Assessment of surgical outcomes of off-clamp open partial nephrectomy without renorrhaphy for ≥T1b renal tumours
ConclusionOpen partial nephrectomy without renal pedicle clamping or renorrhaphy could be safely performed for  ≥ T1b renal tumours, even when tumours were entirely endophytic and located close to the renal pedicle. Mild perioperative eGFR reduction was observed. Although surgical indications should be carefully considered in these cases, off-clamp open partial nephrectomy without renorrhaphy is a feas ible procedure for patients with  ≥ T1b renal tumours. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 16, 2021 Category: Cancer & Oncology Source Type: research

Surgical margin clearance and extended chemotherapy defines survival for synchronous oligometastatic liver lesions of the ductal adenocarcinoma of the pancreas
ConclusionThis is the first study demonstrating a survival benefit after extended surgery for synchronously hepatic-metastasized PDACs. We found no difference in survival outcome of metastasized patients when compared to patients with localized disease. FOLFIRINOX as an adjuvant treatment regime for resected M1surg presumably is worthwhile. Larger multicenter studies are still needed to validate our results. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 16, 2021 Category: Cancer & Oncology Source Type: research

External validation of the Briganti 2019 nomogram to identify candidates for extended pelvic lymph node dissection among patients with high-risk clinically localized prostate cancer
ConclusionThis external validation showed that the Briganti 2019 nomogram was accurate, although there may still be scope for individual adjustments. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 12, 2021 Category: Cancer & Oncology Source Type: research

Lymphocyte –C-reactive protein ratio as a prognostic marker associated with the tumor immune microenvironment in intrahepatic cholangiocarcinoma
ConclusionsLow-LCR status may reflect a poor anti-tumor immune response and predict worse outcomes in ICC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 12, 2021 Category: Cancer & Oncology Source Type: research

CAPP-seq analysis of circulating tumor DNA from patients with EGFR T790M –positive lung cancer after osimertinib
ConclusionsCAPP-seq analysis of ctDNA was able to identify potentially targetable genetic alterations in patients with osimertinib resistance. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 11, 2021 Category: Cancer & Oncology Source Type: research

Incidence of germline variants in Lynch syndrome-related genes among Japanese endometrial cancer patients aged 40  years or younger
Conclusion] The incidence of LS among Japanese endometrial cancer patients of reproductive age ( ≤ 40 years) in this study was at least 1.5%; however, 12.3% of patients had variants of uncertain significance in MMR genes. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 11, 2021 Category: Cancer & Oncology Source Type: research

Real-world safety and effectiveness of nivolumab for recurrent or metastatic head and neck cancer in Japan: a post-marketing surveillance
ConclusionJapanese patients with head and neck cancer treated with nivolumab in the real-world setting manifested no new safety signals.Clinical Trial Registrationclinicaltrials.jp: JapicCTI-184071. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 10, 2021 Category: Cancer & Oncology Source Type: research

The novel index using preoperative C-reactive protein and neutrophil-to-lymphocyte ratio predicts poor prognosis in patients with pancreatic cancer
AbstractBackgroundSeveral kinds of systemic inflammatory response, classified into two types: C-reactive protein (CRP)-based type and blood cell count-based type, were reported as a prognostic indicator in patients with pancreatic cancer (PC). However, there is no consensus which types is more sensitive predictor in patients with PC. Therefore, we here developed a novel biomarker, C-NLR, which consists of both CRP and neutrophil-to-lymphocyte ratio (NLR), and we evaluated the prognostic significance of C-NLR in patients with PC after pancreatic resection.MethodsA total of 217 patients was comprised in this study. We retros...
Source: International Journal of Clinical Oncology - June 10, 2021 Category: Cancer & Oncology Source Type: research

