun Tags: Br J Radiol Source Type: research

Breast-iRRISC: a novel model for predicting the individualised lifetime risk of radiation-induced breast cancer from a single screening event.
CONCLUSIONS: This unique tailored approach to risk assessment will further empower females and clinicians towards a more informed clinical decision process regarding future imaging pathways. It will also inform health policy decisions regarding alternate screening durations and intervals. ADVANCES IN KNOWLEDGE: Breast-iRRISC is a novel tool that provides females, clinicians and health policymakers around the globe with the ability to quantify the lifetime risk of radiation-induced breast cancer from screening mammography on an individual level from a single exposure. PMID: 33031706 [PubMed - as supplied by publis...
Source: The British Journal of Radiology - October 8, 2020 Category: Radiology Authors: Hooshmand S, Reed WM, Suleiman ME, Brennan PC Tags: Br J Radiol Source Type: research

Heavy charged particle beam therapy and related new radiotherapy technologies: The clinical potential, physics and technical developments required to deliver benefit for patients with cancer.
Discussion followed on the scale and features, including which ions should be included, from protons through helium, boron, and lithium to carbon, and even oxygen. The consensus view was that any facility intended to treat patients must be located in a hospital setting while providing dedicated research space for physics, preclinical biology and clinical research with beam lines designed for both in vitro and in vivo research. The facility should to be able to investigate and deliver both ultra-high dose rate FLASH RT and SFRT (GRID, minibeams etc.). Discussion included a number of accelerator design options and whether ga...
Source: The British Journal of Radiology - October 6, 2020 Category: Radiology Authors: Kirkby KJ, Kirkby NF, Burnet NG, Owen H, Mackay RI, Crellin A, Green S Tags: Br J Radiol Source Type: research

The 20th gray lecture 2019: Health and heavy ions.
CONCLUSIONS: Charged particle therapy with controlled beams of protons and carbon ions have significantly impacted targeted cancer therapy, eradicated tumors while sparing normal tissue toxicities, and reduced human suffering. These modalities still require further optimization and technical refinements to reduce cost but should be made available to everyone in need worldwide. The exploration of our Universe in space travel poses the potential risk of exposure to uncontrolled charged particles.However, approaches to shield and provide countermeasures to these potential radiation hazards in LEO have allowed an amazing numbe...
Source: The British Journal of Radiology - October 6, 2020 Category: Radiology Authors: Blakely EA Tags: Br J Radiol Source Type: research

Impact of PI-RADS 3 lesions on the diagnostic accuracy of MRI for detecting prostate cancer and the prevalence of prostate cancer within each PI-RADS category: A systematic review and Meta-Analysis.
Abstract OBJECTIVE: To evaluateProstate Imaging Reporting and Data System (PI-RADS) category three lesions impact on diagnostic test accuracy (DTA) of MRI for prostate cancer (PC) and to derive prevalence of PC within each PI-RADS category. METHODS: MEDLINE and Embase were searched for studies reporting on the DTA of MRI by PI-RADS category. Accuracy metrics were calculated using a bivariate random-effects meta-analysis with PI-RADS three lesions treated as a positive test, negative test, and excluded from the analysis. Differences in DTA were assessed utilizing meta-regression.PC prevalenceby PI-RADS categor...
Source: The British Journal of Radiology - September 30, 2020 Category: Radiology Authors: Wadera A, Alabousi M, Pozdnyakov A, Kashif Al-Ghita M, Jafri A, McInnes MD, Schieda N, van der Pol CB, Salameh JP, Samoilov L, Gusenbauer K, Alabousi A Tags: Br J Radiol Source Type: research

Lesions of the heel fat pad - A Pictorial Review.
CONCLUSION: We highlight a wide spectrum of pathologies that can occur in the HFP. Although rare, clinicians should be aware of these lesions, to initiate appropriate management. PMID: 33002374 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 30, 2020 Category: Radiology Authors: Saad A, Kho J, Almeer G, Azzopardi C, Botchu R Tags: Br J Radiol Source Type: research

CT-detected extramural venous invasion is corelated with presence of lymph node metastasis and progression-free survival in gastric cancer.
CONCLUSION: CT-detected EMVI was significantly associated with lymph node metastasis and progression free survivalinpatients with gastric cancer. Compared to CT-defined N status, ctEMVI provided superior diagnostic performance to predict pathologic Nstatus. ADVANCES IN KNOWLEDGE: Our study proved that CT-detected EMVI is a promising imaging marker to predict lymph node metastasis and poor prognosis, which may contribute to the precise evaluation of gastric cancer before surgery. PMID: 33002375 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 30, 2020 Category: Radiology Authors: Yang YT, Dong SY, Zhao J, Wang WT, Zeng MS, Rao SX Tags: Br J Radiol Source Type: research

