Colorectal obstruction is a potential prognostic factor for stage II colorectal cancer
ConclusionsColorectal obstruction is an independent poor prognostic factor for stage II CRC. Adjuvant chemotherapy might be feasible for stage II CRC with colorectal obstruction. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 15, 2018 Category: Cancer & Oncology Source Type: research

Primary prophylactic granulocyte colony-stimulating factor according to ASCO guidelines has no preventive effect on febrile neutropenia in patients treated with docetaxel, cisplatin, and 5-fluorouracil chemotherapy
ConclusionsPrimary prophylactic G-CSF from day 7 of the first cycle of TPF did not reduce the incidence of FN. Our findings suggest that the timing of primary prophylactic G-CSF, as recommended by the American Society of Clinical Oncology guidelines, should be modified to reduce the incidence of FN in TPF. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 15, 2018 Category: Cancer & Oncology Source Type: research

Changes in programmed death ligand 1 expression in non-small cell lung cancer patients who received anticancer treatments
ConclusionMajor changes of PD-L1 expression in tumor cells were observed in 38% of NSCLC patients who received anticancer treatments. And, treatments with EGFR-TKI may increase PD-L1 expression in NSCLC patients harboringEGFR mutations. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 15, 2018 Category: Cancer & Oncology Source Type: research

Observational study of chemotherapy-induced Clostridium difficile infection in patients with lung cancer
ConclusionsCDI may remain undetected in patients undergoing chemotherapy even in those who had not received antibiotic treatment previously, unless due attention is paid to its possibility. Testing forC. difficile toxins is highly recommended to expedite timely treatment for diarrhea in such patients. Further studies are needed to clarify the relationship between chemotherapy drug use and CDI to facilitate prevention. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 6, 2018 Category: Cancer & Oncology Source Type: research

Secondary cancer after a childhood cancer diagnosis: viewpoints considering primary cancer
ConclusionThe cumulative incidence of secondary cancer varied among primary cancers. The primary cancer was closely associated with the secondary cancer but stem cell transplantation was a common risk factor for secondary cancers among CCSs. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 5, 2018 Category: Cancer & Oncology Source Type: research

Early recurrence after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)
AbstractBackgroundCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are used in the management of selected peritoneal malignancies. While most patients achieve long-term disease-free survival, there remains a group with early recurrence (ER). We aim to investigate the clinical factors associated with ER.MethodsA retrospective review of a prospectively maintained database of CRS-HIPEC patients treated between April 2001 and Feb 2016 was performed. ER was defined as recurrence within 12 months of CRS-HIPEC. Patients were stratified according to time to recurrence and only patients with at leas...
Source: International Journal of Clinical Oncology - June 5, 2018 Category: Cancer & Oncology Source Type: research

Relationships between sunitinib plasma concentration and clinical outcomes in Japanese patients with metastatic renal cell carcinoma
AbstractBackgroundThe aim was to investigate the relationships between total sunitinib plasma concentrations (sunitinib plus its active metabolite;N-desethyl sunitinib) and clinical outcomes in Japanese patients with metastatic renal cell carcinoma (mRCC).MethodsTwenty patients with mRCC were enrolled following treatment with sunitinib. To assess safety, the total sunitinib concentration range up to discontinuation of treatment and dosage reduction associated with adverse events within 6  weeks from initiating administration were analyzed. The longest administered sunitinib dosage was defined as the maintenance dose, ...
Source: International Journal of Clinical Oncology - June 2, 2018 Category: Cancer & Oncology Source Type: research

Influence of incomplete neoadjuvant chemotherapy on esophageal carcinoma
ConclusionsWe suggest that perioperative outcomes and long-term prognosis of patients with locally advanced ESCC were not significantly influenced, even if the patients did not receive a complete cycle of NAC. When certain adverse events occur after the first cycle of NAC, we believe that it is nevertheless possible to discontinue chemotherapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 11, 2018 Category: Cancer & Oncology Source Type: research

