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Radiation therapy versus surgery for patients with cervical squamous cell carcinoma who have undergone neoadjuvant chemotherapy revisited
ConclusionsPost-NAC survival outcomes among patients with chemo-sensitive cervical SCC who then underwent RT were not inferior to those treated with surgery, and NAC did not detract from the efficacy of subsequent RT. Among selected patients who respond favorably to NAC, RT could be a less invasive substitute for surgery without compromising treatment outcomes. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 19, 2017 Category: Cancer & Oncology Source Type: research

A retrospective analysis of ramucirumab monotherapy in previously treated Japanese patients with advanced or metastatic gastric adenocarcinoma
ConclusionsOur data suggest that ramucirumab monotherapy in Japanese patients with previously treated advanced gastric cancer has comparable efficacy and safety profiles as reported in the REGARD trial. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 14, 2017 Category: Cancer & Oncology Source Type: research

BRCA1 gene: function and deficiency
AbstractThe BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in cells. It is well known, along with BRCA 2, to cause hereditary breast and ovarian cancer, but here we will specifically focus on BRCA1. We introduce the mechanism and the latest report on homologous recombination repair, replication, involvement in checkpoint regulation, transcription, chromatin remodeling, and cytoplasmic function (centrosome regulation, apoptosis, selective autophagy), and consider the possibility of carcinogenesis from inhibition of the intrace...
Source: International Journal of Clinical Oncology - September 7, 2017 Category: Cancer & Oncology Source Type: research

Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria
ConclusionsThe mvi was one of the independent risk factors for tumor recurrence in HCC classified within the Milan criteria. Multiple tumors and high AFP-L3 value were independent predictive factors for mvi. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 5, 2017 Category: Cancer & Oncology Source Type: research

A systematic review of publications on charged particle therapy for hepatocellular carcinoma
AbstractCharged particle therapy (proton beam therapy and carbon ion therapy) is a form of radiotherapy which has the unique characteristic of superior depth dose distribution, and has been used for the treatment of hepatocellular carcinoma (HCC) in a limited number of patients, especially in Japan. We undertook a systematic review to define the clinical utility of charged particle therapy for patients with HCC. We searched the MEDLINE database from 1983 to June 2016 to identify clinical studies on charged particle therapy for HCC. Primary outcomes of interest were local control, overall survival, and late radiation morbid...
Source: International Journal of Clinical Oncology - September 4, 2017 Category: Cancer & Oncology Source Type: research

Impact of multiple malignancies on surgical outcomes in patients with 1  cm or smaller non-small cell lung cancer
ConclusionNSCLC of 1  cm or smaller showed good prognoses. The presence of multiple malignancies was a significantly poor prognostic factor, and short treatment intervals also correlated with poor prognosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 1, 2017 Category: Cancer & Oncology Source Type: research

Significance of multiple preoperative laboratory abnormalities as prognostic indicators in patients with urothelial carcinoma of the upper urinary tract following radical nephroureterectomy
ConclusionsThese findings suggest that it is important to consider laboratory abnormalities, particularly the De Ritis ratio and NLR, to predict disease recurrence following RNU in patients with clinically localized UUTUC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 30, 2017 Category: Cancer & Oncology Source Type: research

The insufficient prognostic power of stenosis in patients with esophageal cancer
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 28, 2017 Category: Cancer & Oncology Source Type: research

Hereditary breast cancer: molecular biology and management update
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 24, 2017 Category: Cancer & Oncology Source Type: research

Prognostic factors for disease-free and overall survival of patients with uterine carcinosarcoma
AbstractBackgroundUterine carcinosarcoma (UCS) is a relatively rare and very aggressive tumor. The predictors of survival for patients with UCS have not been determined clearly yet. The aim of the present study was to investigate the possible predictors of disease-free survival (DFS) and overall survival (OS) for patients with UCS.Methods and materialsAll patients with UCS who were treated surgically at a university-based Gynecology Oncology Clinic between January 2008 and December 2014 were recruited into this retrospective cohort study. Data regarding clinical, pathologic and treatment information were obtained retrospec...
Source: International Journal of Clinical Oncology - August 23, 2017 Category: Cancer & Oncology Source Type: research

A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy
ConclusionThe present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 19, 2017 Category: Cancer & Oncology Source Type: research

Clinical outcomes of patients with epithelioid sarcomas: impact and management of nodal metastasis
ConclusionsPeripheral tumor location is associated with a better prognosis. The development of new nodal metastasis tends to be associated with poor prognosis; however, among patients with nodal metastasis, resection of the metastatic lesions has a low impact on survival. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 10, 2017 Category: Cancer & Oncology Source Type: research