Comparison of virtual non-contrast dual-energy CT and a true non-contrast CT for contouring in radiotherapy of 3D printed lung tumour models in motion: a phantom study.
CONCLUSION: ss-DECT VNC images could not sufficiently subtract iodine from water in LTMs inmotion, whereas ds-DECT VNC images might be a valid alternative to a TNC CT. ADVANCES IN KNOWLEDGE: ds-DECT provides a contrasted image for contouring and a non-contrasted image for radiotherapy treatment planning for LTM in motion. PMID: 33002387 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 30, 2020 Category: Radiology Authors: Hering DA, Kröger K, Bauer RW, Eich HT, Haverkamp U Tags: Br J Radiol Source Type: research

Imaging quality and prostate MR: it's time to improve.
Abstract The PI-RADS guidelines set out the minimal technical requirements for the acquisition of multiparametric magnetic resonance imaging (mpMRI) of the prostate. However, the rapid diffusion of this technique has inevitably led to variability in scan quality among centres across the UK and the world. Suboptimal image acquisitionreduces the sensitivity and specificity of this technique for the detection of clinically significant prostate cancer and result in clinicians losing confidence in the technique.Two expert panels (one from the UK and one from the ESUR/ESUI) have stressed the importance to establish qual...
Source: The British Journal of Radiology - September 30, 2020 Category: Radiology Authors: Giganti F, Allen C Tags: Br J Radiol Source Type: research

The effect of ionising radiation on the phenotype of bone marrow-derived extracellular vesicles.
CONCLUSIONS: Ionising radiation induced selective changes in the secretion of EVs by the different BM cell subpopulations. ADVANCES IN KNOWLEDGE: The novelty of the paper consists of performing a detailed phenotyping of BM-derived EVs after in vivo irradiation of mice. PMID: 32997527 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 29, 2020 Category: Radiology Authors: Kis D, Persa E, Szatmári T, Antal L, Bóta A, Csordás IB, Hargitai R, Jezsó B, Kis E, Mihály J, Sáfrány G, Varga Z, Lumniczky K Tags: Br J Radiol Source Type: research

Adding contrast-enhanced ultrasound markers to conventional axillary ultrasound improves specificity for predicting axillary lymph node metastasis in patients with breast cancer.
CONCLUSION: Combining conventional US and CEUS features can enable discrimination of ALN status better than the use of CEUS and conventional US features alone. ADVANCES IN KNOWLEDGE: The axillary lymph node status in breast cancer patients impacts the treatment decision. Our ultrasonic data demonstrated that CEUS features of ALNs in breast cancer patients could be image markers for predicting ALN status. Combining conventional US and CEUS features of ALNs can improve specificity discrimination of ALN status better than the use of CEUS and the conventional US features alone, which will help the treatment planning optim...
Source: The British Journal of Radiology - September 24, 2020 Category: Radiology Authors: Du LW, Liu HL, Gong HY, Ling LJ, Wang S, Li C, Zong M Tags: Br J Radiol Source Type: research

Exploring the perceptions of advanced practitioner radiographers at a single breast screening unit in extending their role from delivering benign to malignant biopsy results; a preliminary study.
CONCLUSION: Identified within their scope of practice; APRs have the ability with appropriate training and peer support to effectively deliver results with a patient-centred approach. ADVANCES IN KNOWLEDGE: This study has identified important enabling factors and challenges concerning role extension in the delivery of breast biopsy results. The apparent suitability of APRs to communicate results may address breast service pressures, with benefit to patients and the radiology profession. PMID: 32976025 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 24, 2020 Category: Radiology Authors: Eden JK, Borgen R Tags: Br J Radiol Source Type: research

Local diagnostic reference levels in pediatric CT examinations: A survey at the largest children's hospital in Greece.
CONCLUSION: CTDI LDRLs were comparable to European DRLs for head and either comparable or lower than European DRLs for body CT examinations. DLP LDRLs were higher than European DRLs for head and lower for body CT examinations. ADVANCES IN KNOWLEDGE: Age- and weight-basedLDRLs for pediatric CT examinations were establishedfor the largest children's hospital in Greece.Further investigations across the country are required for the establishment of national pediatric DRLs in Greece. PMID: 32976036 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 24, 2020 Category: Radiology Authors: Ploussi A, Syrgiamiotis V, Makri T, Hatzigiorgi C, Efstathopoulos E Tags: Br J Radiol Source Type: research