In vivo detection of acute intracellular acidification in glioblastoma multiforme following a single dose of cariporide
This study demonstrates that acute CEST MRI contrast changes, indicative of intracellular acidification, after administration of cariporide could help localize glioblastoma. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 10, 2018 Category: Cancer & Oncology Source Type: research

Rapid decrease of serum alpha-fetoprotein and tumor volume predicts outcome in children with hepatoblastoma treated with neoadjuvant chemotherapy
AbstractBackgroundNeoadjuvant chemotherapy is given to children with unresectable hepatoblastoma to increase the rate and safety of curative complete surgical resection. Elevated levels of serum alpha-fetoprotein (sAFP) decline with tumor shrinkage. In this single-institution retrospective study, we determined early dynamic changes of sAFP levels and tumor volume in children during therapy for unresectable hepatoblastoma.MethodsWe correlated early dynamic changes of sAFP levels and tumor volume and the sum of the longest primary tumor and measurable metastatic disease diameters as per RECIST 1.1 criteria with patient outco...
Source: International Journal of Clinical Oncology - May 9, 2018 Category: Cancer & Oncology Source Type: research

Current clinical topics of Lynch syndrome
AbstractLynch syndrome (LS) is one of the most common genetic cancer syndromes, occurring at a rate of 1 per 250 –1000 in the general population. This autosomal dominant disease is caused by a germline variant in one of the four mismatch repair genes,MSH2, MLH1, MSH6, PMS2, or theEPCAM gene. LS develops at early ages in colorectal cancer (CRC), endometrial cancer, and various other associated tumors. Accurate diagnosis of LS and utilization of various risk-reduction strategies such as surveillance, prophylactic surgery, and chemoprevention could improve clinical outcomes. The efficacy of surveillance has only been pr...
Source: International Journal of Clinical Oncology - May 9, 2018 Category: Cancer & Oncology Source Type: research

Introduction: Lynch syndrome —its molecular mechanism and current topics
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 9, 2018 Category: Cancer & Oncology Source Type: research

Employment status and termination among survivors of pediatric brain tumors: a cross-sectional survey
ConclusionBrain-tumor survivors are associated with high unemployment rates and multiple unemployment-related factors. Education and welfare systems should identify individual methods of social participation for this group. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

Early intervention using high-precision radiotherapy preserved visual function for five consecutive patients with optic nerve sheath meningioma
ConclusionsA paradigm shift is necessary from surgery to early intervention using precision radiotherapy for the treatment of ONSM in Japan. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

Feasibility study of postoperative adjuvant chemotherapy with S-1 in patients with biliary tract cancer
ConclusionAdjuvant chemotherapy with S-1 is feasible treatment in patients with resected biliary tract cancer. It is necessary to conduct a phase III study to confirm the efficacy of adjuvant therapy of S-1 in patients with resected BTC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 28, 2018 Category: Cancer & Oncology Source Type: research

Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a report from the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG)
ConclusionsThe outcome of patients treated with the JN-H-07 protocol showed improvement over the results reported by previous studies conducted in Japan. Molecular and genetic profiling may enable a more precise stratification of the high-risk cohort. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 26, 2018 Category: Cancer & Oncology Source Type: research

Multi-panel assay of serum autoantibodies in colorectal cancer
ConclusionThe measurement of set of 17 autoantibodies allowed autoantibody profiling in patients with colorectal cancer. The combination assay of six tumor antigens (p53, RalA, HSP70, Galectin1, KM-HN-1, and NY-ESO-1) achieved a positive rate of 56%. Such high positive rates will be helpful for detecting colorectal cancer regardless of tumor stages. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 24, 2018 Category: Cancer & Oncology Source Type: research

Impact of the number of removed lymph nodes on recurrence-free survival in stage I ovarian clear cell carcinoma
AbstractBackgroundAlthough there have been several reports regarding the significance of staging lymphadenectomy for early stage ovarian clear cell carcinoma (CCC) patients, there have been few reports focusing on the number of removed lymph nodes. The aim of this study was to evaluate the impact of the number of removed lymph nodes on recurrence-free survival (RFS) in stage I ovarian CCC.MethodsThe subjects were patients with ovarian CCC who underwent surgery between January 1988 and December 2013. Clinicopathological variables were obtained from the medical records retrospectively. Statistical analysis using Kaplan &ndas...
Source: International Journal of Clinical Oncology - April 20, 2018 Category: Cancer & Oncology Source Type: research

