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Recent advances in therapeutic strategies for unresectable or metastatic melanoma and real-world data in Japan
AbstractNew therapeutic strategies including immunotherapy and selective molecular target inhibitors have brought about a new era in the treatment of patients with advanced melanoma. In Japan, the immune checkpoint inhibitors ipilimumab, nivolumab and pembrolizumab, the BRAF inhibitor (BRAFi) vemurafenib, dabrafenib and MEK inhibitor (MEKi) trametinib have been available for the treatment of unresectable and metastatic melanoma. The BRAFi  + MEKi combination shows high response rates (60–70%) and rapid response induction associated with symptom control, with a progression-free survival of 12 months. Ni...
Source: International Journal of Clinical Oncology - February 22, 2018 Category: Cancer & Oncology Source Type: research

Phase I study of primary treatment with 5-FU, oxaliplatin, irinotecan, levofolinate, and panitumumab combination chemotherapy in patients with advanced/recurrent colorectal cancer involving the wild-type RAS gene: the JACCRO CC-14 study
ConclusionThe FOLFOXIRI + panitumumab chemotherapy regimen was well tolerated by our patients with mCRC and showed promising anti-tumor activity. The recommended phase II dose was determined to be the same as the standard doses of this regimen used worldwide. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 20, 2018 Category: Cancer & Oncology Source Type: research

Long-term outcomes of postoperative taxane/platinum chemotherapy for early stage cervical cancer: a retrospective study
ConclusionsPostoperative TP is effective in patients with surgically treated early stage cervical cancer. In these populations, a positive surgical margin could be associated with poor prognosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 14, 2018 Category: Cancer & Oncology Source Type: research

Characteristic findings of high-grade cervical intraepithelial neoplasia or more on magnifying endoscopy with narrow band imaging
ConclusionThe lesions  ≥ CIN 3 demonstrated characteristic ME-NBI findings of h-WE alone, or l-/h-WE with atypical micro-vessels. This study indicates that ME-NBI may have novel value for CIN diagnosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 14, 2018 Category: Cancer & Oncology Source Type: research

The clinical features of squamous cell lung carcinoma with sensitive EGFR mutations
ConclusionThe administration of afatinib to Sq patients after selecting patients using the EGFR mutation test based on their underlying pulmonary disease and smoking status would likely result in a population with a greater sensitivity to afatinib. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 14, 2018 Category: Cancer & Oncology Source Type: research

Neutrophil-to-lymphocyte ratio as an early marker of outcomes in patients with advanced non-small-cell lung cancer treated with nivolumab
AbstractBackgroundThere is an unmet need to identify markers that predict the response to nivolumab in patients with non-small-cell lung cancer (NSCLC). The neutrophil-to-lymphocyte ratio (NLR) was recently recognized as an indicator of a poor prognosis in patients with various cancers. In the present study, we quantified the predictive impact of NLR in patients with NSCLC treated with nivolumab.MethodsWe retrospectively analyzed 101 patients with advanced NSCLC treated with nivolumab at Kansai Medical University Hospital from December 2015 to December 2016. Patients were administered nivolumab at a dose of 3  mg/kg e...
Source: International Journal of Clinical Oncology - February 13, 2018 Category: Cancer & Oncology Source Type: research

Complications within 90  days after radical cystectomy for bladder cancer: results of a multicenter prospective study in Japan
ConclusionsOpen radical cystectomy is associated with a high incidence of postoperative complications. Most, however, are of low grade. Our results suggest that obesity, a smoking history, and increasing comorbidity are risk factors for major complications. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 13, 2018 Category: Cancer & Oncology Source Type: research

Oncologic outcomes for open and laparoscopic radical nephroureterectomy in patients with upper tract urothelial carcinoma
ConclusionSurgical approaches were not independently associated with prognosis in patients with locally advanced UTUC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 12, 2018 Category: Cancer & Oncology Source Type: research

A phase II trial of concurrent chemoradiotherapy with weekly paclitaxel and carboplatin in advanced oesophageal carcinoma
ConclusionsIn patients with locally advanced oesophageal cancer, the combination of weekly doses of paclitaxel and carboplatin was well tolerated and produced comparable results. A three-arm randomised phase III trial (NCT02459457) comparing paclitaxel in combination with cisplatin, carboplatin or 5-fluorouracil with concurrent radiotherapy is on-going at our hospital. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 12, 2018 Category: Cancer & Oncology Source Type: research

