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Significance of prostate-specific antigen kinetics after three-dimensional conformal radiotherapy with androgen deprivation therapy in patients with localized prostate cancer
ConclusionsPost-radiation PSA decline rate of  ≥ 90% was a prognostic factor for biochemical recurrence in localized prostate cancer patients received 3D-CRT with various durations of ADT. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 18, 2017 Category: Cancer & Oncology Source Type: research

Carcinosarcoma of the ovary compared to ovarian high-grade serous carcinoma: impact of optimal cytoreduction and standard adjuvant treatment
AbstractObjectiveThe purpose of this retrospective study was to compare the prognoses of women with ovarian carcinosarcoma (OCS) who had optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy to those of women with ovarian high-grade serous carcinoma (HGSC) treated in the same manner.MethodsA multicenter, retrospective department database review was performed to identify patients with OCS at eight gynecologic oncology centers in Turkey. A total of 54 women with OCS who had undergone optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy between 1999 and 2017...
Source: International Journal of Clinical Oncology - November 16, 2017 Category: Cancer & Oncology Source Type: research

Correction to: S-1 and irinotecan plus bevacizumab as second-line chemotherapy for patients with oxaliplatin-refractory metastatic colorectal cancer: a multicenter phase II study in Japan (KSCC1102)
In the original publication, in Abstract, the sentence that reads as, “Oral S-1 at a dose of 80 mg/m2 was …………. drug-free interval” should read as, “Oral S-1 at a dose of 40 mg/m2 was administered twice daily for 2  weeks, followed by a 1-week drug-free interval. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 14, 2017 Category: Cancer & Oncology Source Type: research

Further augmentation of molecular responses with dasatinib therapy in chronic myeloid leukemia patients who gained major molecular response under imatinib
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 13, 2017 Category: Cancer & Oncology Source Type: research

Selecting patients for hyperthermia combined with preoperative chemoradiotherapy for locally advanced rectal cancer
ConclusionsHyperthermia might selectively enhance the preoperative treatment response in LARC with positive CA9 expression and offset the negative effect of hypoxia on prognosis. Pretreatment evaluation of hypoxia could aid in the selection of patients who might benefit from hyperthermia. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 13, 2017 Category: Cancer & Oncology Source Type: research

Impact of a robotic surgical system on treatment choice for men with clinically organ-confined prostate cancer
AbstractBackgroundIntroducing a new surgical technology may affect behaviors and attitudes of patients and surgeons about clinical practice. Robot-assisted laparoscopic radical prostatectomy (RALP) was approved in 2012 in Japan. We investigated whether the introduction of this system affected the treatment of organ-confined prostate cancer (PCa) and the use of radical prostatectomy (RP).MethodsWe conducted a retrospective multicenter study on 718 patients with clinically determined organ-confined PCa treated at one of three Japanese academic institutions in 2011 (n = 338) or 2013 (n = 380). Two patient ...
Source: International Journal of Clinical Oncology - November 11, 2017 Category: Cancer & Oncology Source Type: research

List of reviewers 2016 –2017
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 8, 2017 Category: Cancer & Oncology Source Type: research

Histological transformation after acquired resistance to epidermal growth factor tyrosine kinase inhibitors
AbstractNon-small-cell lung cancer patients with sensitive epidermal growth factor receptor mutations generally respond well to tyrosine kinase inhibitors (TKIs). However, acquired resistance will eventually develop place after 8 –16 months. Several mechanisms contribute to the resistance including T790M mutation, c-Met amplification, epithelial mesenchymal transformation and PIK3CA mutation; however, histological transformation is a rare mechanism. The patterns and mechanisms underlying histological transformation need t o be explored. We searched PubMed, EMBASE and search engines Google Scholar, Medical Matrix...
Source: International Journal of Clinical Oncology - November 7, 2017 Category: Cancer & Oncology Source Type: research