Validation of the 8th edition of the AJCC/UICC TNM staging system for tongue squamous cell carcinoma
ConclusionsThe classification on T3 in the 8th edition can be seen as reasonable with regard to prognosis. Nodal metastasis was significantly correlated with T classification and DOI; however, the probability of subsequent nodal metastasis in patients with T2N0 was almost same for the criteria in the 7th and 8th editions, therefore, the same careful management as before is required for patients with N0 disease. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 19, 2018 Category: Cancer & Oncology Source Type: research

Treatment outcomes of patients with spinal metastases derived from hepatocellular carcinoma
AbstractBackgroundThe prognosis of hepatocellular carcinoma (HCC) used to be poor, but it has recently improved, which has meant that clinicians have greater opportunity to treat spinal metastases and the associated epidural spinal cord compression. However, there have been few systematic functional studies about HCC-derived spinal metastases. The treatment outcomes of surgical treatment for HCC-derived metastatic spinal tumors were investigated.MethodsThe post-treatment survival period and pain, paralysis, and disturbance of activities of daily living (ADL) were investigated in 60 patients (surgery 25, conservative treatm...
Source: International Journal of Clinical Oncology - April 13, 2018 Category: Cancer & Oncology Source Type: research

Anxiety and depression associated with tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia
ConclusionStopping TKIs outside clinical trials is feasible if the guidelines for stopping are followed and an adequate monitoring system is available. Discontinuation of TKIs requires adequate management of anxiety and depression. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 12, 2018 Category: Cancer & Oncology Source Type: research

Total iron-binding capacity is a novel prognostic marker after curative gastrectomy for gastric cancer
This study investigated preoperative iron status associated with prognosis after curative gastrectomy for gastric cancer.MethodsWe evaluated preoperative serum hemoglobin (Hgb), Fe and total iron-binding capacity (TIBC) in 298 patients who underwent curative gastrectomy for GC without preoperative chemotherapy, and analyzed these factors ’ associations with prognosis after surgery.ResultsOf the 298 patients, 129 (43.2%) had low Hgb levels, and 33 (11.1%) had low TIBC (
Source: International Journal of Clinical Oncology - April 9, 2018 Category: Cancer & Oncology Source Type: research

Recent therapeutic strategies for metastatic melanoma: introduction to invited articles
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 6, 2018 Category: Cancer & Oncology Source Type: research

The predictors and oncological outcomes of repeat surgery for recurrence after hepatectomy for colorectal liver metastases
AbstractPurposeAlthough recurrence after hepatectomy for colorectal liver metastases (CRLM) is common, the optimal treatment strategy remains unclear. The aims of this study were to clarify the impact of repeat surgery and identify the predictive factors for repeat surgery.MethodsAmong the 170 patients who underwent potentially curative surgery for CRLM, 113 developed recurrence. The predictive factors for the performance of repeat surgery were identified and a predictive model was constructed.ResultsThe patterns of recurrence were as follows; single site [n  =  100 (liver,n  =  61; lung,n &thin...
Source: International Journal of Clinical Oncology - April 4, 2018 Category: Cancer & Oncology Source Type: research

MMC/UFT/LV in refractory colorectal cancer: phase II study and analysis of predictive variables of progression
ConclusionThe study failed its primary endpoint. However, some putative indicators of early progressive patients have been described. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 1, 2018 Category: Cancer & Oncology Source Type: research