Can a comparison of clinical and deep space irradiation scenarios shed light on the radiation response of the brain?
Abstract Not surprisingly, our knowledge of the impact of radiation on the brain has evolved considerably. Decades of work have struggled with identifying the critical cellular targets in the brain, the latency of functional change and understanding how irradiation alters the balance between excitatory and inhibitory circuits. Radiation-induced cell kill following clinical fractionation paradigms pointed to both stromal and parenchymal targets but also defined an exquisite sensitivity of neurogenic populations of newly born cells in the brain. It became more and more apparent too, that acute (days) events transpir...
Source: The British Journal of Radiology - September 23, 2020 Category: Radiology Authors: Limoli C Tags: Br J Radiol Source Type: research

Efficacy and safety of percutaneous microwave ablation for hepatocellular carcinomas < 4 cm in difficult location.
Efficacy and safety of percutaneous microwave ablation for hepatocellular carcinomas
Source: The British Journal of Radiology - September 23, 2020 Category: Radiology Authors: Mukund A, Ramalingam R, Anandapara KM, Patidar Y, Kumar Sarin S Tags: Br J Radiol Source Type: research

Treatment outcomes after definitive radio(chemo)therapy for 17 lacrimal sac squamous cell carcinoma.
CONCLUSIONS: Definitive radiotherapy could be a treatment option for those who refuse surgery or have unresectable LSSCC. ADVANCES IN KNOWLEDGE: Radiation alone is a treatment option for LSSCC. PMID: 32970475 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 23, 2020 Category: Radiology Authors: Song X, He H, Zhu Y, Wang S, Wang J, Wang W, Li Y Tags: Br J Radiol Source Type: research

A comparison of two modalities of stereotactic body radiation therapy for peripheral early-stage non-small cell lung cancer: results of a prospective French study.
CONCLUSIONS: No difference in efficiency or toxicity was shown after SBRT of peripheral NSCLC treatment using Linac or Cyberknife®. ADVANCES IN KNOWLEDGE: This is the first large prospective non-randomized study focusing on peripheral localized NSCLC comparing SBRT using an appropriately equipped linac with Cyberknife®. No significant difference in efficiency or toxicity was shown in this situation. PMID: 32970478 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 23, 2020 Category: Radiology Authors: Claude L, Morelle M, Mahé MA, Pasquier D, Boisselier P, Bondiau PY, Touboul E, Peignaux-Casasnovas K, Martel-Lafay I, Gassa F, Perrier L, Dussart S, Beckendorf V Tags: Br J Radiol Source Type: research

A systematic review and practical considerations of stereotactic body radiotherapy in the treatment of head and neck cancer.
CONCLUSION: At present there is a lack of evidence regarding SBRT as a primary treatment option for HNC and definitive answers regarding efficacy and tolerability cannot be provided but there is growing evidence that SBRT reirradiation regimens are safe and effective. In lieu of evidence from large Phase III trials, we define appropriate OAR constraints and prescription doses, with accurate plan summation approaches. Prospective randomised trials are warranted to validate improved treatment outcomes and acceptable treatment morbidity. ADVANCES IN KNOWLEDGE: This article provides a comprehensive review of evidence of u...
Source: The British Journal of Radiology - September 21, 2020 Category: Radiology Authors: Iqbal MS, West N, Richmond N, Willis N, Morgan D, Gray I, Kovarik J, Yazici G, Cengiz M, Paleri V, Kelly C Tags: Br J Radiol Source Type: research

Prompt gamma imaging for the identification of regional proton range deviations due to anatomic change in a heterogeneous region: a case study.
CONCLUSIONS: We report the first clinical application of PG imagingthat detectedsome of the expected small regional proton range deviations due to anatomic change in a heterogeneous region. However, several limitations exist with the technology that may limit its sensitivity to detect range deviations in heterogeneous regions. ADVANCES IN KNOWLEDGE: We report on the first detection of range variations due to anatomic change in a heterogeneous region using PGI. The results confirm the feasibility of using PG based range verification in highly heterogeneous target regions to identify deviations from the treatment plan. ...
Source: The British Journal of Radiology - September 21, 2020 Category: Radiology Authors: Xie Y, Petzoldt J, Janssens G, O'Grady F, Yin L, Bentefour EH, Smeets J, Prieels D, Lustig RA, Lin A, Teo BK Tags: Br J Radiol Source Type: research

