International Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Can contralateral lymph-node metastases be ruled out in prostate cancer patients with only unilaterally positive prostate biopsy?
ConclusionOur study highlights the diagnostic value of bilateral pelvic lymphadenectomy and the need for careful planning in surgery for prostate cancer patients with unilaterally positive prostate biopsy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 7, 2023 Category: Cancer & Oncology Source Type: research

Immune checkpoint inhibitor therapy in neoadjuvant and adjuvant treatment for cancer: A paradigm shift in the treatment of resectable gastrointestinal cancer 3)A paradigm shift in the treatment of colorectal cancer
AbstractImmune checkpoint inhibitors, such as anti-programmed cell death-1, programmed cell death ligand-1, and cytotoxic T-lymphocyte antigen-4 monoclonal antibodies, have been notably effective in various types of cancers. Mismatch repair deficiency and microsatellite instability-high tumors have been established as striking biomarkers for response to immune checkpoint inhibitors. These biomarkers show a higher mutational burden, have cancer-associated neoantigens, and dense immune cell infiltration, which generates a robust immune response. For metastatic colorectal cancer, pembrolizumab and nivolumab, with or without i...
Source: International Journal of Clinical Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research

Association between immune-related adverse events and survival in patients with renal cell carcinoma treated with nivolumab plus ipilimumab: immortal time bias-corrected analysis
ConclusionsDeveloping irAEs, particularly multiple irAEs, is associated with favourable survivals in advanced RCC patients treated with nivolumab plus ipilimumab. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 2, 2023 Category: Cancer & Oncology Source Type: research

Advantages and limitations of estrogen replacement therapy on hypogonadal survivors of childhood cancer
ConclusionIndividualized management strategies beyond ERT are essential to reduce long-term complications in CCS with hypogonadism, considering the type and timing of cancer treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 30, 2023 Category: Cancer & Oncology Source Type: research

Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model
ConclusionThe loss of SMARCA2 and SMARCA4 correlated with poor differentiation, leading to a worse prognosis. SMARCA2, as an independent prognostic factor, combined with other clinicopathological variables, established a novel nomogram prognostic model, which outperformed the AJCC TNM model. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 27, 2023 Category: Cancer & Oncology Source Type: research

Meta-analysis of three randomized trials of capecitabine plus cisplatin (XP) versus S-1 plus cisplatin (SP) as first-line treatment for advanced gastric cancer
ConclusionsSP and XP were both effective and well tolerated. SP might be suitable for the pathological differentiated subtype of AGC.Clinical Trial Registration: The HERBIS-2, HERBIS-4A, and XParTS II trials were registered with UMIN-CTR as UMIN000006105, UMIN000006755, and UMIN000006045, respectively. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 27, 2023 Category: Cancer & Oncology Source Type: research

Superior detection of significant prostate cancer by transperineal prostate biopsy using MRI-transrectal ultrasound fusion image guidance over cognitive registration
ConclusionsTransperineal prostate biopsy using the BioJet system is superior to cognitive registration in detecting significant cancer for targeted and systematic biopsies. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 22, 2023 Category: Cancer & Oncology Source Type: research

Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with DNA mismatch repair deficient (dMMR) tumors, third edition
ConclusionIn this guideline, the committee proposed eight recommendations for performing MMR testing properly to select patients who are likely to benefit from immunotherapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 20, 2023 Category: Cancer & Oncology Source Type: research

Impact of Smad4 and p53 mutations on the prognosis of patients with pancreatic ductal adenocarcinoma undergoing chemotherapy
ConclusionsTissue samples from EUS-FNB were suitable for mutational analysis. Pancreatic cancers with p53 and without Smad4 mutations responded better to chemotherapy and had a better prognosis than those others. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 18, 2023 Category: Cancer & Oncology Source Type: research

Retrospective study of the efficacy and safety of docetaxel/carboplatin combination therapy as postoperative adjuvant chemotherapy for nonsquamous cell carcinoma of the cervix
ConclusionDC therapy at our institution showed good 2  year RFS, and postoperative adjuvant therapy with DC therapy is suggested as a useful strategy for patients with nonsquamous cervical carcinoma. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 16, 2023 Category: Cancer & Oncology Source Type: research

Effects and risk factors of TAS-102 in real-world patients with metastatic colorectal cancer, EROTAS-R study
ConclusionA better OS and PFS comparing TAS-102  + Bev to TAS-102 for CRC was achieved in a large number of real-world patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 14, 2023 Category: Cancer & Oncology Source Type: research

Clinical availability and characteristics of multigene panel testing for recurrent/advanced gynecologic cancer
ConclusionThrough multigene panel testing, although many patients had druggable gene alterations, 10.8% of them received the recommended treatment. TMB-H was mainly observed in cervical/endometrial cancer, suggesting its potential as a therapeutic biomarker of immune checkpoint inhibitors. Furthermore, patients ’ prognosis and performance status should be considered before performing the test. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 13, 2023 Category: Cancer & Oncology Source Type: research

Chapter 2:indications and dosing of anticancer drug therapy in patients with impaired kidney function, from clinical practice guidelines for the management of kidney injury during anticancer drug therapy 2022
AbstractThis comprehensive review discusses the dosing strategies of cancer treatment drugs for patients with impaired kidney function, specifically those with chronic kidney disease (CKD), undergoing hemodialysis, and kidney transplant recipients. CKD patients often necessitate dose adjustments of chemotherapeutic agents, e.g., platinum preparations, pyrimidine fluoride antimetabolites, antifolate agents, molecularly targeted agents, and bone-modifying agents, to prevent drug accumulation and toxicity due to diminished renal clearance of the administered drugs and their metabolites. In hemodialysis patients, factors such ...
Source: International Journal of Clinical Oncology - August 12, 2023 Category: Cancer & Oncology Source Type: research

The diagnostic potential of two exosome-derived circRNAs for papillary thyroid cancer
ConclusionCollectively, we identified two PTC-related circRNAs incorporated in exosomes and uncovered their potential as tumor markers to diagnose PTC, in particular, more aggressive PTC. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 11, 2023 Category: Cancer & Oncology Source Type: research

Oncology drug lag in Japan: has it improved over the last decade?
ConclusionsDrug lag has not decreased over the last decade. The percentage of pivotal trials for US approval that included Japan has increased but should be further increased in the future. Japan may require a scheme to encourage smaller non-Japanese companies to include Japan in their global clinical development plan. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - August 10, 2023 Category: Cancer & Oncology Source Type: research