Identification of curable high-risk prostate cancer using radical prostatectomy alone: who are the good candidates for undergoing radical prostatectomy among patients with high-risk prostate cancer?
AbstractBackgroundCurrently, there is no consensus regarding which patients with high-risk prostate cancer (PCa) would benefit the most by radical prostatectomy (RP). We aimed to identify patients with high-risk PCa who are treatable by RP alone.MethodsWe retrospectively reviewed data on 315 patients with D ’Amico high-risk PCa who were treated using RP without neoadjuvant or adjuvant therapy at the institutions of the Yamaguchi Uro-Oncology Group between 2009 and 2013. The primary endpoint was biochemical progression-free survival (bPFS) after RP. Risk factors for biochemical progression were extrac ted using the Co...
Source: International Journal of Clinical Oncology - March 27, 2018 Category: Cancer & Oncology Source Type: research

Clinical Practice Guidelines for Fertility Preservation in Pediatric, Adolescent, and Young Adults with Cancer
This article reviews the latest information concerning clinical practice guidelines around the world, including the American Society of Clinical Oncology guidelines that were the first to be published in this field. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 26, 2018 Category: Cancer & Oncology Source Type: research

D-dimer predicts postoperative recurrence and prognosis in patients with liver metastasis of colorectal cancer
ConclusionHigh D-dimer levels were associated with poor RFS and CSS. D-dimer was an independent prognostic factor of RFS. Therefore, D-dimer may help predict recurrence and prognosis in patients with CRLM. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 24, 2018 Category: Cancer & Oncology Source Type: research

Efficacy of weekly administration of paclitaxel and carboplatin for advanced ovarian cancer patients with poor performance status
ConclusionOur study suggested that NAC with W-TC for poor PS patients with non-treated ovarian cancer reduced the toxicity of chemotherapy and had the same efficacy as TW-TC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 23, 2018 Category: Cancer & Oncology Source Type: research

A clinicopathological study of parotid carcinoma: 18-year review of 171 patients at a single institution
ConclusionsAlthough a high-grade tumor is the most important prognostic factor, preoperative diagnosis of the grade was not always accurate. Since advanced cancer has a poor prognosis with a limited response to surgery and radiation therapy, development of new treatment strategies, such as molecular-targeting therapies directed against HER-2 and AR, is required. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 21, 2018 Category: Cancer & Oncology Source Type: research

Characteristics and outcomes of non-Hodgkin ’s lymphoma patients with leptomeningeal metastases
This study included 27 non-Hodgkin ’s lymphoma patients with leptomeningeal metastases diagnosed at Tianjin Medical University Cancer Institute and Hospital between 2013 and 2016. Statistical analysis was performed to investigate the overall survival of non-Hodgkin’s lymphoma with leptomeningeal metastases.ResultsDiffuse large B cell lymphoma was the most common cancer subtype (21/27, 78%), and more than half of the patients showed extranodal involvement (18/27, 67%). Survival analysis has shown extranodal involvement (P = 0.0205), International Prognostic Index (P = 0.0112), perform...
Source: International Journal of Clinical Oncology - March 20, 2018 Category: Cancer & Oncology Source Type: research

Recent advances in medical therapy for metastatic urothelial cancer
AbstractCytotoxic chemotherapy has been the mainstay of medical therapy for metastatic urothelial cancer. Currently, the gemcitabine/cisplatin regimen is widely used worldwide as the standard first-line medical treatment. Very recently, in 2017, pembrolizumab, a highly selective, humanized monoclonal IgG4 κ isotype antibody against programmed death 1, was approved as a second-line treatment to be used after platina-based chemotherapy for metastatic urothelial cancer in Japan. Based on its promising anti-tumor efficacy and manageable safety profile as demonstrated in the phase III KEYNOTE-045 trial, pembrolizumab ther...
Source: International Journal of Clinical Oncology - March 20, 2018 Category: Cancer & Oncology Source Type: research

Five-year outcomes following hypofractionated stereotactic radiotherapy delivered in five fractions for acoustic neuromas: the mean cochlear dose may impact hearing preservation
ConclusionsHypo-FSRT delivered in five fractions for unilateral ANs may achieve excellent tumor control with no severe facial or trigeminal complications. The mean BED3 in the cochlea may impact the hearing preservation rate. Therefore, the cochlear dose should be as low as possible. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 19, 2018 Category: Cancer & Oncology Source Type: research