Randomized clinical trial on 7-days-a-week postoperative radiotherapy vs. concurrent postoperative radio-chemotherapy in locally advanced cancer of the oral cavity/oropharynx.
CONCLUSION: Concurrent postoperative RTCT tended to improve locoregional control rate as compared to p-CAIR. This, however, did not transferred into improved overall survival. Postoperative RTCT was associated with a substantial increase in haematological toxicity that negatively affected treatment compliance in this arm. ADVANCES IN KNOWLEDGE: To our knowledge this is the first trial that compares accelerated radiotherapy and radio-chemotherapy in postoperative treatment for oralcavity/oropharyngeal cancer. PMID: 32960662 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 21, 2020 Category: Radiology Authors: Wozniak G, Misiołek M, Idasiak A, Dębosz-Suwińska I, Jaworska M, Bal W, Maciejewski B, Miszczyk L, Składowski K, Suwinski R Tags: Br J Radiol Source Type: research

A preoperative radiomics model for the identification of lymph node metastasis in patients with Early-stage cervical squamous cell carcinoma.
CONCLUSION: The presented radiomics model can be used for preoperative identification of LNM inpatientswith early-stage CSCC. Its performance outperforms that ofSCC-Ag level analysis alone. ADVANCES IN KNOWLEDGE: A radiomics model incorporated radiomics signature and SCC-Ag levels demonstrated good performance in identifying LNM in patientswithearly-stage CSCC. PMID: 32960673 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 21, 2020 Category: Radiology Authors: Yan L, Yao H, Long R, Wu L, Xia H, Li J, Liu Z, Liang C Tags: Br J Radiol Source Type: research

Renal cryoablation - a practical guide for interventional radiologists.
Abstract Renal cryoablation is a treatment option for early stage renal cell carcinomas with excellent oncological outcomes and low morbidity. This review outlines the technique of renal cryoablation and provides a guide for interventional radiologists on setting up an integrated service within a renal cancer network multidisciplinary setting. Patient selection and preparation, together with the technical aspects which ensure optimal oncological outcomes and avoid collateral damage to adjacent organs are highlighted. PMID: 32960674 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 21, 2020 Category: Radiology Authors: Seager M, Kumar S, Lim E, Munneke G, Bandula S, Walkden M Tags: Br J Radiol Source Type: research

Prostate cancer measurements on serial MRI during active surveillance: it's time to be PRECISE.
Abstract OBJECTIVE: The PRECISE criteria for reporting multiparametric MRI in patients on active surveillance (AS) for prostate cancer (PCa) score the likelihood of clinically significant change over time using a 1-5 scale, where 4 or 5 indicates radiological progression. According to the PRECISE recommendations, the index lesion size can be reported using different definitions of volume (planimetry or ellipsoid formula) or by measuring one or two diameters. We compared different measurements using planimetry as the reference standard and stratified changes according to the PRECISE scores. METHODS: We retrosp...
Source: The British Journal of Radiology - September 20, 2020 Category: Radiology Authors: Giganti F, Stavrinides V, Stabile A, Osinibi E, Orczyk C, Radtke JP, Freeman A, Haider A, Punwani S, Allen C, Emberton M, Kirkham A, Moore CM Tags: Br J Radiol Source Type: research

Artificial intelligence in paediatric radiology: Future opportunities.
Abstract Artificial intelligence (AI) has received widespread and growing interest in healthcare, as a method to save time, cost and improve efficiencies. The high-performance statistics and diagnostic accuracies reported by using AI algorithms (with respect to predefined reference standards), particularly from image pattern recognition studies, have resulted in extensive applications proposed for clinical radiology, especially for enhanced image interpretation. Whilst certain sub-speciality areas in radiology, such as those relating to cancer screening, have received wide-spread attention in the media and scienti...
Source: The British Journal of Radiology - September 16, 2020 Category: Radiology Authors: Davendralingam N, Sebire NJ, Arthurs OJ, Shelmerdine SC Tags: Br J Radiol Source Type: research

