Cell-type-specific sensitivity of bortezomib in the methotrexate-resistant primary central nervous system lymphoma cells
ConclusionThese results indicate the cell-type-specific changes downstream of metabolic pathways for MTX and folate, bortezomib sensitivity, and purine and pyrimidine syntheses, in each PCNSL cell line. The MTX-resistant lymphoma cell lines established may be useful for in vitro relapse models for MTX and development of salvage chemotherapy and drug discovery. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Feasibility of initial treatment in elderly patients with ovarian cancer in Japan: a retrospective study
ConclusionsThis study clarified the type of treatment being performed in the field, and the proportion of elderly ovarian cancer patients receiving standard therapy compared with younger patients in Japan. In addition, the actual situation of elderly patients in Japan might be different from that in Western countries. We need to evaluate the appropriate treatment for elderly patients in Japan. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 15, 2019 Category: Cancer & Oncology Source Type: research

Cryosurgery for primary breast cancers, its biological impact, and clinical outcomes
AbstractRecently, a number of new minimally invasive image-guided percutaneous ablation treatments, including cryoablation, radiofrequency ablation, microwave ablation, high-intensity focused ultrasound, laser ablation, and irreversible electroporation have been developed. Several studies have shown the feasibility and safety of these cryoablation therapies for the treatment of benign breast tumors and small invasive breast cancer. Although the complete response rate of cryoablation for breast cancer is reported to be relatively good, most studies enrolled a small number of patients, and so reliable conclusions could not b...
Source: International Journal of Clinical Oncology - April 13, 2019 Category: Cancer & Oncology Source Type: research

Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells
AbstractGastric cancer (GC), one of the most common human cancers, is a heterogeneous disease with different phenotypes, prognoses, and responses to treatment. Understanding the pathogenesis of GC at the molecular level is important for prognosis prediction and determining treatments. Microsatellite instability (MSI), silencing ofMLH1,MGMT, andCDKN2A genes by DNA hypermethylation,KRAS mutation,APC mutation, andERBB2 amplification are frequently found in intestinal type GC. Inactivation ofCDH1 andRARB by DNA hypermethylation, and amplification ofFGFR andMET, are frequently detected in diffuse type GC. In addition,BST2 andPC...
Source: International Journal of Clinical Oncology - April 12, 2019 Category: Cancer & Oncology Source Type: research

Dawn of precision medicine on gastric cancer
ConclusionRemarkable advances in an understanding of molecular profiles of gastric cancer enable the development of novel agents. The better treatment selection of immune checkpoint inhibitors or combination therapy should be established. These developments could facilitate precision medicine on gastric cancer in the near future. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 11, 2019 Category: Cancer & Oncology Source Type: research

High diagnostic efficacy of 5-aminolevulinic acid-induced fluorescent urine cytology for urothelial carcinoma
In this study, we evaluated the diagnostic efficacy of 5-ALA-induced fluorescent urine cytology for UC.MethodsWe included in this study 318 patients comprising 158 non-cancer patients, 84 bladder tumor patients, and 76 upper urinary tract urothelial carcinoma (UUT-UC) patients treated in our institution from March 2013 to September 2018. Using the same voided urine sample, we compared sensitivity and specificity between conventional urine cytology and 5-ALA-induced fluorescent urine cytology.ResultsOverall, the sensitivity of 5-ALA-induced fluorescent urine cytology was significantly higher than that of conventional urine ...
Source: International Journal of Clinical Oncology - April 11, 2019 Category: Cancer & Oncology Source Type: research

Predictive factors for short-term biochemical recurrence-free survival after robot-assisted laparoscopic radical prostatectomy in high-risk prostate cancer patients
ConclusionsPSA level  >  20 ng/mL and/or presence of the Gleason pattern 5 component on biopsy are predictive factors for early biochemical recurrence after robot-assisted laparoscopic radical prostatectomy in high-risk prostate cancer patients. We considered that these patients require a combined modality therapy to im prove their prognosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 10, 2019 Category: Cancer & Oncology Source Type: research

Laparoscopic radical cystectomy in octogenarians: analysis of a Japanese multicenter cohort
ConclusionsThis study revealed that LRC can be performed for selected octogenarians with a complication rate similar to that of younger patients. Appropriate risk evaluation and modification of surgical procedures are necessary for octogenarians. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 10, 2019 Category: Cancer & Oncology Source Type: research