Long-term outcomes of definitive external-beam radiotherapy for non-metastatic castration-resistant prostate cancer
ConclusionDefinitive EBRT achieved a long-term disease-free and clinical failure-free status in approximately one-third of and half of the treated NM-CRPC patients, respectively. This approach was also associated with favorable local relapse-free rates and overall survival outcomes. Definitive EBRT is a promising approach for NM-CRPC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 19, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Biological/pathological functions of the CXCL12/CXCR4/CXCR7 axes in the pathogenesis of bladder cancer
Following the publication from the original article, it came to our attention that we unintentionally neglected to acknowledge some text overlap with previous publications. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 10, 2018 Category: Cancer & Oncology Source Type: research

Type of second primary malignancy after achieving complete response by definitive chemoradiation therapy in patients with esophageal squamous cell carcinoma
ConclusionsBecause second primary malignancy developed often after achieving CR by dCRT for ESCC, it should be followed carefully. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 8, 2018 Category: Cancer & Oncology Source Type: research

Time has come for proton and carbon beam therapy
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 8, 2018 Category: Cancer & Oncology Source Type: research

Optimal management of immune-related adverse events resulting from treatment with immune checkpoint inhibitors: a review and update
AbstractOver the last two decades, molecular-targeted agents have become mainstream treatment for many types of malignancies and have improved the overall survival of patients. However, most patients eventually develop resistance to these targeted therapies. Recently, immunotherapies such as immune checkpoint inhibitors have revolutionized the treatment paradigm for many types of malignancies. Immune checkpoint inhibitors have been approved for treatment of melanoma, non-small cell lung cancer, renal cell carcinoma, head and neck squamous cell carcinoma, Hodgkin ’s lymphoma, bladder cancer and gastric cancer. However...
Source: International Journal of Clinical Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research

Retrospective analysis on the clinical outcomes of recombinant human soluble thrombomodulin for disseminated intravascular coagulation syndrome associated with solid tumors
AbstractBackgroundRecombinant human soluble thrombomodulin (rTM) has been established and introduced in the clinic as a standard treatment for disseminated intravascular coagulation (DIC). However, the efficacy and safety of rTM for DIC associated with solid tumors (DIC-STs) have not been fully established. Here, we performed a retrospective analysis of the clinical outcomes of rTM for DIC-STs and considered a treatment strategy with rTM for DIC-STs.MethodsPatients with DIC-STs between November 2009 and March 2016 in 2 cancer core hospitals were retrospectively analyzed. Data, including patient background, treatment course...
Source: International Journal of Clinical Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research

Hepatectomy for oligo-recurrence of non-small cell lung cancer in the liver
ConclusionsHepatectomy may be equally effective as multidisciplinary therapy for oligo-recurrence of NSCLC in the liver. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 6, 2018 Category: Cancer & Oncology Source Type: research

Fertility preservation for female cancer patients
AbstractAn improvement in the survival rates of cancer patients and recent advancements in assisted reproductive technologies have led to remarkable progress in oncofertility and fertility preservation treatments. Currently, for adults and postpubertal girls, oocyte or embryo cryopreservation is an established method. If their cancer treatment cannot be postponed for 2  weeks, ovarian tissue cryopreservation is offered as an experimental technique. For prepubertal girls, ovarian tissue cryopreservation is the only option. As for ovarian protection, there is insufficient evidence regarding the effectiveness of GnRH ago...
Source: International Journal of Clinical Oncology - March 3, 2018 Category: Cancer & Oncology Source Type: research

Risk of second malignancies among survivors of pediatric thyroid cancer
ConclusionsRace, gender, histological subtypes, and radioactive iodine are potentially significant prognostic factors for the development of SM among pediatric thyroid cancer survivors. Identification of underlying mechanisms that raise the risk of SM is important for both treatment and follow-up strategies. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 28, 2018 Category: Cancer & Oncology Source Type: research

