International Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Association of D-dimer level with thrombotic events, bleeding, and mortality in Japanese patients with solid tumors: a Cancer-VTE Registry subanalysis
ConclusionsIncreases in D-dimer levels were associated with a higher risk of thrombotic events, such as VTE and cerebral infarction/TIA/SEE, during cancer treatment. Furthermore, higher D-dimer levels at cancer diagnosis were associated with a higher mortality rate, regardless of cancer stage. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 2, 2024 Category: Cancer & Oncology Source Type: research

Radiotherapy with or without chemotherapy for locally advanced head and neck cancer in elderly patients: analysis of the Head and Neck Cancer Registry of Japan
ConclusionAlthough aggressive CRT is administered to elderly patients in Japan, its effectiveness is uncertain. Further prospective randomized trials are needed to verify whether CRT is superior to RT alone for elderly patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Effects of postoperative oral elemental nutritional supplement on skeletal muscle loss after gastrectomy for gastric cancer
ConclusionED administration for 6 –8 weeks following gastrectomy had no inhibitory effect on skeletal muscle loss at 1 year postoperatively.Clinical Trial RegistrationUMIN000023455. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Impact of sarcopenia on recurrent biliary obstruction after EUS-guided biliary drainage in patients with malignant biliary obstruction
ConclusionSarcopenia is an independent indicator of RBO in patients with MBO who receive EUS-BD with SEMS. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells
ConclusionFOXM1 cooperates withRacGAP1 to induce CC cell proliferation, migration and invasion, inhibit apoptosis, and regulatePI3K/AKT signaling to promote CC progression. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

EGFR mutation impacts recurrence in high-risk early-stage lung adenocarcinoma in the IASLC grading system
ConclusionsThis study provides evidence that patients withEGFRm-positive stage I lung adenocarcinoma in the high-risk group have an increased risk of recurrence, including CNS metastasis. These findings highlight the need for development of adjuvant treatment in this population. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

The prognostic impact of treatment centralization in patients with testicular germ cell tumors: analysis of hospital-based cancer registry data in Japan
ConclusionOur results indicate that stage II and III TGCT patients experience lower survival rates at low-volume institutions and would benefit from treatment centralization. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Skeletal muscle status and survival among patients with advanced biliary tract cancer
ConclusionsSkeletal muscle quantity and quality and their serial changes were associated with survival outcomes in patients with advanced biliary tract cancer. Our data highlight the importance of designing nutritional and physical interventions for improvements in skeletal muscle status. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Glomerular filtration rate measurement during platinum treatment for urothelial carcinoma: optimal methods for clinical practice
ConclusionCKD-EPI equation emerged as the most suitable for estimating kidney function in this patient group although not meeting benchmark criteria. We recommend its use for initial assessment and ongoing monitoring, and suggest mGFR for patients with a CKD-EPI estimated GFR below 85  ml/min. This approach could reduce costs and decrease laboratory time for 30% of our UC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Low skeletal muscle radiodensity is a risk factor for adjuvant chemotherapy discontinuation in colorectal cancer
ConclusionThe low SMR group showed higher treatment incompletion rates and received lower drug doses during adjuvant chemotherapy. Low SMR independently contributed to treatment non-completion in colorectal cancer patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Impact of prostate position-based image-guidance in intensity-modulated radiation therapy for localized prostate cancer
ConclusionsThe use of P-IGRT with higher doses and smaller margins was correlated with significantly better biochemical control, and a lower incidence of rectal bleeding in IMRT for intermediate-risk prostate cancer. The enhanced accuracy using P-IGRT has the potential to independently improve disease control and reduce late rectal bleeding. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

The efficacy of palbociclib and ribociclib in the first-line treatment of metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer in male patients: a Turkish oncology group (TOG) study
This study is a multicenter, retrospective study. We included male patients with HR  + and HER2-metastatic breast cancer who received palbociclib or ribociclib as first-line treatment. Our primary endpoints were progression-free survival (PFS), overall response rates (ORR), and drug-related adverse effects.ResultsA total of 46 male patients from 27 institutions were enrolled. The median age at initiation of CDK 4/6 inhibitors was 63.64  ± 13.69 years, with a median follow-up of 21.33 (95% CI 14.92–27.74) months. The ORR were 84% for palbociclib and 76.2% for ribociclib. The mPFS for the entire cohort was 28.06Â...
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Treatments and prognostic factors for bone and soft tissue sarcoma in non-urban areas in Japan
ConclusionsPhysical and social factors may affect the prognosis of patients with bone and soft tissue sarcomas, especially those living in non-urban areas. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Announcement: Third Joint Committee Report on Diabetes and Cancer
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Peripheral neuropathy and nerve electrophysiological changes with enfortumab vedotin in patients with advanced urothelial carcinoma: a prospective multicenter cohort study
ConclusionOur results indicated the importance of focusing on enfortumab vedotin-induced neuropathy of the sural nerve to maximize efficacy and improve safety. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 28, 2024 Category: Cancer & Oncology Source Type: research