Carbon-ion radiotherapy for lymph node oligo-recurrence: a multi-institutional study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS)
AbstractBackgroundThe efficacy of carbon-ion radiotherapy (C-ion RT) for lymph node (LN) oligo-recurrence has only been evaluated in limited single-center studies. We aimed to investigate the benefit of C-ion RT for LN oligo-recurrence in a large multi-center study.MethodsPatients who received C-ion RT between December 1996 and December 2015 at 4 participating facilities and who met the following eligibility criteria were included: (i) histological or clinical diagnosis of LN recurrence; (ii) controlled primary lesion; (iii) no recurrence other than LN; (iv) LN recurrence involved in a single lymphatic site; and (v) age &t...
Source: International Journal of Clinical Oncology - April 9, 2019 Category: Cancer & Oncology Source Type: research

Real-world treatment of over 1600 Japanese patients with EGFR mutation-positive non-small cell lung cancer with daily afatinib
ConclusionsReal-world treatment of 1602 Japanese patients with afatinib was associated with a predictable ADR profile. Afatinib showed effectiveness in inoperable/recurrentEGFR mutation-positive NSCLC, especially as first-line treatment. As with other EGFR TKIs, prompt management of adverse events is needed in the Japanese population, to reduce serious events and outcomes, including interstitial lung disease. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 5, 2019 Category: Cancer & Oncology Source Type: research

Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma
ConclusionThe oncologic outcome of patients with MmOC was extremely poor; however, it was almost the same as that of those with PmOC. We should recognize MmOC derived from gastric carcinoma as a highly aggressive malignancy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 2, 2019 Category: Cancer & Oncology Source Type: research

Stereotactic body radiotherapy in patients with chronic obstructive pulmonary disease and interstitial pneumonia: a review
AbstractStereotactic body radiation therapy (SBRT) can yield excellent local tumor control, as well as survival benefit comparable to that of surgery for early-stage lung cancer. However, in terms of toxicity, SBRT might lead to fatal radiation pneumonitis. Lung diseases, such as chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD), are major risk factors for lung cancer. However, these patients are typically not candidates for the gold-standard treatment option, lobectomy, because of the perioperative risks. In addition, patients with poor respiratory function can be excluded in prospective cli...
Source: International Journal of Clinical Oncology - April 1, 2019 Category: Cancer & Oncology Source Type: research

Bortezomib-based strategy with autologous stem cell transplantation for newly diagnosed multiple myeloma: a phase II study by the Japan Study Group for Cell Therapy and Transplantation (JSCT-MM12)
ConclusionsThe study revealed that the treatment protocol consisting of VCD induction, B-HDM/ASCT followed by VTD consolidation, and LEN maintenance could produce highly beneficial responses and favorable tolerability in newly diagnosed MM. However, future study is required for improving treatment in the high-risk group. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 1, 2019 Category: Cancer & Oncology Source Type: research

Identification of SERPINE1, PLAU and ACTA1 as biomarkers of head and neck squamous cell carcinoma based on integrated bioinformatics analysis
ConclusionsSERPINE1, PLAU and ACTA1 played important roles in regulating the initiation and progression of HNSCC, and could be identified as key biomarkers for precise diagnosis and prognosis of HNSCC, which will provide potential targets for clinical therapies. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 1, 2019 Category: Cancer & Oncology Source Type: research

Usefulness of cell-free and concentrated ascites reinfusion therapy in the therapeutic management of advanced ovarian cancer patients with massive ascites
AbstractBackgroundThe management of refractory ascites in advanced ovarian cancer (AOC) is vital for patients with abdominal distention, respiratory distress, and anorexia due to massive ascites with cancer peritonitis. We analyzed the benefits of concentrated ascites reinfusion therapy (CART) in the management of AOC.MethodsWe reviewed records of AOC patients who underwent CART between January 2011 and March 2017. We retrospectively analyzed patients ’ backgrounds and physiological changes, including body weight, abdominal girth, urine volume, blood component values, blood pressure, heart rate, and body temperature ...
Source: International Journal of Clinical Oncology - March 28, 2019 Category: Cancer & Oncology Source Type: research

Neoadjuvant CAPOX and bevacizumab alone for locally advanced rectal cancer: long-term results from the N-SOG 03 trial
ConclusionsPatients with cT4b tumor were not suitable for NAC alone. However, the long-term outcomes of the other patients were satisfactory, and NAC alone might be an option for treatment of LARC. N down-staging was likely to bring favorable PFS, even in patients with cStage III. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 28, 2019 Category: Cancer & Oncology Source Type: research