Efficacy of docetaxel in castration-resistant prostate cancer patients with intraductal carcinoma of the prostate
ConclusionThe presence of IDC-P is an independent prognostic factor in CRPC patients with distant metastases and IDC-P in needle biopsies at the time of initial diagnosis. Docetaxel may prolong CSS and OS in CRPC patients with distant metastases and IDC-P in needle biopsies at the time of initial diagnosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 3, 2018 Category: Cancer & Oncology Source Type: research

Comparison of clinical utility between neutrophil count and neutrophil –lymphocyte ratio in patients with ovarian cancer: a single institutional experience and a literature review
AbstractObjectiveWe retrospectively investigated the prognostic significance and clinical utility of pretreatment neutrophilia and elevated neutrophil –lymphocyte ratio (NLR) in patients with epithelial ovarian cancer.MethodsClinical data were collected from 344 surgically staged ovarian cancer patients between April 2007 and March 2016 and retrospectively reviewed. Neutrophilia and elevated NLR were defined as a neutrophil count ≥ 8,000/μl and an NLR ≥ 4.0, respectively. Univariate or multivariate analysis was conducted to evaluate the association between pretreatment neutrophilia or elevated NLR and clinic...
Source: International Journal of Clinical Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

The 5-year outcomes of moderately hypofractionated radiotherapy (66  Gy in 22 fractions, 3 fractions per week) for localized prostate cancer: a retrospective study
AbstractBackgroundHypofractionated radiotherapy using fewer and larger fractional doses may be more beneficial than conventional external-beam radiotherapy for localized prostate cancer. We evaluated the 5-year outcomes of moderately hypofractionated radiotherapy for localized prostate cancer.MethodsWe retrospectively evaluated 195 patients with localized prostate cancer (T1 –3N0M0) who underwent intensity-modulated radiotherapy (IMRT) (66 Gy delivered in fractions of 3 Gy every other weekday) between May 2005 and December 2011. Patients received androgen deprivation therapy depending on the perceived inter...
Source: International Journal of Clinical Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

A retrospective analysis of 5-fluorouracil plus cisplatin as first-line chemotherapy in the recent treatment strategy for patients with metastatic or recurrent esophageal squamous cell carcinoma
ConclusionsThe results of this study corroborate previous findings on the efficacy of CF and will aid physicians in clinical decision-making and individual patient risk stratification, as well as in the further development of chemotherapy regimens. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 20, 2018 Category: Cancer & Oncology Source Type: research

Hibernation of masses suspected to be remnant tumors after surgical resection of retroperitoneal liposarcoma is related to improved overall survival
ConclusionsHibernation of a recurrence-suspected mass was related to improvement of overall survival in patients with a mass detected within 6  months. This specific patient group should be monitored with care to see if the size of the mass increases. When a mass seemed to be hibernating, a favorable prognosis could be expected. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 19, 2018 Category: Cancer & Oncology Source Type: research

Interleukin-1 receptor antagonist inhibits angiogenesis in gastric cancer
AbstractBackgroundInterleukin-1 alpha (IL-1 α) plays an important role in tumorigenesis and angiogenesis of gastric cancer. The interleukin-1 receptor antagonist (IL-1RA) inhibits IL-1 selectively and specifically through IL-1R type I (IL-1RI). However, the underlying mechanism by which IL-1RA modulates the interactions of tumor cells and th eir micro-environment is poorly understood. We have evaluated the role of IL-1RA in the metastatic process as well as the mutual or reciprocal actions between gastric cancer cells and stromal cells.Materials and methodsThe expressions of IL-1 α, vascular endothelial growth ...
Source: International Journal of Clinical Oncology - January 17, 2018 Category: Cancer & Oncology Source Type: research

The cumulative incidence and risk factors of postoperative inguinal hernia in patients undergoing radical prostatectomy
This study included 1124 patients who had undergone radical prostatectomy or transurethral resection of bladder tumor from 2011 −2016. We compared the cumulative incidence of PIH in the radical prostatectomy groups (460; LRP 341, RARP 119) and the control group (664; transurethral resection of bladder tumor), and we then analyzed the risk factors (age, operative methods, previous abdominal operative history, thickness and width of external oblique muscle and rectus muscle, thickness of abdominal subcutaneous fat layer at Hesselbach’s triangle level, body mass index, prostate-specific antigen, operative time, sp...
Source: International Journal of Clinical Oncology - January 16, 2018 Category: Cancer & Oncology Source Type: research

