Prognostic impact of preoperative FDG-PET positive lymph nodes in lung cancer
ConclusionsAbnormal FDG uptake in the LN is an important prognostic factor. Increased glucose metabolism on FDG-PET appears to be a more efficient postoperative prognostic marker than pathological n-stage in patients with lung cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 19, 2020 Category: Cancer & Oncology Source Type: research

The impact of clinicopathological factors on clinical outcomes in patients with salivary gland adenoid cystic carcinoma: a multi-institutional analysis in Japan
ConclusionsA higher TN classification, a pathologically positive surgical margin, and a higher histological grade were associated with a lower OS. PORT improved LRC rates but neck dissection failed to improve clinical outcomes in patients with cN0. As the distant metastasis was frequent, effective systemic therapy is imperative to improve the survival of AdCC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 18, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Recent advances of the regulation roles of MicroRNA in glioblastoma
The authors would like to update the affiliations and email addresses of the original publication as given in this correction. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 18, 2020 Category: Cancer & Oncology Source Type: research

Prognostic value of pre-treatment risk stratification and post-treatment neutrophil/lymphocyte ratio change for pembrolizumab in patients with advanced urothelial carcinoma
AbstractBackgroundPembrolizumab is effective in a limited number of patients with advanced urothelial carcinoma (UC). Therefore, we evaluated the prognostic value of clinical biomarkers following pembrolizumab treatment in patients with advanced UC.MethodsWe retrospectively reviewed the medical records of 121 patients with platinum-refractory advanced UC who received pembrolizumab. Inflammation-based prognostic scores before and 6  weeks after the treatment were recorded. The categorical variables influencing overall survival (OS) and objective response rate (ORR) were analyzed.ResultsMultivariate analyses showed that...
Source: International Journal of Clinical Oncology - September 18, 2020 Category: Cancer & Oncology Source Type: research

The incidence of newly diagnosed secondary cancer; sub-analysis the prospective study of the second-look procedure for transoral surgery in patients with T1 and T2 head and neck cancer
ConclusionsEarly stages of laryngeal, oropharyngeal, and hypopharyngeal cancer had a risk of secondary cancer, especially hypopharyngeal cancer. Attention to the secondary cancer has to be paid during the follow-up period after controlling the early-stage disease. These findings highlight the need for awareness of the incidence of secondary cancer in cases of early-stage primary head and neck cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 14, 2020 Category: Cancer & Oncology Source Type: research

A phase II trial of dose-reduced nab -paclitaxel for patients with previously treated, advanced or recurrent gastric cancer (OGSG 1302)
ConclusionTri-weeklynab-PTX with a reduced dose (220  mg/m2) is not recommended for AGC in a second-line or later setting, despite demonstrating less toxicity than at 260  mg/m2.Clinical trial registrationThe OGSG1302 trial was registered with UMIN-CTR as UMIN000000714. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 14, 2020 Category: Cancer & Oncology Source Type: research

Apalutamide, enzalutamide, and darolutamide for non-metastatic castration-resistant prostate cancer: a systematic review and network meta-analysis
AbstractManagement of non-metastatic castration-resistant prostate cancer (nmCRPC) has undergone a paradigm shift with next-generation androgen receptor inhibitors. However, direct comparative data are not available to inform treatment decisions and/or guideline recommendations. Therefore, we performed network meta-analysis to indirectly compare the efficacy and safety of currently available treatments. Multiple databases were searched for articles published before June 2020. Studies that compared overall and/or metastasis-free and/or prostate-specific antigen (PSA) progression-free survival (OS/MFS/PSA-PFS) and/or adverse...
Source: International Journal of Clinical Oncology - September 14, 2020 Category: Cancer & Oncology Source Type: research

Clinicopathological features of radiological early malignant pleural mesothelioma with no apparent tumor or pleural thickening
ConclusionsRadiological early MPM occurs in approximately 1 of every 20 patients treated with neoadjuvant chemotherapy and surgery planned at the time of diagnosis in an experienced center. Radiological early MPM was associated with early pathological stage and long-term survival. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 10, 2020 Category: Cancer & Oncology Source Type: research