The use of neoadjuvant therapy for resectable locally advanced thoracic esophageal squamous cell carcinoma in an analysis of 5016 patients from 305 designated cancer care hospitals in Japan
ConclusionsBased on our results, in Japan, relatively few patients with resectable locally advanced thoracic ESCC receive neoadjuvant therapy, with older patients and patients at lower volume hospitals being less likely than other patients to receive the neoadjuvant therapy. We recommend that the process of treatment decision-making be assessed at both the patient and hospital levels so that patients can consider various treatment options, including neoadjuvant therapy with surgery in Japan. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 9, 2017 Category: Cancer & Oncology Source Type: research

Feasibility of dose-dense epirubicin and cyclophosphamide with subcutaneous pegfilgrastim 3.6  mg support: a single-center prospective study in Japan
ConclusionsWith support provided by pegfilgrastim injection at a dose of 3.6  mg, dose-dense EC is feasible and associated with maintenance of a high RDI. There was no clinically significant accumulation of serum G-CSF concentrations associated with the use of a 3.6 mg dose of pegfilgrastim at 2-week intervals. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 8, 2017 Category: Cancer & Oncology Source Type: research

Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma
AbstractBackgroundThe prognostic implications of preoperative serum total cholesterol (TC) level in patients with renal cell carcinoma (RCC) remain poorly understood. We investigated the prognostic role of preoperative serum TC in patients with surgically treated RCC from a large, multi-institutional Korean collaboration.Patients and methodsA database of 3064 patients with RCC who underwent radical or partial nephrectomy between 1999 and 2011 at eight academic centers was analyzed. Preoperative serum TC levels were measured in fasting blood samples.ResultsLow preoperative serum TC level was associated with aggressive tumor...
Source: International Journal of Clinical Oncology - August 8, 2017 Category: Cancer & Oncology Source Type: research

Phase II study of radium-223 dichloride in Japanese patients with symptomatic castration-resistant prostate cancer
ConclusionsRadium-223 is effective and well tolerated in Japanese patients with CRPC and bone metastases. Results were comparable with the Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial.Clinical trial registrationClinicalTrials.gov NCT01929655. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 2, 2017 Category: Cancer & Oncology Source Type: research

Erratum to: Sarcopenia, but not visceral fat amount, is a risk factor of postoperative complications after major hepatectomy
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 28, 2017 Category: Cancer & Oncology Source Type: research

The clinical use of neutrophil-to-lymphocyte ratio in bladder cancer patients: a systematic review and meta-analysis
AbstractThe aim of this study was to evaluate the evidence regarding the neutrophil-to-lymphocyte ratio (NLR) as a factor predictive of survival in bladder cancer patients. A search of PubMed and Embase for relevant studies between January 1, 1966 and November 10, 2016 was performed with the terms [NLR OR (neutrophil lymphocyte ratio)] AND [(bladder cancer) OR BCa OR NMIBC OR MIBC]. Inclusion required studies published in English containing bladder cancer patients and evaluating NLR as a predictive factor. Endpoints of NLR and survival data were extracted for pooled analysis. The pooled results showed that an elevated NLR ...
Source: International Journal of Clinical Oncology - July 27, 2017 Category: Cancer & Oncology Source Type: research

Presurgical axitinib therapy increases fibrotic reactions within tumor thrombus in renal cell carcinoma with thrombus extending to the inferior vena cava
ConclusionsPresurgical axitinib therapy enhanced tumor reduction accompanied by fibrosis and may contribute to surgical risk reduction for selected patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 27, 2017 Category: Cancer & Oncology Source Type: research

Retrospective comparison of S-1 plus cisplatin versus S-1 monotherapy for the treatment of advanced gastric cancer patients with positive peritoneal cytology but without gross peritoneal metastasis
ConclusionAdding cisplatin to long-term S-1 monotherapy did not significantly improve the outcome of CY+ advanced gastric cancer patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 26, 2017 Category: Cancer & Oncology Source Type: research

PD-L1 induced by IFN- γ from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer
ConclusionsIFN- γ was not always successful as an antitumor agent. It also can promote tumor cells to evade immune surveillance. Researchers should be cautious in using IFN-γ as a therapeutic agent for cancer treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 26, 2017 Category: Cancer & Oncology Source Type: research