Oncological outcomes after cytoreductive nephrectomy for patients with metastatic renal cell carcinoma with inferior vena caval tumor thrombus
ConclusionsThe prognosis of mRCC patients with IVC thrombus undergoing cytoreductive nephrectomy may be significantly affected by the type of postoperative systemic therapy rather than the level of the IVC tumor thrombus. Accordingly, cytoreductive nephrectomy should be considered as a major therapeutic option for patients with mRCC involving the IVC, particularly in the era of targeted therapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 13, 2018 Category: Cancer & Oncology Source Type: research

Characteristics of MUTYH variants in Japanese colorectal polyposis patients
ConclusionsTwo patients with biallelicMUTYH variants and two others with monoallelicMUTYH variants were identified among Japanese colorectal polyposis patients. Hotspot variants of theMUTYH gene for Caucasians were not hotspots for Japanese patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 12, 2018 Category: Cancer & Oncology Source Type: research

Meta-analysis of randomized clinical trials in the era of individual patient data sharing
ConclusionsAlthough there are difficulties in conducting, analyzing, and interpreting retrospective IPD meta-analysis utilizing the currently available data-sharing systems, data sharing will play an important role in IPD meta-analysis in the future. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 12, 2018 Category: Cancer & Oncology Source Type: research

Differences in histological features and PD-L1 expression between sporadic microsatellite instability and Lynch-syndrome-associated disease in Japanese patients with colorectal cancer
ConclusionsTherefore, compared with Lynch-syndrome-associated cancers, sporadic MSI cancers are more frequently solid, poorly differentiated medullary cancers that express PD-L1. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 11, 2018 Category: Cancer & Oncology Source Type: research

Efficacy and safety of third-line molecular-targeted therapy in metastatic renal cell carcinoma resistant to first-line vascular endothelial growth factor receptor tyrosine kinase inhibitor and second-line therapy
AbstractBackgroundThe number of studies evaluating the efficacy and safety of third-line molecular-targeted therapy for metastatic renal cell carcinoma (mRCC) is limited.MethodsThe data for 48 patients with disease progression after first-line vascular endothelial growth factor receptor tyrosine kinase inhibitor (TKI) and second-line targeted therapy were evaluated. Patients with prior cytokine therapy were excluded. Overall survival (OS) after first- and second-line therapy initiation was compared between patients with and without third-line therapy. In addition, dose-limiting toxicities (DLTs) were evaluated.ResultsTwent...
Source: International Journal of Clinical Oncology - January 11, 2018 Category: Cancer & Oncology Source Type: research

Prognostic factors in Chinese patients with prostate cancer receiving primary androgen deprivation therapy: validation of Japan Cancer of the Prostate Risk Assessment (J-CAPRA) score and impacts of pre-existing obesity and diabetes mellitus
ConclusionsThe J-CAPRA score presented with good OS differentiation among Chinese patients under PADT. Younger patients (age ≤ 65) had better OS with pre-existing obesity, while older patients (age >  75) had worse OS with pre-existing DM. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 6, 2018 Category: Cancer & Oncology Source Type: research

Prognostic value of the Glasgow Prognostic Score for patients with metastatic renal cell carcinoma treated by cytoreductive nephrectomy
AbstractBackgroundThe aim of the present study was to evaluate the prognostic significance of the Glasgow Prognostic Score (GPS) in metastatic renal cell carcinoma (mRCC) patients treated by cytoreductive nephrectomy (CN), and the accuracy of the GPS as a prognostic factor.MethodsWe retrospectively analyzed the data of patients who underwent CN for mRCC between March 1984 and August 2015. In accordance with the GPS criteria, the patients were classified into three groups: GPS 0: C-reactive protein (CRP)  ≤ 1.0 mg/dl and albumin ≥ 3.5 g/dl; GPS 1: CRP >  1.0 mg/dl or alb...
Source: International Journal of Clinical Oncology - January 5, 2018 Category: Cancer & Oncology Source Type: research

A comparison of the prognosis between adenocarcinoma and squamous cell carcinoma in stage IB –IIA cervical cancer
AbstractObjectiveTo explore differences in prognosis between adenocarcinoma (AC) and squamous cell carcinoma (SCC) and to explore feasibility of ovarian preservation in stage IB –IIA cervical cancer (CC).Materials and methodsMedical records of 810 patients (682 SCC  + 128 AC) with stage IB–IIA CC were reviewed. Clinical and pathological characters of the two groups were compared using the chi-squared test. Kaplan–Meier survival analysis was used in univariate analysis of prognostic factors. Multivariate analysis of prognostic factors was conducted by the Cox hazards regression model.ResultsThe i...
Source: International Journal of Clinical Oncology - January 3, 2018 Category: Cancer & Oncology Source Type: research