APC germline variant analysis in the adenomatous polyposis phenotype in Japanese patients
ConclusionsWe determined the detection rate of theAPC germline variant by phenotype and identifiedAPC mosaicism. Genetic testing of FAP patients is important because it can help with surgical decision-making, monitoring, and genetic counseling. Furthermore, genetic testing by NGS proved to be an effective method of detectingAPC germline variants. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 9, 2021 Category: Cancer & Oncology Source Type: research

Clinico-pathological characteristics of patients with stage IB1 –IB2 (FIGO 2018) uterine cervical cancer: a nationwide study in Japan
AbstractObjectiveThe aim of this retrospective analysis is to reveal clinicopathological findings and clinical outcome of patients with stage IB1/IB2 (FIGO 2018) uterine cervical cancer.MethodsBased on the database of the Japanese Gynecologic Oncology Group, 2194 patients with stage IB1/IB2 (FIGO 2018), who underwent radical hysterectomy between 1/1/2004 –12/31/2008, were identified as eligible for this retrospective study.ResultsPatients with squamous cell carcinoma had significantly frequent lympho-vascular space invasion than those with non-squamous cell carcinoma in both stage IB1 and IB2 (stage IB1; 29.1% vs. 17.1%,p 
Source: International Journal of Clinical Oncology - June 9, 2021 Category: Cancer & Oncology Source Type: research

On-treatment C-reactive protein control could predict response to subsequent anti-PD-1 treatment in metastatic renal cell carcinoma
ConclusionThe on-treatment CRP-control could be the predictive factor for the efficacy of nivolumab in refractory mRCC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 8, 2021 Category: Cancer & Oncology Source Type: research

Analyses of the association between cervical cancer and osteoporosis/osteoporotic fracture: a cross-sectional study using KoGES HEXA data
ConclusionWe concluded that Korean women with cervical cancer had a higher risk of osteoporosis than healthy women, but the same finding was not observed for osteoporotic fracture. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 6, 2021 Category: Cancer & Oncology Source Type: research

Comparison between 1973 and 2004/2016 World Health Organization grading in upper tract urothelial carcinoma treated with radical nephroureterectomy
AbstractAimsThe European Association of Urology guideline for upper tract urothelial carcinoma (UTUC) relies on two grading system: 1973 World Health Organization (WHO) and 2004/2016 WHO. No consensus has been made which classification should supersede the other and both are recommended in clinical practice. We hypothesized that one may be superior to the other.MethodsNewly diagnosed non-metastatic UTUC patients treated with radical nephroureterectomy were abstracted from the Surveillance, Epidemiology, and End Results database (2010 –2016). Kaplan–Meier plots and multivariable Cox regression models (CRMs) test...
Source: International Journal of Clinical Oncology - June 6, 2021 Category: Cancer & Oncology Source Type: research

Benefit of intensive chemotherapy for elderly patients aged 80  years or older with metastatic colorectal cancer: a state-wide multicenter cohort study
This study aimed to investigate the overall survival of Stage IV CRC patients aged ≥ 80 years receiving intensive chemotherapy.MethodsThe study design was a population-based, multicenter, historical cohort study. The extracted participants ’ data were consecutive patients diagnosed as Stage IV CRC between January 2008 and May 2015 in nine hospitals in Japan. Patients were classified into two groups according to age: aged group (≥ 80 years) and younger group (
Source: International Journal of Clinical Oncology - June 5, 2021 Category: Cancer & Oncology Source Type: research

Second primary cancers: a retrospective analysis of real world data using the enhanced medical research engine ConSoRe in a French comprehensive cancer center
ConclusionThe data mining tool ConSoRe contributes to access to real world data, and to better characterize patients with SPC. Expanding such approach to any comprehensive center will allow a global overview of the follow-up of patients with cancer, and help to improve long-term management and adapt surveillance. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 5, 2021 Category: Cancer & Oncology Source Type: research