Impact of major different variants of papillary thyroid microcarcinoma on the clinicopathological characteristics: the study of 1041 cases
AbstractBackgroundThe incidence of papillary thyroid microcarcinoma (PTMC) has been increasing globally in the past few decades. PTMC does not have a distinctive morphology that results in differences in biological behavior. The aim of this study was to classify PTMCs according to the morphological features and explore the relationship with clinicopathological characteristics. Additionally, we sought to evaluate whether different variants of PTMC can be an independent predictor for lymph mode metastasis when considering other risk factors.MethodsBetween December 2014 and December 2015, 1041 PTMC cases undergoing surgical r...
Source: International Journal of Clinical Oncology - July 25, 2017 Category: Cancer & Oncology Source Type: research

Concordance of clinical diagnosis of T classification among physicians for locally advanced unresectable thoracic esophageal cancer
ConclusionsThere were inter-observer variations in clinical diagnosis of the T category of locally advanced, unresectable esophageal cancer. Accurate clinical diagnosis of T classification is required for determining the optimum treatment for each patient. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 25, 2017 Category: Cancer & Oncology Source Type: research

Fatigue associated with newly approved vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: an up-to-date meta-analysis
AbstractThe fatigue associated with five newly approved vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) (regorafenib, vandetanib, cabozantinib, lenvatinib, axitinib) is poorly understood. We conducted this systematic review to fully investigate the fatigue associated with these VEGFR-TKIs in cancer patients. Relevant studies of randomized controlled trials in cancer patients treated with the five VEGFR-TKIs were retrieved and a systematic evaluation was conducted. EMBASE, MEDLINE, and PubMed were searched for articles published until March 2017. Thirteen randomized controlled trials and ...
Source: International Journal of Clinical Oncology - July 21, 2017 Category: Cancer & Oncology Source Type: research

Early response of C-reactive protein as a predictor of survival in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors
AbstractBackgroundPretreatment C-reactive protein (CRP) has been shown to be an independent prognostic factor for metastatic renal cell carcinoma (mRCC) treated with tyrosine kinase inhibitors (TKIs). We further evaluated the early response of CRP after the initiation of TKIs.MethodsA total of 103 patients (80 men and 23 women) were treated with TKIs for mRCC from 2008 −2013. Patients were divided into three groups according to their early CRP kinetics—patients whose baseline CRP levels were20% at 4  weeks after the initiation of TKIs (early CRP responder), and the remaining patients (non-early CRP respond...
Source: International Journal of Clinical Oncology - July 21, 2017 Category: Cancer & Oncology Source Type: research

Aspirin use and head and neck cancer survival: an observational study of 11,623 person-years follow-up
ConclusionOur data illustrated that the use of aspirin or NSAIDs has no effect on survival or recurrence in patients with HNSCC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 19, 2017 Category: Cancer & Oncology Source Type: research

Intraoperative radiotherapy for extremity soft-tissue sarcomas: can long-term local control be achieved?
ConclusionIOERT used as a boost to EBRT provides high local control and limb-sparing rates in patients with STS of the extremities, with less toxicity than EBRT alone. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 17, 2017 Category: Cancer & Oncology Source Type: research

Esophageal stenosis and the Glasgow Prognostic Score as independent factors of poor prognosis for patients with locally advanced unresectable esophageal cancer treated with chemoradiotherapy (exploratory analysis of JCOG0303)
AbstractBackgroundThe aim of this study was to investigate the possible prognostic factors and predictive accuracy of the Glasgow Prognostic Score (GPS) for patients with unresectable locally advanced esophageal squamous cell carcinoma (LAESCC) treated with chemoradiotherapy.MethodsOne hundred forty-two patients were enrolled in JCOG0303 and assigned to the standard cisplatin and 5-fluorouracil (PF)-radiotherapy (RT) group or the low-dose PF-RT group. One hundred thirty-one patients with sufficient data were included in this analysis. A Cox regression model was used to analyze the prognostic factors of patients with unrese...
Source: International Journal of Clinical Oncology - July 17, 2017 Category: Cancer & Oncology Source Type: research

Overall survival of high-risk prostate cancer patients who received neoadjuvant chemohormonal therapy followed by radical prostatectomy at a single institution
ConclusionsRP with neoadjuvant CHT using EMP for high-risk PCa patients provided excellent long-term OS. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 5, 2017 Category: Cancer & Oncology Source Type: research

A meta-analysis survey of appropriate bone turnover markers in the detection of bone metastasis in lung cancer
ConclusionsThe present meta-analysis suggested that serum measurement of TALP, BALP, ICTP and NTX might be helpful in detecting BM in lung cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 4, 2017 Category: Cancer & Oncology Source Type: research

