The presence of lymph node metastases and time to castration resistance predict the therapeutic effect of enzalutamide for castration-resistant prostate cancer
ConclusionsTime to CRPC and lymph node metastasis were predictors of the PSA response rate and PSA –PFS. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 29, 2022 Category: Cancer & Oncology Source Type: research

Prognostic value of PD-L1 expression in recurrent renal cell carcinoma after nephrectomy: a secondary analysis of the ARCHERY study
ConclusionsThis ARCHERY secondary analysis suggests that PD-L1 expression may play a role in predicting OS and risk of recurrence in high-risk patients with localized RCC.Clinical Trial Registration: UMIN000034131. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 19, 2022 Category: Cancer & Oncology Source Type: research

Veliparib with frontline chemotherapy and as maintenance in Japanese women with ovarian cancer: a subanalysis of efficacy, safety, and antiemetic use in the phase 3 VELIA trial
ConclusionsMedian progression-free survival was numerically longer in Japanese patients in the veliparib-throughout versus control arm, consistent with results in the overall study population. Pharmacokinetics were comparable between Japanese and non-Japanese patients. Data for the subgroup of Japanese patients were not powered to show statistical significance but to guide further investigation. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 19, 2022 Category: Cancer & Oncology Source Type: research

Development and validation of neoadjuvant rectal score-based signature nomograms to predict overall survival and disease-free survival in locally advanced rectal cancer: a retrospective, double center, cohort study
ConclusionsThe NAR score can effectively classify patients with LARC into groups with varying outcomes of OS, DFS, LR, and DM. Moreover, the novel nomograms comprising the NAR score were developed and validated to help predict OS and DFS. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 19, 2022 Category: Cancer & Oncology Source Type: research

Comparison of therapeutic features and oncologic outcome in patients with pN1 prostate cancer among robot-assisted, laparoscopic, or open radical prostatectomy
ConclusionRARP, LRP, and ORP provided equal surgical outcomes for pN1 prostate cancer, and the prognosis was relatively good for all procedures. Increased numbers of RLNs may not necessarily affect the oncological outcome. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 17, 2022 Category: Cancer & Oncology Source Type: research