Incidence, risk and prognostic role of anti-epidermal growth factor receptor-induced skin rash in biliary cancer: a meta-analysis
AbstractBackgroundAnti-epidermal growth factor receptor (EGFR)-induced skin rash is a common adverse event and is considered a prognostic factor of various cancers. However, the role of rash is rarely known in biliary cancer, possibly owing to the low incidence of this frequently fatal malignancy. We thus performed a meta-analysis to investigate the incidence, risk and prognostic significance of skin rash related to anti-EGFR treatment for biliary cancer.MethodsEligible studies were enrolled after a systematic search of electronic databases. A fixed-effects or random-effects model was utilized according to the heterogeneit...
Source: International Journal of Clinical Oncology - December 30, 2017 Category: Cancer & Oncology Source Type: research

Lymphatic vessel involvement is predictive for lymph node metastasis and an important prognostic factor in endometrial cancer
ConclusionsOur study suggests that by separately evaluating lymphatic invasion and blood vessel invasion in endometrial cancer cases, useful information for predicting lymph node metastasis and recurrence sites as well as prognostic information can be obtained. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 23, 2017 Category: Cancer & Oncology Source Type: research

No significant impact of response to prior androgen receptor-axis-targeted agents on the efficacy of subsequent docetaxel in patients with metastatic castration-resistant prostate cancer
ConclusionsDisease control by docetaxel may not be affected by the response to a prior ARAT agent. Therefore, a prior response to an ARAT agent should not influence the decision on the subsequent introduction of docetaxel for mCRPC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 23, 2017 Category: Cancer & Oncology Source Type: research

Goshajinkigan for reducing chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis
ConclusionsGoshajinkigan tended to prevent persistence but not severity of CIPN. Higher quality trials using multiple measures are needed in the future to clarify the preventive effect ofGoshajinkigan and to assess the various aspects of CIPN. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 21, 2017 Category: Cancer & Oncology Source Type: research

Effect of postoperative radiotherapy on survival in duodenal adenocarcinoma: a propensity score-adjusted analysis of Surveillance, Epidemiology, and End Results database
ConclusionsWe provide useful insights into the therapeutic role of PORT in adenocarcinoma of the duodenum. Adjuvant strategy with PORT needs to be considered in locally advanced tumors. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 19, 2017 Category: Cancer & Oncology Source Type: research

Effect of everolimus treatment for renal angiomyolipoma associated with tuberous sclerosis complex: an evaluation based on tumor density
AbstractBackgroundThe aim of this study was to evaluate the influence of components of angiomyolipoma (AML) on the efficacy of everolimus.MethodsWe investigated a total of 40 patients with tuberous sclerosis complex (TSC) who had AML ≥4 cm in diameter. The components of the AML were determined using abdominal computed tomography (CT) images. The AML density was measured as the mean Hounsfield unit (HU) values of the whole area of the AML on axial CT images. We classified them into two groups, i.e., a lipid group with a predom inant lipid component (HU ≤ −50) and a solid group with predominant vas...
Source: International Journal of Clinical Oncology - December 18, 2017 Category: Cancer & Oncology Source Type: research

Ultrasound-based logistic regression model LR2 versus magnetic resonance imaging for discriminating between benign and malignant adnexal masses: a prospective study
ConclusionsThe IOTA LR2 model had a similar sensitivity to MRI for discriminating between benign and malignant tumors and a higher specificity compared with MRI. Our findings suggest that the IOTA LR2 model, either alone or in conjunction with MRI, should be included in preoperative evaluation of adnexal masses. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 13, 2017 Category: Cancer & Oncology Source Type: research

Comparison of the diagnostic efficacy and perioperative outcomes of limited versus extended pelvic lymphadenectomy during robot-assisted radical prostatectomy: a multi-institutional retrospective study in Japan
ConclusionsePLND, which significantly increased the console time and blood loss but nearly quadrupled the lymph node yield, is considered a relatively safe and acceptable procedure. Moreover, the results of this study suggest that ePLND improves staging and removes a greater number of metastatic nodes. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 11, 2017 Category: Cancer & Oncology Source Type: research