Randomized phase II study of daily and alternate-day administration of S-1 for advanced gastric cancer (JFMC43-1003)
ConclusionThe alternate-day administration of S-1 was not recommended as the first-line therapy for patients with advanced gastric cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 30, 2017 Category: Cancer & Oncology Source Type: research

Association of decreased mean platelet volume with renal cell carcinoma
ConclusionsRCC patients have remarkably reduced MPV compared to patients with benign renal tumor and healthy control subjects. Moreover, decreased MPV was independently associated with RCC. Our results suggest that detection of MPV may be useful to assess the risk of RCC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 29, 2017 Category: Cancer & Oncology Source Type: research

Brachytherapy in the treatment of breast cancer
AbstractBrachytherapy is an important radio-therapeutic modality for a variety of malignancies, including prostate cancer, cervix cancer, breast cancer, vagina cancer, endometrium cancer, head and neck cancer, and many more. This technique has been shown to be an effective and safe non-pharmaceutical treatment with fewer serious complications and better outcome than other treatments for breast cancer. Every year, hundreds of thousands of patients around the world benefit from brachytherapy, which reliably delivers a relatively higher radiation dose to the intended target. However, the follow-up time, patient eligibility cr...
Source: International Journal of Clinical Oncology - June 29, 2017 Category: Cancer & Oncology Source Type: research

Biphasic malignant tumours of the abdominal cavity
AbstractCarcinosarcomas (CS) are uncommon, highly aggressive, biphasic tumours consisting of both sarcomatous and carcinomatous elements. They appear to originate from a common cell of origin, either via transformation from a single premature precursor or conversion of a mature epithelial cell through an epithelial –mesenchymal transition. CS should be considered a unique cancer subtype with cells typically displaying diffuse mitotic activity and widespread atypical mitoses predisposing to early metastasis and a tendency to local recurrence following resection. This review addresses the pathophysiology of CS and disc...
Source: International Journal of Clinical Oncology - June 27, 2017 Category: Cancer & Oncology Source Type: research

Targeting metabolic reprogramming in KRAS-driven cancers
AbstractMutations ofKRAS are found in a variety of human malignancies, including in pancreatic cancer, colorectal cancer, and non-small cell lung cancer at high frequency. To date, no effective treatments that target mutant variants ofKRAS have been introduced into clinical practice. In recent years, a number of studies have shown that the oncogeneKRAS plays a critical role in controlling cancer metabolism by orchestrating multiple metabolic changes. One of the metabolic hallmarks of malignant tumor cells is their dependency on aerobic glycolysis, known as the Warburg effect. The role of KRAS signaling in the regulation of...
Source: International Journal of Clinical Oncology - June 24, 2017 Category: Cancer & Oncology Source Type: research

Targeting DNA repair and replication stress in the treatment of ovarian cancer
AbstractApproximately half of high-grade serous epithelial ovarian cancers incur alterations in genes of homologous recombination (BRCA1,BRCA2,RAD51C, Fanconi anemia genes), and the rest incur alterations in other DNA repair pathways at high frequencies. Such cancer-specific gene alterations can confer selective sensitivity to DNA damaging agents such as cisplatin and carboplatin, topotecan, etoposide, doxorubicin, and gemcitabine. Originally presumed to inhibit DNA repair, PARP inhibitors that have recently been approved by the FDA for the treatment of advanced ovarian cancer also act as DNA damaging agents by inducing PA...
Source: International Journal of Clinical Oncology - June 22, 2017 Category: Cancer & Oncology Source Type: research

Matched-pair analysis of patients with advanced hypopharyngeal cancer: surgery versus concomitant chemoradiotherapy
In this study, we matched a group of total pharyngolaryngectomy patients with a second group of chemoradiotherapy patients, according to age, gender, subsite, arytenoid fixation, cartilage invasion, and N classification, and analyzed overall survival, disease-specific survival, and locoregional control rates.ResultsThe matched-pair analysis included 254 patients. The 5-year overall survival, disease-specific survival, and locoregional control rates were 58.5% and 53.5% (P = 0.30), 68.9% and 68.0% (P = 0.80), and 82.2% and 63.6% (P 
Source: International Journal of Clinical Oncology - June 17, 2017 Category: Cancer & Oncology Source Type: research

Comparison between chemoselection and definitive radiotherapy in patients with cervical esophageal squamous cell carcinoma
ConclusionThe chemoselection group achieved favorable results. Therefore, chemoselection can be applied as a treatment strategy for CEC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 16, 2017 Category: Cancer & Oncology Source Type: research

