International Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Concordance of ALK fusion gene-rearrangement between immunohistochemistry and next-generation sequencing
ConclusionOur results suggest that IHC and NGS might be complementary tests. In patients suspected of harboring ALK fusion gene-rearrangement, it should be analyzed using another diagnostic method. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 6, 2024 Category: Cancer & Oncology Source Type: research

Glomerular filtration rate measurement during platinum treatment for urothelial carcinoma: optimal methods for clinical practice
ConclusionCKD-EPI equation emerged as the most suitable for estimating kidney function in this patient group although not meeting benchmark criteria. We recommend its use for initial assessment and ongoing monitoring, and suggest mGFR for patients with a CKD-EPI estimated GFR below 85  ml/min. This approach could reduce costs and decrease laboratory time for 30% of our UC patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 5, 2024 Category: Cancer & Oncology Source Type: research

Clinical outcomes of sentinel node navigation surgery in patients with preoperatively estimated stage IA endometrial cancer and evaluation of validity for continuing sentinel node navigation surgery based on dispersion of recurrence probability
ConclusionThis study suggests the validity of SNNS as an alternative to PLND. Even in the absence of evidence from randomized controlled trials, we can confirm the validity of continuing SNNS using our procedure. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 5, 2024 Category: Cancer & Oncology Source Type: research

FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells
ConclusionFOXM1 cooperates withRacGAP1 to induce CC cell proliferation, migration and invasion, inhibit apoptosis, and regulatePI3K/AKT signaling to promote CC progression. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 3, 2024 Category: Cancer & Oncology Source Type: research

Clinical significance of antinuclear antibody as prognostic marker for first-line pembrolizumab in advanced non-small cell lung cancer
ConclusionsAssessment of preexisting ANA titers was useful to prognose PD-1 blockade as a first-line setting, particularly for the PD-L1  ≥ 50% subgroup, but not in the case of combined immunotherapy and chemotherapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 31, 2023 Category: Cancer & Oncology Source Type: research

Radiotherapy with or without chemotherapy for locally advanced head and neck cancer in elderly patients: analysis of the Head and Neck Cancer Registry of Japan
ConclusionAlthough aggressive CRT is administered to elderly patients in Japan, its effectiveness is uncertain. Further prospective randomized trials are needed to verify whether CRT is superior to RT alone for elderly patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 29, 2023 Category: Cancer & Oncology Source Type: research

Phase 2 study of ibrutinib plus venetoclax in Japanese patients with relapsed/refractory mantle cell lymphoma
ConclusionIbrutinib plus venetoclax exhibited high response rates and a well-tolerated safety profile in Japanese patients with R/R MCL. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 29, 2023 Category: Cancer & Oncology Source Type: research

Treatments and prognostic factors for bone and soft tissue sarcoma in non-urban areas in Japan
ConclusionsPhysical and social factors may affect the prognosis of patients with bone and soft tissue sarcomas, especially those living in non-urban areas. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 28, 2023 Category: Cancer & Oncology Source Type: research

Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan
ConclusionsPeriodic endoscopic surveillance of the papilla of Vater and small intestine should be planned for patients with FAP with duodenal polyps. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 24, 2023 Category: Cancer & Oncology Source Type: research

Platform trial for off-label oncology drugs using comprehensive genomic profiling under the universal public healthcare system: the BELIEVE trial
ConclusionThe BELIEVE trial provides hope for patients with actionable genetic abnormalities by facilitating access to targeted therapies through off-label drug administration. It establishes a regulatory framework and promotes collaboration between industry and academia by expanding organ-specific and cross-organ biomarker-based treatments. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 19, 2023 Category: Cancer & Oncology Source Type: research

Diagnosis of colorectal cancer based on folate receptor-positive circulating tumor cell analysis: a retrospective cohort study
ConclusionFR  + CTC counting has excellent diagnostic efficiency in screening of CRC. FR + CTC count can also predict the tumor stage of CRC patients before surgery, and guide the choice of treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 19, 2023 Category: Cancer & Oncology Source Type: research

Comparative assessment of disease recurrence after transurethral resection of non-muscle-invasive bladder cancer with and without a photodynamic diagnosis using 5-aminolevulinic acid: a propensity score-matching analysis
ConclusionThese results suggest that PDD-TURBT prolongs RFS in NMIBC patients, except for those with tumors  ≥ 30 mm. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 19, 2023 Category: Cancer & Oncology Source Type: research

Current status and future perspective of immunotherapy for renal cell carcinoma
This study reviews the current evidence on immunotherapy as a treatment for RCC patients, randomized controlled trials, and ongoing studies including RCC patients and recent findings, and discusses future perspectives. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 18, 2023 Category: Cancer & Oncology Source Type: research

Survival outcome of chemotherapy-na ïve castration-resistant prostate cancer treated with new-generation androgen receptor axis-targeted agents in real-world analysis
ConclusionThis study showed that PSA response, PSA-PFS, TTF, CSS, and OS were better with first-line enzalutamide administration. Direct inhibition of androgen receptor signaling by enzalutamide is associated with better clinical outcomes. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 16, 2023 Category: Cancer & Oncology Source Type: research

Survival outcomes of patients with stage III colorectal cancer aged  ≥ 80 years who underwent curative resection: the HiSCO-04 prospective cohort study
ConclusionsCompletion of adjuvant chemotherapy may improve the prognosis of patients with colorectal cancer aged  ≥ 80 years, although the number of patients who would benefit from it is limited. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 15, 2023 Category: Cancer & Oncology Source Type: research