Clinical outcomes of repeat partial nephrectomy compared to initial partial nephrectomy of a solitary kidney
ConclusionsThe clinical outcomes of RePN were not significantly different compared with those of iPN for patients with sporadic RCC of a solitary kidney. RePN is technically feasible with acceptable complication and local recurrence rates with better postoperative kidney function. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 17, 2020 Category: Cancer & Oncology Source Type: research

Laparoscopic versus abdominal radical hysterectomy for stage IB1 cervical cancer patients with tumor size  ≤ 2 cm: a case-matched control study
ConclusionsPatients with squamous cell carcinoma in stage IB1 cervical cancer with tumor size ≤ 2 cm might be suitable for laparoscopic surgery, while patients with adenocarcinoma or adenosquamous carcinoma with tumor size ≤ 2 cm are not candidates for laparoscopic surgery. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 15, 2020 Category: Cancer & Oncology Source Type: research

A phase I and extension study of S-1 and carboplatin for previously untreated patients aged 75  years or more with advanced non-small cell lung cancer -TCOG 1101-
ConclusionsThe recommended doses for this combination therapy are carboplatin AUC 5 and S-1 80  mg/m2/day every 3  weeks, and this combination is effective with tolerable toxicities for advanced NSCLC patients ≥ 75 years old. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 14, 2020 Category: Cancer & Oncology Source Type: research

Management and new strategy of ovarian clear cell carcinoma
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 13, 2020 Category: Cancer & Oncology Source Type: research

Predictive factors for recurrence after partial nephrectomy for clinical T1 renal cell carcinoma: a retrospective study of 1227 cases from a single institution
ConclusionPatients with high grade tumors and tumors upstaged to pT3 had a high risk of worse RFS, which suggested that careful monitoring is required for such patients after PN, even if a good prognosis is achieved in patients with clinical T1 RCC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 11, 2020 Category: Cancer & Oncology Source Type: research

Current status and future prospective of focal therapy for localized prostate cancer: development of multiparametric MRI, MRI-TRUS fusion image-guided biopsy, and treatment modalities
AbstractMultiparametric magnetic resonance imaging (mpMRI) has been increasingly used to diagnose clinically significant prostate cancer (csPC) because of its usefulness in combination with anatomic and functional data. MRI-targeted biopsy, such as MRI-transrectal ultrasound (TRUS) fusion image-guided prostate biopsy, has high accuracy in the detection and localization of csPC. This novel diagnostic technique contributes to the development of tailor-made medicine as focal therapy, which cures the csPC while preserving the anatomical structures related to urinary and sexual function. In the early days of focal therapy, TRUS...
Source: International Journal of Clinical Oncology - February 10, 2020 Category: Cancer & Oncology Source Type: research

Treatment strategies for neuroendocrine carcinoma of the upper digestive tract
ConclusionsA macroscopically unique appearance, like submucosal tumor, suggests the possibility of NEC. Esophagectomy is an effective treatment option for limited-stage NEC without node metastasis, while gastrectomy followed by adjuvant chemotherapy may be effective for NEC even with node metastasis when R0 resection can be achieved. Systemic chemotherapy is relatively effective for advanced NEC, although early progression frequently develops. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 8, 2020 Category: Cancer & Oncology Source Type: research

Clinical impact of revisions to the WHO classification of diffuse gliomas and associated future problems
AbstractThe publication of the 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 WHO CNS) represented a major change in the classification of brain tumors. It is essential to determine theIDH and 1p/19q statuses of diffuse gliomas to ensure that the final diagnosis is accurate. The integrated diagnostic method outlined in the 2016 WHO CNS has enabled more precise prediction of the prognoses of diffuse gliomas. However, there are further two points that need to be addressed when planning future clinical trials. The first is the problems with the WHO grading system for diffuse glioma...
Source: International Journal of Clinical Oncology - February 4, 2020 Category: Cancer & Oncology Source Type: research