Radiation-related toxicities and outcomes in endometrial cancer: are obese women at a disadvantage?
AbstractObjectiveTo assess the impact of body mass index (BMI) on radiotherapy toxicities in endometrial cancer patients.MethodsThis was a retrospective cohort study of women diagnosed with endometrial cancer between January 2006 and December 2014 at the Royal Cornwall Hospital Trust. Women who received radiotherapy as part of their treatment, including external beam radiotherapy (EBRT) and/or vaginal brachytherapy were included. Radiation-related toxicities were graded according to the Radiation Therapy Oncology Group (RTOG) guidelines. Toxicity outcomes were compared across BMI groups —non-obese (BMI 
Source: International Journal of Clinical Oncology - June 15, 2017 Category: Cancer & Oncology Source Type: research

Gemcitabine monotherapy in patients with heavily treated nasopharyngeal cancer: a case series
ConclusionOur findings suggest that GEM monotherapy is well tolerated and has potential as an active agent in Japanese patients with recurrent/metastatic NPC who have been heavily pretreated. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 14, 2017 Category: Cancer & Oncology Source Type: research

Erratum to: Preplanned safety analysis of the JFMC37-0801 trial: a randomized phase III study of six months versus twelve months of capecitabine as adjuvant chemotherapy for stage III colon cancer
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 12, 2017 Category: Cancer & Oncology Source Type: research

Salvage endoscopic nasopharyngectomy for local recurrent or residual nasopharyngeal carcinoma: a 10-year experience
ConclusionsEndoscopic nasopharyngectomy is a feasible and effective surgical treatment for recurrent and residual nasopharyngeal carcinomas. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 10, 2017 Category: Cancer & Oncology Source Type: research

The rate of facial nerve dysfunction and time to recovery after intraparotid and extraparotid facial nerve exposure and protection in head and neck cutaneous tumor surgery
ConclusionsThe functional outcome, regardless of the different sites of facial nerve exposure, was almost always either complete facial nerve sparing or transient dysfunction that resolved within 6  months. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 9, 2017 Category: Cancer & Oncology Source Type: research

A critical prognostic analysis of neutrophil –lymphocyte ratio for patients undergoing nephroureterectomy due to upper urinary tract urothelial carcinoma
ConclusionFor UUT-UC, NLR is a prognostic factor for PFS and DFS, while LMR is a prognostic indicator for PFS in present series. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 9, 2017 Category: Cancer & Oncology Source Type: research

Recent advances in targeting DNA-repair pathways for the treatment of ovarian cancer: introduction
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 5, 2017 Category: Cancer & Oncology Source Type: research

The efficacy of surgical treatment of recurrent or persistent cervical cancer that develops in a previously irradiated field: a monoinstitutional experience
ConclusionsSalvage surgery is a curative treatment in recurrent or persistent cervical cancer patients. However, considering its high surgical complication rate, salvage surgery should only be offered to carefully selected patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 27, 2017 Category: Cancer & Oncology Source Type: research

High expression of GRP78/BiP as a novel predictor of favorable outcomes in patients with advanced thymic carcinoma
ConclusionsOur findings indicate that the overexpression of GRP78/BiP is a novel predictor of favorable outcomes in patients with ATC who receive combination chemotherapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 26, 2017 Category: Cancer & Oncology Source Type: research

Dasatinib rapidly induces deep molecular response in chronic-phase chronic myeloid leukemia patients who achieved major molecular response with detectable levels of BCR - ABL1 transcripts by imatinib therapy
ConclusionSwitching to dasatinib would be a therapeutic option for CP-CML patients who achieved MMR but not DMR by imatinib, especially for patients who wish to discontinue TKI therapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 26, 2017 Category: Cancer & Oncology Source Type: research

Neoadjuvant chemotherapy with trastuzumab, docetaxel, and carboplatin administered every 3  weeks for Japanese women with HER2-positive primary breast cancer: efficacy and safety
ConclusionAlthough the triweekly six-course regimen of TCbH achieved a high pCR rate, hematological AEs frequently occurred during the latter part of the chemotherapy course. One-third of patients experienced delayed or discontinued chemotherapy.Clinical registration number:http://www.umin.org.auUMIN000013513. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 25, 2017 Category: Cancer & Oncology Source Type: research

A phase II study of 5-fluorouracil/L-leucovorin/oxaliplatin (mFOLFOX6) in Japanese patients with metastatic or unresectable small bowel adenocarcinoma
ConclusionsAlthough the primary endpoint was not met, mFOLFOX6 showed effective and good tolerance as a first-line treatment for SBA. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 23, 2017 Category: Cancer & Oncology Source Type: research