Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50  years of age in Japan
AbstractBackgroundAs the population ages in developed countries, the number of Pap smears for cervical cancer screening of older women is increasing. There is concern that cervical atrophy may cause misinterpretation of results for this segment of the population. The present study evaluated the accuracy of screening for high-grade intraepithelial lesions (HSILs) in women younger or older than 50  years, to determine whether aging affects cytological interpretation.MethodsPatients with HSIL cytology (N = 1565) were dichotomized into those aged 20–49 years or aged ≥ 50 year...
Source: International Journal of Clinical Oncology - December 6, 2021 Category: Cancer & Oncology Source Type: research

Correction to: COVID ‑19 infection in pediatric patients treated for cancer
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 4, 2021 Category: Cancer & Oncology Source Type: research

Preoperative models incorporating the systemic immune-inflammation index for predicting prognosis and muscle invasion in patients with non-metastatic upper tract urothelial carcinoma
ConclusionPreoperative SII is significantly associated with worse survival outcomes and muscle invasion in patients with non-metastatic UTUC. Our preoperative predictive models may serve as a guide to indications for NAC and LND. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 3, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Medical guidelines for Li –Fraumeni syndrome 2019, version 1.1
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 3, 2021 Category: Cancer & Oncology Source Type: research

Palbociclib as an early-line treatment for Japanese patients with hormone receptor –positive/human epidermal growth factor receptor 2–negative advanced breast cancer: a review of clinical trial and real-world data
AbstractBreast cancer is the most common type of cancer among women worldwide and in Japan. The majority of breast cancers are hormone receptor –positive (HR+)/human epidermal growth factor receptor 2–negative (HER2‒), and endocrine therapy is an effective therapy for this type of breast cancer. However, recent substantial advances have been made in the management of HR+/HER2‒ advanced breast cancer (ABC) with the advent of targeted therapies, such as cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, resulting in significant improvements in survival outcomes versus endocrine therapy alone. To evaluate the op...
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