Predisposing factors and clinical impact of high-output syndrome after sphincter-preserving surgery with covering ileostomy for rectal cancer: a retrospective single-center cohort study
ConclusionPreoperative (chemo)radiotherapy, postoperative inflammatory response, and postoperative complications predisposed to high-output syndrome, and it significantly impacted postoperative renal dysfunction. Active monitoring and early intervention are warranted to prevent renal dysfunction in patients with these factors. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 9, 2020 Category: Cancer & Oncology Source Type: research

Gastrointestinal lesion in adult-onset Langerhans cell histiocytosis
ConclusionsAlthough gastrointestinal LCH lesions are rare, they were more common than expected in our cases of multisystem LCH. However, these lesions were relatively small and did not affect the patients ’ clinical courses. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 8, 2020 Category: Cancer & Oncology Source Type: research

TERT promotor region rearrangements analyzed in high-risk neuroblastomas by FISH method and whole genome sequencing
ConclusionsFISH is a useful diagnostic tool for evaluating high-risk NBLs in whichTERT-PR rearrangements have occurred. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 7, 2020 Category: Cancer & Oncology Source Type: research

Evaluation of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer: a single-institution experience
ConclusionAdjuvant chemotherapy after abdominal trachelectomy could be an alternative treatment option from the aspects of effectiveness, safety, and fertility preservation. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Clinical indicators for predicting prognosis after radium-223 administration in castration-resistant prostate cancer with bone metastases
ConclusionsOur study demonstrated that a shorter PSADT, a heavier volume of bone metastases, and a later treatment line before Ra-223 are poor prognostic factors for mCRPC patients. These newly discovered risk factors may help select patients who potentially have long-term OS after Ra-223 treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Source Type: research

Key transporters leading to specific protoporphyrin IX accumulation in cancer cell following administration of aminolevulinic acid in photodynamic therapy/diagnosis
AbstractThe administration of aminolevulinic acid allow the formation and accumulation of protoporphyrin IX specifically in cancer cells, which then lead to photocytotoxicity following light irradiation. This compound, when accumulated at high levels, could also be used in cancer diagnosis as it would emit red fluorescence when being light irradiated. The concentration of protoporphyrin IX is pivotal in ensuring the effectiveness of the therapy. Studies have been carried out and showed the importance of various transporters in regulating the amount of these substrates by controlling the transport of various related metabol...
Source: International Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Source Type: research

High expression of microRNA20b is associated with malignant clinicopathological features and poor prognosis in breast phyllodes tumor
AbstractBackgroundmicroRNAs, which expound the transcriptional regulation of gene expression, have been validated as prognostic markers in many tumors. The deregulated expression of microRNAs has been shown to aid classification of tumors and predict outcome in many tumors including breast PTs. The aim of our study is to investigate the clinical significance and prognostic value of microRNAs in PTs to identify a biomarker which has the potential for predicting prognosis and target therapy.MethodsQuantitative real-time PCR (qRT-PCR) was used to detect the expression level of microRNA20b in 123 breast PTs patients. The corre...
Source: International Journal of Clinical Oncology - August 16, 2020 Category: Cancer & Oncology Source Type: research

Comparison of three different chemotherapy regimens for concomitant chemoradiotherapy in locally advanced non-small cell lung cancer
AbstractPurposeThe optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. Cisplatin-etoposide regimen related toxicity is high, weekly regimens have been investigating. We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context.MethodsA total of 225 patients with locally advanced, unresectable stage III NSCLC were included. Patients who were treated with weekly docetaxel-platin (DP), paclitaxel-platin (PP) and standard dose etoposide-platin (EP) chemotherapy regimens were selected and divided into group...
Source: International Journal of Clinical Oncology - August 14, 2020 Category: Cancer & Oncology Source Type: research

Effect of general self-efficacy on promoting health-related quality of life during recovery from radical prostatectomy: a 1-year prospective study
ConclusionThis study suggests that high GSE was associated with better prostate cancer-specific and general health-related QOL after radical prostatectomy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 14, 2020 Category: Cancer & Oncology Source Type: research