CT colonography evaluation of the relationship between colon anatomy and diverticula.
In this study, we aimed at investigating the relationship between diverticula and in vivo colonic features such as total colon length (TCL), using CTC. We also evaluated polyps, neoplastic lesions and the correlation among them. METHODS: This retrospective study considered a series of patients who underwent CTC in our Hospital from 2010 to 2018. We evaluated TCL, the length of each colon segments and sigmoid colon diameter using dedicated software. We verified the presence of diverticula, polyps and neoplasm and measured the number of diverticula using a five-point class scale, evaluating the colonic segments involved...
Source: The British Journal of Radiology - September 16, 2020 Category: Radiology Authors: Flor N, Martinelli A, Maconi G, Di Pietro S, Perillo N, Maggi L Tags: Br J Radiol Source Type: research

Defining reperfusion post endovascular therapy in ischemic stroke using MR-dynamic contrast enhanced perfusion.
Abstract OBJECTIVES: Cerebral blood flow (CBF) measurements after endovascular therapy (EVT) for acute ischemic stroke are important to distinguish early secondary injury related to persisting ischemia from that related to reperfusion when considering clinical response and infarct growth. METHODS: We compare reperfusion quantified by the modified Thrombolysis in Cerebral Infarction Score (mTICI) with perfusion measured by MRI dynamic contrast-enhanced perfusion within 5 h of EVT anterior circulation stroke. MR perfusion (rCBF, rCBV, rTmax, rT0) and mTICI scores were included in a predictive model for change i...
Source: The British Journal of Radiology - September 16, 2020 Category: Radiology Authors: d'Esterre CD, Sah RG, Assis Z, Talai AS, Demchuk AM, Hill MD, Goyal M, Lee TY, Forkert ND, Barber PA Tags: Br J Radiol Source Type: research

Computed tomography appearances of the lung parenchyma in pulmonary hypertension.
Abstract Computed tomography (CT) is a valuable tool in the workup of patients under investigation for pulmonary hypertension (PH) and may be the first test to suggest the diagnosis. CT parenchymal lung changes can help to differentiate the aetiology of PH. CT can demonstrate interstitial lung disease, emphysema associated with chronic obstructive pulmonary disease, features of left heart failure (including interstitial oedema), and changes secondary to miscellaneous conditions such as sarcoidosis. CT also demonstrates parenchymal changes secondary to chronic thromboembolic disease and venous diseases such as pulm...
Source: The British Journal of Radiology - September 10, 2020 Category: Radiology Authors: Foley RW, Kaneria N, Ross RVM, Suntharalingam J, Hudson BJ, Rodrigues JC, Robinson G Tags: Br J Radiol Source Type: research

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for pretreatment prediction of neoadjuvant chemotherapy response in locally advanced hypopharyngeal cancer.
Conclusion:DCE-MRI especially pretreatment Ktrans can potentially predict the treatment response to neoadjuvant chemotherapy for hypopharyngeal cancer.Advances in knowledge:Few studies of DCE-MRI on hypopharyngeal cancer treated with chemoradiation reported. The results demonstrate that DCE-MRI especially pretreatment Ktrans may be more potential value in predicting the treatment response to neoadjuvant chemotherapy for hypopharyngeal cancer. PMID: 32915647 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 10, 2020 Category: Radiology Authors: Guo W, Zhang Y, Luo D, Yuan H Tags: Br J Radiol Source Type: research

Intrafractional fiducial marker position variations in stereotactic liver radiotherapy during voluntary deep inspiration breath-hold.
CONCLUSION: Difference in marker position of up to 1.0 cm was observed during a single DIBH despite use of narrow external gating window and visual feedback. Stability examination on pre-treatment DIBH CTs was not sufficient to guarantee per-fraction stability. Evaluation of differences in marker position on pre- and post-treatment CBCT did not always reveal the full magnitude of the intrafractional variation. ADVANCES IN KNOWLEDGE: To increase treatment accuracy, it is necessary to apply real-time monitoring of the tumour or a reliable internal surrogate when delivering liver SBRT in voluntary DIBH. PMID:...
Source: The British Journal of Radiology - September 10, 2020 Category: Radiology Authors: Stick LB, Vogelius IR, Risum S, Josipovic M Tags: Br J Radiol Source Type: research

