International Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Availability of genome-matched therapy based on clinical practice
ConclusionThis study demonstrated the usefulness of CGP for patients with sarcoma and HNC in addition to lung cancer in clinical practice. Performing CGP at the front line has the potential to improve the availability of genome-matched therapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 26, 2024 Category: Cancer & Oncology Source Type: research

Significance of radiation therapy in the myxoid round-cell liposarcoma treatment regimen
ConclusionPreoperative radiation therapy for myxoid liposarcoma near vital organs is a good approach because even with a reduced dose of 40  Gy, significant tumor reduction and excellent results were achieved. Definitive radiation therapy is the recommended treatment for older patients with serious comorbidities or inoperable patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research

Short- and long-term post-nephrectomy outcomes for retroperitoneal liposarcoma from a high-volume sarcoma center: a propensity score matching analysis
ConclusionsRLPS resection with nephrectomy is related to a mild progression of renal impairment; however, dialysis is rare. En bloc nephrectomy for complete resection of RLPS is safe and improves local control. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research

Comparison between a single dose of PEG G-CSF and multiple doses of non-PEG G-CSF: a systematic review and meta-analysis from Clinical Practice Guidelines for the use of G-CSF 2022
ConclusionsA single dose of PEG G-CSF is strongly recommended over multiple-dose non-PEG G-CSF therapy for the primary prophylaxis of FN. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research

SlicerPIT: software development and implementation for planning and image-guided therapy in photoimmunotherapy
ConclusionSlicerPIT allows for detailed preoperative treatment planning and accurate puncture. It may be a valuable tool to improve the accuracy of photoimmunotherapy for deep lesions and improve patient outcomes. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research

Biomarker-oriented chemo-immunotherapy for advanced gastric cancer
AbstractThe biomarker-oriented chemo-immunotherapy is useful and promising in the development of new anticancer agents, since the responders can be enriched by selecting patients with biomarkers. Compared to colorectal and lung cancers, the development of biomarker-driven molecular-targeted therapeutics for gastric cancers has been straggled. However, several new biomarkers in gastric cancers have been discovered and clinical trials in enrichment design with certain biomarkers have been conducted. Therefore, there are currently several treatment options to treat gastric cancer patients based on individual biomarker-oriente...
Source: International Journal of Clinical Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research

Clinicopathological characteristics of Lynch-like syndrome
ConclusionsDistinguishing clinically between LS and LLS was challenging, but the incidence of neoplasms was higher in LS than in LLS, suggesting the need for different screening and surveillance methods for the two subtypes. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 20, 2024 Category: Cancer & Oncology Source Type: research

A Japanese multi-institutional phase II study of moderate hypofractionated intensity-modulated radiotherapy with image-guided technique for prostate cancer
ConclusionThe safety and efficacy of moderately hypofractionated IMRT with prostate-based image-guidance was confirmed among Japanese patients with prostate cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research

New therapeutic target molecules for gastric and gastroesophageal junction cancer
AbstractMolecularly targeted therapy for receptor tyrosine kinases (RTKs) has faced limitations in gastric and gastroesophageal junction (G/GEJ) cancer except for HER2-targeted agents, possibly due to inappropriate assay selection that has hindered identification of sensitive patients, in addition to coexisting genetic abnormalities as well as intratumoral heterogeneity. Immunohistochemistry of RTKs has, thus, proved largely unsuccessful for patient selection, and detection of RTK gene amplification as a true oncogenic driver is problematic given the small numbers of affected individuals.FGFR2 amplification is associated w...
Source: International Journal of Clinical Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research

Early experience and future prospects regarding use of newly developed surgical robot system, hinotori, in the field of urologic cancer surgery
AbstractIn the field of urology, robotic surgery has gained rapid and wide acceptance as a standard surgical approach in the majority of major surgeries over the last decade. To date, the da Vinci surgical system has been the dominant platform in robotic surgery; however, several newly developed robotic systems have recently been introduced in routine clinical practice. Of these, hinotori, the first made-in-Japan robotic system, is characterized by various unique and attractive features different from the existing system, and the use of this system has gradually increased mainly in urologic cancer surgeries, including radi...
Source: International Journal of Clinical Oncology - April 16, 2024 Category: Cancer & Oncology Source Type: research

PMDA regulatory update on approval and revision of the precautions for use of anticancer drugs: approval of nivolumab for unresectable advanced or recurrent epithelial skin malignancies in Japan
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 16, 2024 Category: Cancer & Oncology Source Type: research

Current status and prospects of artificial intelligence in breast cancer pathology: convolutional neural networks to prospective Vision Transformers
AbstractBreast cancer is the most prevalent cancer among women, and its diagnosis requires the accurate identification and classification of histological features for effective patient management. Artificial intelligence, particularly through deep learning, represents the next frontier in cancer diagnosis and management. Notably, the use of convolutional neural networks and emerging Vision Transformers (ViT) has been reported to automate pathologists ’ tasks, including tumor detection and classification, in addition to improving the efficiency of pathology services. Deep learning applications have also been extended to t...
Source: International Journal of Clinical Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research

Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndrome
ConclusionsOur data regarding the LS to LLS ratio would be useful for genetic counseling in patients who are suspected to have LS, though the genetic backgrounds for the pathogenesis of LLS need further investigation. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 14, 2024 Category: Cancer & Oncology Source Type: research

English version of Japanese Clinical Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) issued by the Japan Society of Clinical Oncology
AbstractThe Japan Society of Clinical Oncology Clinical Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) have been published in accordance with the Minds Manual for Guideline Development 2014 and 2017. A specialized team independent of the working group for the revision performed a systematic review. Since GIST is a rare type of tumor, clinical evidence is not sufficient to answer several clinical and background questions. Thus, in these guidelines, we considered that consensus among the experts who manage GIST, the balance between benefits and harms, patients ’ wishes, medical economic perspective, etc...
Source: International Journal of Clinical Oncology - April 13, 2024 Category: Cancer & Oncology Source Type: research

Progressive changes in the protein expression profile of alveolar septa in early-stage lung adenocarcinoma
ConclusionsFAP-positive fibroblasts may contribute to tumor stroma formation in early-stage lung adenocarcinoma, and this could influence the development of therapeutic strategies targeting FAP-positive CAFs for disrupting extracellular matrix formation. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 11, 2024 Category: Cancer & Oncology Source Type: research