Precision medicine for ovarian clear cell carcinoma based on gene alterations
AbstractOvarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian carcinoma prevalent in Asians. No clear therapeutic selection based on molecular profile has been implemented for this disease. OncogenicPIK3CA mutation, which activates the PIK3CA/AKT/mTOR signaling pathway, is a promising druggable alteration in OCCC. Recent studies by our group and others have identified theARID1A mutation as another alteration linked to therapeutic selection based on synthetic lethality: deleteriousARID1A mutations, resulting in ARID1A deficiency, make OCCC cells sensitive to drugs targeting poly (ADP-ribose) po...
Source: International Journal of Clinical Oncology - February 4, 2020 Category: Cancer & Oncology Source Type: research

Research on the predicting power of the revised Tokuhashi system: how much time can surgery give to patients with short life expectancy?
ConclusionAccording to our results, the Tokuhashi scoring system makes very conservative predictions and prefers non-surgical palliative or supportive care. Surgical treatment increases the life expectancy of patients in poor condition. We propose modifying the therapeutic options of the revised Tokuhashi system, taking into consideration modern spine surgery techniques. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 28, 2020 Category: Cancer & Oncology Source Type: research

Rethinking of treatment strategies and clinical management in ovarian clear cell carcinoma
AbstractOvarian clear cell carcinoma (OCCC), with unique clinical and molecular characteristics compared with other histological types of epithelial ovarian cancer (EOC), behaves like a distinct entity and has a poorer prognosis than other EOC types, especially in advanced stages. In addition, OCCC comprises approximately 27% of all EOC cases in Japan, compared with 12% in Western countries. Historically, patients with OCCC have been eligible for chemotherapeutic and surgical trials of EOC. It has been difficult to evaluate the specific impact of these trials on the prognosis of women with OCCC because of its rarity and un...
Source: International Journal of Clinical Oncology - January 27, 2020 Category: Cancer & Oncology Source Type: research

Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology
ConclusionIn theNTRK guideline, the committee proposed 15 recommendations for performingNTRK testing properly to select patients who are likely to benefit from tropomyosin receptor kinase inhibitors. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 24, 2020 Category: Cancer & Oncology Source Type: research

Safety of radiotherapy for hemodialysis patients with cancer
ConclusionOur results suggest that RT for HD patients is clinically tolerable. However, some patients can experience severe infections related to treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 21, 2020 Category: Cancer & Oncology Source Type: research

Postradiotherapy persistent lymphopenia as a poor prognostic factor in patients with cervical cancer receiving radiotherapy: a single-center, retrospective study
ConclusionPost-RT persistent lymphopenia could be a poor prognostic factor for patients with cervical cancer who receive RT. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 20, 2020 Category: Cancer & Oncology Source Type: research

Psoas muscle mass in patients undergoing lung cancer surgery: a prognostic difference between squamous cell carcinoma and adenocarcinoma
ConclusionsThe PMI was significantly associated with the survival of lung SCC patients, but not of lung ADC patients, suggesting the presence of a previously unidentified relationship between skeletal muscle and lung SCC progression. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 18, 2020 Category: Cancer & Oncology Source Type: research

Treatment choices and outcomes of non-metastatic hepatocellular carcinoma patients in relationship to neighborhood socioeconomic status: a population-based study
AbstractObjectiveTo assess the impact of socioeconomic status (SES) on treatment choices and outcomes of hepatocellular carcinoma (HCC) patients treated with local therapies (ablation or surgery).MethodsSurveillance, Epidemiology and End Results (SEER) specialized socioeconomic database was accessed. Cases with non-metastatic HCC treated with ablation or surgery between 2000 and 2015 were included. Socioeconomic index stratified patients into three groups (1 –3) where group-1 has the lowest SES and group-3 has the highest SES. Impact of SES on the choice of local treatment was assessed in a multivariate logistic regr...
Source: International Journal of Clinical Oncology - January 18, 2020 Category: Cancer & Oncology Source Type: research

Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments
ConclusionsThe clinical manifestations of RPTs were extremely variable. Recurrence after repeating resection is commonly observed in patients with malignant retroperitoneal sarcoma. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 16, 2020 Category: Cancer & Oncology Source Type: research

Magnitude of advantage in tumor response contributes to a better correlation between treatment effects on overall survival and progression-free survival: a literature-based meta-analysis of clinical trials in patients with metastatic colorectal cancer
ConclusionsThe magnitude of advantage in tumor response was suggested to contribute to a better prediction of OS benefit based on PFS in patients with mCRC. The accuracy of OS estimation in mCRC is expected to be improved by considering the degree of tumor shrinkage in conjunction with PFS. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 16, 2020 Category: Cancer & Oncology Source Type: research

Multicenter prospective phase II trial of nivolumab in patients with unresectable or metastatic mucosal melanoma
ConclusionAlthough this trial met the primary endpoint, the RR was still unsatisfactory. Therefore, further treatment development is required. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 14, 2020 Category: Cancer & Oncology Source Type: research

Immune-resistant mechanisms in cancer immunotherapy
AbstractImmune checkpoint inhibitors (ICI) such as PD-1/PD-L1 antibodies (Abs) and CTLA4 Abs and T cell-based adoptive cell therapies are effective for patients with various cancers. However, response rates of ICI monotherapies are still limited due to lack of immunogenic antigens and various immune-resistant mechanisms. The latter includes adaptive immune resistance that is caused by anti-tumor T cells (e.g. PD-L1 induced by IFN- γ from T cells) and primary immune resistance that is caused by cancer cells (e.g. immunosuppressive cytokines produced by cancer cells). Further understanding of the immune-resistant mecha...
Source: International Journal of Clinical Oncology - January 9, 2020 Category: Cancer & Oncology Source Type: research

Lung cancer incidence and mortality in relationship to hormone replacement therapy use among women participating in the PLCO trial: a post hoc analysis
ConclusionHRT use at the time of PLCO trial entry seems to be associated with lower probability of lung cancer development and death. Further studies are needed to elucidate the biological mechanisms behind this observation. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 9, 2020 Category: Cancer & Oncology Source Type: research

Clinical outcomes and prognostic factors in patients with newly diagnosed metastatic prostate cancer initially treated with androgen deprivation therapy: a retrospective multicenter study in Japan
ConclusionIn this series, CRPC-free and OS of a subset of mHNPC patients in Japan who were treated with ADT or CAB had better CRPC-free and overall survivals in Japan. Risk-adapted treatment based on the presence of novel prognostic factors may be beneficial for selected mHNPC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 9, 2020 Category: Cancer & Oncology Source Type: research

High-grade complication is associated with poor overall survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
AbstractBackgroundCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is increasingly used in peritoneal carcinomatosis (PC) management. This modality is criticized for its high morbidity and mortality. We evaluate the morbidity and mortality of patients undergoing this procedure in our institution.MethodsA review of our institution ’s database was performed. All patients who underwent CRS/HIPEC between July 2011 and March 2018 were divided into three groups: no, low-grade, and high-grade complications. Prognostic factors were determined with Cox regression, while morbidity risk factors ...
Source: International Journal of Clinical Oncology - January 8, 2020 Category: Cancer & Oncology Source Type: research

Prognostic outcomes and safety in patients treated with pembrolizumab for advanced urothelial carcinoma: experience in real-world clinical practice
ConclusionsThe introduction of pembrolizumab can result in favorable cancer control outcomes in Japanese patients with advanced UC, and the prognosis of these patients can be stratified according to three potential parameters, including poor performance status, high number of metastatic organs, and higher relative neutrophil-to-lymphocyte ratio change. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 7, 2020 Category: Cancer & Oncology Source Type: research