Improving the image quality of DWI in breast cancer: comparison of multi-shot DWI using multiplexed sensitivity encoding to conventional single-shot echo-planar imaging DWI.
Abstract OBJECTIVE: To compare diffusion-weighted images (DWI) acquired using single-shot echo-planar imaging (ss-EPI) and multiplexed sensitivity encoding (MUSE) in breast cancer. METHODS: 20 females with pathologically confirmed breast cancer (age 51 ± 12 years) were imaged with ss-EPI-DWI and MUSE-DWI. ADC, normalised ADC (nADC), blur and distortion metrics and qualitative image quality scores were compared. The Crété-Roffet and Mattes mutual information metrics were used to evaluate blurring and distortion, respectively. In a breast phantom, six permutations of MUSE-DWI with varying p...
Source: The British Journal of Radiology - September 8, 2020 Category: Radiology Authors: Baxter GC, Patterson AJ, Woitek R, Allajbeu I, Graves MJ, Gilbert F Tags: Br J Radiol Source Type: research

Pharmacovigilance and radiologists: How well do they get along?
CONCLUSIONS: Radiologists encounter ADRs almost as frequently as the other doctors. Their awareness about PV is similar with other healthcare professionals. They have fewer information about TUFAM and PvCPs. Radiologists generally prefer to communicate with a clinician about an ADR. Overall condition of radiologists about PV is quite similar with other healthcare professionals and education can improve it, as for the others. ADVANCES IN KNOWLEDGE: Radiologists encounters ADRs almost as frequently as the other doctors. Overall condition of radiologists about PV is quite similar with other healthcare professionals and e...
Source: The British Journal of Radiology - September 8, 2020 Category: Radiology Authors: Aydin OC, Aydin S, Guney HZ Tags: Br J Radiol Source Type: research

SOLLID - a single centre study to develop methods to investigate the effects of low radiation doses within nuclear medicine, to enable multicentre epidemiological investigations.
Abstract There is continuing debate concerning the risks of secondary malignancies from low levels of radiation exposure. The current model used for radiation protection is predicated on the assumption that even very low levels of exposure may entail risk. This has profound implications for medical procedures involving ionising radiation as radiation doses must be carefully monitored, and for diagnostic procedures are minimised as far as possible. This incurs considerable expense. The SOLLID study (ClinicalTrials.gov Identifier: NCT03580161) aims to develop the methodology to enable a large-scale epidemiological i...
Source: The British Journal of Radiology - September 8, 2020 Category: Radiology Authors: Flux G, Murray I, Rushforth D, Gape P, Abreu C, Lee M, Ribeiro A, Gregory R, Chittenden S, Thurston J, Du Y, Gear J Tags: Br J Radiol Source Type: research

Diffusion tensor imaging in renal artery stenosis: a preliminary report.
CONCLUSION: The alterations of the diffusional parameters caused by RAS can be detected by DTI and could be useful in the diagnostic evaluation of these patients. ADVANCES IN KNOWLEDGE: 1. Magnetic resonance DTI could provide useful information about renal involvement in RAS.2. Magnetic resonance DTI allows non-invasive repeatable evaluation of the renal parenchyma, without contrast media. PMID: 32903036 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 8, 2020 Category: Radiology Authors: Gaudiano C, Clementi V, Corcioni B, Renzulli M, Mancini E, Golfieri R Tags: Br J Radiol Source Type: research

An update on CT screening for lung cancer: the first major targeted cancer screening programme.
This article describes the key evidence for lung cancer screening, the key factors important for optimisation and the progress towards implementation. PMID: 32894687 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 6, 2020 Category: Radiology Authors: Baldwin DR, Callister MEJ Tags: Br J Radiol Source Type: research

Risk factors of geriatrics index of comorbidity and MDCT findings for predicting mortality in patients with acute mesenteric ischemia due to superior mesenteric artery thromboembolism.
CONCLUSION: Three risk factors for mortality were identified in patients with AMI due to SMA thromboembolism, including PPMVG and four regions of SMA involved by thromboembolism on MDCT images, and class 3 + 4 of comorbidities. Close monitoring of these risk factors could possibly lower the mortality. ADVANCES IN KNOWLEDGE: Risk factors based on GIC and MDCT findings may be used to predict mortality in patients with AMI. Close monitoring of these risk factors could possibly lower the mortality. PMID: 32886528 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 3, 2020 Category: Radiology Authors: Tang W, Jin B, Kuang LQ, Zhang J, Li CX, Wang Y Tags: Br J Radiol Source Type: research