Lymphopenia after induction chemotherapy correlates with incomplete surgical resection in patients with advanced ovarian cancer
ConclusionsPost-IC lymphopenia may predict incomplete resection during IDS and poor prognosis in patients with advanced EOC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 28, 2019 Category: Cancer & Oncology Source Type: research

Efficacy and safety of oxaliplatin-based regimen versus cisplatin-based regimen in the treatment of gastric cancer: a meta-analysis of randomized controlled trials
AbstractBackgroundCisplatin played an important role in the treatment of gastric cancer (GC). Oxaliplatin has been shown to be at least as effective as cisplatin for GC, with less toxicity and a better tolerability profile. We performed a meta-analysis to compare the efficacy and safety of oxaliplatin-based regimen versus cisplatin-based regimen in the treatment of GC.MethodsDatabases of CNKI, CBM, VIP, Wanfang, PubMed, Embase, Cochrane Library were searched for eligible literatures from their establishments to November 2018. Randomized controlled trials that compared the efficacy and safety of oxaliplatin-based regimen wi...
Source: International Journal of Clinical Oncology - March 27, 2019 Category: Cancer & Oncology Source Type: research

Impact of prostate cancer radiotherapy on the biological behavior and specific mortality of subsequent bladder cancer
AbstractBackgroundThe impact of different radiotherapy modalities on the development and characteristics of second primary bladder cancers (BCa) and BCa-specific mortality (BCa-SM) remains unclear. Thus, we evaluated the incidence and biological behavior of subsequent BCa and related survival in patients who underwent radiation therapy for prostate cancer (PCa).MethodsA total of 530,581 patients in the surveillance, epidemiology, and end results database with localized PCa between 1988 and 2013 were identified. PCa treatments included radical prostatectomy (RP), external beam radiotherapy (EBRT), radioactive implants (RI),...
Source: International Journal of Clinical Oncology - March 22, 2019 Category: Cancer & Oncology Source Type: research

Future projection of cancer patients with cardiovascular disease in Japan by the year 2039: a pilot study
AbstractBackgroundThe number of cancer patients in Japan is estimated to rise to 3.5  million by 2025. The disease burden may be further complicated by comorbidities caused by cardiovascular disease (CVD). Predicting the number of cancer patients with CVD can help anticipate future resource needs.MethodsWe used statistics derived from the Niigata Cancer Center CVD Study (2015) as well as population estimates from the National Cancer Center ’s Cancer Registry and Statistics survey of 2017 for convenience. We simply multiplied the projected number of cancer patients through the year 2039 by the CVD prevalence in 2...
Source: International Journal of Clinical Oncology - March 22, 2019 Category: Cancer & Oncology Source Type: research

Removal of the entire internal iliac vessel system is a feasible surgical procedure for locally advanced ovarian carcinoma adhered firmly to the pelvic sidewall
ConclusionsRemoval of the entire internal iliac vessel system is feasible for the complete resection of locally advanced ovarian carcinomas adhered firmly to the pelvic sidewall. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 20, 2019 Category: Cancer & Oncology Source Type: research

Survival and chemotherapy-related risk of second primary malignancy in breast cancer patients: a SEER-based study
AbstractBackgroundWith the improvement in the survival of breast cancer, developing second primary malignancy becomes a serious health issue. The aim of this study was to explore the survival of breast cancer patients with second primary malignancy, and to evaluate the impact of chemotherapy on the risk of different cancer sites.MethodObtaining data from the Surveillance, Epidemiology, and End Results database, we calculated the standardized incidence ratio (SIR) for second primary malignancy in breast cancer survivors between 2000 and 2014. Overall survival and cancer-specific survival were analyzed with Kaplan –Mei...
Source: International Journal of Clinical Oncology - March 19, 2019 Category: Cancer & Oncology Source Type: research

Three-year follow-up of a phase II study of radium-223 dichloride in Japanese patients with symptomatic castration-resistant prostate cancer and bone metastases
ConclusionsIn Japanese patients with symptomatic mCRPC and bone metastases, radium-223 had a favorable long-term safety profile with no second primary malignancies reported. Taken together with median OS, which was comparable to that in the pivotal phase III ALSYMPCA study, these results support continued benefit from radium-223 in Japanese patients with mCRPC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 14, 2019 Category: Cancer & Oncology Source Type: research

