International Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effect of a web-based fertility preservation training program for medical professionals in Japan
ConclusionOur web-based fertility preservation training program improved knowledge and self-confidence regarding fertility preservation issues among healthcare providers caring for adolescents and young adult cancer patients and survivors. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 15, 2023 Category: Cancer & Oncology Source Type: research

Long-term survival outcome of locally advanced gastric cancer patients who achieved a pathological complete response to neoadjuvant chemotherapy
ConclusionsPatients with LAGC who achieved a pCR displayed favorable long-term survival outcome, especially those with adequate cycles ( ≥ 3) of NAC. Besides, poor differentiation at diagnosis might also predict the better OS when pCR achieved. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 15, 2023 Category: Cancer & Oncology Source Type: research

Prescription patterns of analgesics in cancer patients with bone metastases in Japan: a retrospective database study
ConclusionIn Japanese cancer patients with bone metastases, acetaminophen, NSAIDs, and weak or strong opioids were commonly used; their use increased after SREs developed. Opioid use increased closer to death. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 14, 2023 Category: Cancer & Oncology Source Type: research

Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with high tumor mutational burden tumors
AbstractThe development of novel antitumor agents and accompanying biomarkers has improved survival across several tumor types. Previously, we developed recommendations for tumor-agnostic treatments in patients with solid tumors with DNA mismatch repair deficient or neurotrophic receptor tyrosine kinase fusions. Recently, immune checkpoint inhibitors have shown efficacy in patient with tumor mutation burden-high (TMB-H) solid tumors and have been established as a third tumor-agnostic agent, making it necessary to develop the guideline prioritized for these patients. Clinical questions regarding medical care were formulated...
Source: International Journal of Clinical Oncology - June 10, 2023 Category: Cancer & Oncology Source Type: research

Carcinogenesis and management of human papillomavirus-associated cervical cancer
AbstractApproximately 95% of cervical cancer are caused by human papillomavirus (HPV) infection. Although it is estimated that HPV-associated cervical cancer will decrease with the widespread use of HPV vaccine, it may take time for HPV-associated cervical cancer to be eliminated. For the appropriate management of HPV-associated cervical cancer, it is important to understand the detailed mechanisms of cervical cancer development. First, the cellular origin of most cervical cancers is thought to be cells in the squamocolumnar junction (SCJ) of the uterine cervix. Therefore, it is important to understand the characteristics ...
Source: International Journal of Clinical Oncology - June 9, 2023 Category: Cancer & Oncology Source Type: research

The superselective intra-arterial infusion of cisplatin and concomitant radiotherapy (RADPLAT) is effective for metastatic lymph nodes in head and neck squamous cell carcinoma
ConclusionThis study showed that the regional control rate in patients treated with RADPLAT was noninferior to that for IV-CRT. Locally advanced head and neck cancers is a good indication for RADPLAT, even if the patients have neck lymph node metastases. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 8, 2023 Category: Cancer & Oncology Source Type: research

Definitive S-1/mitomycin-C chemoradiotherapy for stage II/III anal canal squamous cell carcinoma: a phase I/II dose-finding and single-arm confirmatory study (JCOG0903)
ConclusionsAlthough the primary endpoint was not met, S-1/mitomycin-C chemoradiotherapy had an acceptable toxicity profile and favorable 3-year survival and could be a treatment option for locally advanced SCCA.Clinical trial informationjRCTs031180002. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 7, 2023 Category: Cancer & Oncology Source Type: research

Impact of prior bevacizumab therapy on the incidence of ramucirumab-induced proteinuria in colorectal cancer: a multi-institutional cohort study
ConclusionSequential FOLFIRI plus RAM after BEV failure, especially within 55  days, may exacerbate proteinuria. Its escalated anti-VEGF toxicity may negatively impact the overall survival. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 1, 2023 Category: Cancer & Oncology Source Type: research

Clinical utility of artificial intelligence assistance in histopathologic review of lymph node metastasis for gastric adenocarcinoma
ConclusionsA wide variety of histological types in gastric adenocarcinoma could account for these relatively low performances; however, this level of algorithm performance could suffice to help pathologists improve diagnostic accuracy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 31, 2023 Category: Cancer & Oncology Source Type: research

Preoperative HALP score is a prognostic factor for intrahepatic cholangiocarcinoma patients undergoing curative hepatic resection: association with sarcopenia and immune microenvironment
ConclusionsWe demonstrated that low HALP score is an independent prognostic factor for ICC patients undergoing curative hepatic resection and is associated with sarcopenia and the immune microenvironment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 29, 2023 Category: Cancer & Oncology Source Type: research

Predictive value of circulating tumor cell counts during the treatment of cancer: interactions with the blood microenvironment
ConclusionThe CTC counts in patients with tumors undergoing treatment were significantly correlated with hematological microenvironment parameters. The detection of CTCs may therefore be used as an indicator of tumor prognosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 27, 2023 Category: Cancer & Oncology Source Type: research

The prognostic significance of the clinical T stage and Grade Group in patients with locally advanced prostate cancer treated via high-dose-rate brachytherapy and external beam radiation
ConclusionThe clinical T stage and GG status were significantly prognostic of oncological outcomes in patients with locally advanced PCa. In patients of GG  ≤ 4 PCa, HDR-BT was effective even in patients with cT3b or cT4 PCa. However, in patients with GG5 PCa, careful monitoring is essential, particularly of patients with cT3b or cT4 PCa. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 25, 2023 Category: Cancer & Oncology Source Type: research

Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors
ConclusionThe committee proposed 14 recommendations for performing NTRK testing properly to select patients who are likely to benefit from TRK inhibitors. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 22, 2023 Category: Cancer & Oncology Source Type: research

Longitudinal health-related quality of life analysis in childhood cancer survivors after proton beam therapy
ConclusionsThe HRQoL scores of CCSs with low initial scores can be greatly changed over time. Appropriate psychosocial support for this population is warranted. PBT may avoid reduction in HRQoL in terms of the psychosocial functioning of CCSs with CNS tumors. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 20, 2023 Category: Cancer & Oncology Source Type: research

Scoring model with serum albumin and CA19-9 for metastatic pancreatic cancer in second-line treatment: results from the NAPOLEON study
ConclusionThe survival advantage of second-line CTx, was observed in patients with scores of 0 and 1 but not in those with score 2. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 20, 2023 Category: Cancer & Oncology Source Type: research