Regulation of MEK inhibitor selumetinib sensitivity by AKT phosphorylation in the novel BRAF L525R mutant

ConclusionsWe established a model system harboringBRAF L525R using HEK293 cells.BRAF L525R constitutively activated ERK. AKT phosphorylation caused sensitivity and resistance to selumetinib. Our results suggest that a comprehensive network analysis may provide insights to identify effective therapies.

http://link.springer.com/10.1007/s10147-023-02318-w

Source: International Journal of Clinical Oncology - March 1, 2023 Category: Cancer & Oncology Source Type: research