FDG-PET might not contribute to improving survival in patients with locally advanced inoperable esophageal cancer
ConclusionsCompared with only CT, additional information from FDG-PET is not associated with improving survival in patients with locally advanced esophageal cancer. Our results suggest that FDG-PET might not have much meaning for survival in locally advanced esophageal cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 12, 2019 Category: Cancer & Oncology Source Type: research

RFA experiences, indications and clinical outcomes
AbstractBackgoundEarly-stage breast cancer is increasingly detected by screening mammography, and we aim to establish radiofrequency ablation therapy (RFA) as a minimally invasive, cost-efficient, and cosmetically acceptable local treatment. Although there were many studies on resection after RFA, none of them provided sufficient evidence to support RFA as a standard therapy for breast cancer.ResultsIn our Phase I study, localized tumors with a maximum diameter of 2  cm, preoperatively diagnosed by imaging and histopathology, were treated with RFA. A 90% complete ablation rate was confirmed histopathologically. Our ph...
Source: International Journal of Clinical Oncology - March 11, 2019 Category: Cancer & Oncology Source Type: research

Resection of pancreatic metastatic renal cell carcinoma: experience and long-term survival outcome from a large center in China
ConclusionsPmRCCs are uncommon, but pancreatic metastasectomy has a relatively good prognosis and may, therefore, be a good therapeutic choice for patients with PmRCCs. Because PmRCC occurs long after the primary tumor resection, long-term follow-up is necessary. Besides, detailed medical history and specific manifestation in imaging features could contribute to avoiding misdiagnosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 7, 2019 Category: Cancer & Oncology Source Type: research

Recent treatment strategy for advanced squamous cell carcinoma of the lung in Japan
AbstractSquamous cell carcinoma of the lung is associated with smoking in its development and comprises about 20 –30% of all lung cancers. Its treatment strategy had been limited for the past decades, inevitably resulting in the poor outcome. However in the 2010s, it has dramatically changed mainly with the recent clinical introduction of immune checkpoint inhibitors. In this review, we will introduce variou s clinical studies involving squamous cell carcinoma of the lung. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 7, 2019 Category: Cancer & Oncology Source Type: research

CT and clinical characteristics that predict risk of EGFR mutation in non-small cell lung cancer: a systematic review and meta-analysis
AbstractIntroductionTo systematically analyze CT and clinical characteristics to find out the risk factors of epidermal growth factor receptor (EGFR) mutation in non-small cell lung cancer (NSCLC). Then the significant characteristics were used to set up a mathematic model to predict EGFR mutation in NSCLC.Materials and methodsPubMed, Web of Knowledge and EMBASE up to August 17, 2018 were systematically searched for relevant studies that investigated the evidence of association between CT and clinical characteristics and EGFR mutation in NSCLC. After study selection, data extraction, and quality assessment, the pooled odds...
Source: International Journal of Clinical Oncology - March 5, 2019 Category: Cancer & Oncology Source Type: research

Japanese subgroup analysis of a phase III study of S-1 versus docetaxel in non-small cell lung cancer patients after platinum-based treatment: EAST-LC
ConclusionsThis Japanese subgroup analysis showed that S-1 had similar efficacy to docetaxel in patients with previously treated advanced NSCLC. These results are similar to those of the overall EAST-LC population. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Correction to: Castration-resistant prostate cancer patients who had poor response on first androgen deprivation therapy would obtain certain clinical benefit from early docetaxel administration
The original article can be found online. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 2, 2019 Category: Cancer & Oncology Source Type: research

Diagnostic value of multimodal ultrasound imaging in differentiating benign and malignant TI-RADS category 4 nodules
ConclusionsThe initial clinical results suggest that multimodal US imaging improves the diagnostic accuracy of TI-RADS-4 nodules and provides additional information for differentiating malignant and benign nodules. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2019 Category: Cancer & Oncology Source Type: research

Factors related to cervical cancer screening among women of childrearing age: a cross-sectional study of a nationally representative sample in Japan
ConclusionsAlthough women of childrearing age tended to undergo cervical cancer screening with advancing age, the increase tended to be restrained among mothers. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2019 Category: Cancer & Oncology Source Type: research

Optimal use of anthracycline-free perioperative chemotherapy in HER2-positive breast cancer patients
ConclusionOur study suggests that anthracyclines can be safely omitted in selected patients with HER2-positive breast cancer, who have cT1N0 or cT2N0 and achieved pathological complete response after receiving neoadjuvant chemotherapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 27, 2019 Category: Cancer & Oncology Source Type: research