Monitoring the estimated glomerular filtration rate (eGFR) in patients with small-cell lung cancer during chemotherapy: equations based on serum creatinine or cystatin C?
ConclusionsThe eGFR calculated by the CKD-EPI equation changed more significantly between each chemotherapy cycle than did the eGFR from the other equations based on Scr or CysC in patients with SCLC. Oncologists should pay more attention to the renal function of specific patient groups during treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 4, 2017 Category: Cancer & Oncology Source Type: research

Combined detection of Twist1, Snail1 and squamous cell carcinoma antigen for the prognostic evaluation of invasion and metastasis in cervical squamous cell carcinoma
AbstractBackgroundCervical cancer is one of the most common malignant tumours of the female reproductive system, ranking second only to breast cancer in morbidity worldwide. Essential features of the progression of cervical cancer are invasion and metastasis, which are closely related to disease prognosis and mortality rate. At the present time there is no effective method to evaluate cancer invasion and metastasis before surgery. Here we report our study on molecular changes in biopsy tissue for the prognostic evaluation of cancer invasion and metastasis.Patients and methodsExpression of the epithelial –mesenchymal ...
Source: International Journal of Clinical Oncology - November 3, 2017 Category: Cancer & Oncology Source Type: research

Acute toxicity of image-guided hypofractionated proton therapy for localized prostate cancer
ConclusionOur results demonstrated the safety of HFPT for localized PCa patients in terms of acute toxicity. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 2, 2017 Category: Cancer & Oncology Source Type: research

The detection of sentinel lymph nodes in laparoscopic surgery can eliminate systemic lymphadenectomy for patients with early stage endometrial cancer
AbstractBackgroundThe examination of a sentinel lymph node (SLN), where lymph node metastasis first occurs, may be advocated as an alternative staging technique. The aim of this study was to evaluate the feasibility and detection rates of an SLN biopsy in patients with endometrial cancer.Study designTwo hundred and eleven patients with endometrial cancer underwent an SLN biopsy at hysterectomy using three kinds of tracers including 99m-technetium-labeled tin colloid (99mTc), indigo carmine and indocyanine green. Factors related to the side-specific detection rate, sensitivity and false negative rate were analyzed.ResultsTh...
Source: International Journal of Clinical Oncology - November 2, 2017 Category: Cancer & Oncology Source Type: research

Significance of sarcopenia as a prognostic factor for metastatic urothelial carcinoma patients treated with systemic chemotherapy
ConclusionNeither PSMI nor TPA could substitute SMI as a predictor for poor outcomes in metastatic urothelial carcinoma patients treated with systemic chemotherapy in our study. SMI stratified by BMI is a useful predictor of prognosis in these patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - November 2, 2017 Category: Cancer & Oncology Source Type: research

Neutrophil-to-lymphocyte ratio after pazopanib treatment predicts response in patients with advanced soft-tissue sarcoma
AbstractBackgroundPazopanib is a multi-tyrosine kinase inhibitor that is used to treat advanced soft-tissue sarcoma, and its efficacy has been confirmed in several clinical trials, although no clinically useful biomarkers have been identified. In other cancers, the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the lymphocyte-to-monocyte ratio (LMR) are associated with chemotherapy response and prognosis. Therefore, we aimed to evaluate the associations of pazopanib response with NLR, PLR, and LMR among patients with advanced soft-tissue sarcoma.MethodsData regarding NLR, PLR, and LMR wer...
Source: International Journal of Clinical Oncology - October 31, 2017 Category: Cancer & Oncology Source Type: research

Radiotherapy for vaginal cancer: a multi-institutional survey study of the Japanese Radiation Oncology Study Group
ConclusionsGood outcomes similar to those of cervical cancer can be achieved with definitive RT delivered by 3DCRT and/or BT for vaginal cancer. Long follow-up is necessary for a continuing risk of local recurrence after 5  years. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 30, 2017 Category: Cancer & Oncology Source Type: research

Esophageal squamous cell neoplasia is an independent negative prognostic factor for head and neck cancer patients
ConclusionsOur study suggests that although the survival of HNC patients with ESCN may be improved by routine EGDS during tumor surveys and by advances in endoscopy, the presence of ESCN still remains an independent negative prognostic factor for HNC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 24, 2017 Category: Cancer & Oncology Source Type: research