Risk factors for lower limb lymphedema in gynecologic cancer patients after initial treatment
ConclusionSimultaneous examination of the relationship between lower limb lymphedema and risk factors, and analysis among the risk factors using generalized structural models, enabled us to construct a clinical model of lower limb lymphedema for use in clinical settings to alleviate this condition and improve quality of life. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 6, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Impact of oral voriconazole during chemotherapy for acute myeloid leukemia and myelodysplastic syndrome: a Japanese nationwide retrospective cohort study
In the original publication, in Figure  1 the month range of DPC Database has been given incorrectly. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 6, 2020 Category: Cancer & Oncology Source Type: research

Current issues and perspectives in PD-1 blockade cancer immunotherapy
AbstractProgrammed cell death 1 (PD-1) signal receptor blockade has revolutionized the field of cancer therapy. Despite their considerable potential for treating certain cancers, drugs targeting PD-1 still present two main drawbacks: the substantial number of unresponsive patients and/or patients showing recurrences, and side effects associated with the autoimmune response. These drawbacks highlight the need for further investigation of the mechanisms underlying the therapeutic effects, as well as the need to develop novel biomarkers to predict the lack of treatment response and to monitor potential adverse events. Combina...
Source: International Journal of Clinical Oncology - January 3, 2020 Category: Cancer & Oncology Source Type: research

Treatment intensity and control rates in combining external-beam radiotherapy and radioactive iodine therapy for metastatic or recurrent differentiated thyroid cancer
ConclusionEBRT of  >  50 Gy and post-EBRT RAIT appeared to be useful for long-term control of EBRT sites for metastatic or recurrent lesions of DTC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 2, 2020 Category: Cancer & Oncology Source Type: research

Efficacy and safety profile of nivolumab for Japanese patients with metastatic renal cell cancer
ConclusionsNivolumab has a relatively favorable efficacy and safety profile for Japanese metastatic renal cell cancer patients in clinical practice. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 1, 2020 Category: Cancer & Oncology Source Type: research

External validation of a postoperative nomogram for the prediction of disease-specific survival in patients with papillary renal cell carcinoma using a large multicenter database
ConclusionsThe nomogram performance was satisfactory for almost all DSS probabilities; hence it can be recommended for application in clinical routine and for counseling of patients with papRCC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 1, 2020 Category: Cancer & Oncology Source Type: research

Risk factors and prognostic significance of lateral pelvic lymph node metastasis in advanced rectal cancer
ConclusionsTumor location (Rb), LPLN metastasis on preoperative imaging and distant metastasis were risk factors for LPLN metastasis. The prognosis of rectal cancer patients with LPLN metastasis is poor. There may not be the indication of LPLN dissection in stage IV lower rectal cancer except cases having complaints due to LPLN metastasis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 1, 2020 Category: Cancer & Oncology Source Type: research

Exosomal miR-1246 in serum as a potential biomarker for early diagnosis of gastric cancer
ConclusionCirculating exosomal miR-1246 was a potential biomarker for the early diagnosis of GC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 1, 2020 Category: Cancer & Oncology Source Type: research

Assessment of the prognostic value and N1b changes of the eighth TNM/AJCC staging system for differentiated thyroid carcinoma
ConclusionsTNM-8 staged a significant number of Chinese patients into lower stages and improved the accuracy of predicting DSS compared with TNM-7. However, changes in lateral LNM definition and classification of TNM-8 have a significant prognostic implication for patients with DTC, especially older patients ( ≥ 55 years). Our data suggest that a modified TNM staging system would be more useful for predicting mortality and determining a proper treatment strategy in patients with DTC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 1, 2020 Category: Cancer & Oncology Source Type: research

Barriers for sperm cryopreservation in advanced germ cell tumor patients: a 20-year experience
ConclusionsNot only offering proper information about sperm cryopreservation, but also shared decision making prior to chemotherapy, and considering fertility preservation before orchiectomy are imperative. The rate of use of preserved sperm was relatively high, but decision making for sperm disposal should also be supported. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 1, 2020 Category: Cancer & Oncology Source Type: research