Feasibility and effectiveness of trifluridine/tipiracil in metastatic colorectal cancer: real-life data from The Netherlands
ConclusionsOur data show that treatment with trifluridine/tipiracil in daily clinical practice is feasible and safe. Differences in patient characteristics between our population and the RECOURSE study population should be taken into account in the interpretation of survival data. Our results argue against the use of trifluridine/tipiracil in patients with ECOG PS 2.FundingJohannes J.M. Kwakman received an unrestricted research grant from Servier. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 4, 2017 Category: Cancer & Oncology Source Type: research

A survival analysis using physique-adjusted tumor size of non-small cell lung cancer
ConclusionsThe physique-adjusted tumor size can separate the survival better than the actual tumor size. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 29, 2017 Category: Cancer & Oncology Source Type: research

Management of hereditary breast and ovarian cancer
AbstractHereditary breast and ovarian cancer (HBOC) syndrome represents 5 −10% of all breast cancers. In Japan, the HBOC syndrome is frequently diagnosed in patients with breast cancer. Therefore, a treatment strategy combining a plan for existing breast cancer and for reduction of future breast and ovarian cancer risk is necessary. Breast cancer risk-reducing managemen t involves three options—surveillance, chemoprevention, and risk-reducing mastectomy (RRM). RRM can prevent>90% of new breast cancers. Ovarian cancer risk management options are more limited, and risk-reduction salpingo-oophorectomy is the on...
Source: International Journal of Clinical Oncology - November 28, 2017 Category: Cancer & Oncology Source Type: research

Repeat cytoreduction and hyperthermic intraperitoneal chemotherapy for recurrent peritoneal carcinomatosis of appendiceal origin
ConclusionsRepeat CRS is oncologically beneficial, and the morbidity rate was as high as that of initial CRS. Complete cytoreduction was the key to successful long-term results. Although further recurrence was common, aggressive resection was useful, even in cases of diffuse recurrence. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 27, 2017 Category: Cancer & Oncology Source Type: research

Risk of fatigue in cancer patients receiving anti-EGFR monoclonal antibodies: results from a systematic review and meta-analysis of randomized controlled trial
ConclusionThe present study suggested that anti-EGFR MAbs may increase the risk of fatigue in cancer patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 27, 2017 Category: Cancer & Oncology Source Type: research

Japan Society of Gynecologic Oncology guidelines 2015 for the treatment of vulvar cancer and vaginal cancer
ConclusionOverall, the objective of these guidelines is to clearly delineate the standard of care for vulvar and vaginal cancer with the goal of ensuring a high standard of care for all women diagnosed with these rare diseases. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 20, 2017 Category: Cancer & Oncology Source Type: research

Significance of prostate-specific antigen kinetics after three-dimensional conformal radiotherapy with androgen deprivation therapy in patients with localized prostate cancer
ConclusionsPost-radiation PSA decline rate of  ≥ 90% was a prognostic factor for biochemical recurrence in localized prostate cancer patients received 3D-CRT with various durations of ADT. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 18, 2017 Category: Cancer & Oncology Source Type: research

Carcinosarcoma of the ovary compared to ovarian high-grade serous carcinoma: impact of optimal cytoreduction and standard adjuvant treatment
AbstractObjectiveThe purpose of this retrospective study was to compare the prognoses of women with ovarian carcinosarcoma (OCS) who had optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy to those of women with ovarian high-grade serous carcinoma (HGSC) treated in the same manner.MethodsA multicenter, retrospective department database review was performed to identify patients with OCS at eight gynecologic oncology centers in Turkey. A total of 54 women with OCS who had undergone optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy between 1999 and 2017...
Source: International Journal of Clinical Oncology - November 16, 2017 Category: Cancer & Oncology Source Type: research

Correction to: S-1 and irinotecan plus bevacizumab as second-line chemotherapy for patients with oxaliplatin-refractory metastatic colorectal cancer: a multicenter phase II study in Japan (KSCC1102)
In the original publication, in Abstract, the sentence that reads as, “Oral S-1 at a dose of 80 mg/m2 was …………. drug-free interval” should read as, “Oral S-1 at a dose of 40 mg/m2 was administered twice daily for 2  weeks, followed by a 1-week drug-free interval. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 14, 2017 Category: Cancer & Oncology Source Type: research

Further augmentation of molecular responses with dasatinib therapy in chronic myeloid leukemia patients who gained major molecular response under imatinib
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 13, 2017 Category: Cancer & Oncology Source Type: research