Retrospective analysis of first-line treatment for follicular lymphoma based on outcomes and medical economics
ConclusionR monotherapy for patients whose diseases show low tumor burden and who are not candidates for local treatment has benefits as a first-line treatment compared to R-CHOP, based on the patients ’ QOL and medical economics. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 24, 2017 Category: Cancer & Oncology Source Type: research

A double-blind randomized phase II dose-finding study of olanzapine 10  mg or 5 mg for the prophylaxis of emesis induced by highly emetogenic cisplatin-based chemotherapy
AbstractPurposeThe aim of this phase II study was to evaluate the efficacy and safety of two doses (10 and 5  mg) of olanzapine in combination with standard antiemetic treatment (aprepitant, palonosetron, and dexamethasone) for patients receiving highly emetogenic chemotherapy (HEC).MethodsA multi-institutional, double-blind, randomized phase II, dose-finding study of olanzapine was performed in patients with a malignant solid tumor who were receiving HEC with cisplatin ( ≥ 50 mg/m2). Patients were randomly assigned either olanzapine 10 or 5  mg orally on days 1–4, combined with standard antiem...
Source: International Journal of Clinical Oncology - October 16, 2017 Category: Cancer & Oncology Source Type: research

First-line bolus 5-fluorouracil plus leucovorin for peritoneally disseminated gastric cancer with massive ascites or inadequate oral intake
ConclusionOur study suggests that bolus 5-FU plusl-leucovorin therapy is feasible and has clinical activity as palliative therapy in patients with severe peritoneal metastases from gastric cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 16, 2017 Category: Cancer & Oncology Source Type: research

Biological/pathological functions of the CXCL12/CXCR4/CXCR7 axes in the pathogenesis of bladder cancer
AbstractCXC chemokine ligand 12 (CXCL12) is an important member of the CXC subfamily of chemokines, and has been extensively studied in various human body organs and systems, both in physiological and clinical states. Ligation of CXCL12 to CXCR4 and CXCR7 as its receptors on peripheral immune cells gives rise to pleiotropic activities. CXCL12 itself is a highly effective chemoattractant which conservatively attracts lymphocytes and monocytes, whereas there exists no evidence to show attraction for neutrophils. CXCL12 regulates inflammation, neo-vascularization, metastasis, and tumor growth, phenomena which are all pivotall...
Source: International Journal of Clinical Oncology - October 11, 2017 Category: Cancer & Oncology Source Type: research

Associations between clinical data and computed tomography features in patients with epidermal growth factor receptor mutations in lung adenocarcinoma
AbstractBackgroundTo analyse the differences in computed tomography (CT) features between patients with lung adenocarcinoma who have epidermal growth factor receptor (EGFR) mutations and those who have wild-type EGFR.MethodsPatients with lung adenocarcinoma (n = 156) were enrolled from October 2013 to March 2016, including 56 patients with wild-type EGFR and 100 patients with EGFR mutations. Two independent radiologists evaluated patient characteristics and imaging features. Chi-squared test, Fisher’s exact test or ANOVA was applied to discriminate c linical and CT characteristics between the genotypes. A p...
Source: International Journal of Clinical Oncology - October 7, 2017 Category: Cancer & Oncology Source Type: research

Nomogram predicting long-term survival after the diagnosis of intrahepatic recurrence of hepatocellular carcinoma following an initial liver resection
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 7, 2017 Category: Cancer & Oncology Source Type: research

HPV vaccination in Japan: results of a 3-year follow-up survey of obstetricians and gynecologists regarding their opinions toward the vaccine
ConclusionsOur re-survey of Japan ’s obstetricians and gynecologists regarding their opinions about the HPV vaccine found that their opinions have changed, potentially leading to a more positive future re-engagement for HPV vaccination in Japan. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 6, 2017 Category: Cancer & Oncology Source Type: research