Oxaliplatin-induced increase in splenic volume: experiences from multicenter study in Japan
ConclusionThis study can be verified the findings observed in our previous single-center study, oxaliplatin-based adjuvant chemotherapy was associated with an increase in SV. Furthermore, this increase can persist for  >  1 year. The continuous presence of SOS may have a negative impact on prognosis in patients that develop recurrent disease. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 12, 2020 Category: Cancer & Oncology Source Type: research

Accuracy of histological grades from intraoperative frozen-section diagnoses of soft-tissue tumors
ConclusionsHistological grades from frozen-section diagnoses yielded low diagnostic accuracies in adipocytic and fibroblastic/myofibroblastic tumors. Treatment should be planned based on permanent-section diagnosis and radiological findings for these tumors. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 10, 2020 Category: Cancer & Oncology Source Type: research

Clinicopathologic and survival analysis of patients with adenoid cystic carcinoma of vulva: single-institution experience
ConclusionRadical resection towards negative margins seems to be acceptable as initial treatment. Adjuvant radiotherapy is a preferable treatment modality for patients with high-risk factors pathologically or patients with local recurrence. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 10, 2020 Category: Cancer & Oncology Source Type: research

The impact of complications after initial prostate biopsy on repeat protocol biopsy acceptance rate. Results from the Prostate Cancer Research International: Active Surveillance JAPAN study
AbstractBackgroundPatients with favorable-risk prostate cancer on active surveillance (AS) are strictly followed for safer execution. Repeat protocol biopsy is essential for evaluating cancer aggressiveness. However, the acceptance rate of repeat biopsy is not high enough because of the burdens of biopsy. We assessed the impact of complications after the initial biopsy on repeat protocol biopsy at 1  year using data from the Prostate Cancer Research International: Active Surveillance (PRIAS)-JAPAN study.MethodsWe performed a retrospective analysis using a prospective cohort in the PRIAS-JAPAN study. Patients with favo...
Source: International Journal of Clinical Oncology - August 8, 2020 Category: Cancer & Oncology Source Type: research

FLOX (5-fluorouracil  + leucovorin + oxaliplatin) chemotherapy for colorectal cancer leads to long-term orofacial neurotoxicity: a STROBE-guided longitudinal prospective study
AbstractBackgroundColorectal carcinoma (CRC) is widely treated by chemotherapy based on an intensely neurotoxic drug: oxaliplatin (OXL). We objective to evaluate prospectively the orofacial neurotoxicity during FLOX (fluorouracil  + leucovorin + OXL) chemotherapy.MethodsSo, 46 patients with CRC were prospectively evaluated during FLOX chemotherapy by 3 cycles (C) of 6  weeks (W) each. We weekly applied the orofacial section of the Acute and Chronic Neuropathy Questionnaire of Common Toxicity Criteria for Adverse Events of the National Cancer Institute of the United States of America (Oxalip...
Source: International Journal of Clinical Oncology - August 6, 2020 Category: Cancer & Oncology Source Type: research

Oncolytic virus combined with traditional treatment versus traditional treatment alone in patients with cancer: a meta-analysis
ConclusionDespite partially increased toxicity, the combination therapy improves the effectiveness of cancer treatment. However, high-quality, large-scale studies are needed to evaluate its effectiveness and safety. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 5, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a report from the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG)
In the October 2018 issue of International Journal of Clinical Oncology. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 4, 2020 Category: Cancer & Oncology Source Type: research

Effect of core needle biopsy number on intraductal carcinoma of the prostate (IDC-P) diagnosis in patients with metastatic hormone-sensitive prostate cancer
ConclusionsGiven the IDC-P detection and its value as a prognostic marker, we propose the performance of  ≥ 10 core biopsy procedures in patients diagnosed with mHSPC to minimize the sampling error of the IDC-P. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 3, 2020 Category: Cancer & Oncology Source Type: research

Positive node burden rather than the number of removed nodes impacts survival in patients with node-positive prostate cancer
This study aims to test the effects of the number of removed lymph nodes (RLN), positive nodes (pLN), and pLN ratio (pLNR) on cancer-specific survival (CSS) in patients with node-positive prostate cancer (PCa).MethodsA total of 2458 patients with a greater than 5% probability of lymph node invasion according to the updated Briganti nomogram who harboured pathologically confirmed positive nodes in the Surveillance, Epidemiology, and End Results database between 2004 and 2015 were identified. Multivariable Cox regression with forward stepwise selection was performed to identify independent risk factors for CSS. Maximally sel...
Source: International Journal of Clinical Oncology - August 3, 2020 Category: Cancer & Oncology Source Type: research