The prognostic significance of surgical treatment for excessive elderly patients with soft tissue sarcoma
AbstractBackgroundSoft tissue sarcoma (STS) mainly occurs in middle-aged and senior citizens. Although a poorer prognosis has been reported for older patients, few studies have examined advanced elderly excessive older patients. We evaluated the clinical features of advanced elderly patients with STS.MethodsOne hundred and forty-four patients were included in this retrospective study, and we divided them into two groups based on a cut-off age of 85 (older and younger groups). The patients ’ information, including age, tumor type, location, size, presence of metastasis, AJCC stage, FNCLCC classification, treatment-rel...
Source: International Journal of Clinical Oncology - February 27, 2018 Category: Cancer & Oncology Source Type: research

Early stage non-small cell lung cancer patients need brain imaging regardless of symptoms
ConclusionIn clinical T1-2aN0 lung cancer patients with brain metastasis, almost all patients were asymptomatic. Patients with EGFR mutations and brain metastasis were likely to be asymptomatic. Regardless of central nervous system symptoms, routine brain imaging seems warranted in all NSCLC patients, especially in areas where patients have a higher frequency of EGFR mutations. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 26, 2018 Category: Cancer & Oncology Source Type: research

Impact of RAS/BRAF mutation status in locally advanced rectal cancer treated with preoperative chemotherapy
ConclusionRAS/BRAF mutations did not affect the response to NAC. However, the RFS was likely to be poor for those in the MT group who did not achieve favorable pathological response. In contrast, the RFS was favorable in the WT group regardless of the pathological response. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 24, 2018 Category: Cancer & Oncology Source Type: research

Recent advances in therapeutic strategies for unresectable or metastatic melanoma and real-world data in Japan
AbstractNew therapeutic strategies including immunotherapy and selective molecular target inhibitors have brought about a new era in the treatment of patients with advanced melanoma. In Japan, the immune checkpoint inhibitors ipilimumab, nivolumab and pembrolizumab, the BRAF inhibitor (BRAFi) vemurafenib, dabrafenib and MEK inhibitor (MEKi) trametinib have been available for the treatment of unresectable and metastatic melanoma. The BRAFi  + MEKi combination shows high response rates (60–70%) and rapid response induction associated with symptom control, with a progression-free survival of 12 months. Ni...
Source: International Journal of Clinical Oncology - February 22, 2018 Category: Cancer & Oncology Source Type: research

Phase I study of primary treatment with 5-FU, oxaliplatin, irinotecan, levofolinate, and panitumumab combination chemotherapy in patients with advanced/recurrent colorectal cancer involving the wild-type RAS gene: the JACCRO CC-14 study
ConclusionThe FOLFOXIRI + panitumumab chemotherapy regimen was well tolerated by our patients with mCRC and showed promising anti-tumor activity. The recommended phase II dose was determined to be the same as the standard doses of this regimen used worldwide. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 20, 2018 Category: Cancer & Oncology Source Type: research

Long-term outcomes of postoperative taxane/platinum chemotherapy for early stage cervical cancer: a retrospective study
ConclusionsPostoperative TP is effective in patients with surgically treated early stage cervical cancer. In these populations, a positive surgical margin could be associated with poor prognosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 14, 2018 Category: Cancer & Oncology Source Type: research

Characteristic findings of high-grade cervical intraepithelial neoplasia or more on magnifying endoscopy with narrow band imaging
ConclusionThe lesions  ≥ CIN 3 demonstrated characteristic ME-NBI findings of h-WE alone, or l-/h-WE with atypical micro-vessels. This study indicates that ME-NBI may have novel value for CIN diagnosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 14, 2018 Category: Cancer & Oncology Source Type: research

The clinical features of squamous cell lung carcinoma with sensitive EGFR mutations
ConclusionThe administration of afatinib to Sq patients after selecting patients using the EGFR mutation test based on their underlying pulmonary disease and smoking status would likely result in a population with a greater sensitivity to afatinib. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 14, 2018 Category: Cancer & Oncology Source Type: research