Radiation therapy versus surgery for patients with cervical squamous cell carcinoma who have undergone neoadjuvant chemotherapy revisited
ConclusionsPost-NAC survival outcomes among patients with chemo-sensitive cervical SCC who then underwent RT were not inferior to those treated with surgery, and NAC did not detract from the efficacy of subsequent RT. Among selected patients who respond favorably to NAC, RT could be a less invasive substitute for surgery without compromising treatment outcomes. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 19, 2017 Category: Cancer & Oncology Source Type: research

A retrospective analysis of ramucirumab monotherapy in previously treated Japanese patients with advanced or metastatic gastric adenocarcinoma
ConclusionsOur data suggest that ramucirumab monotherapy in Japanese patients with previously treated advanced gastric cancer has comparable efficacy and safety profiles as reported in the REGARD trial. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 14, 2017 Category: Cancer & Oncology Source Type: research

BRCA1 gene: function and deficiency
AbstractThe BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in cells. It is well known, along with BRCA 2, to cause hereditary breast and ovarian cancer, but here we will specifically focus on BRCA1. We introduce the mechanism and the latest report on homologous recombination repair, replication, involvement in checkpoint regulation, transcription, chromatin remodeling, and cytoplasmic function (centrosome regulation, apoptosis, selective autophagy), and consider the possibility of carcinogenesis from inhibition of the intrace...
Source: International Journal of Clinical Oncology - September 7, 2017 Category: Cancer & Oncology Source Type: research

Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria
ConclusionsThe mvi was one of the independent risk factors for tumor recurrence in HCC classified within the Milan criteria. Multiple tumors and high AFP-L3 value were independent predictive factors for mvi. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 5, 2017 Category: Cancer & Oncology Source Type: research

A systematic review of publications on charged particle therapy for hepatocellular carcinoma
AbstractCharged particle therapy (proton beam therapy and carbon ion therapy) is a form of radiotherapy which has the unique characteristic of superior depth dose distribution, and has been used for the treatment of hepatocellular carcinoma (HCC) in a limited number of patients, especially in Japan. We undertook a systematic review to define the clinical utility of charged particle therapy for patients with HCC. We searched the MEDLINE database from 1983 to June 2016 to identify clinical studies on charged particle therapy for HCC. Primary outcomes of interest were local control, overall survival, and late radiation morbid...
Source: International Journal of Clinical Oncology - September 4, 2017 Category: Cancer & Oncology Source Type: research

Impact of multiple malignancies on surgical outcomes in patients with 1  cm or smaller non-small cell lung cancer
ConclusionNSCLC of 1  cm or smaller showed good prognoses. The presence of multiple malignancies was a significantly poor prognostic factor, and short treatment intervals also correlated with poor prognosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 1, 2017 Category: Cancer & Oncology Source Type: research

Significance of multiple preoperative laboratory abnormalities as prognostic indicators in patients with urothelial carcinoma of the upper urinary tract following radical nephroureterectomy
ConclusionsThese findings suggest that it is important to consider laboratory abnormalities, particularly the De Ritis ratio and NLR, to predict disease recurrence following RNU in patients with clinically localized UUTUC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 30, 2017 Category: Cancer & Oncology Source Type: research

The insufficient prognostic power of stenosis in patients with esophageal cancer
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 28, 2017 Category: Cancer & Oncology Source Type: research

Hereditary breast cancer: molecular biology and management update
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 24, 2017 Category: Cancer & Oncology Source Type: research

Prognostic factors for disease-free and overall survival of patients with uterine carcinosarcoma
AbstractBackgroundUterine carcinosarcoma (UCS) is a relatively rare and very aggressive tumor. The predictors of survival for patients with UCS have not been determined clearly yet. The aim of the present study was to investigate the possible predictors of disease-free survival (DFS) and overall survival (OS) for patients with UCS.Methods and materialsAll patients with UCS who were treated surgically at a university-based Gynecology Oncology Clinic between January 2008 and December 2014 were recruited into this retrospective cohort study. Data regarding clinical, pathologic and treatment information were obtained retrospec...
Source: International Journal of Clinical Oncology - August 23, 2017 Category: Cancer & Oncology Source Type: research