Epidemiology and survival outcomes of primary gastrointestinal melanoma: a SEER-based population study
ConclusionPatients with primary GI melanoma trended to  present with advanced-stage disease. Overall, GI melanoma had a poor prognosis, but the outcome differed according to the primary sites. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 1, 2020 Category: Cancer & Oncology Source Type: research

Short hydration with 20  mEq of magnesium supplementation for lung cancer patients receiving cisplatin-based chemotherapy: a prospective study
ConclusionA short hydration regimen with 20  mEq of magnesium supplementation is safe and feasible for patients with lung cancer receiving cisplatin-based chemotherapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 1, 2020 Category: Cancer & Oncology Source Type: research

Prognostic value of the AJCC 8th edition staging system for Japanese patients treated with surgery followed by radiotherapy for breast cancer
ConclusionsCompared with the 7th edition in breast cancer, AJCC 8th edition prognostic stage system has more precise stratification and superior prognostic value, providing a more accurate reference for the choice of radiotherapy for patients with breast cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 31, 2020 Category: Cancer & Oncology Source Type: research

Cellular immunotherapy plus chemotherapy ameliorates survival in gastric cancer patients: a meta-analysis
AbstractThe efficacy of cellular immunotherapy plus chemotherapy in treatment of gastric cancer (GC) remains inconsistent even controversial. Hence, we performed a meta-analysis to better comprehend the clinical value of cellular immunotherapy plus chemotherapy for GC patients. We searched PubMed, Embase and EBSCO databases to identify the studies evaluating the association of cellular immunotherapy plus chemotherapy and overall survival (OS) and/or disease-free survival (DFS) in patients with GC, and then combined relevant data into hazard ratios (HRs) for OS, DFS and clinicopathological features such as TNM stage, etc. w...
Source: International Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Source Type: research

Optimal treatment strategy for paratesticular liposarcoma: retrospective analysis of 265 reported cases
ConclusionComplete resection with high inguinal orchiectomy is the optimal treatment for paratesticular liposarcoma. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Daratumumab therapy for relapsed or refractory multiple myeloma: a single-center retrospective study
ConclusionDARA is an effective treatment option for most patients and is tolerable. However, patients with heavy treatment before DARA therapy and mass lesions are likely to show poorer outcomes. Our findings suggest the use of DARA therapy early in the course of the disease. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

The clinical prognostic factors and treatment outcomes of adult patients with Ewing sarcoma
ConclusionsApproximately two-third of adult patients with localized Ewing sarcoma survive 5  years. In order to improve survival of this patients the multidisciplinary treatment in referral center is mandatory. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 25, 2020 Category: Cancer & Oncology Source Type: research

Interim analysis for post-marketing surveillance of dabrafenib and trametinib combination therapy in Japanese patients with unresectable and metastatic melanoma with BRAF V600 mutation
ConclusionsNo new safety or efficacy concerns were observed in this interim PMS analysis in Japanese patients with unresectable and metastatic melanoma withBRAF gene mutation who received dabrafenib and trametinib combination therapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 22, 2020 Category: Cancer & Oncology Source Type: research

Swallowing dysfunction following surgery for well-differentiated thyroid cancer with extrathyroid invasion
ConclusionThese results indicate that tracheostomy placement and resection of the IPCMs, together with total thyroidectomy, extends the tube feeding duration in the postoperative period. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 18, 2020 Category: Cancer & Oncology Source Type: research

Prognostic value of testosterone for the castration-resistant prostate cancer patients: a systematic review and meta-analysis
ConclusionThis meta-analysis demonstrated that the PFS and OS were significantly greater in patients with CRPC in those with higher testosterone levels than that of those with lower testosterone levels. In the subgroup analyses, lower testosterone levels were a consistently poor prognostic factor for OS in patients treated with ARTAs, but not in those treated with chemotherapy. Therefore, higher testosterone levels could be a useful biomarker to identify patient subgroups in which ARTAs should be preferentially recommended in the CRPC setting. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 17, 2020 Category: Cancer & Oncology Source Type: research