Impact of preoperative nutritional support and rehabilitation therapy in patients undergoing pancreaticoduodenectomy
ConclusionsPreoperative nutritional support and prehabilitation may reduce the incidence of pancreatic fistula in patients with SM loss and improve the surgical outcomes of patients undergoing pancreaticoduodenectomy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 4, 2021 Category: Cancer & Oncology Source Type: research

Predictors of the need for prophylactic percutaneous endoscopic gastrostomy in head and neck cancer patients treated with concurrent chemoradiotherapy
ConclusionsProphylactic PEG is effective for patients treated with definitive CCRT and is especially required for patients with PS2 or oropharyngeal cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 4, 2021 Category: Cancer & Oncology Source Type: research

LINC00943 is correlated with gastric cancer and regulates cancer cell proliferation and chemosensitivity via hsa-miR-101-3p
ConclusionIn summary, our results indicated that LINC00943 was correlated with gastric cancer and regulates cancer cell proliferation and chemosensitivity via hsa-miR-101-3p. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 4, 2021 Category: Cancer & Oncology Source Type: research

Comparison of intracorporeal versus extracorporeal urinary diversion after robot-assisted radical cystectomy at a medium-sized facility
AbstractBackgroundThe aim of this study is to compare the perioperative outcomes and learning curves between intracorporeal and extracorporeal urinary diversion at our medium-sized institution.MethodsBetween January 2018 and September 2020, a single surgeon at our institution performed 46 consecutive robot-assisted radical cystectomies with ileal conduit. We compared the perioperative outcomes between patients who underwent intracorporeal versus extracorporeal urinary diversion. We also investigated learning curves for the first and last 10 patients in each group.ResultsThe extracorporeal group had shorter overall operativ...
Source: International Journal of Clinical Oncology - June 4, 2021 Category: Cancer & Oncology Source Type: research

History of whole pelvis plus para-aortic radiation is a risk factor associated with febrile neutropenia during chemotherapy for recurrent cervical cancer
This study aimed to investigate the relationship between prior irradiation field size and FN development during recurrent chemotherapy.MethodsThis retrospective, observational study included cervical cancer patients who received recurrent chemotherapy between November 2006 and June 2020. The patients were classified into two groups based on the area of irradiation fields. The first group included patients with a history of whole pelvis (WP) irradiation (WP group). The second group had patients who underwent WP plus para-aortic lymph node (PAN) irradiation (WP  + PAN group). The incidences of hematological tox...
Source: International Journal of Clinical Oncology - June 4, 2021 Category: Cancer & Oncology Source Type: research

Negative impact of neoadjuvant hormonal therapy on detecting biochemical recurrence after radical prostatectomy
We examined the impact of NHT on the PSA-doubling time (DT) following BCR at different times after RP.ResultsThe median PSA-DTs in non-NHT patients who experienced BCR in the first year after surgery, between 1 and 2  years, between 2 and 3 years, between 3 and 4 years, between 4 and 5 years, and at >  5 years were 5.5, 8.8, 11.3, 17.7, 18.2, and 18.4 months, respectively. On the other hand, those in NHT patients were 1.4, 4.1, 9.1, 13.4, 27.2, and 19.3 months, respectively. The differences of PSA-DTs in the first year after surgery (p 
Source: International Journal of Clinical Oncology - June 4, 2021 Category: Cancer & Oncology Source Type: research

Comparison of model fit and discriminatory ability of the 8th edition of the tumor-node-metastasis classification and the 9th edition of the Japanese classification to identify stage III colorectal cancer
ConclusionThese results suggest that the 9th JCCRC system has superior discriminative ability to the 8th TNM system, because the 9th JCCRC accounts for the presence of TD and N3 disease, which were both significant predictors of poor prognosis. Reconsidering the clinical value of these two factors in the TNM system could improve its clinical significance. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 3, 2021 Category: Cancer & Oncology Source Type: research