The cancer ‐related transcription factor Runx2 combined with osteopontin: a novel prognostic biomarker in resected osteosarcoma
ConclusionsThese results suggest that a combined Runx2/OPN expression could be a valuable independent predictor of tumor metastasis and survival in osteosarcoma patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Assessment of button-type jejunostomy for nutritional management after esophagectomy in 201 cases
AbstractBackgroundMany surgeons preferably place a trans-nasal feeding tube or a feeding enterostomy for post-operative nutritional management after esophagectomy. Various types of tubes (such as nasogastric, transgastric, transduodenal, or transjejunal tubes) have been used for enteral feeding; however, the appropriate enteral feeding routes have not yet been proposed. Therefore, this study aimed to evaluate the feasibility and safety of button-type jejunostomy.MethodsWe reviewed 201 patients who underwent esophagectomy with placement of a button-type jejunostomy at the Jikei University Hospital (Tokyo, Japan) between 200...
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Risk assessment of multi-factorial complications after transrectal ultrasound-guided prostate biopsy: a single institutional retrospective cohort study
AbstractBackgroundTransrectal ultrasound-guided prostate biopsy (TRUSPB) is widely used to diagnose prostate cancer (PCa). The aim of this study was to evaluate the risk of multi-factorial complications (febrile genitourinary tract infection (GUTI), rectal bleeding, and urinary retention) after TRUSPB.MethodsN = 2053 patients were Japanese patients undergoing transrectal or transperineal TRUSPB for suspicious of PCa. To assess risk of febrile GUTI adequately, the patients were divided into four groups: low-risk patients before starting a rectal culture, low-risk patients after starting a rectal cultu re, high...
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Computed tomography-derived biomarker for predicting the treatment response to neoadjuvant chemoradiotherapy of rectal cancer
ConclusionsCT-derived texture parameters could be potential biomarkers for predicting the therapeutic response of rectal cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Phase III study of adjuvant gemcitabine compared with adjuvant uracil-tegafur in patients with completely resected pathological stage IB –IIIA non-small cell lung cancer (WJTOG0101)
ConclusionAlthough GEM-based adjuvant therapy for patients with completely resected stage IB –IIIA NSCLC was associated with acceptable toxicity, it did not provide longer OS than did UFT. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Efficacy of neoadjuvant chemotherapy in patients with high-risk resectable colorectal liver metastases
This study aimed to assess the efficacy of NAC in patients with resectable CRLM, especially in high-risk subgroups for recurrence, with special reference to synchronicity and the CRLM grade in the Japanese classification system.MethodsA retrospective analysis of a multi-institutional cohort who was diagnosed with resectable CRLM was performed. CRLM was classified into three grades (A, B, and C) according to the combination of H stage (H1:  ≤ 4 lesions and ≤ 5 cm, H2: ≥ 5 lesions or >  5 cm, H3: ≥ 5 lesions and > &thinsp...
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Surveillance of radical hysterectomy for early-stage cervical cancer in the early experienced period of minimally invasive surgery in Japan
ConclusionThe survival rate of the Japanese patients underwent radical hysterectomy for early-stage cervical cancer was favorable. No significant differences were observed for DFS and OS between open and MIS performed by a limited number of surgeons at a limited number of facilities in Japan. Further investigations are required to identify the appropriate patients might benefit from MIS. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Impact of the changes in the completion lymph node dissection criteria and approval of adjuvant therapies on the real-world outcomes of Japanese stage III melanoma patients
AbstractBackgroundCompletion lymph node dissection (CLND) has long been the standard treatment for stage III melanomas identified as metastasis on the sentinel node (SN-positive). Two major changes occurred in 2017 and 2018, the change in the CLND criteria for SN-positive patients and the approval of several adjuvant therapies could revolutionize such management approach. However, their effects have not been fully investigated on the real-world outcomes of stage III melanoma patients. Therefore, we investigated the impact of these changes on the prognosis of Japanese stage III melanoma patients.MethodsTotally, 119 stage II...
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Clinical management and outcomes associated with etoposide, doxorubicin, and cisplatin plus mitotane treatment in metastatic adrenocortical carcinoma: a single institute experience
ConclusionsThe EDP-M regimen had similar PFS to that observed in FIRM-ACT. Adrenal insufficiency was more frequent in the current study, but this could be managed with supportive endocrinological care such as cortisol replacement. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Adjuvant radiotherapy improves overall survival when added to surgery and chemotherapy for uterine carcinosarcoma: a surveillance, epidemiology, and end results analysis
AbstractBackgroundUterine carcinosarcoma (UCS) confers a high recurrence risk following surgery, and adjuvant chemotherapy (CHT) is typically administered in all stages. The benefit of radiation therapy (RT) in UCS, when added to adjuvant CHT, is unknown. We sought to analyze the Surveillance, Epidemiology, and End Results (SEER) database to ascertain whether RT improves overall survival (OS) when added to surgery and CHT for UCS.MethodsSEER 18 Custom Data registries (Nov 2018 submission) were queried for uterine (ICD10 C54.1-9, C55.9) carcinosarcoma (ICD-0-3 8980-3). Patients with stage I-III UCS who underwent surgery and...
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

The expression and clinical significance of the tRNA aspartic acid methyltransferase 1 protein in gastric cancer
This study aimed to investigate the role of the tRNA aspartic acid methyltransferase 1 (TRDMT1) protein in the  development and progression of gastric cancer (GC).MethodsThe 90 GC tissues and 35 paracancerous tissues (gastric mucosa) were collected from patients (31 males and 59 females; average age 66), who were pathologically diagnosed as GC. The expression of TRDMT1 in three GC cell lines (MKN28, BGC823, and MGC803) and tissues from GC patients were detected by western blotting and immunological staining, respectively. The relationship between TRDMT1 expression and clinicopathological parameters in GC patients was ...
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