Mean platelet volume may not be a significant prognostic factor in patients with metastatic castration-resistant prostate cancer
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 16, 2020 Category: Cancer & Oncology Source Type: research

Neo-adjuvant chemotherapy alone for the locally advanced rectal cancer: a systematic review
AbstractNeo-adjuvant chemoradiation (NA-CRT) is the standard of management for the locally advanced rectal cancer (LARC), achieving very low rates of local recurrence (LR). However, NA-CRT fails to control distant recurrence and improve survival, whilst it is associated with increased postoperative morbidity and increased acute and late toxicity. In recent years, neo-adjuvant chemotherapy (NACTx) appears in the literature as an alternative to NA-CRT in patients with LARC. In the present study, the authors review all current evidence on the specific subject. Following a systematic search of the literature, 25 studies were i...
Source: International Journal of Clinical Oncology - July 14, 2020 Category: Cancer & Oncology Source Type: research

Impact of single-heterozygous UGT1A1 on the clinical outcomes of irinotecan monotherapy after fluoropyrimidine and platinum-based combination therapy for gastric cancer: a multicenter retrospective study
ConclusionThere was no significant difference in the efficacy of irinotecan monotherapy between UGT1A1 WT and UGT1A1 SH, but UGT1A1 SH was associated with a high frequency of severe hematological toxicity. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 14, 2020 Category: Cancer & Oncology Source Type: research

Role of the DEK oncogene in the development of squamous cell carcinoma
AbstractDEK is a highly conserved nuclear factor that plays an important role in the regulation of multiple cellular processes.DEK was discovered to be an oncogene as a fusion withNUP214 gene, which results in producing DEK-NUP214 proteins, in a subset of patients with acute myeloid leukemia. Subsequently, DEK overexpression was reported in many cancers, thus DEK itself is considered to be an oncoprotein. DEK has been reported to play important roles in the progression of early and late stage squamous cell carcinoma (SCC) and is useful for early diagnosis of the disease. These findings have made DEK an attractive therapeut...
Source: International Journal of Clinical Oncology - July 12, 2020 Category: Cancer & Oncology Source Type: research

Intracellular accumulation of PD-1 molecules in circulating T lymphocytes in advanced malignant melanoma: an implication for immune evasion mechanism
ConclusionsAccumulated(int)PD-1 in T cells may contribute to enhanced immune evasion in AMM. Evaluation of intracellular PD-1 expression would be useful for better management of nivolumab-treated AMM patients in view of predicting treatment response and the incidence of irAE. Our findings further support the necessity of periodical administration of nivolumab for treating AMM. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 12, 2020 Category: Cancer & Oncology Source Type: research

Evaluation of COVID 19 infection in 279 cancer patients treated during a 90-day period in 2020 pandemic
ConclusionPatients with cancer who need treatment can be treated by taking some measures. These measures include observing individual and collective protection principles in patients and health-care personnel, increasing patients ’ awareness particularly about self-care behavior, performing a COVID-19 test, and taking a chest X-ray, before the treatment starts (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 11, 2020 Category: Cancer & Oncology Source Type: research

Clinical characteristics and predictors of permanent stoma in rectal cancer patients underwent anterior resections: the value of preoperative prognostic nutritional index
This study was aimed to investigate the correlation between preoperative prognostic nutritional index (PNI) and permanent stoma (PS) in patients with defunctioning stoma (DS) after anterior resections and, based on it, to reveal the clinical value of PNI on clinical strategies about the selection of stoma location.MethodsA total of 281 consecutive rectal cancer patients who accepted anterior resection and DS in the National Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University from June 2008 to June 2018 were enrolled in this study. Receiver operating characteristic (ROC) curve for P...
Source: International Journal of Clinical Oncology - July 11, 2020 Category: Cancer & Oncology Source Type: research