A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy
ConclusionThe present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 19, 2017 Category: Cancer & Oncology Source Type: research

Clinical outcomes of patients with epithelioid sarcomas: impact and management of nodal metastasis
ConclusionsPeripheral tumor location is associated with a better prognosis. The development of new nodal metastasis tends to be associated with poor prognosis; however, among patients with nodal metastasis, resection of the metastatic lesions has a low impact on survival. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 10, 2017 Category: Cancer & Oncology Source Type: research

The use of neoadjuvant therapy for resectable locally advanced thoracic esophageal squamous cell carcinoma in an analysis of 5016 patients from 305 designated cancer care hospitals in Japan
ConclusionsBased on our results, in Japan, relatively few patients with resectable locally advanced thoracic ESCC receive neoadjuvant therapy, with older patients and patients at lower volume hospitals being less likely than other patients to receive the neoadjuvant therapy. We recommend that the process of treatment decision-making be assessed at both the patient and hospital levels so that patients can consider various treatment options, including neoadjuvant therapy with surgery in Japan. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 9, 2017 Category: Cancer & Oncology Source Type: research

Feasibility of dose-dense epirubicin and cyclophosphamide with subcutaneous pegfilgrastim 3.6  mg support: a single-center prospective study in Japan
ConclusionsWith support provided by pegfilgrastim injection at a dose of 3.6  mg, dose-dense EC is feasible and associated with maintenance of a high RDI. There was no clinically significant accumulation of serum G-CSF concentrations associated with the use of a 3.6 mg dose of pegfilgrastim at 2-week intervals. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 8, 2017 Category: Cancer & Oncology Source Type: research

Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma
AbstractBackgroundThe prognostic implications of preoperative serum total cholesterol (TC) level in patients with renal cell carcinoma (RCC) remain poorly understood. We investigated the prognostic role of preoperative serum TC in patients with surgically treated RCC from a large, multi-institutional Korean collaboration.Patients and methodsA database of 3064 patients with RCC who underwent radical or partial nephrectomy between 1999 and 2011 at eight academic centers was analyzed. Preoperative serum TC levels were measured in fasting blood samples.ResultsLow preoperative serum TC level was associated with aggressive tumor...
Source: International Journal of Clinical Oncology - August 8, 2017 Category: Cancer & Oncology Source Type: research

Phase II study of radium-223 dichloride in Japanese patients with symptomatic castration-resistant prostate cancer
ConclusionsRadium-223 is effective and well tolerated in Japanese patients with CRPC and bone metastases. Results were comparable with the Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial.Clinical trial registrationClinicalTrials.gov NCT01929655. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 2, 2017 Category: Cancer & Oncology Source Type: research

Erratum to: Sarcopenia, but not visceral fat amount, is a risk factor of postoperative complications after major hepatectomy
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 28, 2017 Category: Cancer & Oncology Source Type: research

The clinical use of neutrophil-to-lymphocyte ratio in bladder cancer patients: a systematic review and meta-analysis
AbstractThe aim of this study was to evaluate the evidence regarding the neutrophil-to-lymphocyte ratio (NLR) as a factor predictive of survival in bladder cancer patients. A search of PubMed and Embase for relevant studies between January 1, 1966 and November 10, 2016 was performed with the terms [NLR OR (neutrophil lymphocyte ratio)] AND [(bladder cancer) OR BCa OR NMIBC OR MIBC]. Inclusion required studies published in English containing bladder cancer patients and evaluating NLR as a predictive factor. Endpoints of NLR and survival data were extracted for pooled analysis. The pooled results showed that an elevated NLR ...
Source: International Journal of Clinical Oncology - July 27, 2017 Category: Cancer & Oncology Source Type: research

Presurgical axitinib therapy increases fibrotic reactions within tumor thrombus in renal cell carcinoma with thrombus extending to the inferior vena cava
ConclusionsPresurgical axitinib therapy enhanced tumor reduction accompanied by fibrosis and may contribute to surgical risk reduction for selected patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 27, 2017 Category: Cancer & Oncology Source Type: research