The effectiveness of high-dose-rate brachytherapy with external beam radiotherapy for clinically locally advanced and node-positive prostate cancer: long-term results of a retrospective study
ConclusionsHDR-BT combined with EBRT and long-term ADT shows promising disease control and tolerant toxicities for clinically locally advanced and LN-positive PC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Impact of prostate-specific antigen screening on tumor size in patients with prostate cancer in a super-aging district in Kyoto, Japan
In this study, we assessed biopsy-proven maximum cancer core length (MCCL) and maximum cancer diameter on magnetic resonance imaging (MRI; MCDM) in prostate biopsy and multiparametric MRI (mp-MRI) by PCa detection.MethodsWe retrospectively assessed 214 male PCa patients and 187 PCa patients with Prostate Imaging Reporting and Data System version 2 (PI-RADS) category 3 –5 lesions in pre-biopsy mp-MRI and targeted biopsy characteristics. The mean biopsy-proven MCCL and MCDM were compared among three PSA screening groups, namely the population-based PSA screening (PBS), opportunistic PSA screening (OPS), and symptomatic...
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Efficacy and safety of nivolumab in Japanese patients with first recurrence of glioblastoma: an open-label, non-comparative study
ConclusionsThe 1-year overall survival with nivolumab monotherapy in Japanese patients with glioblastoma met the prespecified efficacy criterion. The safety profile of nivolumab was consistent with that observed in other tumor types.Clinical Trial RegistrationJapicCTI-152967. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Clinical and pathological outcomes of risk-reducing salpingo-oophorectomy for Japanese women with hereditary breast and ovarian cancer
ConclusionsThe rate of occult neoplasms was similar to those reported by studies performed in other countries. Although women with occult cancer were diagnosed with FIGO stage I, the MRI performed 1 month preoperatively did not show any such malignant findings. Thus, RRSO is the only promising method that can improve the prognosis in women with germline pathogenicBRCA1/2 variants. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

List of reviewers 2020 –2021
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 19, 2021 Category: Cancer & Oncology Source Type: research

Palbociclib as an early-line treatment for Japanese patients with hormone receptor –positive/human epidermal growth factor receptor 2–negative advanced breast cancer: a review of clinical trial and real-world data
AbstractBreast cancer is the most common type of cancer among women worldwide and in Japan. The majority of breast cancers are hormone receptor –positive (HR+)/human epidermal growth factor receptor 2–negative (HER2‒), and endocrine therapy is an effective therapy for this type of breast cancer. However, recent substantial advances have been made in the management of HR+/HER2‒ advanced breast cancer (ABC) with the advent of targeted therapies, such as cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, resulting in significant improvements in survival outcomes versus endocrine therapy alone. To evaluate the op...
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