Discrimination between breast invasive ductal carcinomas and benign lesions by optimizing quantitative parameters derived from dynamic contrast-enhanced MRI using a semi-automatic method
AbstractBackgroundTo propose a semi-automatic method for distinguishing invasive ductal carcinomas from benign lesions on breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).Methods142 cases were included. In the conventional method, the region of interest for a breast lesion was drawn manually and the corresponding mean time –signal intensity curve (TIC) was qualitatively categorized. Only one quantitative parameter was obtained: the maximum slope of increase (MSI). By contrast, the proposed method extracted the suspicious breast lesion semi-automatically. Besides MSI, more quantitative parameters ...
Source: International Journal of Clinical Oncology - February 27, 2019 Category: Cancer & Oncology Source Type: research

Long-term outcomes and prognostic factors of pulmonary metastasectomy for osteosarcoma and soft tissue sarcoma
AbstractBackgroundThe prognostic factors of pulmonary metastasectomy in patients with osteosarcoma and soft tissue sarcoma remain controversial. The purpose of our analysis was to explore the prognostic factors and outcomes of patients with osteosarcoma and soft tissue sarcoma who underwent pulmonary metastasectomy at our institution.MethodsWe reviewed the data of 44 patients who underwent resection of pulmonary metastases from 1996 to 2016  at our institution. The Kaplan–Meier method, log-rank test and multivariate Cox hazard model were used for comparison and survival analyses.ResultsThere was no perioperative...
Source: International Journal of Clinical Oncology - February 26, 2019 Category: Cancer & Oncology Source Type: research

External validation of nomograms for prediction of progression-free survival and liver toxicity in patients with advanced renal cell carcinoma treated with pazopanib
ConclusionThe clinical effect and safety of pazopanib reported in this study was similar to previous studies. This study suggests careful application of nomograms to Japanese patients treated with pazopanib. We have developed a new nomogram for predicting 12-month PFS with pazopanib therapy from Japanese patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 23, 2019 Category: Cancer & Oncology Source Type: research

Analysis of major BCR-ABL1 mRNA by digital polymerase chain reaction is useful for prediction of international scale
ConclusionsDigital PCR technology is promising for predicting the IS value with similar efficacy to real-time PCR and should be useful for simple monitoring of the effects of tyrosine kinase inhibitor (TKI) treatments. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 23, 2019 Category: Cancer & Oncology Source Type: research

Induction TPF chemotherapy followed by CRT with fractionated administration of cisplatin in patients with unresectable locally advanced head and neck cancer
ConclusionTPF IC is feasible and CRT with fractionated administration of cisplatin after IC is tolerable. IC followed by CRT appears to be a useful and safe sequential treatment. (Trial registration no. UMIN000024686). (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 22, 2019 Category: Cancer & Oncology Source Type: research

Lymph node ratio has impact on relapse and outcome in patients with stage III melanoma
ConclusionOur results suggest that, apart from the conventional nodal status, NR is an independent prognostic factor-regarding both RFS and OS in stage III cutaneous melanoma. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 20, 2019 Category: Cancer & Oncology Source Type: research

Control of intracranial disease is associated with improved survival in patients with brain metastasis from hepatocellular carcinoma
AbstractBackgroundBrain metastasis is a rare event in patients with hepatocellular carcinoma (HCC). This retrospective study aimed to identify the prognostic factors and determine the outcomes of patients with brain metastases from HCC.MethodsAbout 86 patients with brain metastases (0.6%) from HCC were identified from two institutions; of them, 32 underwent tumor-removing surgery or stereotactic radiosurgery (SRS) with or without adjuvant whole brain radiotherapy (WBRT) (group 1), 30 had WBRT alone (group 2), and 24 received conservative treatment (group 3). Estimates for overall survival (OS) after brain metastases were d...
Source: International Journal of Clinical Oncology - February 20, 2019 Category: Cancer & Oncology Source Type: research

A prognostic parameter in advanced non-small cell lung cancer: the ratio of hemoglobin-to-red cell distribution width
This study aims to investigate the prognostic value of the ratio of hemoglobin –RDW (HRR) at diagnosis, in terms of overall survival (OS) and progression-free survival in patients with advanced non-small cell lung cancer (NSCLC).MethodsPatients with metastatic NCCLC who attended two separate medical oncology clinics between April 2013 and December 2017 were retrospectively screened. HRR was calculated as Hgb (g/dL) divided by the RDW (%). Patients were assigned to either the low HRR group or high HRR group.ResultsA total of 153 patients were included in the study. The cuff-value for HRR was taken as 0.88. Among the l...
Source: International Journal of Clinical Oncology - February 19, 2019 Category: Cancer & Oncology Source Type: research