LINC00163 inhibits the invasion and metastasis of gastric cancer cells as a ceRNA by sponging miR-183 to regulate the expression of AKAP12
ConclusionOur results demonstrated that weak LINC00163 expression in GC can sponge miR-183 to promote AKAP12. We established that the LINC00163/miR-183/AKAP12 axis plays an important role in GC invasion and metastasis and may be a potential biomarker and target for GC treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 1, 2020 Category: Cancer & Oncology Source Type: research

Association of the primary tumor ’s SUVmax with survival after surgery for clinical stage IA esophageal cancer: a single-center retrospective study
ConclusionThe SUVmax of the primary tumor is a predictor of postoperative survival for clinical stage IA esophageal cancer. Thus, using fluorodeoxyglucose-positron emission tomography to evaluate the primary tumor ’s glucose metabolism may reflect the tumor’s grade and potentially compensate for inaccuracies in tumor-node-metastasis staging. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 23, 2019 Category: Cancer & Oncology Source Type: research

Postoperative D-dimer elevation affects tumor recurrence and the long-term survival in gastric cancer patients who undergo gastrectomy
AbstractIntroductionWe retrospectively evaluated the blood coagulation activity using the D-dimer level in the early period after gastrectomy and investigated whether postoperative hypercoagulation affects tumor recurrence and long-term survival in gastric cancer patients.MethodsThe study involved 650 patients who underwent curative resection for gastric cancer at Kanagawa Cancer Center between July 2009 and July 2013. They were divided into a low-D-dimer group (LD group) and high-D-dimer group (HD group) according to the median D-dimer level on postoperative day (POD) 7. The risk factors for overall survival (OS) and rela...
Source: International Journal of Clinical Oncology - December 21, 2019 Category: Cancer & Oncology Source Type: research

Comparable efficacy and safety between second-line and later-line nivolumab therapy for metastatic renal cell carcinoma
ConclusionsThe efficacy of nivolumab did not deteriorate and the tolerability was also maintained even in later-line therapy. However, a tendency of longer OS and a higher chance of subsequent therapy after nivolumab failure were observed with nivolumab as second-line therapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 19, 2019 Category: Cancer & Oncology Source Type: research

Impact of peripheral neuropathy induced by platinum in first-line chemotherapy on second-line chemotherapy with paclitaxel for advanced gastric cancer
ConclusionsThe severity of PN and tolerability of 2nd-PTX may be affected by first-line chemotherapy with L-OHP or CDDP for AGC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 18, 2019 Category: Cancer & Oncology Source Type: research

Prognostic scores for evaluating the survival benefit of regorafenib or trifluridine/tipiracil in patients with metastatic colorectal cancer: an exploratory analysis of the REGOTAS study
ConclusionThese prognostic scores are useful for identifying patients with mCRC who will obtain survival benefits from these drugs. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 14, 2019 Category: Cancer & Oncology Source Type: research

Prognostic significance of serum p53 antibody according to KRAS status in metastatic colorectal cancer patients
AbstractBackgroundSerum anti-p53 antibody is used clinically as a tumor marker of colorectal cancer. However, its prognostic significance in patients with metastatic colorectal cancer (mCRC) remains unclear.KRAS status may influence the host immune response against tumor progression. In the present study, we investigated the prognostic significance of serum anti-p53 in mCRC patients with wild-typeKRAS and mutantKRAS treated with systemic chemotherapy.MethodsA retrospective study of 150 mCRC patients in whom serum anti-p53 antibody was measured before first-line chemotherapy was conducted. The patients were divided into two...
Source: International Journal of Clinical Oncology - December 13, 2019 Category: Cancer & Oncology Source Type: research

Associations between expression levels of nine core nucleotide excision repair genes in lymphocytes and risk of head and neck squamous cell carcinomas in a Chinese population
ConclusionReduced mRNA expression levels ofXPB were associated with an increased risk of HNSCCs in a Chinese population. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 12, 2019 Category: Cancer & Oncology Source Type: research

Lack of association between interleukin-22 gene polymorphisms and cancer risk: a case –control study and a meta-analysis
ConclusionConsequently, the rs1179251, rs2227485, rs2227511, and rs2227473 polymorphisms may not be associated with cancer risk. However, further investigations using larger samples in different ethnic populations are required. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 12, 2019 Category: Cancer & Oncology Source Type: research