The cancer ‐related transcription factor Runx2 combined with osteopontin: a novel prognostic biomarker in resected osteosarcoma
ConclusionsThese results suggest that a combined Runx2/OPN expression could be a valuable independent predictor of tumor metastasis and survival in osteosarcoma patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Assessment of button-type jejunostomy for nutritional management after esophagectomy in 201 cases
AbstractBackgroundMany surgeons preferably place a trans-nasal feeding tube or a feeding enterostomy for post-operative nutritional management after esophagectomy. Various types of tubes (such as nasogastric, transgastric, transduodenal, or transjejunal tubes) have been used for enteral feeding; however, the appropriate enteral feeding routes have not yet been proposed. Therefore, this study aimed to evaluate the feasibility and safety of button-type jejunostomy.MethodsWe reviewed 201 patients who underwent esophagectomy with placement of a button-type jejunostomy at the Jikei University Hospital (Tokyo, Japan) between 200...
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Risk assessment of multi-factorial complications after transrectal ultrasound-guided prostate biopsy: a single institutional retrospective cohort study
AbstractBackgroundTransrectal ultrasound-guided prostate biopsy (TRUSPB) is widely used to diagnose prostate cancer (PCa). The aim of this study was to evaluate the risk of multi-factorial complications (febrile genitourinary tract infection (GUTI), rectal bleeding, and urinary retention) after TRUSPB.MethodsN = 2053 patients were Japanese patients undergoing transrectal or transperineal TRUSPB for suspicious of PCa. To assess risk of febrile GUTI adequately, the patients were divided into four groups: low-risk patients before starting a rectal culture, low-risk patients after starting a rectal cultu re, high...
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Computed tomography-derived biomarker for predicting the treatment response to neoadjuvant chemoradiotherapy of rectal cancer
ConclusionsCT-derived texture parameters could be potential biomarkers for predicting the therapeutic response of rectal cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Phase III study of adjuvant gemcitabine compared with adjuvant uracil-tegafur in patients with completely resected pathological stage IB –IIIA non-small cell lung cancer (WJTOG0101)
ConclusionAlthough GEM-based adjuvant therapy for patients with completely resected stage IB –IIIA NSCLC was associated with acceptable toxicity, it did not provide longer OS than did UFT. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Surveillance of radical hysterectomy for early-stage cervical cancer in the early experienced period of minimally invasive surgery in Japan
ConclusionThe survival rate of the Japanese patients underwent radical hysterectomy for early-stage cervical cancer was favorable. No significant differences were observed for DFS and OS between open and MIS performed by a limited number of surgeons at a limited number of facilities in Japan. Further investigations are required to identify the appropriate patients might benefit from MIS. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Impact of the changes in the completion lymph node dissection criteria and approval of adjuvant therapies on the real-world outcomes of Japanese stage III melanoma patients
AbstractBackgroundCompletion lymph node dissection (CLND) has long been the standard treatment for stage III melanomas identified as metastasis on the sentinel node (SN-positive). Two major changes occurred in 2017 and 2018, the change in the CLND criteria for SN-positive patients and the approval of several adjuvant therapies could revolutionize such management approach. However, their effects have not been fully investigated on the real-world outcomes of stage III melanoma patients. Therefore, we investigated the impact of these changes on the prognosis of Japanese stage III melanoma patients.MethodsTotally, 119 stage II...
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Adjuvant radiotherapy improves overall survival when added to surgery and chemotherapy for uterine carcinosarcoma: a surveillance, epidemiology, and end results analysis
AbstractBackgroundUterine carcinosarcoma (UCS) confers a high recurrence risk following surgery, and adjuvant chemotherapy (CHT) is typically administered in all stages. The benefit of radiation therapy (RT) in UCS, when added to adjuvant CHT, is unknown. We sought to analyze the Surveillance, Epidemiology, and End Results (SEER) database to ascertain whether RT improves overall survival (OS) when added to surgery and CHT for UCS.MethodsSEER 18 Custom Data registries (Nov 2018 submission) were queried for uterine (ICD10 C54.1-9, C55.9) carcinosarcoma (ICD-0-3 8980-3). Patients with stage I-III UCS who underwent surgery and...
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

The expression and clinical significance of the tRNA aspartic acid methyltransferase 1 protein in gastric cancer
This study aimed to investigate the role of the tRNA aspartic acid methyltransferase 1 (TRDMT1) protein in the  development and progression of gastric cancer (GC).MethodsThe 90 GC tissues and 35 paracancerous tissues (gastric mucosa) were collected from patients (31 males and 59 females; average age 66), who were pathologically diagnosed as GC. The expression of TRDMT1 in three GC cell lines (MKN28, BGC823, and MGC803) and tissues from GC patients were detected by western blotting and immunological staining, respectively. The relationship between TRDMT1 expression and clinicopathological parameters in GC patients was ...
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Impact of prostate-specific antigen screening on tumor size in patients with prostate cancer in a super-aging district in Kyoto, Japan
In this study, we assessed biopsy-proven maximum cancer core length (MCCL) and maximum cancer diameter on magnetic resonance imaging (MRI; MCDM) in prostate biopsy and multiparametric MRI (mp-MRI) by PCa detection.MethodsWe retrospectively assessed 214 male PCa patients and 187 PCa patients with Prostate Imaging Reporting and Data System version 2 (PI-RADS) category 3 –5 lesions in pre-biopsy mp-MRI and targeted biopsy characteristics. The mean biopsy-proven MCCL and MCDM were compared among three PSA screening groups, namely the population-based PSA screening (PBS), opportunistic PSA screening (OPS), and symptomatic...
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Efficacy and safety of nivolumab in Japanese patients with first recurrence of glioblastoma: an open-label, non-comparative study
ConclusionsThe 1-year overall survival with nivolumab monotherapy in Japanese patients with glioblastoma met the prespecified efficacy criterion. The safety profile of nivolumab was consistent with that observed in other tumor types.Clinical Trial RegistrationJapicCTI-152967. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Clinical and pathological outcomes of risk-reducing salpingo-oophorectomy for Japanese women with hereditary breast and ovarian cancer
ConclusionsThe rate of occult neoplasms was similar to those reported by studies performed in other countries. Although women with occult cancer were diagnosed with FIGO stage I, the MRI performed 1 month preoperatively did not show any such malignant findings. Thus, RRSO is the only promising method that can improve the prognosis in women with germline pathogenicBRCA1/2 variants. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