Development of a novel apoptosis-based tumor regression grade to assess the efficacy of preoperative chemoradiotherapy for rectal cancer: a retrospective single-center study
ConclusionThe proposed modifTRG truly reflected the therapeutic effects of chemoradiotherapy and may be superior to the convTRG to stratify rectal cancer patients treated with chemoradiotherapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 3, 2021 Category: Cancer & Oncology Source Type: research

Correlation between oncological family history and clinical outcome in a large monocentric cohort of pediatric patients with rhabdomyosarcoma
ConclusionOur study not only reports an interesting and not previously described association between a poor clinical outcome and ARMS in patients with young cancer-affected relatives, but also stimulates the discussion on oncological family history in RMS, to improve the clinical management of these young patients and their families. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 1, 2021 Category: Cancer & Oncology Source Type: research

Prognostic impact of bone metastatic volume beyond vertebrae and pelvis in patients with metastatic hormone-sensitive prostate cancer
AbstractBackgroundAlthough bone metastasis beyond the vertebrae and pelvis has been a key factor in prognostic models of metastatic hormone-sensitive prostate cancer (mHSPC), the clinical significance of it is still unclear. The present study evaluated the prognostic impact of the volume of bone metastasis beyond the vertebrae and pelvis on the outcomes of mHSPC and created an ideal risk classification based on it.MethodsWe retrospectively reviewed 197 patients with mHSPC who were treated with combined androgen blockade as the initial treatment between June 2003 and October 2019. We calculated the bone scan index (BSI), in...
Source: International Journal of Clinical Oncology - May 28, 2021 Category: Cancer & Oncology Source Type: research

High FRMD3 expression is prognostic for worse survival in rectal cancer patients treated with CCRT
AbstractBackgroundRectal cancer patients can conceivably obtain relief from neoadjuvant concurrent chemoradiotherapy (CCRT) for downstaging before resection, but the stratification of risk and clinical outcomes remains challenging. Therefore, identifying effective predictive biomarkers offers clinicians the opportunity to individually tailor early interventions, which would help optimize therapy.MethodsUsing a public rectal cancer transcriptome dataset (GSE35452), we focused on cytoskeletal protein binding (GO: 0008092)-related genes and identified FERM domain containing 3 (FRMD3) as the most significant differentially exp...
Source: International Journal of Clinical Oncology - May 27, 2021 Category: Cancer & Oncology Source Type: research

Effect of SIB-IMRT-based selective dose escalation of local tumor on the prognosis of patients with esophageal cancer
ConclusionThe selective dose escalation to local tumors based on SIB-IMRT technique can improve the survival of patients received radical radiotherapy without increasing toxicities. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 27, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Clinical usefulness of eribulin as first- or second-line chemotherapy for recurrent HER2-negative breast cancer: a randomized phase II study (JBCRG-19)
In the original publication, the name of the fourth author should be: Takafumi Sangai and his affiliation should be. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 27, 2021 Category: Cancer & Oncology Source Type: research

4-step, 2-h carboplatin desensitization in Japanese patients with ovarian cancer: a prospective study
ConclusionThis 4-step, 2-h carboplatin desensitization protocol is safe and feasible. Patients require careful monitoring with a rapid response to HSRs, especially during the administration of undiluted solutions. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 26, 2021 Category: Cancer & Oncology Source Type: research

Prognostic factors in patients with metastatic urothelial carcinoma who have treated with Atezolizumab
In this study, we present a retrospective analysis of 113 patients with urothelial cancer treated with ATZ after progression on first-line chemotherapy. Data of the patients was obtained from patient files and hospital records. Eligible patients included metastatic urothelial carcinoma patients treated with at least one course of ATZ. Univariate analysis was used to identify clinical and laboratory factors that significantly impact OS. Variables were retained for multivariate analysis if they had a statistical relationship with OS (p 
Source: International Journal of Clinical Oncology - May 23, 2021 Category: Cancer & Oncology Source Type: research