Long-term outcomes of multimodal therapy combining definitive chemoradiotherapy and salvage surgery for T4 esophageal squamous cell carcinoma
AbstractBackgroundSurvival outcomes of patients with cT4 esophageal squamous cell carcinoma (ESCC) remain extremely poor. We aimed to investigate long-term outcomes and identify prognostic factors in patients treated by definitive chemoradiotherapy (dCRT) alone or with dCRT plus salvage surgery (SALV) for cT4 ESCC.Patients and methodsIn total, 73 patients completing dCRT were analyzed. Patients achieving clinical complete response (CR) received follow-up evaluations thereafter. For patients diagnosed with clinical partial response (PR), potentially curative SALV was generally performed. Possible prognostic factors included...
Source: International Journal of Clinical Oncology - December 11, 2019 Category: Cancer & Oncology Source Type: research

Efficacy of modified FOLFOX6 chemotherapy for patients with unresectable pseudomyxoma peritonei
ConclusionsmFOLFOX6 might be an effective and tolerable treatment option for patients with unresectable PMP. To our knowledge, this is the first case series of mFOLFOX6 in patients with unresectable PMP and the first case series of systemic chemotherapy for Asian patients with unresectable PMP. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 10, 2019 Category: Cancer & Oncology Source Type: research

A randomized, double-blind, comparison of radium-223 and placebo, in combination with abiraterone acetate and prednisolone, in castration-resistant metastatic prostate cancer: subgroup analysis of Japanese patients in the ERA 223 study
ConclusionsIn the Japanese ERA 223 subgroup, concurrent treatment with AAP and radium-223 did not significantly improve SSE-FS and increased the incidence of fracture, similar to outcomes achieved in the overall population, while an increased incidence of death was not evident. The combination of radium-223 with AAP is not recommended in Japanese patients with asymptomatic or mildly symptomatic mCRPC and bone metastases.Clinical trial registrationClinical trial registration no: NCT02043678. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 10, 2019 Category: Cancer & Oncology Source Type: research

Changing pattern of tumor markers in recurrent colorectal cancer patients before surgery to recurrence: serum p53 antibodies, CA19-9 and CEA
ConclusionsPostoperative serum p53 antibody status should only be followed in patients with preoperative-positive status. Carcinoembryonic antigen and carbohydrate antigen19-9 should be followed even in preoperative-negative patients. Unlike carcinoembryonic antigen- and carbohydrate antigen19-9-positive status, serum p53 antibody-positive status as recurrence was not a poor prognostic indicator. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 9, 2019 Category: Cancer & Oncology Source Type: research

Low incidence of late recurrence in patients with intermediate-risk prostate cancer treated by intensity-modulated radiation therapy plus short-term androgen deprivation therapy
ConclusionIMRT at a dose up to 78  Gy combined with short-term neoadjuvant ADT resulted in excellent long-term disease-free outcomes with acceptable morbidities among patients with IR PCa. In addition, the incidence of late recurrence was very low. Further investigation is warranted to confirm our findings. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 9, 2019 Category: Cancer & Oncology Source Type: research

Prognostic significance of hyponatremia induced by systemic chemotherapy in a hospital-based propensity score-matched analysis
ConclusionThis study suggests that severe HIC in the first treatment cycle affects survival time. Chemotherapy patients receiving extensive hydration should be required to undergo frequent monitoring of serum sodium levels, especially patients receiving platinum-containing regimens. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 6, 2019 Category: Cancer & Oncology Source Type: research

Therapeutic drug monitoring of regorafenib and its metabolite M5 can predict treatment efficacy and the occurrence of skin toxicities
ConclusionsThe use of regorafenib may not be suitable in patients with a lowCtrough value. To prevent skin toxicities, theCtrough value of M5 should be monitored. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 5, 2019 Category: Cancer & Oncology Source Type: research