Selecting patients for hyperthermia combined with preoperative chemoradiotherapy for locally advanced rectal cancer
ConclusionsHyperthermia might selectively enhance the preoperative treatment response in LARC with positive CA9 expression and offset the negative effect of hypoxia on prognosis. Pretreatment evaluation of hypoxia could aid in the selection of patients who might benefit from hyperthermia. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 13, 2017 Category: Cancer & Oncology Source Type: research

Impact of a robotic surgical system on treatment choice for men with clinically organ-confined prostate cancer
AbstractBackgroundIntroducing a new surgical technology may affect behaviors and attitudes of patients and surgeons about clinical practice. Robot-assisted laparoscopic radical prostatectomy (RALP) was approved in 2012 in Japan. We investigated whether the introduction of this system affected the treatment of organ-confined prostate cancer (PCa) and the use of radical prostatectomy (RP).MethodsWe conducted a retrospective multicenter study on 718 patients with clinically determined organ-confined PCa treated at one of three Japanese academic institutions in 2011 (n = 338) or 2013 (n = 380). Two patient ...
Source: International Journal of Clinical Oncology - November 11, 2017 Category: Cancer & Oncology Source Type: research

List of reviewers 2016 –2017
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 8, 2017 Category: Cancer & Oncology Source Type: research

Histological transformation after acquired resistance to epidermal growth factor tyrosine kinase inhibitors
AbstractNon-small-cell lung cancer patients with sensitive epidermal growth factor receptor mutations generally respond well to tyrosine kinase inhibitors (TKIs). However, acquired resistance will eventually develop place after 8 –16 months. Several mechanisms contribute to the resistance including T790M mutation, c-Met amplification, epithelial mesenchymal transformation and PIK3CA mutation; however, histological transformation is a rare mechanism. The patterns and mechanisms underlying histological transformation need t o be explored. We searched PubMed, EMBASE and search engines Google Scholar, Medical Matrix...
Source: International Journal of Clinical Oncology - November 7, 2017 Category: Cancer & Oncology Source Type: research

Monitoring the estimated glomerular filtration rate (eGFR) in patients with small-cell lung cancer during chemotherapy: equations based on serum creatinine or cystatin C?
ConclusionsThe eGFR calculated by the CKD-EPI equation changed more significantly between each chemotherapy cycle than did the eGFR from the other equations based on Scr or CysC in patients with SCLC. Oncologists should pay more attention to the renal function of specific patient groups during treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 4, 2017 Category: Cancer & Oncology Source Type: research

Combined detection of Twist1, Snail1 and squamous cell carcinoma antigen for the prognostic evaluation of invasion and metastasis in cervical squamous cell carcinoma
AbstractBackgroundCervical cancer is one of the most common malignant tumours of the female reproductive system, ranking second only to breast cancer in morbidity worldwide. Essential features of the progression of cervical cancer are invasion and metastasis, which are closely related to disease prognosis and mortality rate. At the present time there is no effective method to evaluate cancer invasion and metastasis before surgery. Here we report our study on molecular changes in biopsy tissue for the prognostic evaluation of cancer invasion and metastasis.Patients and methodsExpression of the epithelial –mesenchymal ...
Source: International Journal of Clinical Oncology - November 3, 2017 Category: Cancer & Oncology Source Type: research

Acute toxicity of image-guided hypofractionated proton therapy for localized prostate cancer
ConclusionOur results demonstrated the safety of HFPT for localized PCa patients in terms of acute toxicity. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 2, 2017 Category: Cancer & Oncology Source Type: research

The detection of sentinel lymph nodes in laparoscopic surgery can eliminate systemic lymphadenectomy for patients with early stage endometrial cancer
AbstractBackgroundThe examination of a sentinel lymph node (SLN), where lymph node metastasis first occurs, may be advocated as an alternative staging technique. The aim of this study was to evaluate the feasibility and detection rates of an SLN biopsy in patients with endometrial cancer.Study designTwo hundred and eleven patients with endometrial cancer underwent an SLN biopsy at hysterectomy using three kinds of tracers including 99m-technetium-labeled tin colloid (99mTc), indigo carmine and indocyanine green. Factors related to the side-specific detection rate, sensitivity and false negative rate were analyzed.ResultsTh...
Source: International Journal of Clinical Oncology - November 2, 2017 Category: Cancer & Oncology Source Type: research