Jab1/Cops5: a promising target for cancer diagnosis and therapy
AbstractC-Jun activation domain-binding protein1 (Jab1), the fifth component of the constitutive photomorphogenic-9 signalosome (COPS5/Csn5) complex, functions in several cellular processes to affect different signaling pathways. Dysregulation of Jab1/Csn5 both restrains tumor suppressors and activates oncogenes to contribute oncogenesis. Jab1 overexpressed in various tumors  and played an essential part in cancer initiation, progression and prognosis, which has spurred strong research interest in developing inhibitors for cancer therapy. Here, we summarize the multiple signaling pathways and functions of Jab1/Csn5 in...
Source: International Journal of Clinical Oncology - May 21, 2021 Category: Cancer & Oncology Source Type: research

Multi-institutional survey of cancer disparities in disabled patients in the region of northwestern Japan
ConclusionThese results indicate that deep disparities between cancer patients with and without disabilities are not apparent and that the disabled patients in the region of northwestern Japan receive appropriate hospital follow-up. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 19, 2021 Category: Cancer & Oncology Source Type: research

EGFL7 as a novel therapeutic candidate regulates cell invasion and anoikis in colorectal cancer through PI3K/AKT signaling pathway
ConclusionOverall, our findings suggested that EGFL7 acts as an oncogene, regulated CRC invasion and anoikis through PI3K/AKT signaling, which provided a theoretical basis for EGFL7 as a potential therapeutic target of CRC treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 19, 2021 Category: Cancer & Oncology Source Type: research

Contributions of HOTAIR polymorphisms to the susceptibility of cancer
ConclusionsThese findings of the meta-analysis suggest thatHOTAIR polymorphisms may predispose to cancer susceptibility. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 19, 2021 Category: Cancer & Oncology Source Type: research

Intra-corporeal robot-assisted versus open radical cystectomy: a propensity score-matched analysis comparing perioperative and long-term survival outcomes and recurrence patterns
AbstractBackgroundTo compare perioperative and long-term oncological outcomes and recurrence patterns between robot-assisted radical cystectomy with intra-corporeal urinary diversion (iRARC) and open radical cystectomy (ORC).MethodsWe retrospectively analyzed 177 bladder cancer patients who received iRARC or ORC at Fujita Health University between 2008 and 2020. Our primary endpoint was long-term oncological outcomes. As a secondary endpoint, we examined perioperative outcomes, complications, and recurrence patterns. These outcome measures were compared between the propensity score (PS)-matched cohorts.ResultsPS-matched an...
Source: International Journal of Clinical Oncology - May 19, 2021 Category: Cancer & Oncology Source Type: research

Validation of tissue factor pathway inhibitor 2 as a specific biomarker for preoperative prediction of clear cell carcinoma of the ovary
ConclusionsHigh specificity of TFPI2 for preoperative detection of CCC was verified with the defined cutoff level of TFPI2 in clinical practice. TFPI2 and CA125 may contribute substantially to precise prediction of intractable CCC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 19, 2021 Category: Cancer & Oncology Source Type: research

Risk factors of mFOLFOX6-induced hyperammonemia in patients with colorectal cancer: an observational study
We examined 74 patients who received mFOLFOX6 therapy with or without biologics for CRC between April 2013 and March 2018 in Yaizu City Hospital. Clinicopathological factors were retrospectively reviewed in association with hyperammonemia, and risk factors of hyperammonemia during mFOLFOX6 therapy were analyzed in 32 patients with the available data.ResultsSeven patients developed hyperammonemia, with onset exclusively on day 2 or 3 in the first cycle of therapy. They were treated with branched chain amino acid administration and hydration; however, one patient with stage G4 chronic kidney disease (CKD) died. By multivaria...
Source: International Journal of Clinical Oncology - May 15, 2021 Category: Cancer & Oncology Source Type: research