Surgical outcome and graded prognostic assessment of patients with brain metastasis from adult sarcoma: multi-institutional retrospective study in Japan
This study involved a retrospective analysis of 22 patients with BM from sarcomas who underwent resection at six institutes in Japan. Prognostic factors were analyzed to develop a graded prognostic assessment (GPA) using the log-rank test and Cox regression analysis. For validation of this GPA, we collected data on 100 surgical cases from 48 published reports.ResultsPostoperative Karnofsky Performance Status (KPS) improved in 50% of our patients. Median overall survival (OS) was 21  months. Multivariate analysis showed age and alveolar soft part sarcoma (ASPS) were significant preoperative prognostic factors (P 
Source: International Journal of Clinical Oncology - July 9, 2020 Category: Cancer & Oncology Source Type: research

Prognostic impact of preoperative renal function in patients treated with radical cystectomy: a multi-institutional retrospective study
This study aimed to investigate the prognostic role of UD, with a subgroup analysis of that of preoperative renal function.MethodsFrom 1990 to 2015, 279 patients underwent RC for bladder cancer at six hospitals affiliated with Kitasato University in Japan. All patients were divided into three groups: cutaneous ureterostomy (CU;n = 54), ileal conduit (IC;n = 139), and orthotopic neobladder (NB;n = 86). Patients were also stratified into three groups based on preoperative estimated glomerular filtration rate (eGFR) (mL/min/1.73 m2): normal eGFR (>  60 mL/min/1.73&...
Source: International Journal of Clinical Oncology - July 9, 2020 Category: Cancer & Oncology Source Type: research

Efficacy and feasibility of induction chemotherapy with paclitaxel, carboplatin and cetuximab for locally advanced unresectable head and neck cancer patients ineligible for combination treatment with docetaxel, cisplatin, and 5-fluorouracil
AbstractBackgroundDocetaxel, cisplatin, and 5-fluorouracil (TPF) induction chemotherapy (ICT) is a treatment option for locally advanced unresectable head and neck squamous cell carcinoma (LA-HNSCC). However, patients with advanced age, or renal, cardiac or neurogenic dysfunction are ineligible for ICT-TPF.MethodsWe retrospectively assessed 24 unresectable LA-HNSCC patients who received paclitaxel, carboplatin and cetuximab (PCE) as ICT at the Shizuoka Cancer Center between April 2013 and October 2018.ResultsPatient characteristics were as follows: median age, 72  years (range 60–81); 0, 1, and 2 performance sta...
Source: International Journal of Clinical Oncology - July 9, 2020 Category: Cancer & Oncology Source Type: research

Oncologic outcomes for patients with endometrial cancer who received minimally invasive surgery: a retrospective observational study
ConclusionsLaparoscopic procedures are not associated with a poorer outcome than laparotomy in patients with advanced endometrial cancer or uterine-confined endometrial cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 9, 2020 Category: Cancer & Oncology Source Type: research

Long-term cognitive outcome in adult survivors of an early childhood posterior fossa brain tumour
ConclusionsVIQ and PIQ deficits persist in adulthood, suggesting the effect of a fixed injury imposing on cognitive development, rather than an ongoing pathological process.Implications for cancer survivorsThe findings will help parents and others supporting survivors of an early life PFT to identify and plan for possible cognitive outcomes, and highlight the importance of early interventions to optimize cognitive function during the developmental period. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 8, 2020 Category: Cancer & Oncology Source Type: research

Why is renal impairment associated with poorer cancer specific survival in breast cancer patients?: a comparison with patients with other comorbidities
AbstractBackgroundOur aim is to assess whether the poor breast cancer specific survival (BCSS) seen in women with breast cancer and impaired renal function can be explained by associations with other prognostic factors.MethodsThe study group was a consecutive series of patients undergoing breast ultrasound (US) who had invasive breast cancer (n = 1171). All women had their US diameter and mean stiffness (kPa) at shear wave elastography (SWE) recorded. The core biopsy grade and receptor status were noted. Core biopsy of abnormal axillary nodes and the patient referral source was also noted. Survival including ...
Source: International Journal of Clinical Oncology - July 2, 2020 Category: Cancer & Oncology Source Type: research

Protective effect of the oral administration of cystine and theanine on oxaliplatin-induced peripheral neuropathy: a pilot randomized trial
ConclusionThe results demonstrated the daily oral administration of cystine and theanine attenuated OXLIPN. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 27, 2020 Category: Cancer & Oncology Source Type: research