Multimodality imaging review of complex pelvic lesions in female pelvis.
Abstract Complex pelvic lesions can originate from various anatomical structures in the pelvis and pose a diagnostic dilemma due to a wide range of possible diagnoses. Accurate characterisation of these lesions would often require an algorithmic approach, which incorporates clinical findings, sequential use of multiple imaging modalities and a multiparametric approach. This approach usually aims at identifying key imaging features, which aid in anatomical localisation, morphology and tissue characterisation. There have been various attempts to standardise the lexicon used for describing adnexal masses in female pa...
Source: The British Journal of Radiology - September 3, 2020 Category: Radiology Authors: Chandramohan A, Bhat TA, John R, Simon B Tags: Br J Radiol Source Type: research

Pretreatment structural and arterial spin labeling MRI is predictive for p53 mutation in high-grade gliomas.
Abstract OBJECTIVES: To determine the performance of pretreatment structural and arterial spin labelling (ASL) MRI in predicting p53 mutation in patients with high-grade gliomas (HGGs). METHODS: Pre-treatment structural and ASL MRI were performed in 57 patients with histologically confirmed HGGs and information of p53 status. Whole-lesion histogram analysis of cerebral blood flow (CBF) images of the enhancing tumour and the peritumoral oedema in the HGGs were performed. Visually AcceSAble Rembrandt Images features were used as qualitative analysis. The differences of ASL histogram parameters and Visually Acce...
Source: The British Journal of Radiology - September 1, 2020 Category: Radiology Authors: Mao J, Deng D, Yang Z, Wang W, Cao M, Huang Y, Shen J Tags: Br J Radiol Source Type: research

How we provided appropriate breast imaging practices in the epicentre of the COVID-19 outbreak in Italy.
We report the re-organisation which our institute (IEO, European Institute of Oncology), a cancer referral centre in Lombardy, went through to make our breast-imaging division pandemic-proof. Using personal-protective-equipment and innovative protocols, we provided essential breast-imaging procedures during COVID-19 pandemic without compromising cancer outcomes.The emergency management and infection-control-measures implemented in our division protected both the patients and the staff, making this experience useful for other radiology departments dealing with the pandemic. PMID: 32877209 [PubMed - as supplied by publi...
Source: The British Journal of Radiology - September 1, 2020 Category: Radiology Authors: Pesapane F, Penco S, Rotili A, Nicosia L, Bozzini A, Trentin C, Dominelli V, Priolo F, Farina M, Marinucci I, Meroni S, Abbate F, Meneghetti L, Latronico A, Pizzamiglio M, Cassano E Tags: Br J Radiol Source Type: research

Manual and semi-automated delineation of locally advanced rectal cancer subvolumes with diffusion-weighted MRI.
CONCLUSION: Contours based on co-registered T2W and DW-MRI could be used for delineation of biologically relevant tumour subvolumes. Semi-automated delineation based on patient-specific intratumoral ADC thresholds may standardise subvolume delineation if registration between acquisitions is sufficiently accurate. ADVANCES IN KNOWLEDGE: This is the first study to evaluate the feasibility of semi-automated diffusion-based subvolume delineation in LARC. This approach could be applied to dose escalation or 'dose painting' protocols to improve delineation reproducibility. PMID: 32877210 [PubMed - as supplied by publis...
Source: The British Journal of Radiology - September 1, 2020 Category: Radiology Authors: Hearn N, Bugg W, Chan A, Vignarajah D, Cahill K, Atwell D, Lagopoulos J, Min M Tags: Br J Radiol Source Type: research

Imaging patients with stable chest pain special feature: introductory editorial.
PMID: 32815396 [PubMed - in process] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - August 22, 2020 Category: Radiology Authors: Oudkerk M, van Beek EJ Tags: Br J Radiol Source Type: research

Identifying corpus luteum rupture as the culprit for haemoperitoneum - a pictorial review.
Abstract Corpus luteum rupture presenting as acute abdomen is an underdiagnosed condition. Although a self-limiting entity, its differentiation from other causes is essential to prevent unnecessary surgical procedures. The radiologist should be aware of the possibility of a ruptured haemorrhagic ovarian cyst in a female of reproductive age group presenting with pelvic pain and a large amount of haemorrhagic ascites. Imaging characteristically reveals a thick-walled cystic structure in the adnexa with internal echoes, focal discontinuity or irregularity of its wall with haemoperitoneum. While sonography is usually ...
Source: The British Journal of Radiology - August 20, 2020 Category: Radiology Authors: Pulappadi VP, Manchanda S, Sk P, Hari S Tags: Br J Radiol Source Type: research