Biweekly S-1 plus oxaliplatin (SOX) reintroduction in previously treated metastatic colorectal cancer patients (ORION 2 study): a phase II study to evaluate the efficacy and safety
ConclusionBiweekly SOX regimen with reintroduction of oxaliplatin could be exploitable as the third- and/or later-line treatments for patients with mCRC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 18, 2019 Category: Cancer & Oncology Source Type: research

Oncologic and reproductive outcomes of cystectomy as a fertility-sparing treatment for early-stage epithelial ovarian cancer
ConclusionsAlthough oophorectomy is considered as an appropriate fertility-preserving operation, cystectomy may be an unavoidable option when it is the only surgical procedure available. It is desirable to verify the utility by accumulating larger numbers of patients through a future registry system. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 15, 2019 Category: Cancer & Oncology Source Type: research

Adjuvant therapy in renal cell carcinoma: the perspective of urologists
AbstractBackgroundUntil recently, there was no approved adjuvant therapy (AT) for renal cell carcinoma (RCC) unless sunitinib was approved in the US. We evaluated clinical opinion and estimated use regarding different treatment options and patient selection of AT in RCC patients based on current scientific data and individual experience in Germany.MethodsWe conducted an anonymous survey during a national urology conference in 01/2017. Answers of 157 urologists treating RCC patients could be included. Questions were related to practice setting, treatment of RCC, follow-up strategy, physicians ’ personal opinion and in...
Source: International Journal of Clinical Oncology - February 13, 2019 Category: Cancer & Oncology Source Type: research

Use of direct oral anti-coagulants for the treatment of venous thromboembolism in patients with advanced cancer: a prospective observational study
ConclusionsOur findings confirm the risk of bleeding during DOAC treatment for VTE in Japanese patients with advanced cancer, particularly those with poor PS and those using NSAIDs. The risk of bleeding in these patients may be reduced by avoiding the combined use of DOACs and NSAIDs. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 12, 2019 Category: Cancer & Oncology Source Type: research

Survivin rs9904341 polymorphism significantly increased the risk of cancer: evidence from an updated meta-analysis of case –control studies
AbstractAimsSurvivin, a member of inhibitor of apoptosis protein family, is involved in the regulation of cell cycle and apoptosis. Several studies inspected the association between survivin polymorphisms and the risk of various cancers, but the findings remain controversial. We conducted a meta-analysis intending to certify the association between survivin polymorphisms and cancer risk.MethodsAll analyses were achieved using RevMan 5.3 software and STATA 14.1 software. Eligible studies were collected by comprehensive literature searching Web of Science, PubMed, Scopus, and Google scholar databases. Pooled estimates of odd...
Source: International Journal of Clinical Oncology - February 12, 2019 Category: Cancer & Oncology Source Type: research

Prolonged conservative treatment in patients with recurrent endometrial cancer after primary fertility-sparing therapy: 15-year experience
ConclusionsFor patients with recurrent EC after primary fertility-preserving treatment, repeated fertility-preserving treatment can still achieve a promising response and patients have possibilities of completing childbirth. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 12, 2019 Category: Cancer & Oncology Source Type: research

Saddle pulmonary embolism and in-hospital mortality in patients with cancer
ConclusionIn this retrospective study of admissions for acute PE in patients with comorbid cancer, saddle PE was associated with a higher odds of in-hospital mortality. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 12, 2019 Category: Cancer & Oncology Source Type: research

Enzalutamide versus flutamide for castration-resistant prostate cancer after combined androgen blockade therapy with bicalutamide: a retrospective study
ConclusionsAAT with subsequent flutamide after CAB therapy with bicalutamide may be suitable for some CRPC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 11, 2019 Category: Cancer & Oncology Source Type: research

Patterns of lymph node metastasis and the management of neck dissection for parotid carcinomas: a single-institute experience
ConclusionElective neck dissection may be most appropriate for parotid carcinoma patients with high grade disease and/or an advanced T classification. Because preoperative evaluation of the histological grade of parotid carcinoma has limited reliability, it is important to decide the indications and range of neck dissection from the results of frozen section biopsy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 9, 2019 Category: Cancer & Oncology Source Type: research