Retrospective comparison of S-1 plus cisplatin versus S-1 monotherapy for the treatment of advanced gastric cancer patients with positive peritoneal cytology but without gross peritoneal metastasis
ConclusionAdding cisplatin to long-term S-1 monotherapy did not significantly improve the outcome of CY+ advanced gastric cancer patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 26, 2017 Category: Cancer & Oncology Source Type: research

PD-L1 induced by IFN- γ from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer
ConclusionsIFN- γ was not always successful as an antitumor agent. It also can promote tumor cells to evade immune surveillance. Researchers should be cautious in using IFN-γ as a therapeutic agent for cancer treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 26, 2017 Category: Cancer & Oncology Source Type: research

Impact of major different variants of papillary thyroid microcarcinoma on the clinicopathological characteristics: the study of 1041 cases
AbstractBackgroundThe incidence of papillary thyroid microcarcinoma (PTMC) has been increasing globally in the past few decades. PTMC does not have a distinctive morphology that results in differences in biological behavior. The aim of this study was to classify PTMCs according to the morphological features and explore the relationship with clinicopathological characteristics. Additionally, we sought to evaluate whether different variants of PTMC can be an independent predictor for lymph mode metastasis when considering other risk factors.MethodsBetween December 2014 and December 2015, 1041 PTMC cases undergoing surgical r...
Source: International Journal of Clinical Oncology - July 25, 2017 Category: Cancer & Oncology Source Type: research

Concordance of clinical diagnosis of T classification among physicians for locally advanced unresectable thoracic esophageal cancer
ConclusionsThere were inter-observer variations in clinical diagnosis of the T category of locally advanced, unresectable esophageal cancer. Accurate clinical diagnosis of T classification is required for determining the optimum treatment for each patient. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 25, 2017 Category: Cancer & Oncology Source Type: research

Fatigue associated with newly approved vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: an up-to-date meta-analysis
AbstractThe fatigue associated with five newly approved vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) (regorafenib, vandetanib, cabozantinib, lenvatinib, axitinib) is poorly understood. We conducted this systematic review to fully investigate the fatigue associated with these VEGFR-TKIs in cancer patients. Relevant studies of randomized controlled trials in cancer patients treated with the five VEGFR-TKIs were retrieved and a systematic evaluation was conducted. EMBASE, MEDLINE, and PubMed were searched for articles published until March 2017. Thirteen randomized controlled trials and ...
Source: International Journal of Clinical Oncology - July 21, 2017 Category: Cancer & Oncology Source Type: research

Early response of C-reactive protein as a predictor of survival in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors
AbstractBackgroundPretreatment C-reactive protein (CRP) has been shown to be an independent prognostic factor for metastatic renal cell carcinoma (mRCC) treated with tyrosine kinase inhibitors (TKIs). We further evaluated the early response of CRP after the initiation of TKIs.MethodsA total of 103 patients (80 men and 23 women) were treated with TKIs for mRCC from 2008 −2013. Patients were divided into three groups according to their early CRP kinetics—patients whose baseline CRP levels were20% at 4  weeks after the initiation of TKIs (early CRP responder), and the remaining patients (non-early CRP respond...
Source: International Journal of Clinical Oncology - July 21, 2017 Category: Cancer & Oncology Source Type: research

Aspirin use and head and neck cancer survival: an observational study of 11,623 person-years follow-up
ConclusionOur data illustrated that the use of aspirin or NSAIDs has no effect on survival or recurrence in patients with HNSCC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 19, 2017 Category: Cancer & Oncology Source Type: research

Intraoperative radiotherapy for extremity soft-tissue sarcomas: can long-term local control be achieved?
ConclusionIOERT used as a boost to EBRT provides high local control and limb-sparing rates in patients with STS of the extremities, with less toxicity than EBRT alone. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 17, 2017 Category: Cancer & Oncology Source Type: research