Patient-based low dose cone beam CT acquisition settings for prostate image guided radiotherapy treatments on a varian TrueBeam linear accelerator.
CONCLUSIONS: A reduction of about 60% of the dose is feasible for patients withsize below 100 cm. The visibility of low contrast features can be compromised if using the low dose acquisition settings for patients with hip size above 100 cm. ADVANCES IN KNOWLEDGE: Low dose Cone Beam CT acquisition protocols for the pelvis based on subjective evaluation of patient images. PMID: 32822249 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - August 20, 2020 Category: Radiology Authors: Piliero MA, Casiraghi M, Bosetti DG, Cima S, Deantonio L, Leva S, Martucci F, Tettamanti M, Pupillo F, Bellesi L, Presilla S, Richetti A Tags: Br J Radiol Source Type: research

Stereotactic body radiotherapy for adrenal oligometastasis in lung cancer patients.
CONCLUSION: SBRT was effective and safe in lung cancer adrenal metastases. A dose-response relationship was found between BED10>72 Gy and better local control. No significant toxicity was registered thanks to the respect of dose constraints and suspension of chemo- and target-therapies. ADVANCES IN KNOWLEDGE: SBRT with a BED10>72 Gy is an effective treatment for adrenal oligometastatic lung cancer patients. PMID: 32822540 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - August 20, 2020 Category: Radiology Authors: Arcidiacono F, Aristei C, Marchionni A, Italiani M, Fulcheri CPL, Saldi S, Casale M, Ingrosso G, Anselmo P, Maranzano E Tags: Br J Radiol Source Type: research

Sharp recanalization of peripheral arterial chronic total occlusions.
Abstract Peripheral arterial chronic total occlusions (CTOs) usually have calcified caps at either ends. When attempting endovascular recanalization, these calcified CTO caps may prevent the interventionist in crossing the lesion with conventional catheter and guidewire techniques. Using specialized CTO devices or re-entry devices can help crossing the CTO, but such devices are usually expensive, not always readily available and require specialist training prior to usage."Sharp recanalization" is an alternative method of crossing the CTOs. If it is not possible to cross the CTO with conventional catheter...
Source: The British Journal of Radiology - August 20, 2020 Category: Radiology Authors: Kim K, Moore C, Alfahad A Tags: Br J Radiol Source Type: research

Radiomic signatures derived from multiparametric magnetic resonance imaging for the pretreatment prediction of response to neoadjuvant chemotherapy in breast cancer.
CONCLUSIONS: The combined radiomic signature and nomogram model exhibited potential predictive power for predicting effective NAC treatment which can aid in the prognosis and guidance of treatment regimens. ADVANCES IN KNOWLEDGE: Identifying a means of assessing the efficacy of NAC before surgery can guide follow-up treatment and avoid chemotherapy-induced toxicity. PMID: 32822542 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - August 20, 2020 Category: Radiology Authors: Bian T, Wu Z, Lin Q, Wang H, Ge Y, Duan S, Fu G, Cui C, Su X Tags: Br J Radiol Source Type: research

Challenges for managing the cumulative effective dose for patients.
Abstract Notwithstanding that 100 mSv is not a threshold for radiation effects, cumulative effective dose (CED) for patients of ≥100 mSv derived from recurrent imaging procedures with ionising radiationhas been recently the topic of several publications. The ICRP has alerted on the problems to use effective dose for risk estimation in individual patients but has accepted to use this quantity for comparison the relative radiation risks between different imaging modalities. A new ICRP document on the use of effective dose (including medicine), is in preparation. Recently published data on the number of patients w...
Source: The British Journal of Radiology - August 20, 2020 Category: Radiology Authors: Vano E Tags: Br J Radiol Source Type: research

What's New for Clinical Whole-body MRI (WB-MRI) in the 21st Century.
Abstract Whole body MRI (WB-MRI) has evolved since its first introduction in the 1970's as an imaging technique to detect and survey disease across multiple sites and organ systems in the body. The development of diffusion-weighted MRI (DWI) has added a new dimension to the implementation of WB-MRI on modern scanners, offering excellent lesion-to-background contrast, while achieving acceptable spatial resolution to detect focal lesions 5 to 10 mm in size. MRI hardware and software advances have reduced acquisition times, with studies taking 40-50 min to complete.The rising awareness of medical radiat...
Source: The British Journal of Radiology - August 20, 2020 Category: Radiology Authors: Tunariu N, Blackledge M, Messiou C, Petralia G, Padhani A, Curcean S, Curcean A, Koh DM Tags: Br J Radiol Source Type: research