Current trend in treatment of glioblastoma in Japan: a national survey using the diagnostic procedure combination database (J-ASPECT study-glioblastoma)
AbstractBackgroundIn the treatment for glioblastoma (GBM), treatment modalities, such as bevacizumab (BEV) and carmustine wafers implants have been approved in Japan since 2013. However, it is unclear whether such a trend in treatment complexity can accelerate treatment centralization. The aim of this study was to reveal the current trend in the treatment of GBM in Japan.MethodsWe used diagnostic procedure combination (DPC) database to analyze the data of 1,774 patients from 305 institutions between April 2016 and March 2019. To analyze the situations associated with first-line BEV use during concurrent TMZ (temozolomide)-...
Source: International Journal of Clinical Oncology - May 11, 2021 Category: Cancer & Oncology Source Type: research

Laboratory prognostic score for predicting 14-day mortality in terminally ill patients with gynecologic malignancy
AbstractBackgroundThere are few studies developing a scoring system for short-term survival of patients with gynecologic malignancy.MethodsSeventy-three terminally ill patients with gynecologic malignancy who were admitted to our palliative care unit (PCU) from June 2009 to February 2018 were included. We accumulated routine blood data within 3  months before PCU discharge. Receiver-operating characteristic analysis was performed on each blood factor, and area under the curve (AUC) was calculated to determine the predictive value for 14-day survival after the blood test. Multivariable logistic regression analysis was ...
Source: International Journal of Clinical Oncology - May 9, 2021 Category: Cancer & Oncology Source Type: research

Otorhinolaryngologists/head and neck surgeons ’ knowledge, attitudes, and practices regarding fertility preservation in young cancer patients treated with chemotherapy: an anonymous questionnaire survey
ConclusionsAlthough fertility preservation has been discussed at professional conferences and seminars, consideration and actions in the field of otorhinolaryngology/head and neck surgery have not been sufficient. We hope that the results of this survey will help raise awareness of fertility preservation. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

Cost-effectiveness of self-expandable metallic stents as bridge to surgery for obstructive colorectal cancer
AbstractAimSelf-expandable metallic stent (SEMS) placement is an emergent decompression approach for patients with obstructive colorectal cancer, alongside drainage tube (DT) and emergency surgery (ES). Few reports have compared the health care cost of each treatment. We aimed to compare the efficacy of SEMS as a bridge to surgery (BTS), including health care costs during decompression and colorectal resection, with those of DT and ES.MethodsThis retrospective study enrolled patients treated for acute obstructed colorectal cancer at a single institution from January 2007 to December 2019. A total of 45 patients that underw...
Source: International Journal of Clinical Oncology - May 2, 2021 Category: Cancer & Oncology Source Type: research

Percutaneous biliary stent with intraluminal brachytherapy versus palliative surgery in the management of extrahepatic cholangiocarcinoma
AbstractBackgroundTo compare the efficacy and outcomes of self-expandable metallic stent combined with catheter-loaded iodine-125 seeds (SEMS-CL-125I) brachytherapy versus conventional palliative surgery (PS) in advanced extrahepatic cholangiocarcinoma (EHCC).MethodsThe retrospective analysis consisted of 101 advanced EHCC patients who received SEMS-CL-125I (n = 67) or underwent PS (n = 34). The clinical characteristics, postoperative complications and overall survival (OS) were compared between the two groups.ResultsSerum levels of bilirubin, transaminase, and albumin (ALB) were significantly i...
Source: International Journal of Clinical Oncology - April 19, 2021 Category: Cancer & Oncology Source Type: research

Efficacy and safety of 188 Re-HEDP in lung cancer patients with bone metastases: a randomized, multicenter, multiple-dose phase IIa study
Conclusions188Re-HEDP at dose of 40 and 50  MBq/kg was generally effective to alleviate pain and improve QOL in lung cancer patients with painful bone metastases.188Re-HEDP was safe and well-tolerated. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 13, 2021 Category: Cancer & Oncology Source Type: research