List of reviewers 2020 –2021
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 11, 2021 Category: Cancer & Oncology Source Type: research

Pretreatment clinical and hematologic prognostic factors of metastatic urothelial carcinoma treated with pembrolizumab: a systematic review and meta-analysis
AbstractPembrolizumab is the standard for the first and second lines in treating metastatic urothelial carcinoma (UC). This systematic review and meta-analysis aimed to assess the value of pretreatment clinical characteristics and hematologic biomarkers for prognosticating response to pembrolizumab in patients with metastatic UC. PUBMED®, Web of Science ™, and Scopus® databases were searched for articles published before May 2021 according to the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) statement. Studies were deemed eligible if they evaluated overall survival (OS) in patient...
Source: International Journal of Clinical Oncology - November 10, 2021 Category: Cancer & Oncology Source Type: research

COVID-19 infection in pediatric patients treated for cancer
ConclusionIn pediatric patients with cancer who test positive for COVID-19, yet are asymptomatic or have mild symptoms, the continuance of antineoplastic therapy may be considered. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 6, 2021 Category: Cancer & Oncology Source Type: research

Preoperative sarcopenia is a poor prognostic factor in lower rectal cancer patients undergoing neoadjuvant chemoradiotherapy: a retrospective study
ConclusionsSarcopenia is a poor prognostic indicator in lower advanced rectal cancer patients treated with CRT. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 6, 2021 Category: Cancer & Oncology Source Type: research

Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for the treatment of locally advanced esophageal cancer: a population-based analysis
ConclusionThe present study based on large cohort demonstrated that no significant survival difference was observed between LAEC patients treated with neo-CRT versus neo-CT. However, the results needed to be confirmed in well-designed prospective trials. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 3, 2021 Category: Cancer & Oncology Source Type: research

EGF rs4444903 polymorphism is associated with risk of HCV-related cirrhosis and HBV/HCV-related hepatocellular carcinoma
ConclusionsThe study supports thatEGF rs4444903 polymorphism is a genetic contributor to liver cirrhosis and HCC in the overall population. Nevertheless, this conclusion must be confirmed by larger studies with more diverse ethnic populations. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research

Gilteritinib versus chemotherapy in Japanese patients with FLT3-mutated relapsed/refractory acute myeloid leukemia
AbstractBackgroundUntil recently, no effective targeted therapies forFLT3-mutated (FLT3mut+) relapsed/refractory (R/R) acute myeloid leukemia (AML) were available in Japan. The FLT3 inhibitor, gilteritinib, was approved in Japan for patients withFLT3mut+ R/R AML based on the phase 3 ADMIRAL trial, which demonstrated the superiority of gilteritinib over salvage chemotherapy (SC) with respect to overall survival (OS; median OS, 9.3 vs 5.6  months, respectively; hazard ratio, 0.64 [95% confidence interval 0.49, 0.83];P 
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research

