Clinical practice guidelines for molecular tumor marker, 2nd edition review part 2
AbstractIn recent years, rapid advancement in gene/protein analysis technology has resulted in target molecule identification that may be useful in cancer treatment. Therefore, “Clinical Practice Guidelines for Molecular Tumor Marker, Second Edition” was published in Japan in September 2021. These guidelines were established to align the clinical usefulness of external diagnostic products with the evaluation criteria of the Pharmaceuticals and Medical Devices Agency. T he guidelines were scoped for each tumor, and a clinical questionnaire was developed based on a serious clinical problem. This guideline was based on a ...
Source: International Journal of Clinical Oncology - March 17, 2024 Category: Cancer & Oncology Source Type: research

Salivary gland-type cancers: cross-organ demographics of a rare cancer
ConclusionsThis cross-organ study highlights the clinical significance of SGTCs, underscoring the need for developing novel therapies for this rare disease entity. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 16, 2024 Category: Cancer & Oncology Source Type: research

An approach for improvement of the accuracy of cancer gene panel testing
ConclusionWe identified various factors associated with efficient and accurate CGP testing using relevant information obtained from real-world data, suggesting that thorough selection and preparation of tissue sections could optimize CGP and maximize useful information. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 12, 2024 Category: Cancer & Oncology Source Type: research

Association between comorbidities and survival in patients with metastatic urothelial carcinoma treated with pembrolizumab
ConclusionsHigh CCI was associated with a higher risk of disease progression as well as overall mortality in mUC patients treated with second-line pembrolizumab. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 2, 2024 Category: Cancer & Oncology Source Type: research

Association of D-dimer level with thrombotic events, bleeding, and mortality in Japanese patients with solid tumors: a Cancer-VTE Registry subanalysis
ConclusionsIncreases in D-dimer levels were associated with a higher risk of thrombotic events, such as VTE and cerebral infarction/TIA/SEE, during cancer treatment. Furthermore, higher D-dimer levels at cancer diagnosis were associated with a higher mortality rate, regardless of cancer stage. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 2, 2024 Category: Cancer & Oncology Source Type: research

Association between comorbidities and survival in patients with metastatic urothelial carcinoma treated with pembrolizumab
ConclusionsHigh CCI was associated with a higher risk of disease progression as well as overall mortality in mUC patients treated with second-line pembrolizumab. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 2, 2024 Category: Cancer & Oncology Source Type: research

Association of D-dimer level with thrombotic events, bleeding, and mortality in Japanese patients with solid tumors: a Cancer-VTE Registry subanalysis
ConclusionsIncreases in D-dimer levels were associated with a higher risk of thrombotic events, such as VTE and cerebral infarction/TIA/SEE, during cancer treatment. Furthermore, higher D-dimer levels at cancer diagnosis were associated with a higher mortality rate, regardless of cancer stage. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 2, 2024 Category: Cancer & Oncology Source Type: research

Radiotherapy with or without chemotherapy for locally advanced head and neck cancer in elderly patients: analysis of the Head and Neck Cancer Registry of Japan
ConclusionAlthough aggressive CRT is administered to elderly patients in Japan, its effectiveness is uncertain. Further prospective randomized trials are needed to verify whether CRT is superior to RT alone for elderly patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Effects of postoperative oral elemental nutritional supplement on skeletal muscle loss after gastrectomy for gastric cancer
ConclusionED administration for 6 –8 weeks following gastrectomy had no inhibitory effect on skeletal muscle loss at 1 year postoperatively.Clinical Trial RegistrationUMIN000023455. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Impact of sarcopenia on recurrent biliary obstruction after EUS-guided biliary drainage in patients with malignant biliary obstruction
ConclusionSarcopenia is an independent indicator of RBO in patients with MBO who receive EUS-BD with SEMS. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells
ConclusionFOXM1 cooperates withRacGAP1 to induce CC cell proliferation, migration and invasion, inhibit apoptosis, and regulatePI3K/AKT signaling to promote CC progression. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

EGFR mutation impacts recurrence in high-risk early-stage lung adenocarcinoma in the IASLC grading system
ConclusionsThis study provides evidence that patients withEGFRm-positive stage I lung adenocarcinoma in the high-risk group have an increased risk of recurrence, including CNS metastasis. These findings highlight the need for development of adjuvant treatment in this population. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

The prognostic impact of treatment centralization in patients with testicular germ cell tumors: analysis of hospital-based cancer registry data in Japan
ConclusionOur results indicate that stage II and III TGCT patients experience lower survival rates at low-volume institutions and would benefit from treatment centralization. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Skeletal muscle status and survival among patients with advanced biliary tract cancer
ConclusionsSkeletal muscle quantity and quality and their serial changes were associated with survival outcomes in patients with advanced biliary tract cancer. Our data highlight the importance of designing nutritional and physical interventions for improvements in skeletal muscle status. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Glomerular filtration rate measurement during platinum treatment for urothelial carcinoma: optimal methods for clinical practice
ConclusionCKD-EPI equation emerged as the most suitable for estimating kidney function in this patient group although not meeting benchmark criteria. We recommend its use for initial assessment and ongoing monitoring, and suggest mGFR for patients with a CKD-EPI estimated GFR below 85  ml/min. This approach could reduce costs and decrease laboratory time for 30% of our UC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research