Comparison of prognostic impact between positive intraoperative peritoneal and lavage cytologies in colorectal cancer
AbstractBackgroundThe prognostic value of positive intraoperative peritoneal cytology and lavage cytology, including the differences in their prognostic impact, in colorectal cancer is controversial. We aimed to investigate the prognostic values of positive peritoneal cytology and lavage cytology findings for colorectal cancer and compare their prognostic impact.MethodsWe retrospectively evaluated 592 clinical stage II –IV colorectal cancer patients who underwent peritoneal cytology (n = 225) or lavage cytology (n = 367) between November 1993 and December 2018. The prognostic factors for c...
Source: International Journal of Clinical Oncology - April 12, 2021 Category: Cancer & Oncology Source Type: research

Epidemiology and prognosis of lymphoepithelioma-like carcinoma: a comprehensive analysis of surveillance, epidemiology, and end results (SEER) database
AbstractAimLymphoepithelioma-like carcinoma (LELC) is a rare histological types of solid tumors. The present study aims to comprehensively describe the demographic and clinical features of LELC using surveillance, epidemiology, and end results (SEER) database, with an emphasis on the prognostic difference according to primary tumor sites of LELC.Materials and methodsA population cohort with histologically diagnosed LELC were identified from SEER database between 1973 and 2016. Age-adjusted incidence rates and cancer-specific survival (CSS) were determined. Cox-regression proportional hazards model was used for both univari...
Source: International Journal of Clinical Oncology - April 12, 2021 Category: Cancer & Oncology Source Type: research

Are all ALK variants created equal? Clinicopathologic features and outcomes: a propensity-matched study
We present a large data set evaluating clinical and outcome differences between ALK variants. The unique standpoint of this study involves the propensity-weighted model to account for differences among the groups, with no prognostic differences between Variant 1 and Variant 3, which is distinct from literature. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 12, 2021 Category: Cancer & Oncology Source Type: research

Association of albumin –bilirubin score in patients with colorectal cancer receiving later-line chemotherapy with regorafenib
ConclusionALBI was strongly associated with the prognosis of patients with mCRC treated with regorafenib and with the occurrence of liver-related adverse events. These findings may imply that patients with a high ALBI score should not be treated with regorafenib. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 11, 2021 Category: Cancer & Oncology Source Type: research

The carcinoembryonic antigen ratio is a potential predictor of survival in recurrent colorectal cancer
AbstractBackgroundThe carcinoembryonic antigen (CEA) “value” itself is often useless in patients with a normal CEA level at initial presentation and those with tumor-irrelevant elevated CEA. Although the unified marker using CEA has been desirable for recurrent tumor staging as well as for primary tumor staging, little is known concerning its rela tionship with the survival of patients with recurrent colorectal cancer in particular.MethodsThis retrospective historical study included patients who experienced disease relapse after curative surgery for stage I –III colorectal cancer between 2006 and 2018. A ...
Source: International Journal of Clinical Oncology - April 11, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Effectiveness and safety of nivolumab in patients with head and neck cancer in Japanese real ‑world clinical practice: a multicentre retrospective clinical study
The article Effectiveness and safety of nivolumab in patients with head and neck cancer in Japanese real ‑world clinical practice: a multicentre retrospective clinical study, written by. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 10, 2021 Category: Cancer & Oncology Source Type: research

The usefulness of microRNA in urine and saliva as a biomarker of gastroenterological cancer
AbstractMicroRNA (miR) is a type of short non-coding RNA comprising 21 –25 nucleotides. While it has been researched widely, its relationship with cancer was clarified recently and it was found to play a significant role in the development and progression of cancer. Furthermore, miR can remain stable for relatively long periods in the blood by being present in exosom es (extracellular microvesicles) or by forming a complex with the Ago2 protein, which gives rise to cancer-specific miR. It is known that miR can indicate the presence and extent of cancer progression. Several reports have proved that miR in urine and sa...
Source: International Journal of Clinical Oncology - April 9, 2021 Category: Cancer & Oncology Source Type: research