International Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Impact of MIR31HG polymorphisms on risk of breast cancer in Chinese women
ConclusionsThe results indicated that theMIR31HG polymorphisms were associated with a reduced risk of BC in Chinese women. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 8, 2023 Category: Cancer & Oncology Source Type: research

Impact of skeletal muscle mass on the prognosis of patients undergoing neoadjuvant chemotherapy for resectable or borderline resectable pancreatic cancer
ConclusionLow TPA is a risk factor of poor survival in patients undergoing neoadjuvant chemotherapy for borderline resectable pancreatic cancer. TPA evaluation could potentially suggest the treatment strategy in this disease. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 6, 2023 Category: Cancer & Oncology Source Type: research

Nephrotoxicity associated with anticancer agents: perspective on onconephrology from nephrologists
AbstractNephrotoxicity is one of the most important complications in cancer patients. In particular, acute kidney injury (AKI) is known to be associated with discontinuing effective oncological treatments, longer hospitalizations, increased costs, and a higher risk of death. In addition to acute kidney injury, clinical signs associated with nephrotoxicity during treatment with anticancer agents include chronic kidney disease, proteinuria, hypertension, electrolyte abnormalities, and other characteristic manifestations. Many of these signs are caused both by cancer treatment as well as by cancer itself. Therefore, it is imp...
Source: International Journal of Clinical Oncology - March 5, 2023 Category: Cancer & Oncology Source Type: research

piggyBac-transposon-mediated CAR-T cells for the treatment of hematological and solid malignancies
AbstractSince the introduction of the use of chimeric antigen receptor T-cell therapy (CAR-T therapy) dramatically changed the therapeutic strategy for B cell tumors, various CAR-T cell products have been developed and applied to myeloid and solid tumors. Although viral vectors have been widely used to produce genetically engineered T cells, advances in genetic engineering have led to the development of methods for producing non-viral, gene-modified CAR-T cells. Recent progress has revealed that non-viral CAR-T cells have a significant impact not only on the simplicity of the production process and the accessibility of non...
Source: International Journal of Clinical Oncology - March 2, 2023 Category: Cancer & Oncology Source Type: research

Risk factors of SARS-CoV-2 infection and complications from COVID-19 in lung  cancer patients
Conclusions The mortality of lung cancer patients from COVID-19 disease in the present cohort was less than previously reported in the literature. The identification of risk factors associated with severe or fatal outcomes informs management of patients with lung cancer who develop COVID-19 disease. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2023 Category: Cancer & Oncology Source Type: research

Regulation of MEK inhibitor selumetinib sensitivity by AKT phosphorylation in the novel BRAF L525R mutant
ConclusionsWe established a model system harboringBRAF L525R using HEK293 cells.BRAF L525R constitutively activated ERK. AKT phosphorylation caused sensitivity and resistance to selumetinib. Our results suggest that a comprehensive network analysis may provide insights to identify effective therapies. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2023 Category: Cancer & Oncology Source Type: research

Recent advances in surgical techniques for breast reconstruction
AbstractAlthough the number of patients with breast cancer continues to rise worldwide, survival rates for these patients have significantly improved. As a result, breast cancer survivors are living longer, and quality of life after treatment is of increasing importance. Breast reconstruction is an important component that affects quality of life after breast cancer surgery. With the development of silicone gel implants in the 1960s, autologous tissue transfer in the 1970s, and tissue expanders in the 1980s, breast reconstruction has advanced over the decades. Furthermore, the advent of perforator flaps and introduction of...
Source: International Journal of Clinical Oncology - February 27, 2023 Category: Cancer & Oncology Source Type: research

Association of microbiota with cancer treatment
AbstractThe impact of immune checkpoint molecule inhibitors on cancer treatment is significant. At the same time, further improvement in their efficacy has become essential. For this reason, there has been increasing interest in investigating the state of the cancer microenvironment in which efficacy can be demonstrated. The gut microbiota plays an important role in the cancer microenvironment. Recent developments in the study of gut microbiota have been explosive, benefiting from technological innovations in next-generation sequencing. Gut microbiota are specific enough to identify an individual and change gently with age...
Source: International Journal of Clinical Oncology - February 27, 2023 Category: Cancer & Oncology Source Type: research

Rubicon can predict prognosis in patients with pancreatic ductal adenocarcinoma after neoadjuvant chemoradiotherapy
ConclusionsHigh Rubicon expression is a significant, unfavorable prognostic factor in pancreatic ductal adenocarcinoma after neoadjuvant chemoradiotherapy. Downregulation of Rubicon expression improves invasion ability and cell viability in gemcitabine-resistant pancreatic ductal adenocarcinoma. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 24, 2023 Category: Cancer & Oncology Source Type: research

Health care professionals ’ experiences of dealing with cancer cachexia
ConclusionThis study underlines the deficiencies in knowledge and training of CC which has implications for patients ’ function, well-being and survival. HCP training and a structured approach to CC management is advocated for optimal and continued patient care. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 23, 2023 Category: Cancer & Oncology Source Type: research

Comparison of outcomes in high-risk prostate cancer patients treated with low-/high-dose-rate brachytherapy plus external beam radiotherapy
ConclusionOur analysis of long-term outcomes in patients with high-risk localized prostate cancer shows no significant differences in oncological outcomes between LDR-BT and HDR-BT, but some differences in toxicity, and offers patients and clinicians useful information in deciding management strategies for high-risk localized prostate cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 22, 2023 Category: Cancer & Oncology Source Type: research

Correction to: Repeated SARS-CoV-2 vaccination in cancer patients treated with immune checkpoint inhibitors: induction of high-avidity anti-RBD neutralizing antibodies
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 20, 2023 Category: Cancer & Oncology Source Type: research

Cancer may accelerate locomotive syndrome and deteriorate quality of life: a single-centre cross-sectional study of locomotive syndrome in cancer patients
ConclusionsThe ratio of LS in cancer patients was extremely high, and the LS stage correlated with physical QOL. Even those with PS 0 can have severe LS; thus, LS can be a sensitive detector of physical disability of cancer patients than PS. The improvement of LS can be a key to the preservation of their ADL and QOL. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 19, 2023 Category: Cancer & Oncology Source Type: research

Macroscopic and multiple metastases in sentinel lymph node biopsy are respectively associated with poor prognosis in early oral cancer
ConclusionsIn patients who underwent SLNB, a poorer prognosis was associated with macrometastasis or having  ≥ 2 metastatic SLNs. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 16, 2023 Category: Cancer & Oncology Source Type: research

Correction to: Definitive radiotherapy consisting of whole pelvic radiotherapy with no central shielding and CT-based intracavitary brachytherapy for cervical cancer: feasibility, toxicity, and oncologic outcomes in Japanese patients
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 16, 2023 Category: Cancer & Oncology Source Type: research