International Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Modified neoadjuvant rectal score as a novel prognostic model for rectal cancer patients who underwent chemoradiotherapy
ConclusionWe established a novel prognostic model, for rectal cancer patients that have undergone neoadjuvant chemoradiotherapy, using a combination of apoptosis-detecting immunohistochemistry and neoadjuvant rectal scores. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 9, 2024 Category: Cancer & Oncology Source Type: research

Exploratory analysis of serum HER2 extracellular domain for HER2 positive gastric cancer treated with SOX plus trastuzumab
ConclusionsBaseline sHER2 ECD levels and its early decline may be useful biomarkers for SOX plus trastuzumab efficacy in HER2 positive gastric cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 8, 2024 Category: Cancer & Oncology Source Type: research

Psoas mass index at the level of the third lumbar vertebra on computed tomography is a prognostic predictor for metastatic castration-sensitive prostate cancer
ConclusionsPretreatment psoas muscle index is an independent predictor of poor castration-resistant prostate cancer-free survival and overall survival in patients with N1 and/or M1 metastatic castration-sensitive prostate cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 8, 2024 Category: Cancer & Oncology Source Type: research

Development and validation of a nomogram to predict overall survival in patients with redefined anaplastic thyroid carcinoma based on the SEER database
ConclusionWe constructed a nomogram to provide a convenient and reliable tool for predicting OS in rATC patients. Prognostic factors influencing CSS were not identical in patients with ATC and PSCCTh. These findings indicate that different clinical treatment and management plans are required for patients with these two types of thyroid cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 7, 2024 Category: Cancer & Oncology Source Type: research

Impact of disease volume on survival efficacy of triplet therapy for metastatic hormone-sensitive prostate cancer: a systematic review, meta-analysis, and network meta-analysis
ConclusionsTriplet therapy improves OS in mHSPC patients compared to docetaxel-based doublet therapy, irrespective of disease volume. However, based on treatment ranking, triplet therapy should preferably be considered for patients with high-volume mHSPC while those with low-volume are likely to be adequately treated with ARSI  + ADT. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 6, 2024 Category: Cancer & Oncology Source Type: research

MMP1, IL-1 β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors
ConclusionMMP1 may be associated with severe irAE, and MMP1, IL-1 β, sTNFR-1, and IL-6 could serve as prognostic factors in unresectable or metastatic RCC treated with ICIs. MMP1 and IL-6 were independent predictors of PFS and OS, respectively. Thus, inhibiting these soluble factors may be promising for enhancing antitumor responses in patients with RCC treated w ith ICIs. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 6, 2024 Category: Cancer & Oncology Source Type: research

Effectiveness of G-CSF in chemotherapy for digestive system tumors: a systematic review of the Clinical Practice Guidelines for the Use of G-CSF 2022 delineated by the Japan Society of Clinical Oncology
ConclusionThe use of G-CSF for primary prophylaxis in chemotherapy for colorectal cancer is inappropriate. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 5, 2024 Category: Cancer & Oncology Source Type: research

Albumin-myosteatosis gauge as a prognostic factor in patients with advanced pancreatic cancer undergoing first-line chemotherapy
ConclusionThe study findings suggest the prognostic value of AMG in patients with advanced PDAC undergoing first-line chemotherapy. Further studies are warranted to validate these findings and assess potential predictive role of AMG in guiding treatment selection. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research

Magnesium supplementation therapy to prevent cisplatin-induced acute nephrotoxicity in pediatric cancer: a randomized phase-2 trial
ConclusionsThe study design, which treated a single chemotherapy course as a study object, failed to detect a statistically significant benefit of Mg supplementation for preventing CIN in pediatric cancer patients.Trial registrationJRCT (https://jrct.niph.go.jp/) Identifier UMIN000029215 jRCTs031180251. UMIN-CTR (http://www.umin.ac.jp/icdr/index.html) Identifier UMIN000029215. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research

Survival impact of sequential chemotherapy following pembrolizumab for recurrent or metastatic head and neck squamous cell carcinoma
ConclusionThis study indicates that cetuximab-containing second-line chemotherapy can improve outcomes in R/M HNSCC, even after first-line therapy failure or intolerance. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 30, 2024 Category: Cancer & Oncology Source Type: research

Lymphatic drainage patterns of malignant skin tumors in the head and neck region: a single-center retrospective study
ConclusionThese findings have considerable significance in terms of understanding lymphatic drainage patterns for malignant skin tumors in the head and neck and may be useful for clinical decision-making and when planning treatment. Further research and clinical applications are expected to contribute to an improved prognosis in patients with cutaneous head and neck malignancies. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 30, 2024 Category: Cancer & Oncology Source Type: research

Bridging horizons beyond CIRCULATE-Japan: a new paradigm in molecular residual disease detection via whole genome sequencing-based circulating tumor DNA assay
AbstractCirculating tumor DNA (ctDNA) is the fraction of cell-free DNA in patient blood that originates from a tumor. Advances in DNA sequencing technologies and our understanding of the molecular biology of tumors have increased interest in exploiting ctDNA to facilitate detection of molecular residual disease (MRD). Analysis of ctDNA as a promising MRD biomarker of solid malignancies has a central role in precision medicine initiatives exemplified by our CIRCULATE-Japan project involving patients with resectable colorectal cancer. Notably, the project underscores the prognostic significance of the ctDNA status at 4  wee...
Source: International Journal of Clinical Oncology - March 29, 2024 Category: Cancer & Oncology Source Type: research

PMDA regulatory update on approval of new drugs and revisions of precautions; approval of talazoparib tosilate for prostate and breast cancer, and luspatercept for myelodysplastic syndrome in Japan
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 29, 2024 Category: Cancer & Oncology Source Type: research

Effectiveness and safety of primary prophylaxis of G-CSF during chemotherapy for prostate cancer, Japanese clinical guideline for appropriate use of G-CSF: clinical practice guidelines for the use of G-CSF 2022
ConclusionG-CSF may be beneficial as primary prophylaxis during CBZ administration for metastatic castration resistant prostate cancer, and we made a “weak recommendation to perform” with an annotation of the relevant regimen. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research

MRI-based volumetric tumor parameters before and during chemoradiation predict tumor recurrence and patient survival in locally advanced cervical cancer: a subgroup analysis of a phase II prospective trial
ConclusionsInitial tumor size and restaging tumor volume that are easily accessible during radiotherapy provide valuable prognostic information for cervical cancer. MRI-based measurable volumetric scoring system can be readily applied in real-world practice of cervical cancer.Clinical trial information: This study is a subgroup analysis of prospective trial registered at ClinicalTrials.gov Identifier: NCT02993653. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 26, 2024 Category: Cancer & Oncology Source Type: research