The efficacy and safety profile of 2-weekly dosing of bevacizumab-containing chemotherapy for platinum-resistant recurrent ovarian cancer
AbstractBackgroundDespite being widely used, to date (June 2021), the regimen of bevacizumab 10  mg/kg every 2 weeks (Q2W) combined with chemotherapy is not approved in Japan for patients with platinum-resistant recurrent ovarian cancer. In this retrospective analysis, we evaluated the usage patterns of bevacizumab administered for platinum-resistant recurrent ovarian cancer.MethodsWe obtained clinical data from 155 Japanese medical facilities between November 2013 and December 2018 via a survey. Items included the number of cases of platinum-resistant recurrent ovarian cancer treated with bevacizumab according t...
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research

A phase II study of FOLFIRINOX with primary prophylactic pegfilgrastim for chemotherapy-na ïve Japanese patients with metastatic pancreatic cancer
ConclusionsThis phase II study could not demonstrate any reduction in the incidence of FN, nevertheless some patients experience benefits for efficacy by maintaining dose intensity using prophylactic pegfilgrastim.Trial registrationhttp://www.umin.ac.jp/ctr/index-j.htm, UMIN000017538. Date of registration: May/13/2015 (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research

Circulating cell-free DNA in the peripheral blood plasma of patients is an informative biomarker for multiple myeloma relapse
ConclusionThese results suggest the potential utility of cfDNA in the PB plasma of patients as a relevant early biomarker for MM relapse. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research

Tolerability and safety of adjuvant chemoradiotherapy with S-1 after limited surgery for T1 or T2 lower rectal cancer
ConclusionCRT with S-1 after limited surgery for T1 or T2 lower rectal cancer resulted in a low incidence of toxicities and maintenance of anal function. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research

Metastatic clear cell renal cell carcinoma: computed tomography texture analysis as predictive biomarkers of survival in patients treated with nivolumab
AbstractIntroductionTo evaluate the value of image-based texture analysis for predicting progression-free survival (PFS) and overall survival (OS) in patients with metastatic clear cell renal carcinoma (cCCR) treated with nivolumab.MethodsThis retrospective study included 48 patients with metastatic cCCR treated with nivolumab. Nivolumab was used as a second- or third-line monotherapy. Texture analysis of metastatic lesions was performed on CT scanners obtained within 1  month before treatment. Texture features related to the gray-level histogram, gray-level co-occurrence, run-length matrix features, autoregressive mo...
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research

Prognostic value of programmed death-ligand 1 status in Japanese patients with renal cell carcinoma
ConclusionsThis study suggests PD-L1 status was not an independent prognostic factor in recurrent/metastatic RCC during the study period because PD-L1 positivity was associated with poor prognostic factors, especially MSKCC risk status. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research

Potential intrinsic subtype dependence on the association between metformin use and survival in surgically resected breast cancer: a Korean national population-based study
AbstractPurposeNumerous studies have suggested that metformin treatment can increase breast cancer survival; however, it is unclear whether its effects interact with intrinsic subtype or diabetic status. Therefore, we conducted a large nationwide study to assess this in women with surgically resected invasive breast cancer.MethodsPatients with newly diagnosed breast cancer between 2007 and 2016 were identified using the national health insurance claims database of South Korea. Metformin or other drug exposures was defined as medication for  ≥ 90 days. Breast cancer subtypes were classified into four g...
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research

Preoperative iron status is a prognosis factor for stage II and III colorectal cancer
ConclusionBoth low and high preoperative iron in Stage II –III CRC patients were associated with unfavorable OS in univariate and multivariate analyses. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research

Effects of transurethral resection under general anesthesia on tumor recurrence in non-muscle invasive bladder cancer
ConclusionsThe RFS rate was lower in NMIBC patients who received GA during TURBT than in those who received SA. Volatile anesthesia may increase tumor recurrence, particularly in high-risk NMIBC patients, which may be due to the inhibition of the immune response system during surgery. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 23, 2021 Category: Cancer & Oncology Source Type: research